The network for 'urea metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

urea metabolic process

The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2.

NameDescriptionProbabilityFunc Analog Organism
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.998
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.984
CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 190.953
CYP2C18cytochrome P450, family 2, subfamily C, polypeptide 180.706
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.580
CLTCclathrin, heavy chain (Hc)0.561
ADH6alcohol dehydrogenase 6 (class V)0.456
ALDOBaldolase B, fructose-bisphosphate0.409
NAT2N-acetyltransferase 2 (arylamine N-acetyltransferase)0.350
HIP1huntingtin interacting protein 10.333
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.278
CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 60.232
TADA3transcriptional adaptor 30.201
SULT1B1sulfotransferase family, cytosolic, 1B, member 10.192
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.167
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.163
CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 120.159
AADACarylacetamide deacetylase (esterase)0.154
CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 430.131
NCOA1nuclear receptor coactivator 10.122
ANXA10annexin A100.119
CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 40.117
HAO1hydroxyacid oxidase (glycolate oxidase) 10.100
ELP4elongation protein 4 homolog (S. cerevisiae)0.099
FABP1fatty acid binding protein 1, liver0.092
CYP2D6cytochrome P450, family 2, subfamily D, polypeptide 60.090
TTPAtocopherol (alpha) transfer protein0.088
ASCC2activating signal cointegrator 1 complex subunit 20.077
CLTCL1clathrin, heavy chain-like 10.073
ACRV1acrosomal vesicle protein 10.070
HRGhistidine-rich glycoprotein0.067
BAATbile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)0.064
PDCD7programmed cell death 70.059
AGXT2alanine--glyoxylate aminotransferase 20.058
FMO4flavin containing monooxygenase 40.058
ENTPD5ectonucleoside triphosphate diphosphohydrolase 50.057
SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.056
CYP4F3cytochrome P450, family 4, subfamily F, polypeptide 30.054
GSTA3glutathione S-transferase alpha 30.052
C8Bcomplement component 8, beta polypeptide0.050
GPLD1glycosylphosphatidylinositol specific phospholipase D10.049
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.049
AKR1C4aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)0.049
SLC22A1solute carrier family 22 (organic cation transporter), member 10.048
SERPINB9serpin peptidase inhibitor, clade B (ovalbumin), member 90.048
LAMC3laminin, gamma 30.048
F11coagulation factor XI0.047
MAT1Amethionine adenosyltransferase I, alpha0.046
GYS2glycogen synthase 2 (liver)0.046
ELP3elongation protein 3 homolog (S. cerevisiae)0.046
OTCornithine carbamoyltransferase0.044
ELP2elongation protein 2 homolog (S. cerevisiae)0.043
CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 80.043
HGDhomogentisate 1,2-dioxygenase0.043
POU2F1POU class 2 homeobox 10.042
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 20.042
GATMglycine amidinotransferase (L-arginine:glycine amidinotransferase)0.041
SLC2A2solute carrier family 2 (facilitated glucose transporter), member 20.040
ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.040
DNM1dynamin 10.040
XDHxanthine dehydrogenase0.039
RAB3DRAB3D, member RAS oncogene family0.038
ORM1orosomucoid 10.038
DNASE1L3deoxyribonuclease I-like 30.037
SGSM2small G protein signaling modulator 20.037
CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 10.036
ITIH4inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)0.036
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.036
PON1paraoxonase 10.035
F13Bcoagulation factor XIII, B polypeptide0.035
ARG1arginase, liver0.034
GBA3glucosidase, beta, acid 3 (cytosolic)0.034
UGT2B15UDP glucuronosyltransferase 2 family, polypeptide B150.033
ANGPTL3angiopoietin-like 30.032
HOXB7homeobox B70.031
MEP1Bmeprin A, beta0.031
MAST1microtubule associated serine/threonine kinase 10.031
CYP7A1cytochrome P450, family 7, subfamily A, polypeptide 10.031
MTTPmicrosomal triglyceride transfer protein0.030
AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)0.030
SERPINB4serpin peptidase inhibitor, clade B (ovalbumin), member 40.029
A1CFAPOBEC1 complementation factor0.029
SERPINA7serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 70.028
HAVCR1hepatitis A virus cellular receptor 10.028
FASLGFas ligand (TNF superfamily, member 6)0.028
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)0.027
CPB2carboxypeptidase B2 (plasma)0.027
HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)0.027
MAN2A2mannosidase, alpha, class 2A, member 20.026
HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.026
APOBEC1apolipoprotein B mRNA editing enzyme, catalytic polypeptide 10.026
FOXO1forkhead box O10.026
ATP10BATPase, class V, type 10B0.026
KLKB1kallikrein B, plasma (Fletcher factor) 10.025
C9orf68chromosome 9 open reading frame 680.025
HSD17B2hydroxysteroid (17-beta) dehydrogenase 20.024
TM4SF4transmembrane 4 L six family member 40.024
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.781
Insrinsulin receptor0.470
Apoeapolipoprotein E0.445
Stat3signal transducer and activator of transcription 30.432
Cav1caveolin 1, caveolae protein0.266
Rxraretinoid X receptor alpha0.225
Pnpla2patatin-like phospholipase domain containing 20.124
Plin1perilipin 10.123
Scd1stearoyl-Coenzyme A desaturase 10.122
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.119
Siglec5sialic acid binding Ig-like lectin 50.106
Trp53transformation related protein 530.105
Lrp1low density lipoprotein receptor-related protein 10.079
Nos3nitric oxide synthase 3, endothelial cell0.076
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.064
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.059
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.052
Csf1colony stimulating factor 1 (macrophage)0.051
Tgfb1transforming growth factor, beta 10.049
Pthlhparathyroid hormone-like peptide0.047
Ppargperoxisome proliferator activated receptor gamma0.044
Nos1nitric oxide synthase 1, neuronal0.035
Agpat21-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)0.030
Ncoa3nuclear receptor coactivator 30.029
Foxo1forkhead box O10.027
Nos2nitric oxide synthase 2, inducible0.027
Igf1insulin-like growth factor 10.026
Npc1Niemann Pick type C10.026
Esr1estrogen receptor 1 (alpha)0.025
Ptgs2prostaglandin-endoperoxide synthase 20.024
Nr1i2nuclear receptor subfamily 1, group I, member 20.023
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.022
Il6stinterleukin 6 signal transducer0.022
Btrcbeta-transducin repeat containing protein0.021
Adipoqadiponectin, C1Q and collagen domain containing0.020
Rdh16retinol dehydrogenase 160.019
Klk1b4kallikrein 1-related pepidase b40.018
Trib1tribbles homolog 1 (Drosophila)0.018
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.018
Lipelipase, hormone sensitive0.017
Bhlhe41basic helix-loop-helix family, member e410.017
Fam20cfamily with sequence similarity 20, member C0.016
Fabp1fatty acid binding protein 1, liver0.016
Abca3ATP-binding cassette, sub-family A (ABC1), member 30.016
Cideccell death-inducing DFFA-like effector c0.016
Cyp3a13cytochrome P450, family 3, subfamily a, polypeptide 130.015
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.015
Ldlrlow density lipoprotein receptor0.015
Hnf4ahepatic nuclear factor 4, alpha0.015
Esrraestrogen related receptor, alpha0.014
Nr1h4nuclear receptor subfamily 1, group H, member 40.014
Sult1b1sulfotransferase family 1B, member 10.014
Sult1d1sulfotransferase family 1D, member 10.014
Apoa4apolipoprotein A-IV0.013
Smad3MAD homolog 3 (Drosophila)0.013
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.013
Fabp2fatty acid binding protein 2, intestinal0.013
Bscl2Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)0.012
Pkm2pyruvate kinase, muscle0.012
Ltbrlymphotoxin B receptor0.012
Lrp5low density lipoprotein receptor-related protein 50.012
Zbtb7bzinc finger and BTB domain containing 7B0.011
Otcornithine transcarbamylase0.011
Rab17RAB17, member RAS oncogene family0.011
Ptpn11protein tyrosine phosphatase, non-receptor type 110.011
Cyp2b10cytochrome P450, family 2, subfamily b, polypeptide 100.011
Sik3SIK family kinase 30.011
Bhlhe40basic helix-loop-helix family, member e400.011
Nr0b2nuclear receptor subfamily 0, group B, member 20.010
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.010
Klk1b1kallikrein 1-related peptidase b10.010
Lipalysosomal acid lipase A0.010
Gcgrglucagon receptor0.010
Axin1axin 10.010
Aldobaldolase B, fructose-bisphosphate0.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gcgroup specific component0.421
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.402
Hrghistidine-rich glycoprotein0.297
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.241
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.238
Pzppregnancy-zone protein0.206
Pahphenylalanine hydroxylase0.192
Pklrpyruvate kinase, liver and RBC0.150
Tdo2tryptophan 2,3-dioxygenase0.121
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.120
Fbp1fructose-1,6-bisphosphatase 10.101
Itih4inter alpha-trypsin inhibitor, heavy chain 40.101
Fgafibrinogen alpha chain0.093
Aadataminoadipate aminotransferase0.089
Aldobaldolase B, fructose-bisphosphate0.082
Hsd17b6hydroxysteroid (17-beta) dehydrogenase 60.066
Cpb2carboxypeptidase B2 (plasma)0.058
Otcornithine carbamoyltransferase0.055
F2coagulation factor II (thrombin)0.054
Aqp8aquaporin 80.051
Gnmtglycine N-methyltransferase0.049
Dakdihydroxyacetone kinase 2 homolog (S. cerevisiae)0.045
Fetubfetuin B0.043
Prlrprolactin receptor0.042
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.041
Apobapolipoprotein B0.038
Slc17a1solute carrier family 17 (sodium phosphate), member 10.038
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.038
Kynukynureninase (L-kynurenine hydrolase)0.037
Apohapolipoprotein H (beta-2-glycoprotein I)0.031
Acsm2acyl-CoA synthetase medium-chain family member 20.030
Mbl2mannose-binding lectin (protein C) 20.029
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.029
Pelopelota homolog (Drosophila)0.027
Apoa1apolipoprotein A-I0.025
Tattyrosine aminotransferase0.024
Lipclipase, hepatic0.022
Agxt2alanine-glyoxylate aminotransferase 20.022
Faahfatty acid amide hydrolase0.021
Qprtquinolinate phosphoribosyltransferase0.019
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.018
Slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.018
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.018
Rup2urinary protein 20.016
LOC293989cytochrome P450-like0.015
Mat1amethionine adenosyltransferase I, alpha0.015
Azgp1alpha-2-glycoprotein 1, zinc-binding0.014
Fggfibrinogen gamma chain0.014
Akr1c12aldo-keto reductase family 1, member C120.014
Fam35afamily with sequence similarity 35, member A0.014
Cficomplement factor I0.013
Hpgdshematopoietic prostaglandin D synthase0.012
Uoxurate oxidase0.012
Nipsnap1nipsnap homolog 1 (C. elegans)0.012
Slc23a1solute carrier family 23 (nucleobase transporters), member 10.012
Ddx41DEAD (Asp-Glu-Ala-Asp) box polypeptide 410.012
C9complement component 90.012
Stxbp2syntaxin binding protein 20.011
Cyp2c12cytochrome P450, family 2, subfamily c, polypeptide 120.011
Cyp2c7cytochrome P450, family 2, subfamily c, polypeptide 70.011
Aspgasparaginase homolog (S. cerevisiae)0.011
Cbscystathionine beta synthase0.011
Apoa2apolipoprotein A-II0.010