The network for 'response to epidermal growth factor' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to epidermal growth factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MAP3K5mitogen-activated protein kinase kinase kinase 50.569
GDF9growth differentiation factor 90.191
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.169
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.138
INSRinsulin receptor0.075
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.053
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.050
MAP2K1mitogen-activated protein kinase kinase 10.049
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.049
ARRB1arrestin, beta 10.048
GRB2growth factor receptor-bound protein 20.046
LATlinker for activation of T cells0.045
RAB6ARAB6A, member RAS oncogene family0.040
SMN1survival of motor neuron 1, telomeric0.039
SETDB1SET domain, bifurcated 10.037
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.037
SHC1SHC (Src homology 2 domain containing) transforming protein 10.036
IL1RAPinterleukin 1 receptor accessory protein0.035
IL1Binterleukin 1, beta0.035
CARD11caspase recruitment domain family, member 110.034
IGFBP3insulin-like growth factor binding protein 30.034
PLATplasminogen activator, tissue0.033
DUSP1dual specificity phosphatase 10.030
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.028
MYO6myosin VI0.026
IL1RNinterleukin 1 receptor antagonist0.025
ARRB2arrestin, beta 20.025
JUBjub, ajuba homolog (Xenopus laevis)0.022
MTORmechanistic target of rapamycin (serine/threonine kinase)0.022
DCTN1dynactin 10.022
TOM1L1target of myb1 (chicken)-like 10.022
LRRK2leucine-rich repeat kinase 20.020
FN1fibronectin 10.019
DUSP3dual specificity phosphatase 30.018
PTPRJprotein tyrosine phosphatase, receptor type, J0.018
COL1A2collagen, type I, alpha 20.018
MAPTmicrotubule-associated protein tau0.017
EGR1early growth response 10.017
ZNF277zinc finger protein 2770.017
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.017
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.016
ACTBactin, beta0.016
LRP6low density lipoprotein receptor-related protein 60.016
GSK3Bglycogen synthase kinase 3 beta0.016
TSG101tumor susceptibility gene 1010.015
GNL3Lguanine nucleotide binding protein-like 3 (nucleolar)-like0.015
IQGAP1IQ motif containing GTPase activating protein 10.014
RARAretinoic acid receptor, alpha0.014
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.014
TAF15TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa0.014
BBS1Bardet-Biedl syndrome 10.013
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.013
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.013
CLTCclathrin, heavy chain (Hc)0.013
HMOX2heme oxygenase (decycling) 20.012
BLNKB-cell linker0.012
TICAM2toll-like receptor adaptor molecule 20.012
PTPN1protein tyrosine phosphatase, non-receptor type 10.012
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.012
TOP1topoisomerase (DNA) I0.011
ACTA1actin, alpha 1, skeletal muscle0.011
PIM1pim-1 oncogene0.011
CDK5RAP2CDK5 regulatory subunit associated protein 20.011
PEBP4phosphatidylethanolamine-binding protein 40.011
CHN2chimerin (chimaerin) 20.011
NRP1neuropilin 10.010
FBLN1fibulin 10.010
STAP2signal transducing adaptor family member 20.010
COL3A1collagen, type III, alpha 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.955
Ptpn11protein tyrosine phosphatase, non-receptor type 110.929
Vegfavascular endothelial growth factor A0.917
Leprleptin receptor0.805
Stat5asignal transducer and activator of transcription 5A0.714
Meox2mesenchyme homeobox 20.610
Ptenphosphatase and tensin homolog0.513
Col3a1collagen, type III, alpha 10.503
Lmnalamin A0.456
Ppargperoxisome proliferator activated receptor gamma0.442
Nf1neurofibromatosis 10.418
Vhlvon Hippel-Lindau tumor suppressor0.362
Itgb1integrin beta 1 (fibronectin receptor beta)0.251
Nos3nitric oxide synthase 3, endothelial cell0.206
Ccl2chemokine (C-C motif) ligand 20.198
Sqstm1sequestosome 10.197
Hspg2perlecan (heparan sulfate proteoglycan 2)0.186
Rb1retinoblastoma 10.181
Sox2SRY-box containing gene 20.160
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.152
Zeb1zinc finger E-box binding homeobox 10.150
Cav1caveolin 1, caveolae protein0.147
Efnb2ephrin B20.132
Prkceprotein kinase C, epsilon0.126
Plcg1phospholipase C, gamma 10.122
Shesrc homology 2 domain-containing transforming protein E0.122
Sox4SRY-box containing gene 40.122
Rps2ribosomal protein S20.121
Ghrgrowth hormone receptor0.114
Lrp2low density lipoprotein receptor-related protein 20.112
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.109
Ikbkapinhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein0.109
Pax6paired box gene 60.108
Ednrbendothelin receptor type B0.106
Thbs1thrombospondin 10.104
Gata4GATA binding protein 40.104
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.102
Ldb3LIM domain binding 30.102
Hspa1bheat shock protein 1B0.100
Flt1FMS-like tyrosine kinase 10.099
Gli3GLI-Kruppel family member GLI30.097
Col1a1collagen, type I, alpha 10.096
Stat3signal transducer and activator of transcription 30.095
Epas1endothelial PAS domain protein 10.088
Hes1hairy and enhancer of split 1 (Drosophila)0.086
Grb2growth factor receptor bound protein 20.084
Mapk1mitogen-activated protein kinase 10.083
Shc1src homology 2 domain-containing transforming protein C10.082
Hif1ahypoxia inducible factor 1, alpha subunit0.082
Isl1ISL1 transcription factor, LIM/homeodomain0.081
Igf1insulin-like growth factor 10.079
Kdrkinase insert domain protein receptor0.078
Nostrinnitric oxide synthase trafficker0.076
Pitx2paired-like homeodomain transcription factor 20.076
Alx4aristaless-like homeobox 40.075
Hspb8heat shock protein 80.075
Sox17SRY-box containing gene 170.075
Mknk2MAP kinase-interacting serine/threonine kinase 20.073
Hhexhematopoietically expressed homeobox0.073
Mapk3mitogen-activated protein kinase 30.069
Sox7SRY-box containing gene 70.063
Cux1cut-like homeobox 10.063
Ppiapeptidylprolyl isomerase A0.063
Trp53transformation related protein 530.062
Kitkit oncogene0.062
Ypel3yippee-like 3 (Drosophila)0.061
Bcl2B-cell leukemia/lymphoma 20.061
Acot1acyl-CoA thioesterase 10.060
Scd1stearoyl-Coenzyme A desaturase 10.059
Hand1heart and neural crest derivatives expressed transcript 10.058
Gata6GATA binding protein 60.058
Pnpla2patatin-like phospholipase domain containing 20.057
Diap1diaphanous homolog 1 (Drosophila)0.057
Emx1empty spiracles homolog 1 (Drosophila)0.056
Col2a1collagen, type II, alpha 10.056
Bmpr1abone morphogenetic protein receptor, type 1A0.056
Aplnrapelin receptor0.056
Sox11SRY-box containing gene 110.054
Tnfaip3tumor necrosis factor, alpha-induced protein 30.053
Bcl6bB-cell CLL/lymphoma 6, member B0.053
Tmem45atransmembrane protein 45a0.053
Akt2thymoma viral proto-oncogene 20.052
Hoxa5homeobox A50.052
Errfi1ERBB receptor feedback inhibitor 10.051
Dab1disabled homolog 1 (Drosophila)0.051
Ahraryl-hydrocarbon receptor0.051
Mapkap1mitogen-activated protein kinase associated protein 10.050
Atf2activating transcription factor 20.047
Apoeapolipoprotein E0.047
Vav2vav 2 oncogene0.046
Actn2actinin alpha 20.045
Lef1lymphoid enhancer binding factor 10.045
Dusp6dual specificity phosphatase 60.045
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.045
Edarectodysplasin-A receptor0.043
Igf1rinsulin-like growth factor I receptor0.043
Tlr4toll-like receptor 40.042
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col3a1collagen, type III, alpha 10.673
Mgst1microsomal glutathione S-transferase 10.285
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.234
Col5a2collagen, type V, alpha 20.224
Col1a2collagen, type I, alpha 20.161
Col1a1collagen, type I, alpha 10.156
Fggfibrinogen gamma chain0.078
Col14a1collagen, type XIV, alpha 10.054
Fbn1fibrillin 10.051
Gstm1glutathione S-transferase mu 10.051
Pcolceprocollagen C-endopeptidase enhancer0.050
Postnperiostin, osteoblast specific factor0.048
Akap1A kinase (PRKA) anchor protein 10.047
Ephx1epoxide hydrolase 1, microsomal0.045
Socs3suppressor of cytokine signaling 30.045
Cyp4a2cytochrome P450, family 4, subfamily a, polypeptide 20.036
Metmet proto-oncogene0.035
Acot2acyl-CoA thioesterase 20.033
Col12a1collagen, type XII, alpha 10.031
Rnf213ring finger protein 2130.031
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.028
Akr7a3aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)0.027
Orm1orosomucoid 10.025
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.024
Mgst2microsomal glutathione S-transferase 20.024
Jak1Janus kinase 10.022
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.022
Col5a1collagen, type V, alpha 10.021
Slc17a1solute carrier family 17 (sodium phosphate), member 10.019
Fstl1follistatin-like 10.018
Fndc1fibronectin type III domain containing 10.018
Mipmajor intrinsic protein of lens fiber0.018
Acot1acyl-CoA thioesterase 10.018
Loxl1lysyl oxidase-like 10.017
Ahraryl hydrocarbon receptor0.017
Pdk4pyruvate dehydrogenase kinase, isozyme 40.017
Col4a2collagen, type IV, alpha 20.017
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.017
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.017
Atp1a4ATPase, Na+/K+ transporting, alpha 4 polypeptide0.017
Hiat1hippocampus abundant gene transcript 10.016
Mcm6minichromosome maintenance complex component 60.016
Ubn2ubinuclein 20.016
Fut4fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)0.016
Mfap4microfibrillar-associated protein 40.015
Cercamcerebral endothelial cell adhesion molecule0.015
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.014
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.014
RGD1305347similar to RIKEN cDNA 2610528J110.014
Nr5a1nuclear receptor subfamily 5, group A, member 10.014
Gja1gap junction protein, alpha 10.014
Rpa2replication protein A20.014
Loxlysyl oxidase0.014
Ggt1gamma-glutamyltransferase 10.014
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.013
Csn3casein kappa0.013
Prrx1paired related homeobox 10.012
Amelxamelogenin X chromosome0.012
Dmgdhdimethylglycine dehydrogenase0.012
Ccdc80coiled-coil domain containing 800.012
Haao3-hydroxyanthranilate 3,4-dioxygenase0.012
Psg19pregnancy specific glycoprotein 190.012
Iappislet amyloid polypeptide0.012
RT1-ClRT1 class Ib, locus Cl0.011
Slc13a1solute carrier family 13 (sodium/sulfate symporters), member 10.011
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.011
Lamc1laminin, gamma 10.011
Nid2nidogen 20.011
Sellselectin L0.011
Tbc1d2bTBC1 domain family, member 2B0.011
Ccl11chemokine (C-C motif) ligand 110.011
Vdac1voltage-dependent anion channel 10.011
Leprel2leprecan-like 20.011
Pim1pim-1 oncogene0.011
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.011
Cd86CD86 molecule0.011
Il1rapinterleukin 1 receptor accessory protein0.010
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.010
Pgcprogastricsin (pepsinogen C)0.010
Fen1flap structure-specific endonuclease 10.010
Col15a1collagen, type XV, alpha 10.010
Grb2growth factor receptor bound protein 20.010
Arrb1arrestin, beta 10.010
Bcl2l2Bcl2-like 20.010
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.010
Ugt1a7cUDP glucuronosyltransferase 1 family, polypeptide A7C0.010
Pdzk1PDZ domain containing 10.010