The network for 'signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

NameDescriptionProbabilityFunc Analog Organism
STE4Ste4p0.985
TOR1Tor1p0.964
STE20Ste20p0.949
CLA4Cla4p0.946
PBS2Pbs2p0.945
BCK1Bck1p0.944
GPA1Gpa1p0.914
HOG1Hog1p0.911
PPH21Pph21p0.908
SNF1Snf1p0.906
FUS3Fus3p0.897
SLT2Slt2p0.881
CKA1Cka1p0.872
GPA2Gpa2p0.868
STE5Ste5p0.847
TPK2Tpk2p0.845
SHO1Sho1p0.837
FAR1Far1p0.824
RHO1Rho1p0.815
BMH2Bmh2p0.808
VPS64Vps64p0.799
MKS1Mks1p0.788
CRZ1Crz1p0.782
FAR11Far11p0.755
MSN2Msn2p0.727
ERP4Erp4p0.715
RTG3Rtg3p0.714
TPK1Tpk1p0.696
IRE1Ire1p0.687
BEM2Bem2p0.685
STE12Ste12p0.684
STE2Ste2p0.684
VPS71Vps71p0.683
GLN3Gln3p0.674
ROM2Rom2p0.657
RPT3Rpt3p0.655
STE11Ste11p0.646
SSK2Ssk2p0.639
PDE2Pde2p0.637
YPT1Ypt1p0.634
CDC34Cdc34p0.633
TPS1Tps1p0.622
CMP2Cmp2p0.621
AKL1Akl1p0.604
KSP1Ksp1p0.598
STE50Ste50p0.588
RUD3Rud3p0.586
RRI1Rri1p0.580
SKP1Skp1p0.571
PTK2Ptk2p0.570
PRB1Prb1p0.569
KOG1Kog1p0.557
MKT1Mkt1p0.553
SLG1Slg1p0.547
ERP2Erp2p0.545
END3End3p0.540
FPK1Fpk1p0.536
GIS4Gis4p0.523
MKK1Mkk1p0.499
TFB1Tfb1p0.493
LHS1Lhs1p0.489
BEM1Bem1p0.489
RLM1Rlm1p0.477
SLA2Sla2p0.476
LAS17Las17p0.473
BEM3Bem3p0.470
CDC55Cdc55p0.460
CDC24Cdc24p0.457
NBP2Nbp2p0.456
PLC1Plc1p0.450
PTC1Ptc1p0.443
RIM101Rim101p0.441
KSS1Kss1p0.438
BMH1Bmh1p0.426
BBC1Bbc1p0.423
SCH9Sch9p0.421
MEC1Mec1p0.410
MSH3Msh3p0.410
IRA1Ira1p0.408
PFK26Pfk26p0.406
RDI1Rdi1p0.404
SKN7Skn7p0.399
PMT2Pmt2p0.393
STE18Ste18p0.391
PPH3Pph3p0.389
HSP60Hsp60p0.386
BEM4Bem4p0.382
SSK1Ssk1p0.381
REG1Reg1p0.378
RAS2Ras2p0.378
STE7Ste7p0.372
SEC7Sec7p0.368
AVO1Avo1p0.366
PIL1Pil1p0.361
PIK1Pik1p0.359
RPN4Rpn4p0.358
YPT10Ypt10p0.354
PAF1Paf1p0.345
PRK1Prk1p0.344
PKH2Pkh2p0.339
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.981
vab-3Protein VAB-30.923
atn-1Protein ATN-10.917
faah-1Protein FAAH-10.845
plc-1Protein PLC-10.767
cam-1Protein CAM-10.761
pry-1Protein PRY-10.752
K10D6.4Protein K10D6.40.740
unc-9Protein UNC-90.732
bar-1Protein BAR-10.731
nhr-45Protein NHR-450.731
sma-6Protein SMA-60.715
par-5Protein PAR-50.711
mig-2Protein MIG-20.699
atg-2Protein ATG-20.699
CELE_T05E11.3Protein T05E11.30.693
pdfr-1Protein PDFR-10.692
lag-1Protein LAG-10.688
dre-1Protein DRE-10.681
npp-7Protein NPP-70.679
B0361.6Protein B0361.60.677
unc-37Protein UNC-370.661
pkg-1Protein PKG-10.658
uig-1Protein UIG-10.654
epi-1Protein EPI-10.634
egl-30Protein EGL-300.620
acs-4Protein ACS-40.607
unc-62Protein UNC-620.606
sas-4Protein SAS-40.594
alx-1Protein ALX-10.583
pqn-54Protein PQN-540.580
abu-8Protein ABU-80.574
lin-25Protein LIN-250.572
gana-1Protein GANA-10.568
hsp-16.2Protein HSP-16.20.567
cki-2Protein CKI-20.565
hmg-1.2Protein HMG-1.20.558
skn-1Protein SKN-10.547
akt-1Protein AKT-10.546
egal-1Protein EGAL-10.543
ceh-18Protein CEH-180.543
sur-2Protein SUR-20.541
pha-4Protein PHA-40.540
vav-1Protein VAV-10.535
drp-1Protein DRP-10.525
Y47D3B.6Protein Y47D3B.60.525
rhi-1Protein RHI-10.522
trim-9Protein TRIM-90.519
rab-5Protein RAB-50.507
ceh-20Protein CEH-200.503
abu-11Protein ABU-110.498
csn-4Protein CSN-40.495
hsp-16.1Protein HSP-16.10.494
gsk-3Protein GSK-30.488
unc-52Protein UNC-520.482
abu-15Protein ABU-150.481
dpy-22Protein DPY-220.480
unc-32Protein UNC-320.480
teg-1Protein TEG-10.472
ztf-7Protein ZTF-70.465
Y44E3A.6Protein Y44E3A.60.464
osm-5Protein OSM-50.462
daf-12Protein DAF-120.462
CELE_F25B4.5Protein F25B4.50.461
lev-1Protein LEV-10.458
abts-3Protein ABTS-30.457
lmn-1Protein LMN-10.454
egl-8Protein EGL-80.451
wrm-1Protein WRM-10.449
F44E5.4Protein F44E5.40.448
mpz-2Protein MPZ-20.447
egl-13Protein EGL-130.442
let-23Protein LET-230.437
dnj-10Protein DNJ-100.436
nipi-3Protein NIPI-30.436
cye-1Protein CYE-10.435
fln-2Protein FLN-20.435
vang-1Protein VANG-10.435
zyg-9Protein ZYG-90.434
vab-8Protein VAB-80.431
ztf-4Protein ZTF-40.428
cey-1Protein CEY-10.426
flp-22Protein FLP-220.426
zyg-8Protein ZYG-80.426
lin-11Protein LIN-110.425
tam-1Protein TAM-10.423
mbk-1Protein MBK-10.417
arf-3Protein ARF-30.415
par-3Protein PAR-30.413
egg-6Protein EGG-60.413
pxf-1Protein PXF-10.410
hsp-16.41Protein HSP-16.410.409
sur-6Protein SUR-60.403
daf-4Protein DAF-40.402
ubq-1Protein UBQ-10.402
unc-86Protein UNC-860.400
unc-79Protein UNC-790.398
ida-1Protein IDA-10.397
zyg-1Protein ZYG-10.397
lin-5Protein LIN-50.392
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chdchordin1.000
ntlano tail a0.997
shhasonic hedgehog a0.996
tbx1T-box 10.996
notch1anotch homolog 1a0.991
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.986
bmp2bbone morphogenetic protein 2b0.986
sox9bSRY-box containing gene 9b0.986
crabp2acellular retinoic acid binding protein 2, a0.984
dusp6dual specificity phosphatase 60.981
tbx16T-box gene 160.978
dzip1DAZ interacting protein 10.976
fn1fibronectin 10.972
fgf3fibroblast growth factor 30.970
gscgoosecoid0.965
flt4fms-related tyrosine kinase 40.961
alcambactivated leukocyte cell adhesion molecule b0.960
pax8paired box gene 80.957
hey1hairy/enhancer-of-split related with YRPW motif 10.951
ndr2nodal-related 20.950
cdh5cadherin 50.947
otpaorthopedia homolog a0.945
gdf6agrowth differentiation factor 6a0.944
tshbthyroid stimulating hormone, beta subunit0.943
lef1lymphocyte enhancer binding factor 10.943
fras1Fraser syndrome 10.942
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.940
spry4sprouty (Drosophila) homolog 40.940
wnt8bwingless-type MMTV integration site family, member 8b0.936
isl1islet10.934
dharmadharma0.930
sox9aSRY-box containing gene 9a0.926
irf6interferon regulatory factor 60.926
lhx1aLIM homeobox 1a0.922
pcdh18bprotocadherin 18b0.922
otx1aorthodenticle homolog 1a0.919
snai1bsnail homolog 1b (Drosophila)0.915
evx1even-skipped homeobox 10.913
junjun proto-oncogene0.909
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.907
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.900
fzd10frizzled homolog 100.899
apoebapolipoprotein Eb0.895
pitx3paired-like homeodomain transcription factor 30.892
rarabretinoic acid receptor, alpha b0.886
sall1asal-like 1a (Drosophila)0.885
arl13bADP-ribosylation factor-like 13b0.875
notch3notch homolog 30.874
cdh1cadherin 1, epithelial0.866
zeb1zinc finger E-box binding homeobox 10.860
frem3Fras1 related extracellular matrix 30.860
lmo4aLIM domain only 4a0.859
gng3guanine nucleotide binding protein (G protein), gamma 30.855
runx2brunt-related transcription factor 2b0.854
adra2aadrenergic, alpha-2A-, receptor0.850
voxventral homeobox0.849
fzd8afrizzled homolog 8a0.846
sox19aSRY-box containing gene 19a0.845
gli2aGLI-Kruppel family member GLI2a0.844
lft1lefty10.844
wnt2wingless-type MMTV integration site family member 20.843
brd4bromodomain containing 40.840
rasl11bRAS-like, family 11, member B0.840
pkd2polycystic kidney disease 20.839
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.835
ptgs2aprostaglandin-endoperoxide synthase 2a0.830
gro1groucho 10.829
ephb4beph receptor B4b0.825
rag1recombination activating gene 10.825
tbx6T-box gene 60.824
nog3noggin 30.819
mc2rmelanocortin 2 receptor0.818
myhz2myosin, heavy polypeptide 2, fast muscle specific0.812
ldb1aLIM-domain binding factor 1a0.812
pdgfaaplatelet-derived growth factor alpha a0.812
tll1tolloid-like 10.810
ptpraprotein tyrosine phosphatase, receptor type, A0.804
psen1presenilin 10.803
her6hairy-related 60.803
robo3roundabout homolog 30.799
cluap1clusterin associated protein 10.799
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.797
bbc3BCL2 binding component 30.797
gpc4glypican 40.795
oepone-eyed pinhead0.795
ift88intraflagellar transport 88 homolog0.793
wnt10bwingless-type MMTV integration site family, member 10b0.792
tagln2transgelin 20.787
sox2SRY-box containing gene 20.787
foxa2forkhead box A20.783
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.782
per3period homolog 3 (Drosophila)0.780
lmx1b.1LIM homeobox transcription factor 1, beta 10.779
tgfb3transforming growth factor, beta 30.775
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.773
metmet proto-oncogene (hepatocyte growth factor receptor)0.771
nrp2bneuropilin 2b0.770
fzd7bfrizzled homolog 7b0.769
gro2groucho 20.766
mecomMDS1 and EVI1 complex locus0.763
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism