The network for 'regulation of vacuole organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of vacuole organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.

Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PEP5Pep5p0.978
VAM6Vam6p0.924
PEP3Pep3p0.921
VPS16Vps16p0.896
RHO1Rho1p0.740
VPS41Vps41p0.545
VAM7Vam7p0.244
PGK1Pgk1p0.243
ENO1Eno1p0.185
TPI1Tpi1p0.135
VPS33Vps33p0.110
VPS3Vps3p0.108
ENO2Eno2p0.103
RDI1Rdi1p0.096
ERR3Err3p0.085
CNB1Cnb1p0.061
RHO4Rho4p0.059
MON1Mon1p0.058
FBA1Fba1p0.057
GPM1Gpm1p0.055
SGE1Sge1p0.054
VPS15Vps15p0.051
PRS2Prs2p0.050
VPS38Vps38p0.047
DNF1Dnf1p0.045
APL5Apl5p0.044
GEA2Gea2p0.043
MER1Mer1p0.041
CDC19Cdc19p0.040
ADH1Adh1p0.039
DRS2Drs2p0.039
YPT7Ypt7p0.037
RUP1Rup1p0.037
SRD1Srd1p0.032
FAA2Faa2p0.032
CPD1Cpd1p0.031
THG1Thg1p0.031
STP2Stp2p0.031
IML1Iml1p0.030
PGI1Pgi1p0.028
GLN1Gln1p0.027
AAP1Aap1p0.027
ARP10Arp10p0.026
YNL058Chypothetical protein0.026
GET4Get4p0.026
YOL038C-Ahypothetical protein0.026
BEM4Bem4p0.025
YPL109Chypothetical protein0.025
ZPS1Zps1p0.025
LEU2Leu2p0.025
VAM3Vam3p0.024
YLR162Whypothetical protein0.024
NVJ1Nvj1p0.024
YLR264C-Ahypothetical protein0.023
ABM1Abm1p0.023
YAR068Whypothetical protein0.023
SAC7Sac7p0.023
ADH2Adh2p0.022
VPS8Vps8p0.022
DAL81Dal81p0.022
GSH2Gsh2p0.022
PEP7Pep7p0.021
DIF1Dif1p0.021
TYE7Tye7p0.021
SEC4Sec4p0.021
MON2Mon2p0.021
URA3Ura3p0.021
PPX1Ppx1p0.021
YMR1Ymr1p0.020
VPS21Vps21p0.020
GPR1Gpr1p0.020
OPT2Opt2p0.020
AAD6Aad6p0.020
YPR157Whypothetical protein0.020
SCP1Scp1p0.020
CHS1Chs1p0.020
RCY1Rcy1p0.020
HOR2Hor2p0.020
YLR042Chypothetical protein0.020
DUR1,2Dur1,2p0.019
ATP6Atp6p0.019
ICS2Ics2p0.019
CUP1-1Cup1-1p0.019
ARE2Are2p0.019
BNA4Bna4p0.019
UBC6Ubc6p0.019
ECT1Ect1p0.019
PMA2Pma2p0.019
GIC2Gic2p0.018
TSC3Tsc3p0.018
HPF1Hpf1p0.018
YAR066Whypothetical protein0.018
YBR013Chypothetical protein0.018
YIP3Yip3p0.018
VPS45Vps45p0.017
AUA1Aua1p0.017
ARR2Arr2p0.017
YOL013W-Ahypothetical protein0.017
YPR063Chypothetical protein0.017
VID24Vid24p0.017
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.253
MON1BMON1 homolog B (yeast)0.245
IRS1insulin receptor substrate 10.103
MTMR12myotubularin related protein 120.088
MTM1myotubularin 10.042
RRAGARas-related GTP binding A0.037
GOLGA2golgin A20.034
LAMTOR1late endosomal/lysosomal adaptor, MAPK and MTOR activator 10.029
TNFAIP1tumor necrosis factor, alpha-induced protein 1 (endothelial)0.020
PTPN23protein tyrosine phosphatase, non-receptor type 230.019
TSG101tumor susceptibility gene 1010.017
INSRinsulin receptor0.015
IRS2insulin receptor substrate 20.015
GRB10growth factor receptor-bound protein 100.013
SH3GL2SH3-domain GRB2-like 20.011
RHOAras homolog gene family, member A0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rac1RAS-related C3 botulinum substrate 10.993
Grb10growth factor receptor bound protein 100.563
Mtormechanistic target of rapamycin (serine/threonine kinase)0.220
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.210
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.185
Igf2rinsulin-like growth factor 2 receptor0.135
Apehacylpeptide hydrolase0.124
Irs2insulin receptor substrate 20.121
Ift57intraflagellar transport 57 homolog (Chlamydomonas)0.108
Dalrd3DALR anticodon binding domain containing 30.108
Mlf2myeloid leukemia factor 20.101
Rap1bRAS related protein 1b0.095
Kif3akinesin family member 3A0.094
Slc25a11solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 110.092
Nptnneuroplastin0.092
Igf2insulin-like growth factor 20.088
Wbp1WW domain binding protein 10.088
Wdr1WD repeat domain 10.082
Sdcbpsyndecan binding protein0.081
Pef1penta-EF hand domain containing 10.080
Tecrtrans-2,3-enoyl-CoA reductase0.075
Capza2capping protein (actin filament) muscle Z-line, alpha 20.073
Sik3SIK family kinase 30.072
Arhgap1Rho GTPase activating protein 10.072
Arf4ADP-ribosylation factor 40.069
Gdi2guanosine diphosphate (GDP) dissociation inhibitor 20.065
Arcn1archain 10.061
Arl8bADP-ribosylation factor-like 8B0.061
Rnf167ring finger protein 1670.060
Mrpl10mitochondrial ribosomal protein L100.056
Arf1ADP-ribosylation factor 10.055
Rnd3Rho family GTPase 30.048
Nr1h2nuclear receptor subfamily 1, group H, member 20.048
Ssr3signal sequence receptor, gamma0.048
Copb1coatomer protein complex, subunit beta 10.048
Azin1antizyme inhibitor 10.048
Mapkap1mitogen-activated protein kinase associated protein 10.047
Smpd2sphingomyelin phosphodiesterase 2, neutral0.047
Bsgbasigin0.047
Stx7syntaxin 70.046
Actr3ARP3 actin-related protein 3 homolog (yeast)0.046
Fam108afamily with sequence similarity 108, member A0.045
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.044
Atp6v0d1ATPase, H+ transporting, lysosomal V0 subunit D10.044
Rab5aRAB5A, member RAS oncogene family0.043
Nedd4neural precursor cell expressed, developmentally down-regulated 40.043
Arl1ADP-ribosylation factor-like 10.041
Vps25vacuolar protein sorting 25 (yeast)0.040
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.040
Dhrs1dehydrogenase/reductase (SDR family) member 10.040
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.039
Sim1single-minded homolog 1 (Drosophila)0.039
Igf1rinsulin-like growth factor I receptor0.038
Rnf115ring finger protein 1150.038
Cftrcystic fibrosis transmembrane conductance regulator homolog0.038
Morf4l2mortality factor 4 like 20.037
Snx2sorting nexin 20.037
Eif5eukaryotic translation initiation factor 50.036
2510006D16RikRIKEN cDNA 2510006D16 gene0.036
Ift81intraflagellar transport 81 homolog (Chlamydomonas)0.035
Snap23synaptosomal-associated protein 230.035
Rhoaras homolog gene family, member A0.035
RictorRPTOR independent companion of MTOR, complex 20.034
Ppargperoxisome proliferator activated receptor gamma0.034
Adssadenylosuccinate synthetase, non muscle0.032
Dusp1dual specificity phosphatase 10.032
0610031J06RikRIKEN cDNA 0610031J06 gene0.032
Cltcclathrin, heavy polypeptide (Hc)0.031
Akap8lA kinase (PRKA) anchor protein 8-like0.031
Sec22bSEC22 vesicle trafficking protein homolog B (S. cerevisiae)0.031
Brebrain and reproductive organ-expressed protein0.031
Sh3glb2SH3-domain GRB2-like endophilin B20.030
Rab18RAB18, member RAS oncogene family0.029
Ddx3xDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked0.029
Mgrn1mahogunin, ring finger 10.029
Nprl2nitrogen permease regulator-like 2 (S. cerevisiae)0.028
Stxbp3asyntaxin binding protein 3A0.028
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.028
Pex19peroxisomal biogenesis factor 190.028
Uck1uridine-cytidine kinase 10.028
MlxMAX-like protein X0.028
Vapavesicle-associated membrane protein, associated protein A0.027
FosFBJ osteosarcoma oncogene0.027
Foxg1forkhead box G10.027
Ube2d3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.027
Atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.027
Aesamino-terminal enhancer of split0.027
Tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 30.026
Josd2Josephin domain containing 20.026
Ciao1cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)0.026
Rnf5ring finger protein 50.026
Trnt1tRNA nucleotidyl transferase, CCA-adding, 10.025
Nr1h4nuclear receptor subfamily 1, group H, member 40.025
Smurf2SMAD specific E3 ubiquitin protein ligase 20.025
Vps35vacuolar protein sorting 350.025
Vps26avacuolar protein sorting 26 homolog A (yeast)0.025
Nrbp1nuclear receptor binding protein 10.025
Uso1USO1 homolog, vesicle docking protein (yeast)0.024
Serp1stress-associated endoplasmic reticulum protein 10.024
Sepn1selenoprotein N, 10.024
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism