The network for 'posttranslational protein targeting to membrane' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

posttranslational protein targeting to membrane

The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.

NameDescriptionProbabilityFunc Analog Organism
SEC62Sec62p0.997
SBH1Sbh1p0.992
SEC63Sec63p0.991
SSS1Sss1p0.955
GET3Get3p0.938
SGT2Sgt2p0.887
MDY2Mdy2p0.834
SEC72Sec72p0.656
KAR2Kar2p0.488
SEC66Sec66p0.449
SEC61Sec61p0.425
ERP2Erp2p0.204
GET4Get4p0.144
WBP1Wbp1p0.118
OST4Ost4p0.098
GET1Get1p0.090
RPN14Rpn14p0.090
SBH2Sbh2p0.078
SIL1Sil1p0.073
CAF130Caf130p0.054
PRP45Prp45p0.046
SPC2Spc2p0.046
YLR264C-Ahypothetical protein0.043
SRD1Srd1p0.043
CUE4Cue4p0.042
OST2Ost2p0.040
RPL15BRpl15bp0.039
SWC7Swc7p0.038
SCJ1Scj1p0.037
LEU2Leu2p0.035
ARP10Arp10p0.032
YOL038C-Ahypothetical protein0.032
CUP1-1Cup1-1p0.031
SRP14Srp14p0.030
YLR042Chypothetical protein0.030
UBC4Ubc4p0.029
TSC3Tsc3p0.028
SPC1Spc1p0.027
YLR162Whypothetical protein0.027
MER1Mer1p0.027
ERO1Ero1p0.026
HXT3Hxt3p0.026
SAR1Sar1p0.026
YLR126Chypothetical protein0.024
ATP6Atp6p0.022
EGD1Egd1p0.021
SPL2Spl2p0.021
LCL2Lcl2p0.021
YSY6Ysy6p0.021
ERD2Erd2p0.021
YAR068Whypothetical protein0.021
YBR013Chypothetical protein0.021
REE1Ree1p0.021
YPR157Whypothetical protein0.020
ARG8Arg8p0.020
ZPS1Zps1p0.020
URA3Ura3p0.019
ARO10Aro10p0.019
UPS3Ups3p0.019
CPD1Cpd1p0.019
TYE7Tye7p0.019
HPF1Hpf1p0.019
NOP10Nop10p0.018
ERJ5Erj5p0.018
AUA1Aua1p0.018
BSC1Bsc1p0.018
FMT1Fmt1p0.018
YCH1Ych1p0.018
PMT1Pmt1p0.017
MF(ALPHA)2Mf(alpha)2p0.017
SEC20Sec20p0.017
YOL013W-Ahypothetical protein0.017
YDL085C-Ahypothetical protein0.017
YLR040Chypothetical protein0.017
YDL012Chypothetical protein0.017
YPL067Chypothetical protein0.016
CRP1Crp1p0.016
FMN1Fmn1p0.016
RPL41ARpl41ap0.015
OPT2Opt2p0.015
YJL107Chypothetical protein0.015
PTR2Ptr2p0.015
ALT2Alt2p0.015
GYL1Gyl1p0.014
LIF1Lif1p0.014
YER134Chypothetical protein0.014
YPR159C-Ahypothetical protein0.014
YKR075Chypothetical protein0.014
APA1Apa1p0.014
YIR035Chypothetical protein0.014
DIC1Dic1p0.014
NRG2Nrg2p0.014
JEM1Jem1p0.014
YPR096Chypothetical protein0.013
YAL064Whypothetical protein0.013
PRS2Prs2p0.013
YAL037C-Ahypothetical protein0.013
YAR066Whypothetical protein0.013
YOL014Whypothetical protein0.013
SRP54Srp54p0.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PTPN23protein tyrosine phosphatase, non-receptor type 230.534
NACAnascent polypeptide-associated complex alpha subunit0.134
DNAJB11DnaJ (Hsp40) homolog, subfamily B, member 110.106
GET4golgi to ER traffic protein 4 homolog (S. cerevisiae)0.060
CANXcalnexin0.055
SURF4surfeit 40.045
SEC61A1Sec61 alpha 1 subunit (S. cerevisiae)0.033
ATF7IPactivating transcription factor 7 interacting protein0.028
USP54ubiquitin specific peptidase 540.022
CRELD2cysteine-rich with EGF-like domains 20.015
SELSselenoprotein S0.015
DNAJC10DnaJ (Hsp40) homolog, subfamily C, member 100.014
MANFmesencephalic astrocyte-derived neurotrophic factor0.014
BAG6BCL2-associated athanogene 60.014
PPIBpeptidylprolyl isomerase B (cyclophilin B)0.012
TMEM173transmembrane protein 1730.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hsp90b1heat shock protein 90, beta (Grp94), member 10.355
P4hbprolyl 4-hydroxylase, beta polypeptide0.181
Pdia3protein disulfide isomerase associated 30.150
Surf4surfeit gene 40.097
Bdnfbrain derived neurotrophic factor0.097
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.096
Prkcshprotein kinase C substrate 80K-H0.094
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.076
Pdia6protein disulfide isomerase associated 60.074
Canxcalnexin0.071
Tram1translocating chain-associating membrane protein 10.068
Magt1magnesium transporter 10.063
Mll5myeloid/lymphoid or mixed-lineage leukemia 50.061
Gorasp2golgi reassembly stacking protein 20.053
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.048
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.046
Dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.045
Clasp1CLIP associating protein 10.041
Spna2spectrin alpha 20.036
Dnajc5DnaJ (Hsp40) homolog, subfamily C, member 50.036
Ssr3signal sequence receptor, gamma0.036
Arcn1archain 10.036
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.035
Spnb2spectrin beta 20.034
Uso1USO1 homolog, vesicle docking protein (yeast)0.034
Slc35b1solute carrier family 35, member B10.031
Ssr1signal sequence receptor, alpha0.031
Lrrc59leucine rich repeat containing 590.029
Creld2cysteine-rich with EGF-like domains 20.028
Rrbp1ribosome binding protein 10.028
Slc39a7solute carrier family 39 (zinc transporter), member 70.027
Hspa5heat shock protein 50.027
Sel1lsel-1 suppressor of lin-12-like (C. elegans)0.027
Sec31aSec31 homolog A (S. cerevisiae)0.027
Sec63SEC63-like (S. cerevisiae)0.026
Ntf3neurotrophin 30.023
FastkFas-activated serine/threonine kinase0.023
D730040F13RikRIKEN cDNA D730040F13 gene0.022
Sec23bSEC23B (S. cerevisiae)0.022
Hspa13heat shock protein 70 family, member 130.022
Dync1h1dynein cytoplasmic 1 heavy chain 10.022
Nrg1neuregulin 10.022
Xbp1X-box binding protein 10.020
Usp9xubiquitin specific peptidase 9, X chromosome0.019
Nomo1nodal modulator 10.019
Txndc5thioredoxin domain containing 50.019
Ttc3tetratricopeptide repeat domain 30.019
Copgcoatomer protein complex, subunit gamma0.019
Kif1bkinesin family member 1B0.019
Dctn1dynactin 10.019
Invsinversin0.018
Uba5ubiquitin-like modifier activating enzyme 50.018
Lmnalamin A0.018
Kpna3karyopherin (importin) alpha 30.017
Calucalumenin0.017
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.016
Usp48ubiquitin specific peptidase 480.015
Ddostdolichyl-di-phosphooligosaccharide-protein glycotransferase0.015
Rock2Rho-associated coiled-coil containing protein kinase 20.015
Rpn2ribophorin II0.015
Tnrc6atrinucleotide repeat containing 6a0.014
HgsHGF-regulated tyrosine kinase substrate0.014
Gnl1guanine nucleotide binding protein-like 10.014
Cdc42bpaCDC42 binding protein kinase alpha0.014
Dag1dystroglycan 10.013
Dlg1discs, large homolog 1 (Drosophila)0.013
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.013
Nclnnicalin homolog (zebrafish)0.013
Clasp2CLIP associating protein 20.013
Epn1epsin 10.013
Clptm1cleft lip and palate associated transmembrane protein 10.012
Lamc1laminin, gamma 10.012
Mapk8mitogen-activated protein kinase 80.012
Git1G protein-coupled receptor kinase-interactor 10.012
Glg1golgi apparatus protein 10.012
Copb2coatomer protein complex, subunit beta 2 (beta prime)0.012
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.012
Atp2a2ATPase, Ca++ transporting, cardiac muscle, slow twitch 20.012
Rpn1ribophorin I0.012
Lman1lectin, mannose-binding, 10.012
Hyou1hypoxia up-regulated 10.011
Hdlbphigh density lipoprotein (HDL) binding protein0.011
Mlecmalectin0.011
Ahi1Abelson helper integration site 10.011
Dscaml1Down syndrome cell adhesion molecule-like 10.011
ORF61open reading frame 610.011
Spcs3signal peptidase complex subunit 3 homolog (S. cerevisiae)0.011
Ubr4ubiquitin protein ligase E3 component n-recognin 40.011
Sdf2l1stromal cell-derived factor 2-like 10.011
Pex14peroxisomal biogenesis factor 140.011
Atp9aATPase, class II, type 9A0.011
LppLIM domain containing preferred translocation partner in lipoma0.011
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.011
Csnk1g2casein kinase 1, gamma 20.011
Erp44endoplasmic reticulum protein 440.010
Mtap4microtubule-associated protein 40.010
Pdia4protein disulfide isomerase associated 40.010
Slc27a4solute carrier family 27 (fatty acid transporter), member 40.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism