The network for 'negative regulation of mitotic metaphase anaphase transition' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of mitotic metaphase anaphase transition

Any process that stops, prevents, or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition.

NameDescriptionProbabilityFunc Analog Organism
MAD2Mad2p0.927
CTF3Ctf3p0.888
SPC105Spc105p0.879
MTW1Mtw1p0.873
PPH21Pph21p0.871
CDC55Cdc55p0.822
AME1Ame1p0.812
DSN1Dsn1p0.812
SLK19Slk19p0.796
NSL1Nsl1p0.794
CSE4Cse4p0.742
SLI15Sli15p0.739
PPH22Pph22p0.734
IML3Iml3p0.649
TID3Tid3p0.633
CDC20Cdc20p0.566
CHL4Chl4p0.564
HHF2Hhf2p0.555
MAD1Mad1p0.506
BUB1Bub1p0.427
MIF2Mif2p0.414
SMC4Smc4p0.409
MCM21Mcm21p0.362
CTF13Ctf13p0.347
BUB3Bub3p0.340
KIP1Kip1p0.313
MPS1Mps1p0.299
SPC24Spc24p0.276
MAD3Mad3p0.270
YPI1Ypi1p0.260
PIG2Pig2p0.233
IPL1Ipl1p0.211
DAM1Dam1p0.174
OKP1Okp1p0.158
MCM22Mcm22p0.141
NUF2Nuf2p0.130
YBP2Ybp2p0.129
NNF1Nnf1p0.122
ASE1Ase1p0.104
CBF2Cbf2p0.090
FMP48Fmp48p0.088
GIP2Gip2p0.077
CIN8Cin8p0.072
SDS22Sds22p0.064
SMC5Smc5p0.058
TIP41Tip41p0.057
PDS1Pds1p0.052
RTS1Rts1p0.050
BRN1Brn1p0.048
CSM1Csm1p0.048
PPZ1Ppz1p0.048
SPC25Spc25p0.047
SMC6Smc6p0.044
SMC2Smc2p0.044
PSH1Psh1p0.042
SCC2Scc2p0.041
CBF1Cbf1p0.040
NBL1Nbl1p0.039
ECO1Eco1p0.039
CAB3Cab3p0.038
STU1Stu1p0.038
VIK1Vik1p0.037
ZDS1Zds1p0.037
GLC7Glc7p0.035
MMS21Mms21p0.033
HST3Hst3p0.032
NTO1Nto1p0.032
YNL144Chypothetical protein0.032
CDC16Cdc16p0.032
KIC1Kic1p0.031
YLR407Whypothetical protein0.030
SPO12Spo12p0.030
FIN1Fin1p0.029
HTA1Hta1p0.029
SRD1Srd1p0.028
RAD61Rad61p0.027
PRE10Pre10p0.027
SCM3Scm3p0.026
PRS2Prs2p0.026
SGO1Sgo1p0.025
CHL1Chl1p0.025
YLR162Whypothetical protein0.025
PKC1Pkc1p0.024
CRP1Crp1p0.024
LEU2Leu2p0.024
GAC1Gac1p0.024
SMC3Smc3p0.024
VHS3Vhs3p0.023
GLG1Glg1p0.023
YOL038C-Ahypothetical protein0.023
RDH54Rdh54p0.023
PTI1Pti1p0.023
YLR264C-Ahypothetical protein0.022
PSY4Psy4p0.022
ESP1Esp1p0.022
PCT1Pct1p0.022
ARG8Arg8p0.022
SWI1Swi1p0.021
PDR15Pdr15p0.021
BFA1Bfa1p0.021
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
ZK507.6Protein ZK507.60.108
npp-11Protein NPP-110.054
rnr-1Protein RNR-10.049
cec-5Protein CEC-50.044
imb-2Protein IMB-20.043
his-42Protein HIS-420.043
htz-1Protein HTZ-10.040
cye-1Protein CYE-10.040
dsh-2Protein DSH-20.039
cdl-1Protein CDL-10.038
lmn-1Protein LMN-10.037
bmk-1Protein BMK-10.037
math-33Protein MATH-330.034
C49H3.9Protein C49H3.90.031
C49H3.6Protein C49H3.60.030
rsd-6Protein RSD-60.029
spdl-1Protein SPDL-10.029
gpr-2Protein GPR-20.028
gpr-1Protein GPR-10.026
his-32Protein HIS-320.026
mcm-5Protein MCM-50.025
cyk-4Protein CYK-40.024
T08A11.2Protein T08A11.20.023
CELE_C24H12.5Protein C24H12.50.023
pri-2Protein PRI-20.023
knl-1Protein KNL-10.022
his-45Protein HIS-450.022
hcp-1Protein HCP-10.020
air-2Protein AIR-20.019
air-1Protein AIR-10.018
F12F6.1Protein F12F6.10.018
sas-5Protein SAS-50.018
ani-1Protein ANI-10.018
brc-1Protein BRC-10.017
his-6Protein HIS-60.017
C02B10.5Protein C02B10.50.017
ZK1053.4Protein ZK1053.40.016
F36A2.2Protein F36A2.20.016
let-502Protein LET-5020.016
tba-2Protein TBA-20.016
crml-1Protein CRML-10.016
pqn-82Protein PQN-820.015
hpo-10Protein HPO-100.015
rab-1Protein RAB-10.015
mus-101Protein MUS-1010.015
attf-2Protein ATTF-20.015
pcn-1Protein PCN-10.015
rfc-4Protein RFC-40.015
cin-4Protein CIN-40.015
scc-1Protein SCC-10.014
flh-1Protein FLH-10.014
psf-1Protein PSF-10.014
asd-1Protein ASD-10.014
T28D9.4Protein T28D9.40.014
ttll-4Protein TTLL-40.014
F33H2.3Protein F33H2.30.014
rod-1Protein ROD-10.013
rga-1Protein RGA-10.013
tba-1Protein TBA-10.013
rpt-5Protein RPT-50.012
R11A8.7Protein R11A8.70.012
mcm-2Protein MCM-20.012
ddx-19Protein DDX-190.012
Y59E9AL.4Protein Y59E9AL.40.012
sop-3Protein SOP-30.011
lin-9Protein LIN-90.011
wht-7Protein WHT-70.011
kin-10Protein KIN-100.011
tam-1Protein TAM-10.011
spr-1Protein SPR-10.011
knl-3Protein KNL-30.011
bub-1Protein BUB-10.011
pod-1Protein POD-10.011
cids-2Protein CIDS-20.011
uaf-1Protein UAF-10.011
mcm-7Protein MCM-70.011
suf-1Protein SUF-10.010
spt-5Protein SPT-50.010
cyb-1Protein CYB-10.010
CELE_W02D7.6Protein W02D7.60.010
gck-1Protein GCK-10.010
lag-1Protein LAG-10.010
mcm-3Protein MCM-30.010
ebp-2Protein EBP-20.010
CELE_C39E9.12Protein C39E9.120.010
T05E8.3Protein T05E8.30.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
aslasterless0.158
CycBCyclin B0.158
IswiImitation SWI0.139
ncdnon-claret disjunctional0.095
CycB3Cyclin B30.076
fzyfizzy0.059
BubR1Bub1-related kinase0.044
gwlgreatwall0.043
Cdc37CG12019 gene product from transcript CG12019-RA0.037
Klp61FKinesin-like protein at 61F0.034
dupdouble parked0.030
DrefDNA replication-related element factor0.030
CycACyclin A0.029
cmetCENP-meta0.027
Cks30ACyclin-dependent kinase subunit 30A0.026
Cap-GCG34438 gene product from transcript CG34438-RF0.023
bambag of marbles0.023
IncenpInner centromere protein0.023
Pp1-87BProtein phosphatase 1 at 87B0.023
SMC2CG10212 gene product from transcript CG10212-RA0.022
mus301mutagen-sensitive 3010.022
Klp3AKinesin-like protein at 3A0.021
ruxroughex0.020
pavpavarotti0.020
nodno distributive disjunction0.019
Nup153Nucleoporin 1530.018
poloCG12306 gene product from transcript CG12306-RA0.017
thrthree rows0.016
Mcm10Sensitized chromosome inheritance modifier 190.015
Sep2Septin-20.015
piepineapple eye0.015
nbsCG6754 gene product from transcript CG6754-RC0.015
msb1lCG10364 gene product from transcript CG10364-RA0.015
NiPp1Nuclear inhibitor of Protein phosphatase 10.014
dpadisc proliferation abnormal0.014
DNApol-alpha60DNA polymerase alpha 60kD0.014
pimpimples0.013
DetDeterin0.013
CG6439CG6439 gene product from transcript CG6439-RA0.012
wispwispy0.012
prodproliferation disrupter0.012
cavcaravaggio0.012
spn-Dspindle D0.011
alphaTub67Calpha-Tubulin at 67C0.011
pngpan gu0.011
flflfalafel0.011
aspabnormal spindle0.011
Spc105RSpc105-related0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDK2cyclin-dependent kinase 20.995
CCNA2cyclin A20.987
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.967
CCNB1cyclin B10.940
CDC20cell division cycle 20 homolog (S. cerevisiae)0.926
CDC27cell division cycle 27 homolog (S. cerevisiae)0.864
BRCA2breast cancer 2, early onset0.811
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.790
H2AFXH2A histone family, member X0.742
CKS1BCDC28 protein kinase regulatory subunit 1B0.577
CCT8chaperonin containing TCP1, subunit 8 (theta)0.551
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.513
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.500
NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.490
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.422
CDKN3cyclin-dependent kinase inhibitor 30.402
SKP2S-phase kinase-associated protein 2 (p45)0.379
SKA1spindle and kinetochore associated complex subunit 10.351
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.300
BRCA1breast cancer 1, early onset0.287
AURKBaurora kinase B0.271
CBX5chromobox homolog 50.251
UHRF2ubiquitin-like with PHD and ring finger domains 20.219
TTKTTK protein kinase0.204
TPX2TPX2, microtubule-associated, homolog (Xenopus laevis)0.195
SKA2spindle and kinetochore associated complex subunit 20.169
CDK1cyclin-dependent kinase 10.141
CCNB2cyclin B20.126
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.120
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.116
NEK2NIMA (never in mitosis gene a)-related kinase 20.114
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.110
CKS2CDC28 protein kinase regulatory subunit 20.105
CHEK2CHK2 checkpoint homolog (S. pombe)0.105
CCT4chaperonin containing TCP1, subunit 4 (delta)0.099
PRNPprion protein0.095
CDT1chromatin licensing and DNA replication factor 10.093
CASC5cancer susceptibility candidate 50.091
CHAF1Achromatin assembly factor 1, subunit A (p150)0.088
TINF2TERF1 (TRF1)-interacting nuclear factor 20.088
SKA3spindle and kinetochore associated complex subunit 30.086
ANAPC11anaphase promoting complex subunit 110.084
CCNE2cyclin E20.080
FBXO5F-box protein 50.079
CCDC99coiled-coil domain containing 990.077
PTTG1pituitary tumor-transforming 10.076
KIF18Akinesin family member 18A0.073
NUF2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.072
SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.070
FOXM1forkhead box M10.070
CENPEcentromere protein E, 312kDa0.069
UHRF1ubiquitin-like with PHD and ring finger domains 10.066
CEP55centrosomal protein 55kDa0.066
RAD51AP1RAD51 associated protein 10.064
PRC1protein regulator of cytokinesis 10.063
SMC4structural maintenance of chromosomes 40.062
CCNE1cyclin E10.060
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.060
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.059
CDC25Acell division cycle 25 homolog A (S. pombe)0.059
HMMRhyaluronan-mediated motility receptor (RHAMM)0.057
KIF11kinesin family member 110.057
C19orf39chromosome 19 open reading frame 390.056
UBE2Cubiquitin-conjugating enzyme E2C0.056
C13orf34chromosome 13 open reading frame 340.054
TERF2IPtelomeric repeat binding factor 2, interacting protein0.054
ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)0.051
CCND1cyclin D10.049
CHEK1CHK1 checkpoint homolog (S. pombe)0.049
SGOL1shugoshin-like 1 (S. pombe)0.047
ANAPC4anaphase promoting complex subunit 40.047
CDC25Ccell division cycle 25 homolog C (S. pombe)0.047
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.045
BLMBloom syndrome, RecQ helicase-like0.043
PLK4polo-like kinase 40.043
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.042
ANKRD52ankyrin repeat domain 520.041
HERC2hect domain and RLD 20.040
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.039
DEPDC1DEP domain containing 10.038
TOP2Atopoisomerase (DNA) II alpha 170kDa0.038
CENPFcentromere protein F, 350/400kDa (mitosin)0.038
KIF14kinesin family member 140.037
TP53BP1tumor protein p53 binding protein 10.034
SPC24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.034
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.034
C12orf48chromosome 12 open reading frame 480.034
RB1retinoblastoma 10.033
PPME1protein phosphatase methylesterase 10.033
MAD2L1BPMAD2L1 binding protein0.032
SGOL2shugoshin-like 2 (S. pombe)0.032
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.032
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.032
RBL1retinoblastoma-like 1 (p107)0.031
MYST1MYST histone acetyltransferase 10.031
ZWINTZW10 interactor0.031
BIRC5baculoviral IAP repeat containing 50.029
INCENPinner centromere protein antigens 135/155kDa0.029
PLK1polo-like kinase 10.027
OTUB1OTU domain, ubiquitin aldehyde binding 10.027
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.484
Cdk1cyclin-dependent kinase 10.472
Ccnb1cyclin B10.347
Ccna2cyclin A20.273
Ccnb2cyclin B20.183
Birc5baculoviral IAP repeat-containing 50.156
Brca1breast cancer 10.138
Prc1protein regulator of cytokinesis 10.127
Kif22kinesin family member 220.124
Kif20akinesin family member 20A0.101
Ccnfcyclin F0.092
Aurkaaurora kinase A0.079
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.066
Cdca8cell division cycle associated 80.065
Cdk2cyclin-dependent kinase 20.064
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.053
Kif2ckinesin family member 2C0.039
Brca2breast cancer 20.036
C330027C09RikRIKEN cDNA C330027C09 gene0.036
Ube2cubiquitin-conjugating enzyme E2C0.035
Kif11kinesin family member 110.033
Mki67antigen identified by monoclonal antibody Ki 670.031
Cdc25ccell division cycle 25 homolog C (S. pombe)0.031
Spag5sperm associated antigen 50.031
Aurkbaurora kinase B0.031
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.030
Plk1polo-like kinase 1 (Drosophila)0.029
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.028
Ctnnb1catenin (cadherin associated protein), beta 10.027
Mis18bp1MIS18 binding protein 10.026
Gtse1G two S phase expressed protein 10.025
Kif4kinesin family member 40.025
Cdca5cell division cycle associated 50.024
Kif23kinesin family member 230.023
Cdkn1bcyclin-dependent kinase inhibitor 1B0.023
Top2atopoisomerase (DNA) II alpha0.022
Ccdc99coiled-coil domain containing 990.019
Ckap2cytoskeleton associated protein 20.019
Rrm2ribonucleotide reductase M20.018
Ezh2enhancer of zeste homolog 2 (Drosophila)0.017
Wdhd1WD repeat and HMG-box DNA binding protein 10.017
Trim59tripartite motif-containing 590.017
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.016
Ooepoocyte expressed protein homolog (dog)0.016
Sgol2shugoshin-like 2 (S. pombe)0.016
Lmnb1lamin B10.015
Gsg2germ cell-specific gene 20.014
Tacc3transforming, acidic coiled-coil containing protein 30.014
Hmmrhyaluronan mediated motility receptor (RHAMM)0.013
Hmgb2high mobility group box 20.013
Dlgap5discs, large (Drosophila) homolog-associated protein 50.013
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.013
Dtldenticleless homolog (Drosophila)0.013
Incenpinner centromere protein0.012
Ect2ect2 oncogene0.012
Ptenphosphatase and tensin homolog0.012
Mdm2transformed mouse 3T3 cell double minute 20.012
Sgol1shugoshin-like 1 (S. pombe)0.012
Rb1retinoblastoma 10.012
H2afxH2A histone family, member X0.011
Tcf19transcription factor 190.011
Trip13thyroid hormone receptor interactor 130.011
Melkmaternal embryonic leucine zipper kinase0.011
Smad3MAD homolog 3 (Drosophila)0.011
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.011
E2f8E2F transcription factor 80.011
Cenpacentromere protein A0.011
Plk4polo-like kinase 4 (Drosophila)0.011
Dna2DNA replication helicase 2 homolog (yeast)0.011
Racgap1Rac GTPase-activating protein 10.011
Tmpothymopoietin0.011
Ube2tubiquitin-conjugating enzyme E2T (putative)0.011
Chek1checkpoint kinase 1 homolog (S. pombe)0.011
Cenpkcentromere protein K0.010
Anlnanillin, actin binding protein0.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism