The network for 'positive regulation of mitotic metaphase anaphase transition' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of mitotic metaphase anaphase transition

Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition.

Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC23Cdc23p0.760
CDC16Cdc16p0.710
CDC27Cdc27p0.515
APC2Apc2p0.342
DOC1Doc1p0.341
SWM1Swm1p0.253
APC4Apc4p0.219
CDC26Cdc26p0.214
APC1Apc1p0.193
MND2Mnd2p0.174
APC5Apc5p0.077
CDC20Cdc20p0.064
PDS1Pds1p0.026
NSE4Nse4p0.025
MMS21Mms21p0.021
CLB1Clb1p0.019
APC11Apc11p0.019
SRD1Srd1p0.014
KRE29Kre29p0.014
ARP10Arp10p0.013
SLK19Slk19p0.013
LEU2Leu2p0.012
MER1Mer1p0.012
YLR264C-Ahypothetical protein0.012
YOL038C-Ahypothetical protein0.012
MAD3Mad3p0.011
SMC4Smc4p0.011
YLR162Whypothetical protein0.011
SPL2Spl2p0.011
SPC42Spc42p0.011
YPR157Whypothetical protein0.011
YAR068Whypothetical protein0.010
CUP1-1Cup1-1p0.010
ARG8Arg8p0.010
ATP6Atp6p0.010
FMT1Fmt1p0.010
SPC105Spc105p0.010
YLR042Chypothetical protein0.010
YBR013Chypothetical protein0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cmetCENP-meta0.574
CycACyclin A0.403
bratbrain tumor0.233
pimpimples0.205
BubR1Bub1-related kinase0.177
hpohippo0.159
aspabnormal spindle0.114
SseSeparase0.113
cavcaravaggio0.112
Mcm10Sensitized chromosome inheritance modifier 190.111
tefutelomere fusion0.107
pashapartner of drosha0.099
Cenp-CCG31258 gene product from transcript CG31258-RA0.098
idaimaginal discs arrested0.086
ncdnon-claret disjunctional0.083
Nuf2CG8902 gene product from transcript CG8902-RA0.080
Klp61FKinesin-like protein at 61F0.077
dupdouble parked0.074
gwlgreatwall0.062
stgstring0.059
Spc105RSpc105-related0.058
barrbarren0.057
marsCG17064 gene product from transcript CG17064-RB0.054
MybMyb oncogene-like0.048
tumtumbleweed0.041
CG9772CG9772 gene product from transcript CG9772-RB0.039
Klp3AKinesin-like protein at 3A0.037
Psf2CG18013 gene product from transcript CG18013-RA0.036
Orc2Origin recognition complex subunit 20.034
Cks30ACyclin-dependent kinase subunit 30A0.030
IncenpInner centromere protein0.029
stisticky0.027
dpadisc proliferation abnormal0.026
mus304mutagen-sensitive 3040.025
CycBCyclin B0.025
phopleiohomeotic0.024
thrthree rows0.023
dapdacapo0.023
Ptp69DProtein tyrosine phosphatase 69D0.023
Ndc80CG9938 gene product from transcript CG9938-RA0.023
Su(var)2-10Suppressor of variegation 2-100.022
CG4680CG4680 gene product from transcript CG4680-RA0.021
Nek2CG17256 gene product from transcript CG17256-RA0.021
Cdc27CG8610 gene product from transcript CG8610-RA0.020
Klp10ACG1453 gene product from transcript CG1453-RA0.020
shtdshattered0.020
Rca1Regulator of cyclin A10.019
vtdverthandi0.019
pblpebble0.019
Orc5Origin recognition complex subunit 50.018
DrefDNA replication-related element factor0.017
l(1)dd4lethal (1) discs degenerate 40.017
Mis12CG18156 gene product from transcript CG18156-RA0.017
Su(H)Suppressor of Hairless0.017
nbsCG6754 gene product from transcript CG6754-RC0.017
Vap-33-1CG5014 gene product from transcript CG5014-RB0.017
larpLa related protein0.016
CycECyclin E0.016
DNApol-alpha60DNA polymerase alpha 60kD0.015
ParpPoly-(ADP-ribose) polymerase0.015
pitaCG3941 gene product from transcript CG3941-RA0.015
SMC2CG10212 gene product from transcript CG10212-RA0.015
l(1)G0148lethal (1) G01480.014
CycB3Cyclin B30.014
fzyfizzy0.014
Dap160Dynamin associated protein 1600.014
Cap-GCG34438 gene product from transcript CG34438-RF0.013
jumujumeau0.013
lkb1CG9374 gene product from transcript CG9374-RJ0.012
weeCG4488 gene product from transcript CG4488-RA0.012
ballballchen0.012
Spc25CG7242 gene product from transcript CG7242-RA0.012
cdc23CG2508 gene product from transcript CG2508-RA0.011
wun2wunen-20.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDC20cell division cycle 20 homolog (S. cerevisiae)0.901
CDC27cell division cycle 27 homolog (S. cerevisiae)0.735
ANAPC4anaphase promoting complex subunit 40.282
ANAPC7anaphase promoting complex subunit 70.217
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.173
RB1retinoblastoma 10.115
E2F1E2F transcription factor 10.043
CDK2cyclin-dependent kinase 20.039
CDC26cell division cycle 26 homolog (S. cerevisiae)0.029
RBBP8retinoblastoma binding protein 80.025
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.025
RBL2retinoblastoma-like 2 (p130)0.023
GTSE1G-2 and S-phase expressed 10.023
PLK1polo-like kinase 10.023
ANAPC11anaphase promoting complex subunit 110.022
CCNA2cyclin A20.022
NUF2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.021
PTTG1pituitary tumor-transforming 10.019
MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 20.017
CDC23cell division cycle 23 homolog (S. cerevisiae)0.017
NSMCE1non-SMC element 1 homolog (S. cerevisiae)0.014
E2F4E2F transcription factor 4, p107/p130-binding0.012
CLSPNclaspin0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 11.000
Trp53transformation related protein 531.000
Ptenphosphatase and tensin homolog0.990
Apcadenomatosis polyposis coli0.963
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.860
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.696
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.643
Plk1polo-like kinase 1 (Drosophila)0.572
Cdkn1bcyclin-dependent kinase inhibitor 1B0.484
Leprleptin receptor0.452
Ube2cubiquitin-conjugating enzyme E2C0.373
Ccnfcyclin F0.292
Kitkit oncogene0.279
Smad3MAD homolog 3 (Drosophila)0.268
Ckap2cytoskeleton associated protein 20.247
Dlgap5discs, large (Drosophila) homolog-associated protein 50.239
Ccnb2cyclin B20.236
Mki67antigen identified by monoclonal antibody Ki 670.219
Kif22kinesin family member 220.188
Rb1retinoblastoma 10.182
Ccna2cyclin A20.178
Usp9xubiquitin specific peptidase 9, X chromosome0.172
Notch1Notch gene homolog 1 (Drosophila)0.167
Mdm2transformed mouse 3T3 cell double minute 20.137
Axin1axin 10.135
Mybl2myeloblastosis oncogene-like 20.125
Kif2ckinesin family member 2C0.123
Ranbp9RAN binding protein 90.121
Gtse1G two S phase expressed protein 10.119
Rrm2ribonucleotide reductase M20.110
Zeb1zinc finger E-box binding homeobox 10.108
Brca1breast cancer 10.106
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.103
Cdc25ccell division cycle 25 homolog C (S. pombe)0.102
Psen1presenilin 10.100
Chd7chromodomain helicase DNA binding protein 70.094
Prmt5protein arginine N-methyltransferase 50.091
Aurkbaurora kinase B0.090
Kif4kinesin family member 40.089
Spag5sperm associated antigen 50.087
BrafBraf transforming gene0.083
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.081
Ccnb1cyclin B10.077
Pax3paired box gene 30.076
Hmmrhyaluronan mediated motility receptor (RHAMM)0.075
Ptpn11protein tyrosine phosphatase, non-receptor type 110.070
Cenpecentromere protein E0.068
Fam64afamily with sequence similarity 64, member A0.065
Ptch1patched homolog 10.061
Lmnb1lamin B10.060
Cdca5cell division cycle associated 50.058
Atf2activating transcription factor 20.056
E2f1E2F transcription factor 10.055
E2f8E2F transcription factor 80.054
Lrp6low density lipoprotein receptor-related protein 60.053
Bmpr1abone morphogenetic protein receptor, type 1A0.053
Cdk1cyclin-dependent kinase 10.053
Cenpfcentromere protein F0.051
Col1a1collagen, type I, alpha 10.050
Cdca8cell division cycle associated 80.050
Hif1ahypoxia inducible factor 1, alpha subunit0.050
Lin7clin-7 homolog C (C. elegans)0.049
Kitlkit ligand0.049
Ncapd2non-SMC condensin I complex, subunit D20.049
Itgb1integrin beta 1 (fibronectin receptor beta)0.042
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.041
Ckap2lcytoskeleton associated protein 2-like0.040
Kif20akinesin family member 20A0.039
Kpna1karyopherin (importin) alpha 10.039
Sgol1shugoshin-like 1 (S. pombe)0.039
Tcf3transcription factor 30.037
Dazap1DAZ associated protein 10.037
Aurkaaurora kinase A0.036
Iqgap3IQ motif containing GTPase activating protein 30.036
E130303B06RikRIKEN cDNA E130303B06 gene0.036
H2afxH2A histone family, member X0.034
Espl1extra spindle poles-like 1 (S. cerevisiae)0.034
Foxm1forkhead box M10.033
Esr1estrogen receptor 1 (alpha)0.032
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.032
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.032
Cenpncentromere protein N0.030
Ncapgnon-SMC condensin I complex, subunit G0.029
Nf2neurofibromatosis 20.029
Incenpinner centromere protein0.027
Ccne1cyclin E10.026
Ap2a1adaptor protein complex AP-2, alpha 1 subunit0.025
StilScl/Tal1 interrupting locus0.025
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.025
Ppargperoxisome proliferator activated receptor gamma0.024
Ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.024
Bmp7bone morphogenetic protein 70.023
Exo1exonuclease 10.023
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.023
Thrathyroid hormone receptor alpha0.022
U2af2U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 20.022
Cenpmcentromere protein M0.022
Meox2mesenchyme homeobox 20.021
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.021
Apoeapolipoprotein E0.021
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism