The network for 'positive regulation of lyase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of lyase activity

Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.

NameDescriptionProbabilityFunc Analog Organism
UBI4Ubi4p0.016
MRT4Mrt4p0.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
adrb2aadrenergic receptor, beta 2a0.467
nf1aneurofibromin 1a0.334
calcrlacalcitonin receptor-like a0.104
LOC559201similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3)0.074
nf1bneurofibromin 1b0.065
si:ch211-14k19.8si:ch211-14k19.80.060
plp1bproteolipid protein 1b0.051
uts1urotensin 10.041
LOC555482tachykinin receptor 3-like0.041
grk7aG-protein-coupled receptor kinase 7a0.035
LOC555504novel protocadherin protein0.032
pdlim1PDZ and LIM domain 1 (elfin)0.031
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.031
ryr2aryanodine receptor 2a (cardiac)0.030
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.029
vegfabvascular endothelial growth factor Ab0.029
gc3guanylyl cyclase 30.029
LOC569642hypothetical protein LOC5696420.027
pmchpro-melanin concentrating hormone0.025
gap43growth associated protein 430.024
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.024
sagbS-antigen; retina and pineal gland (arrestin) b0.023
mpp5bmembrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5b)0.022
sagaS-antigen; retina and pineal gland (arrestin) a0.022
pdcaphosducin a0.020
mpzmyelin protein zero0.020
guca1cguanylate cyclase activator 1C0.019
lhbluteinizing hormone, beta polypeptide0.018
irx4biroquois homeobox protein 4b0.017
syt11asynaptotagmin XIa0.017
cldnkclaudin k0.017
alkanaplastic lymphoma kinase (Ki-1)0.016
fgf13bfibroblast growth factor 13b0.016
zgc:162213zgc:1622130.016
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.015
prdx4peroxiredoxin 40.014
npbneuropeptide B0.013
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.013
palmparalemmin0.013
cyb5r4cytochrome b5 reductase 40.013
terttelomerase reverse transcriptase0.013
arr3aarrestin 3a, retinal (X-arrestin)0.013
guca1dguanylate cyclase activator 1d0.013
trpc1transient receptor potential cation channel, subfamily C, member 10.012
thrbthyroid hormone receptor beta0.011
tsc2tuberous sclerosis 20.011
ywhag13-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 10.011
penkaproenkephalin a0.011
rs1retinoschisis (X-linked, juvenile) 10.010
eng2aengrailed 2a0.010
adora2aaadenosine A2a receptor a0.010
pi4kbphosphatidylinositol 4-kinase, catalytic, beta0.010
adrb2badrenergic receptor, beta 2b0.010
bsk146brain specific kinase 1460.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG13253CG13253 gene product from transcript CG13253-RB0.813
Octbeta2RCG33976 gene product from transcript CG33976-RA0.724
TbhTyramine beta hydroxylase0.460
oa2octopamine receptor 20.281
VmatVesicular monoamine transporter0.197
perperiod0.177
PIP5K59BCG3682 gene product from transcript CG3682-RE0.170
fd85Eforkhead domain 85E0.128
CG31146CG31146 gene product from transcript CG31146-RD0.100
CG34400CG34400 gene product from transcript CG34400-RD0.100
Ank2Ankyrin 20.086
CG34353CG34353 gene product from transcript CG34353-RA0.067
ShawShaker cognate w0.067
mipleCG1221 gene product from transcript CG1221-RA0.058
RicRas which interacts with Calmodulin0.053
GluRIIAGlutamate receptor IIA0.051
CG3262CG3262 gene product from transcript CG3262-RD0.051
tauCG31057 gene product from transcript CG31057-RA0.047
5-HT1ASerotonin receptor 1A0.046
CG9997CG9997 gene product from transcript CG9997-RA0.043
CaMKIICalcium/calmodulin-dependent protein kinase II0.042
jebjelly belly0.036
CRMPCollapsin Response Mediator Protein0.035
CG12187CG12187 gene product from transcript CG12187-RA0.035
Ast-CAllatostatin C0.034
Nmdar1NMDA receptor 10.033
CG18437CG18437 gene product from transcript CG18437-RB0.032
crycryptochrome0.030
CG14191CG14191 gene product from transcript CG14191-RA0.030
CCKLR-17D1CCK-like receptor at 17D10.030
RanBPMRan-binding protein M0.028
nordCG30418 gene product from transcript CG30418-RA0.026
neuroliginCG13772 gene product from transcript CG13772-RA0.026
Gienovel GTPase indispensable for equal segregation of chromosomes0.025
Task6CG9637 gene product from transcript CG9637-RC0.025
Ilp2Insulin-like peptide 20.025
timtimeless0.024
mGluRAmetabotropic glutamate receptor0.022
RdlResistant to dieldrin0.021
ST6GalSialyltransferase0.021
Fer248 related 20.021
CG14989CG14989 gene product from transcript CG14989-RB0.020
CG7646CG7646 gene product from transcript CG7646-RB0.020
5-HT1BSerotonin receptor 1B0.019
CG34139CG34139 gene product from transcript CG34139-RD0.019
Cpr97EbCuticular protein 97Eb0.019
Ilp3Insulin-like peptide 30.018
CG9335CG9335 gene product from transcript CG9335-RA0.018
G-oalpha47AG protein oalpha 47A0.018
Atf-2Activating transcription factor-20.018
SP2353CG8403 gene product from transcript CG8403-RA0.018
ClkClock0.017
brpbruchpilot0.016
pdfrPDF receptor0.016
Pdp1PAR-domain protein 10.016
Sh3betaCG8582 gene product from transcript CG8582-RD0.014
CG6983CG6983 gene product from transcript CG6983-RA0.014
DskDrosulfakinin0.013
fuslfuseless0.013
pHClCG33989 gene product from transcript CG33989-RD0.013
CG10804CG10804 gene product from transcript CG10804-RB0.012
GluClalphaCG7535 gene product from transcript CG7535-RG0.012
DmsDromyosuppressin0.012
SamDCS-adenosylmethionine decarboxylase0.012
CG3907CG3907 gene product from transcript CG3907-RB0.012
CG16778CG16778 gene product from transcript CG16778-RA0.012
TuspCG5586 gene product from transcript CG5586-RE0.011
CG13920CG13920 gene product from transcript CG13920-RA0.011
PtenCG5671 gene product from transcript CG5671-RB0.011
CG6329CG6329 gene product from transcript CG6329-RA0.011
Frq2Frequenin 20.011
Tdc2Tyrosine decarboxylase 20.011
calscalsyntenin-10.011
emcextra macrochaetae0.011
dpr14CG10946 gene product from transcript CG10946-RA0.010
Teh4tipE homolog 40.010
ActbetaActivin-beta0.010
CanA1Calcineurin A10.010
CG1909CG1909 gene product from transcript CG1909-RA0.010
CG3625CG3625 gene product from transcript CG3625-RC0.010
igligloo0.010
2mitCG42573 gene product from transcript CG42573-RA0.010
unc-13-4ACG32381 gene product from transcript CG32381-RB0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CALM1calmodulin 1 (phosphorylase kinase, delta)0.902
NOSTRINnitric oxide synthase trafficker0.636
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.584
DRD2dopamine receptor D20.494
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.269
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.176
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.143
VAC14Vac14 homolog (S. cerevisiae)0.114
CRHcorticotropin releasing hormone0.108
MPDZmultiple PDZ domain protein0.096
ADORA2Aadenosine A2a receptor0.057
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.056
GFI1Bgrowth factor independent 1B transcription repressor0.047
RIN1Ras and Rab interactor 10.045
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.043
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.040
RASSF5Ras association (RalGDS/AF-6) domain family member 50.030
RALBP1ralA binding protein 10.030
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.030
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.029
MEOX2mesenchyme homeobox 20.029
RASSF1Ras association (RalGDS/AF-6) domain family member 10.026
ADORA1adenosine A1 receptor0.025
SOD1superoxide dismutase 1, soluble0.024
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.021
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.021
DTX2deltex homolog 2 (Drosophila)0.020
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.019
PAWRPRKC, apoptosis, WT1, regulator0.019
RALGDSral guanine nucleotide dissociation stimulator0.019
ARRDC3arrestin domain containing 30.017
DAXXdeath-domain associated protein0.016
NAMPTnicotinamide phosphoribosyltransferase0.016
AKAP10A kinase (PRKA) anchor protein 100.015
ROD1ROD1 regulator of differentiation 1 (S. pombe)0.014
HTR1A5-hydroxytryptamine (serotonin) receptor 1A0.014
SRIsorcin0.013
STK3serine/threonine kinase 30.013
TSHRthyroid stimulating hormone receptor0.013
NELL2NEL-like 2 (chicken)0.013
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.012
ADRB3adrenergic, beta-3-, receptor0.012
ABL2v-abl Abelson murine leukemia viral oncogene homolog 20.012
RAP2BRAP2B, member of RAS oncogene family0.012
PEBP1phosphatidylethanolamine binding protein 10.012
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.011
RAMP3receptor (G protein-coupled) activity modifying protein 30.011
SSTR3somatostatin receptor 30.011
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.011
KCNH1potassium voltage-gated channel, subfamily H (eag-related), member 10.011
NECAB2N-terminal EF-hand calcium binding protein 20.011
BAG1BCL2-associated athanogene0.011
GPR6G protein-coupled receptor 60.011
HTR45-hydroxytryptamine (serotonin) receptor 40.011
NOS1APnitric oxide synthase 1 (neuronal) adaptor protein0.011
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Klklotho0.854
Drd2dopamine receptor D20.508
Adrb1adrenergic receptor, beta 10.313
Esr1estrogen receptor 1 (alpha)0.230
Ptenphosphatase and tensin homolog0.175
Leprleptin receptor0.158
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.126
Pnpla2patatin-like phospholipase domain containing 20.123
Ppargperoxisome proliferator activated receptor gamma0.110
Pax8paired box gene 80.109
Tgfb1transforming growth factor, beta 10.106
Cdkn1bcyclin-dependent kinase inhibitor 1B0.094
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.089
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.088
Nos3nitric oxide synthase 3, endothelial cell0.088
Adam17a disintegrin and metallopeptidase domain 170.086
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.080
Thrbthyroid hormone receptor beta0.071
Trp53transformation related protein 530.071
BrafBraf transforming gene0.069
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.069
Rhorhodopsin0.064
Ghrgrowth hormone receptor0.063
Arandrogen receptor0.049
Cckbrcholecystokinin B receptor0.045
Adrb3adrenergic receptor, beta 30.045
Hif1ahypoxia inducible factor 1, alpha subunit0.044
Fshrfollicle stimulating hormone receptor0.044
Ptpn11protein tyrosine phosphatase, non-receptor type 110.043
Oprk1opioid receptor, kappa 10.041
Crhr1corticotropin releasing hormone receptor 10.040
Grid1glutamate receptor, ionotropic, delta 10.040
Lhcgrluteinizing hormone/choriogonadotropin receptor0.037
Mc5rmelanocortin 5 receptor0.035
Lhx6LIM homeobox protein 60.035
Sstr4somatostatin receptor 40.035
Kcnd1potassium voltage-gated channel, Shal-related family, member 10.030
Shc3src homology 2 domain-containing transforming protein C30.029
Amhr2anti-Mullerian hormone type 2 receptor0.029
Cgaglycoprotein hormones, alpha subunit0.028
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.028
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.027
Mdm2transformed mouse 3T3 cell double minute 20.027
Ctnnb1catenin (cadherin associated protein), beta 10.026
Krt86keratin 860.025
Adora2aadenosine A2a receptor0.025
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.025
Vipvasoactive intestinal polypeptide0.024
Lepleptin0.024
Gpr27G protein-coupled receptor 270.024
Slc12a1solute carrier family 12, member 10.023
Duox2dual oxidase 20.022
Tpothyroid peroxidase0.022
Mmp24matrix metallopeptidase 240.021
Tshrthyroid stimulating hormone receptor0.021
Pcsk2proprotein convertase subtilisin/kexin type 20.021
Fam164cfamily with sequence similarity 164, member C0.021
Actr3ARP3 actin-related protein 3 homolog (yeast)0.021
Vdrvitamin D receptor0.020
Fgf10fibroblast growth factor 100.020
Sult4a1sulfotransferase family 4A, member 10.020
Gsx1GS homeobox 10.020
Slc16a8solute carrier family 16 (monocarboxylic acid transporters), member 80.020
Npy5rneuropeptide Y receptor Y50.019
Npy2rneuropeptide Y receptor Y20.019
Nptx1neuronal pentraxin 10.019
Cbln1cerebellin 1 precursor protein0.018
RorbRAR-related orphan receptor beta0.018
Plxna1plexin A10.018
Gnrhrgonadotropin releasing hormone receptor0.018
Nr3c1nuclear receptor subfamily 3, group C, member 10.018
Trpm1transient receptor potential cation channel, subfamily M, member 10.017
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.017
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.017
Sntb1syntrophin, basic 10.017
Ptmsparathymosin0.017
Grm2glutamate receptor, metabotropic 20.017
Adra2aadrenergic receptor, alpha 2a0.017
Klk4kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)0.017
Mbmyoglobin0.017
Nrasneuroblastoma ras oncogene0.016
Chrm1cholinergic receptor, muscarinic 1, CNS0.015
Nxph2neurexophilin 20.015
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.015
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.015
Chrna6cholinergic receptor, nicotinic, alpha polypeptide 60.015
Foxf2forkhead box F20.015
Vav2vav 2 oncogene0.015
Khdc1bKH domain containing 1B0.014
Gng4guanine nucleotide binding protein (G protein), gamma 40.014
Htr75-hydroxytryptamine (serotonin) receptor 70.014
Trpv1transient receptor potential cation channel, subfamily V, member 10.014
Raf1v-raf-leukemia viral oncogene 10.013
Ptgs2prostaglandin-endoperoxide synthase 20.013
Rac1RAS-related C3 botulinum substrate 10.013
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.013
Ptafrplatelet-activating factor receptor0.013
Tacr2tachykinin receptor 20.013
Prkccprotein kinase C, gamma0.013
Inhbcinhibin beta-C0.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.112
Thbdthrombomodulin0.053
Ptp4a2protein tyrosine phosphatase 4a20.051
Kcnh3potassium voltage-gated channel, subfamily H (eag-related), member 30.045
Il8rainterleukin 8 receptor, alpha0.045
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.045
Nfascneurofascin0.041
Dynll1dynein light chain LC8-type 10.040
Sub1SUB1 homolog (S. cerevisiae)0.036
Htr75-hydroxytryptamine (serotonin) receptor 70.034
Fgf14fibroblast growth factor 140.029
Gpr176G protein-coupled receptor 1760.028
Adora1adenosine A1 receptor0.027
Csf1colony stimulating factor 1 (macrophage)0.027
Cckbrcholecystokinin B receptor0.026
Cdc34cell division cycle 34 homolog (S. cerevisiae)0.026
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.026
Gpr6G protein-coupled receptor 60.026
Rgs9regulator of G-protein signaling 90.023
Ncanneurocan0.023
Pdynprodynorphin0.023
Odf4outer dense fiber of sperm tails 40.023
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.022
Crhbpcorticotropin releasing hormone binding protein0.022
Sgp158proline-rich glycoprotein (sgp158)0.022
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.022
Grin3aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A0.021
Grin2cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.021
Pla2g2cphospholipase A2, group IIC0.020
Pgam1phosphoglycerate mutase 1 (brain)0.020
Hrh2histamine receptor H 20.020
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.020
Hpcahippocalcin0.020
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.020
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.019
Grik3glutamate receptor, ionotropic, kainate 30.019
Csrnp2cysteine-serine-rich nuclear protein 20.018
Scn10asodium channel, voltage-gated, type X, alpha subunit0.018
Sfrp4secreted frizzled-related protein 40.018
Rin1Ras and Rab interactor 10.018
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.018
Abcc9ATP-binding cassette, subfamily C (CFTR/MRP), member 90.018
Drd2dopamine receptor D20.017
Cav1caveolin 1, caveolae protein0.017
Agtr1aangiotensin II receptor, type 1a0.017
Olr1078olfactory receptor 10780.017
Tacr1tachykinin receptor 10.017
Hpcal4hippocalcin-like 40.016
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.016
Gad2glutamate decarboxylase 20.016
Cd14CD14 molecule0.016
Adora2aadenosine A2a receptor0.016
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.016
Gzmkgranzyme K0.016
Drd1adopamine receptor D1A0.016
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.016
Fkbp1aFK506 binding protein 1a0.016
Gnrh1gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)0.015
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.015
Mchr1melanin-concentrating hormone receptor 10.015
Kcnh6potassium voltage-gated channel, subfamily H (eag-related), member 60.015
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.015
Gabrdgamma-aminobutyric acid (GABA) A receptor, delta0.015
Rhorhodopsin0.015
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.014
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.014
Bap1BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)0.014
Kcnn3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 30.014
Pecam1platelet/endothelial cell adhesion molecule 10.014
Uhmk1U2AF homology motif (UHM) kinase 10.014
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.014
Ifitm3interferon induced transmembrane protein 30.014
Syt8synaptotagmin VIII0.014
Pde1bphosphodiesterase 1B, calmodulin-dependent0.014
Tubb3tubulin, beta 30.013
Cysscystatin S0.013
Adcyap1r1adenylate cyclase activating polypeptide 1 receptor 10.013
Cacng5calcium channel, voltage-dependent, gamma subunit 50.013
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.013
Unc5aunc-5 homolog A (C. elegans)0.013
NrarpNotch-regulated ankyrin repeat protein0.013
Arandrogen receptor0.013
Ppp2r2cprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform0.013
Calcacalcitonin-related polypeptide alpha0.013
Adam10ADAM metallopeptidase domain 100.013
Ap2s1adaptor-related protein complex 2, sigma 1 subunit0.013
Nrp2neuropilin 20.012
Ube2d4ubiquitin-conjugating enzyme E2D 40.012
Rgs12regulator of G-protein signaling 120.012
Chrna7cholinergic receptor, nicotinic, alpha 70.012
Prp15proline-rich protein 150.012
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.012
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.012
KlKlotho0.012
Kcnb2potassium voltage gated channel, Shab-related subfamily, member 20.012
Oprk1opioid receptor, kappa 10.012
Oxtroxytocin receptor0.012
Cxcr5chemokine (C-X-C motif) receptor 50.012
Adra1aadrenergic, alpha-1A-, receptor0.012
Cgm4carcinoembryonic antigen gene family 40.012