The network for 'positive regulation of macromolecule metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of macromolecule metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

NameDescriptionProbabilityFunc Analog Organism
YAP1Yap1p0.998
RPD3Rpd3p0.988
RTF1Rtf1p0.982
PBS2Pbs2p0.980
SIN3Sin3p0.972
GLN3Gln3p0.970
LSM1Lsm1p0.969
GCN5Gcn5p0.942
BMH1Bmh1p0.935
MET4Met4p0.933
GAL11Gal11p0.919
SNF2Snf2p0.913
MSN2Msn2p0.909
SPT15Spt15p0.897
CKA2Cka2p0.890
RSP5Rsp5p0.880
SSN3Ssn3p0.877
CDC28Cdc28p0.875
STE20Ste20p0.873
SPT16Spt16p0.868
SNF1Snf1p0.858
CTI6Cti6p0.853
SPT8Spt8p0.850
RPT6Rpt6p0.847
ADA2Ada2p0.813
RPT3Rpt3p0.807
DNM1Dnm1p0.794
SNF5Snf5p0.792
FKH2Fkh2p0.773
SNF6Snf6p0.771
RPN4Rpn4p0.769
MOT2Mot2p0.759
CLB5Clb5p0.751
CHD1Chd1p0.722
ATG1Atg1p0.721
PPH21Pph21p0.720
CTK3Ctk3p0.717
POP2Pop2p0.710
MED1Med1p0.706
TAF14Taf14p0.699
ROX3Rox3p0.697
CDC7Cdc7p0.696
YAK1Yak1p0.691
CLA4Cla4p0.691
HST1Hst1p0.689
RGR1Rgr1p0.688
TOR1Tor1p0.686
RTG3Rtg3p0.678
SET2Set2p0.676
RAD23Rad23p0.674
HMO1Hmo1p0.673
SET3Set3p0.672
MIG1Mig1p0.670
INO2Ino2p0.665
MUS81Mus81p0.661
SDS3Sds3p0.655
STE7Ste7p0.654
CYC8Cyc8p0.654
UBP6Ubp6p0.642
UBP3Ubp3p0.639
ARP9Arp9p0.636
PAT1Pat1p0.636
MED6Med6p0.636
HSL1Hsl1p0.607
SRB4Srb4p0.603
PAF1Paf1p0.596
MSS4Mss4p0.594
MKS1Mks1p0.593
CSR2Csr2p0.589
SNF4Snf4p0.584
STE11Ste11p0.583
YFH1Yfh1p0.575
MYO5Myo5p0.568
NNK1Nnk1p0.567
KSP1Ksp1p0.558
CTK1Ctk1p0.557
TPS1Tps1p0.555
KSS1Kss1p0.552
FKH1Fkh1p0.550
PCC1Pcc1p0.548
SSN8Ssn8p0.547
STB5Stb5p0.544
AFT1Aft1p0.538
RCK1Rck1p0.530
CTR9Ctr9p0.530
MET30Met30p0.528
GAL4Gal4p0.526
IXR1Ixr1p0.522
SWI6Swi6p0.516
RXT2Rxt2p0.512
PUB1Pub1p0.508
PHO85Pho85p0.508
SMC3Smc3p0.503
DOA4Doa4p0.498
STB4Stb4p0.492
HAP5Hap5p0.489
YKE2Yke2p0.489
CSE2Cse2p0.488
RLM1Rlm1p0.488
MSG5Msg5p0.486
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pha-4Protein PHA-40.996
elt-6Protein ELT-60.982
egl-18Protein EGL-180.957
cam-1Protein CAM-10.930
nhr-67Protein NHR-670.920
rps-2Protein RPS-20.913
nhr-49Protein NHR-490.876
egl-13Protein EGL-130.862
mat-3Protein MAT-30.845
eya-1Protein EYA-10.840
egl-46Protein EGL-460.818
vab-3Protein VAB-30.770
hlh-2Protein HLH-20.759
zip-7Protein ZIP-70.755
sas-5Protein SAS-50.696
T09B4.5Protein T09B4.50.681
cnd-1Protein CND-10.677
hlh-1Protein HLH-10.661
unc-42Protein UNC-420.647
lin-36Protein LIN-360.642
unc-37Protein UNC-370.634
fkh-2Protein FKH-20.630
unc-40Protein UNC-400.624
glp-1Protein GLP-10.601
skp-1Protein SKP-10.600
pry-1Protein PRY-10.581
soc-2Protein SOC-20.581
nhr-34Protein NHR-340.559
mig-5Protein MIG-50.555
daf-1Protein DAF-10.533
his-64Protein HIS-640.529
his-5Protein HIS-50.513
mcm-7Protein MCM-70.507
ldb-1Protein LDB-10.497
pal-1Protein PAL-10.493
unc-73Protein UNC-730.465
ceh-34Protein CEH-340.464
ten-1Protein TEN-10.462
zyg-9Protein ZYG-90.461
aap-1Protein AAP-10.456
cdl-1Protein CDL-10.453
madf-5Protein MADF-50.450
CELE_C25A1.4Protein C25A1.40.449
tct-1Protein TCT-10.441
Y48E1A.1Protein Y48E1A.10.432
lin-12Protein LIN-120.427
hbl-1Protein HBL-10.426
CELE_C17E4.6Protein C17E4.60.418
pch-2Protein PCH-20.412
sel-5Protein SEL-50.412
lin-11Protein LIN-110.395
flh-2Protein FLH-20.392
his-1Protein HIS-10.390
R11A8.7Protein R11A8.70.382
epn-1Protein EPN-10.379
apl-1Protein APL-10.379
uaf-1Protein UAF-10.377
bra-2Protein BRA-20.376
atg-2Protein ATG-20.371
mix-1Protein MIX-10.368
alg-2Protein ALG-20.365
daf-14Protein DAF-140.359
F33H1.4Protein F33H1.40.358
unc-84Protein UNC-840.357
frm-7Protein FRM-70.355
DH11.5Protein DH11.50.353
D1081.8Protein D1081.80.346
abl-1Protein ABL-10.345
sdz-28Protein SDZ-280.344
F18A1.6Protein F18A1.60.338
saeg-1Protein SAEG-10.336
chd-7Protein CHD-70.335
aak-2Protein AAK-20.335
npp-2Protein NPP-20.333
ajm-1Protein AJM-10.333
hda-3Protein HDA-30.322
flt-1Protein FLT-10.321
Y47D3A.29Protein Y47D3A.290.320
rnp-4Protein RNP-40.319
inx-3Protein INX-30.319
rpn-3Protein RPN-30.315
cdk-1Protein CDK-10.313
rad-51Protein RAD-510.310
lin-1Protein LIN-10.309
dre-1Protein DRE-10.309
lsy-2Protein LSY-20.307
nhr-6Protein NHR-60.307
mep-1Protein MEP-10.307
lin-66Protein LIN-660.303
his-46Protein HIS-460.298
gla-3Protein GLA-30.296
unc-62Protein UNC-620.294
lntl-1Protein LNTL-10.291
zif-1Protein ZIF-10.289
F28C1.1Protein F28C1.10.289
icd-1Protein ICD-10.289
ucr-2.3Protein UCR-2.30.285
ceh-27Protein CEH-270.283
Y17G7B.20Protein Y17G7B.200.281
hrp-1Protein HRP-10.281
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tp53tumor protein p530.968
dlx3bdistal-less homeobox gene 3b0.951
notch1anotch homolog 1a0.941
dlx2adistal-less homeobox gene 2a0.913
gata3GATA-binding protein 30.909
nkx2.2aNK2 transcription factor related 2a0.879
gli1GLI-Kruppel family member 10.878
flhfloating head0.872
prdm1aPR domain containing 1a, with ZNF domain0.868
evx1even-skipped homeobox 10.855
her7hairy and enhancer of split related-70.846
pitx2paired-like homeodomain transcription factor 20.832
wu:fv91b12wu:fv91b120.829
runx2brunt-related transcription factor 2b0.827
myf5myogenic factor 50.804
dlcdeltaC0.803
otpaorthopedia homolog a0.795
lmx1b.1LIM homeobox transcription factor 1, beta 10.793
shhasonic hedgehog a0.792
runx2arunt-related transcription factor 2a0.791
foxi1forkhead box I10.789
spry4sprouty (Drosophila) homolog 40.772
bmp4bone morphogenetic protein 40.760
ndr2nodal-related 20.753
otpborthopedia homolog b0.739
wnt1wingless-type MMTV integration site family, member 10.735
nanos3nanos homolog 30.702
lhx1aLIM homeobox 1a0.700
dlx5adistal-less homeobox gene 5a0.685
sox9aSRY-box containing gene 9a0.684
myod1myogenic differentiation 10.682
bmp2bbone morphogenetic protein 2b0.680
egr2bearly growth response 2b0.669
pax7apaired box gene 7a0.651
gata6GATA-binding protein 60.648
neo1neogenin 10.647
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.643
fezf2FEZ family zinc finger 20.641
fgfr3fibroblast growth factor receptor 30.623
foxa2forkhead box A20.603
pcnaproliferating cell nuclear antigen0.599
pax8paired box gene 80.594
tbx2aT-box gene 2a0.589
tpm4tropomyosin 40.570
hnf1baHNF1 homeobox Ba0.563
pax2apaired box gene 2a0.560
fzd5frizzled homolog 50.553
oepone-eyed pinhead0.548
trpm7transient receptor potential cation channel, subfamily M, member 70.544
wnt10awingless-type MMTV integration site family, member 10a0.541
kdrlkinase insert domain receptor like0.511
col2a1acollagen type II, alpha-1a0.510
raraaretinoic acid receptor, alpha a0.504
tfap2atranscription factor AP-2 alpha0.498
egr1early growth response 10.497
smad9MAD homolog 9 (Drosophila)0.493
emx3empty spiracles homeobox 30.485
sox19bSRY-box containing gene 19b0.479
tal1T-cell acute lymphocytic leukemia 10.478
pax6bpaired box gene 6b0.477
oprm1opioid receptor, mu 10.463
jag2jagged 20.462
gata4GATA-binding protein 40.462
ascl1aachaete-scute complex-like 1a (Drosophila)0.461
twist3twist30.448
pea3ETS-domain transcription factor pea30.439
rad21RAD21 homolog (S. pombe)0.437
mab21l2mab-21-like 20.429
bmp2abone morphogenetic protein 2a0.418
tgfb3transforming growth factor, beta 30.409
cx43connexin 430.404
mstnbmyostatin b0.401
foxd3forkhead box D30.398
fgf17fibroblast growth factor 170.398
csnk1a1casein kinase 1, alpha 10.394
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.378
sox4bSRY-box containing gene 4b0.378
nr2e1nuclear receptor subfamily 2, group E, member 10.372
hoxd10ahomeo box D10a0.369
eomesaeomesodermin homolog a0.369
rasl11bRAS-like, family 11, member B0.362
hey1hairy/enhancer-of-split related with YRPW motif 10.362
foxh1forkhead box H10.360
junbjun B proto-oncogene0.359
nrg2aneuregulin 2a0.358
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.354
fn1fibronectin 10.347
sulf1sulfatase 10.344
her1hairy-related 10.341
znf503zinc finger protein 5030.329
lhx5LIM homeobox 50.317
wnt3awingless-type MMTV integration site family, member 3A0.316
tnfrsfatumor necrosis factor receptor superfamily, member a0.315
hoxb1bhomeo box B1b0.313
rargaretinoic acid receptor gamma a0.313
barhl2BarH-like 20.310
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.306
eng2aengrailed 2a0.303
fzd10frizzled homolog 100.301
myogmyogenin0.297
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Akt1CG4006 gene product from transcript CG4006-RA1.000
Ras85DRas oncogene at 85D1.000
Su(H)Suppressor of Hairless0.998
wgwingless0.997
MadMothers against dpp0.996
Fmr1CG6203 gene product from transcript CG6203-RC0.994
sdscalloped0.993
hephemipterous0.992
phlpole hole0.992
nmonemo0.992
EgfrEpidermal growth factor receptor0.989
twstwins0.989
dcodiscs overgrown0.988
slmbsupernumerary limbs0.988
bcdbicoid0.987
lolalongitudinals lacking0.985
sggshaggy0.984
eygeyegone0.982
foxoforkhead box, sub-group O0.980
grogroucho0.980
mammastermind0.979
Rac1CG2248 gene product from transcript CG2248-RA0.975
InRInsulin-like receptor0.973
UbxUltrabithorax0.972
DllDistal-less0.971
dshdishevelled0.968
eyaeyes absent0.964
putpunt0.960
G-oalpha47AG protein oalpha 47A0.960
EcREcdysone receptor0.957
rlrolled0.953
ykiyorkie0.949
lwrlesswright0.946
TER94CG2331 gene product from transcript CG2331-RA0.945
cicubitus interruptus0.944
Tao-1CG14217 gene product from transcript CG14217-RF0.942
CycECyclin E0.941
aopanterior open0.937
E(spl)Enhancer of split0.937
CkIIalphaCasein kinase II alpha subunit0.933
ftz-f1ftz transcription factor 10.932
cnccap-n-collar0.929
wtswarts0.925
RYBPRing and YY1 Binding Protein0.925
PcPolycomb0.924
RhebCG1081 gene product from transcript CG1081-RA0.924
ash2absent, small, or homeotic discs 20.923
dmdiminutive0.917
Src42ASrc oncogene at 42A0.916
drkdownstream of receptor kinase0.910
SaraSmad anchor for receptor activation0.902
acachaete0.900
HLHm7E(spl) region transcript m70.899
ovoCG6824 gene product from transcript CG6824-RE0.895
bsblistered0.890
roboroundabout0.889
brmbrahma0.889
tkvthickveins0.888
p120ctnAdherens junction protein p1200.886
jubAjuba LIM protein0.886
psqpipsqueak0.882
nejnejire0.880
SerSerrate0.879
pbproboscipedia0.879
agoarchipelago0.876
shishibire0.874
MED15Mediator complex subunit 150.873
panpangolin0.873
vgvestigial0.872
kaykayak0.870
snasnail0.868
osoutstretched0.866
CTCFCG8591 gene product from transcript CG8591-RA0.866
Vap-33-1CG5014 gene product from transcript CG5014-RB0.865
Bre1CG10542 gene product from transcript CG10542-RA0.858
Cdc42CG12530 gene product from transcript CG12530-RA0.858
eIF-4EEukaryotic initiation factor 4E0.858
Atg1Autophagy-specific gene 10.854
RpII215RNA polymerase II 215kD subunit0.851
smt3CG4494 gene product from transcript CG4494-RA0.846
SosSon of sevenless0.844
kiskismet0.844
nkdnaked cuticle0.841
chicoCG5686 gene product from transcript CG5686-RB0.839
wlswntless0.838
bskbasket0.833
MntCG13316 gene product from transcript CG13316-RD0.830
ssspineless0.825
rkrickets0.824
hbshibris0.822
RbfRetinoblastoma-family protein0.821
effeffete0.820
kluklumpfuss0.818
toytwin of eyeless0.817
Pp2B-14DProtein phosphatase 2B at 14D0.809
osaCG7467 gene product from transcript CG7467-RD0.807
Gap1GTPase-activating protein 10.803
shotshort stop0.800
Cp190Centrosomal protein 190kD0.797
dockdreadlocks0.790
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism