The network for 'negative regulation of macromolecule biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of macromolecule biosynthetic process

Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

NameDescriptionProbabilityFunc Analog Organism
RPD3Rpd3p0.999
RLF2Rlf2p0.994
SIR2Sir2p0.982
SIR4Sir4p0.981
HHT1Hht1p0.978
SIN3Sin3p0.975
RAP1Rap1p0.973
HDA1Hda1p0.959
CTI6Cti6p0.931
HOG1Hog1p0.931
HHF1Hhf1p0.925
SPT16Spt16p0.921
SUM1Sum1p0.915
SIN4Sin4p0.912
CTF18Ctf18p0.908
GCN5Gcn5p0.907
RCO1Rco1p0.904
RTT106Rtt106p0.903
PGD1Pgd1p0.898
RXT2Rxt2p0.895
SIR3Sir3p0.893
PHO23Pho23p0.888
CYC8Cyc8p0.876
SSN3Ssn3p0.871
RPN4Rpn4p0.867
RIF1Rif1p0.866
ROX3Rox3p0.852
SET1Set1p0.845
ISW2Isw2p0.844
ASF1Asf1p0.842
GAL11Gal11p0.841
GLC7Glc7p0.813
SNF5Snf5p0.801
SNF1Snf1p0.788
HDA3Hda3p0.781
ORC5Orc5p0.779
SDS3Sds3p0.769
UME1Ume1p0.763
SAS2Sas2p0.761
SNT1Snt1p0.752
HMO1Hmo1p0.747
SSN8Ssn8p0.741
ADR1Adr1p0.722
PLC1Plc1p0.711
MED2Med2p0.703
EAF3Eaf3p0.702
PRI1Pri1p0.696
HAT2Hat2p0.681
HRK1Hrk1p0.676
RIM101Rim101p0.674
RGR1Rgr1p0.673
SET3Set3p0.667
SCH9Sch9p0.664
HTB1Htb1p0.656
BDF1Bdf1p0.645
BMH1Bmh1p0.643
SAP30Sap30p0.641
KSP1Ksp1p0.638
AFT1Aft1p0.636
ORC2Orc2p0.619
BRE2Bre2p0.614
CDC6Cdc6p0.612
HHF2Hhf2p0.611
HAT1Hat1p0.608
ITC1Itc1p0.607
FKH2Fkh2p0.607
PUB1Pub1p0.607
TUP1Tup1p0.598
UME6Ume6p0.592
FUN30Fun30p0.591
DEP1Dep1p0.588
ORC3Orc3p0.588
MET4Met4p0.587
RLM1Rlm1p0.586
EAF1Eaf1p0.584
SPT21Spt21p0.583
ISW1Isw1p0.579
CSE2Cse2p0.578
LGE1Lge1p0.575
DHH1Dhh1p0.572
SAS4Sas4p0.566
PAP2Pap2p0.565
NUP133Nup133p0.561
SPT10Spt10p0.560
ZDS1Zds1p0.557
STM1Stm1p0.555
SUI3Sui3p0.554
IFH1Ifh1p0.548
MOT1Mot1p0.548
NTO1Nto1p0.547
VPS36Vps36p0.545
IZH4Izh4p0.542
DED1Ded1p0.541
NRG1Nrg1p0.535
UBP8Ubp8p0.532
CCR4Ccr4p0.528
SWD1Swd1p0.528
SRM1Srm1p0.527
TAF14Taf14p0.523
MED4Med4p0.510
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.973
elt-6Protein ELT-60.709
let-502Protein LET-5020.683
hlh-2Protein HLH-20.604
lin-53Protein LIN-530.525
pha-4Protein PHA-40.501
his-1Protein HIS-10.481
his-5Protein HIS-50.474
eya-1Protein EYA-10.468
hcp-3Protein HCP-30.422
his-46Protein HIS-460.395
mes-4Protein MES-40.380
his-31Protein HIS-310.361
his-16Protein HIS-160.358
nhr-2Protein NHR-20.343
csn-4Protein CSN-40.343
plk-3Protein PLK-30.332
his-64Protein HIS-640.328
lin-35Protein LIN-350.301
daf-14Protein DAF-140.283
his-68Protein HIS-680.274
B0464.2Protein B0464.20.268
ceh-27Protein CEH-270.264
zip-7Protein ZIP-70.259
spd-5Protein SPD-50.257
his-3Protein HIS-30.246
rsp-1Protein RSP-10.244
mab-5Protein MAB-50.234
his-52Protein HIS-520.233
nhr-67Protein NHR-670.230
mcm-2Protein MCM-20.228
unc-62Protein UNC-620.215
pry-1Protein PRY-10.215
rha-1Protein RHA-10.211
his-51Protein HIS-510.197
ztf-2Protein ZTF-20.196
CELE_T26A8.4Protein T26A8.40.192
egl-46Protein EGL-460.190
his-62Protein HIS-620.188
CELE_C24H12.5Protein C24H12.50.177
mix-1Protein MIX-10.177
rfp-1Protein RFP-10.173
CELE_F19F10.9Protein F19F10.90.171
fkh-2Protein FKH-20.170
his-4Protein HIS-40.166
lin-11Protein LIN-110.165
tbx-8Protein TBX-80.163
odd-2Protein ODD-20.163
drap-1Protein DRAP-10.159
lin-17Protein LIN-170.158
his-61Protein HIS-610.156
hil-2Protein HIL-20.155
hum-5Protein HUM-50.155
rnr-2Protein RNR-20.154
lin-40Protein LIN-400.150
peb-1Protein PEB-10.148
his-29Protein HIS-290.147
his-24Protein HIS-240.146
sur-2Protein SUR-20.146
his-42Protein HIS-420.144
unc-37Protein UNC-370.143
his-38Protein HIS-380.142
cam-1Protein CAM-10.140
mcm-7Protein MCM-70.139
egl-27Protein EGL-270.135
daf-1Protein DAF-10.134
asd-1Protein ASD-10.133
atg-2Protein ATG-20.133
xnd-1Protein XND-10.131
hlh-1Protein HLH-10.131
snr-2Protein SNR-20.130
egl-13Protein EGL-130.130
eor-1Protein EOR-10.129
dpy-22Protein DPY-220.129
mls-2Protein MLS-20.128
imb-2Protein IMB-20.127
CELE_K08F4.2Protein K08F4.20.125
wrm-1Protein WRM-10.123
hbl-1Protein HBL-10.121
nhr-25Protein NHR-250.120
npp-3Protein NPP-30.120
CELE_C12D8.1Protein C12D8.10.120
his-48Protein HIS-480.119
smp-1Protein SMP-10.119
his-47Protein HIS-470.118
mex-5Protein MEX-50.116
rad-26Protein RAD-260.115
daf-4Protein DAF-40.115
his-50Protein HIS-500.114
CELE_W03F9.10Protein W03F9.100.114
T28F4.1Protein T28F4.10.109
spr-5Protein SPR-50.109
hmg-1.1Protein HMG-1.10.109
ntl-2Protein NTL-20.108
edc-3Protein EDC-30.105
cnd-1Protein CND-10.105
hda-1Protein HDA-10.102
daf-21Protein DAF-210.101
rskn-2Protein RSKN-20.100
C50D2.5Protein C50D2.50.100
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.880
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.856
tbx1T-box 10.829
gata6GATA-binding protein 60.794
foxa3forkhead box A30.770
ndr2nodal-related 20.764
foxi1forkhead box I10.690
isl1islet10.686
dlx2adistal-less homeobox gene 2a0.619
notch1anotch homolog 1a0.549
igf1rbinsulin-like growth factor 1b receptor0.549
hey1hairy/enhancer-of-split related with YRPW motif 10.534
pou3f3aPOU class 3 homeobox 3a0.490
jag2jagged 20.477
sox9bSRY-box containing gene 9b0.476
dlx5adistal-less homeobox gene 5a0.463
dlx3bdistal-less homeobox gene 3b0.456
vcanaversican a0.428
mab21l2mab-21-like 20.425
gli1GLI-Kruppel family member 10.396
dlcdeltaC0.377
pcnaproliferating cell nuclear antigen0.375
wnt5bwingless-type MMTV integration site family, member 5b0.367
fgf3fibroblast growth factor 30.347
gbx2gastrulation brain homeo box 20.341
fgf8afibroblast growth factor 8 a0.340
sox19aSRY-box containing gene 19a0.333
tbx6T-box gene 60.331
egr1early growth response 10.330
sox1aSRY-box containing gene 1a0.323
wt1awilms tumor 1a0.311
spry4sprouty (Drosophila) homolog 40.302
fezf2FEZ family zinc finger 20.294
smosmoothened homolog (Drosophila)0.287
pax6apaired box gene 6a0.283
wnt2bbwingless-type MMTV integration site family, member 2Bb0.281
spawsouthpaw0.279
lhx1aLIM homeobox 1a0.277
fstafollistatin a0.276
hoxb1bhomeo box B1b0.276
whsc1Wolf-Hirschhorn syndrome candidate 10.271
lhx5LIM homeobox 50.265
gro1groucho 10.256
ripply1ripply10.247
her7hairy and enhancer of split related-70.244
hapln1ahyaluronan and proteoglycan link protein 1a0.238
vsx1visual system homeobox 1 homolog, chx10-like0.228
dlx1adistal-less homeobox gene 1a0.228
six4bsine oculis homeobox homolog 4b0.226
bmp4bone morphogenetic protein 40.222
gscgoosecoid0.211
gata3GATA-binding protein 30.211
twist3twist30.209
six2asine oculis-related homeobox 2a0.208
per2period homolog 2 (Drosophila)0.208
gcm2glial cells missing homolog 2 (Drosophila)0.206
snai1bsnail homolog 1b (Drosophila)0.204
robo3roundabout homolog 30.203
tbx24T-box 240.202
dlx6adistal-less homeobox gene 6a0.199
hmgb1bhigh-mobility group box 1b0.197
sox11bSRY-box containing gene 11b0.194
otx2orthodenticle homolog 20.189
notch1bnotch homolog 1b0.188
fgf19fibroblast growth factor 190.187
otx1borthodenticle homolog 1b0.186
six3bsine oculis homeobox homolog 3b0.182
pax8paired box gene 80.181
zic5zic family member 5 (odd-paired homolog, Drosophila)0.180
her11hairy-related 110.179
dlx4bdistal-less homeobox gene 4b0.178
tfap2btranscription factor AP-2 beta0.174
dnmt7DNA (cytosine-5-)-methyltransferase 70.174
opn4aopsin 4a (melanopsin)0.172
ptf1apancreas specific transcription factor, 1a0.172
kdrlkinase insert domain receptor like0.171
hoxd4ahomeo box D4a0.169
sox3SRY-box containing gene 30.168
nkx1.2laNK1 transcription factor related 2-like,a0.165
eya1eyes absent homolog 10.162
tcf7transcription factor 7 (T-cell specific, HMG-box)0.157
hmx1H6 homeo box 10.156
ppargperoxisome proliferator activated receptor gamma0.155
myod1myogenic differentiation 10.154
tfap2atranscription factor AP-2 alpha0.153
sox19bSRY-box containing gene 19b0.151
sox2SRY-box containing gene 20.150
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.149
aldh1a2aldehyde dehydrogenase 1 family, member A20.147
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.146
hp1bp3heterochromatin protein 1, binding protein 30.144
rxrgaretinoid x receptor, gamma a0.144
vsx2visual system homeobox 20.143
nova2neuro-oncological ventral antigen 20.143
nr2e1nuclear receptor subfamily 2, group E, member 10.142
hoxa5ahomeo box A5a0.140
gata2aGATA-binding protein 2a0.140
cbx2chromobox homolog 2 (Drosophila Pc class)0.139
spsb4asplA/ryanodine receptor domain and SOCS box containing 4a0.139
dusp6dual specificity phosphatase 60.138
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
IswiImitation SWI0.999
hephemipterous0.999
PclPolycomblike0.999
CTCFCG8591 gene product from transcript CG8591-RA0.997
Snr1Snf5-related 10.993
NNotch0.992
cicubitus interruptus0.992
Pp1-87BProtein phosphatase 1 at 87B0.989
Sir2CG5216 gene product from transcript CG5216-RA0.988
atoatonal0.988
Nf-YCNuclear factor Y-box C0.976
magomago nashi0.974
His2AvHistone H2A variant0.972
mormoira0.971
E(spl)Enhancer of split0.970
dcodiscs overgrown0.966
osaCG7467 gene product from transcript CG7467-RD0.965
ash1absent, small, or homeotic discs 10.963
ScmSex comb on midleg0.962
lwrlesswright0.961
escextra sexcombs0.956
slp1sloppy paired 10.955
gppgrappa0.953
D1D1 chromosomal protein0.952
brkbrinker0.950
panpangolin0.944
CycBCyclin B0.941
tlltailless0.932
shnschnurri0.932
Rpd3CG7471 gene product from transcript CG7471-RA0.931
nejnejire0.931
enengrailed0.926
SceSex combs extra0.922
Abd-BAbdominal B0.921
Fmr1CG6203 gene product from transcript CG6203-RC0.920
CtBPC-terminal Binding Protein0.917
Su(var)205Suppressor of variegation 2050.912
mrnmarionette0.910
UbxUltrabithorax0.909
gsbgooseberry0.909
MadMothers against dpp0.904
PcPolycomb0.904
knknot0.903
SerSerrate0.893
snasnail0.890
bratbrain tumor0.884
piwiCG6122 gene product from transcript CG6122-RA0.883
snostrawberry notch0.883
E(var)3-9Enhancer of variegation 3-90.878
mirrmirror0.872
alaristaless0.870
phylphyllopod0.858
stisticky0.852
TrlTrithorax-like0.851
HLHm7E(spl) region transcript m70.850
RbfRetinoblastoma-family protein0.847
dapdacapo0.846
pbproboscipedia0.842
abd-Aabdominal A0.841
smt3CG4494 gene product from transcript CG4494-RA0.841
CaMKIICalcium/calmodulin-dependent protein kinase II0.841
tantantalus0.840
Su(var)2-10Suppressor of variegation 2-100.838
domdomino0.835
hthhomothorax0.834
waplwings apart-like0.833
OptixCG18455 gene product from transcript CG18455-RA0.818
ushu-shaped0.813
grogroucho0.807
polybromoCG11375 gene product from transcript CG11375-RA0.799
kaykayak0.794
nubnubbin0.791
mammastermind0.785
hhairy0.782
HLHmdeltaE(spl) region transcript mdelta0.778
crmcramped0.775
poloCG12306 gene product from transcript CG12306-RA0.773
lolalongitudinals lacking0.772
araaraucan0.772
Su(z)12CG8013 gene product from transcript CG8013-RA0.772
Caf1Chromatin assembly factor 1 subunit0.768
E2f2E2F transcription factor 20.766
ssspineless0.764
apapterous0.763
acachaete0.760
emsempty spiracles0.759
BEAF-32Boundary element-associated factor of 32kD0.756
nmonemo0.750
wgwingless0.738
JraJun-related antigen0.732
Doc2Dorsocross20.732
InRInsulin-like receptor0.731
sqdsquid0.722
reptreptin0.717
CSN8COP9 complex homolog subunit 80.717
nabCG33545 gene product from transcript CG33545-RC0.717
CG9986CG9986 gene product from transcript CG9986-RA0.716
HLHmbetaE(spl) region transcript mbeta0.712
lealeak0.711
oddodd skipped0.708
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Junbjun B proto-oncogene0.857
FosFBJ osteosarcoma oncogene0.771
JunJun oncogene0.655
Btg2BTG family, member 20.629
Egr1early growth response 10.565
Dusp1dual specificity phosphatase 10.555
Sf1splicing factor 10.518
Tgfbr2transforming growth factor, beta receptor II0.503
Tcfe2atranscription factor E2a0.461
Metmet proto-oncogene0.403
Nedd4neural precursor cell expressed, developmentally down-regulated 40.377
Id1inhibitor of DNA binding 10.370
Ier2immediate early response 20.369
Socs3suppressor of cytokine signaling 30.353
Nr1d2nuclear receptor subfamily 1, group D, member 20.343
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.341
Nfibnuclear factor I/B0.335
Ubtfupstream binding transcription factor, RNA polymerase I0.332
Hnrnpkheterogeneous nuclear ribonucleoprotein K0.326
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.320
Hoxb7homeo box B70.312
Jak1Janus kinase 10.308
Neurog1neurogenin 10.303
Pim1pim-1 oncogene0.294
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.293
RGD1564664similar to LOC387763 protein0.287
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.278
Siah1aseven in absentia 1A0.274
Hoxc4homeo box C40.268
S100a8S100 calcium binding protein A80.253
Zfp36zinc finger protein 360.249
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.244
Nfianuclear factor I/A0.238
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.237
Klf2Kruppel-like factor 2 (lung)0.234
Grk1G protein-coupled receptor kinase 10.232
Klf4Kruppel-like factor 4 (gut)0.227
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.227
Hnrnprheterogeneous nuclear ribonucleoprotein R0.222
Ahraryl hydrocarbon receptor0.219
Add2adducin 2 (beta)0.219
Hes1hairy and enhancer of split 1 (Drosophila)0.217
Nr2f2nuclear receptor subfamily 2, group F, member 20.216
Fntafarnesyltransferase, CAAX box, alpha0.212
S100a6S100 calcium binding protein A60.211
Wbp11WW domain binding protein 110.209
Pgam1phosphoglycerate mutase 1 (brain)0.197
Foxe1forkhead box E1 (thyroid transcription factor 2)0.196
Atf3activating transcription factor 30.195
Tmem88transmembrane protein 880.195
Metap2methionyl aminopeptidase 20.195
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.194
Lnpepleucyl/cystinyl aminopeptidase0.191
Nr4a3nuclear receptor subfamily 4, group A, member 30.190
Cand1cullin-associated and neddylation-dissociated 10.187
Lzts2leucine zipper, putative tumor suppressor 20.182
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.181
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.180
Gzmbgranzyme B0.180
Usf2upstream transcription factor 2, c-fos interacting0.176
Arf6ADP-ribosylation factor 60.175
Ptpn1protein tyrosine phosphatase, non-receptor type 10.173
Gse1genetic suppressor element 10.173
Kcnt1potassium channel, subfamily T, member 10.169
Pde4bphosphodiesterase 4B, cAMP specific0.167
Eedembryonic ectoderm development0.167
Bmpr1abone morphogenetic protein receptor, type IA0.165
Eif4heukaryotic translation initiation factor 4H0.164
Trim47tripartite motif-containing 470.161
Csdacold shock domain protein A0.160
Kdm6blysine (K)-specific demethylase 6B0.160
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.158
Baiap2BAI1-associated protein 20.158
Nfyanuclear transcription factor-Y alpha0.155
S100a9S100 calcium binding protein A90.152
Arih1ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)0.151
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.149
Fgfr1Fibroblast growth factor receptor 10.149
Pcnaproliferating cell nuclear antigen0.149
Sp1Sp1 transcription factor0.149
Psma4proteasome (prosome, macropain) subunit, alpha type 40.147
Rxrbretinoid X receptor beta0.146
Ncr3natural cytotoxicity triggering receptor 30.142
Hdac2histone deacetylase 20.142
UncxUNC homeobox0.140
Prrx1paired related homeobox 10.140
Nr5a2nuclear receptor subfamily 5, group A, member 20.140
Eif1ayeukaryotic translation initiation factor 1A, Y-linked0.139
Mapk7mitogen-activated protein kinase 70.139
Rph3arabphilin 3A0.139
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.138
Palmparalemmin0.138
Csnk1g2casein kinase 1, gamma 20.137
Rab13RAB13, member RAS oncogene family0.136
Igfbp5insulin-like growth factor binding protein 50.134
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.132
Nononon-POU domain containing, octamer-binding0.131
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.130
Cxxc5CXXC finger 50.130
Rhobras homolog gene family, member B0.130