The network for 'phosphatidylinositol biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

phosphatidylinositol biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.

NameDescriptionProbabilityFunc Analog Organism
GAA1Gaa1p0.972
LAS21Las21p0.911
GAB1Gab1p0.799
GPI17Gpi17p0.693
GWT1Gwt1p0.415
GPI16Gpi16p0.390
TGL1Tgl1p0.292
ALG6Alg6p0.258
GPI8Gpi8p0.243
OSH7Osh7p0.162
SLC1Slc1p0.152
MMF1Mmf1p0.139
ARV1Arv1p0.136
EMP24Emp24p0.131
MCD4Mcd4p0.121
CNE1Cne1p0.115
ACF2Acf2p0.106
GLO3Glo3p0.104
SPF1Spf1p0.101
ELO1Elo1p0.092
ERV29Erv29p0.089
SEC59Sec59p0.088
SPT14Spt14p0.083
YLR036Chypothetical protein0.083
CHS7Chs7p0.080
PMT3Pmt3p0.078
YJR012Chypothetical protein0.077
ERD2Erd2p0.075
ARF3Arf3p0.073
FIG4Fig4p0.070
MOB2Mob2p0.069
DIE2Die2p0.068
VPS1Vps1p0.066
PMT2Pmt2p0.061
YDR186Chypothetical protein0.060
SNA3Sna3p0.059
PFA4Pfa4p0.059
GPI13Gpi13p0.058
AGE1Age1p0.058
CBK1Cbk1p0.056
GPI1Gpi1p0.055
CHA1Cha1p0.055
AXL2Axl2p0.054
SFB3Sfb3p0.054
YLR264C-Ahypothetical protein0.053
BET2Bet2p0.053
CDC1Cdc1p0.053
ADH4Adh4p0.052
YJR015Whypothetical protein0.052
NEO1Neo1p0.052
MID1Mid1p0.051
MEC3Mec3p0.051
SRD1Srd1p0.051
KRE5Kre5p0.051
PFA5Pfa5p0.049
ARP10Arp10p0.049
BST1Bst1p0.049
YAE1Yae1p0.048
ERV25Erv25p0.047
GPI11Gpi11p0.046
GMH1Gmh1p0.046
ARG8Arg8p0.045
VPS74Vps74p0.045
LEU2Leu2p0.044
CHO1Cho1p0.044
RUD3Rud3p0.044
CNB1Cnb1p0.043
SSL1Ssl1p0.043
VPS15Vps15p0.043
SMP3Smp3p0.042
YOL038C-Ahypothetical protein0.041
MST27Mst27p0.040
LDB16Ldb16p0.040
YER186Chypothetical protein0.039
JLP2Jlp2p0.039
DCR2Dcr2p0.039
TTI2Tti2p0.039
WAR1War1p0.039
CUP1-1Cup1-1p0.037
ARO10Aro10p0.037
SFT1Sft1p0.037
GPI2Gpi2p0.037
AVT4Avt4p0.037
YLR042Chypothetical protein0.036
OPT2Opt2p0.036
SAP1Sap1p0.036
MER1Mer1p0.036
UTR4Utr4p0.035
VBA5Vba5p0.035
PGS1Pgs1p0.035
YLR162Whypothetical protein0.034
SCM4Scm4p0.034
YMR122W-Ahypothetical protein0.034
CPR2Cpr2p0.034
AGP1Agp1p0.033
IZH4Izh4p0.033
TSC3Tsc3p0.033
FMT1Fmt1p0.033
UPS3Ups3p0.032
ARK1Ark1p0.032
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
disp1dispatched homolog 1 (Drosophila)0.046
satb2SATB homeobox 20.029
pdgfabplatelet derived growth factor alpha b0.026
ift88intraflagellar transport 88 homolog0.025
jag1bjagged 1b0.023
nkx2.3NK2 transcription factor related 30.023
rcbtb1regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 10.018
chmchoroideremia0.018
foxa1forkhead box A10.018
si:dkeyp-50f5.1si:dkeyp-50f5.10.017
caprin2caprin family member 20.015
nae1nedd8 activating enzyme E1 subunit 10.015
fam20bfamily with sequence similarity 20, member B (H. sapiens)0.013
rp2retinitis pigmentosa 2 (X-linked recessive)0.013
ndrg1N-myc downstream regulated gene 10.013
prickle2prickle-like 2 (Drosophila)0.012
npntnephronectin0.012
wnk1WNK lysine deficient protein kinase 10.012
zgc:55413zgc:554130.012
cul5acullin 5a0.012
nr2f2nuclear receptor subfamily 2, group F, member 20.012
tmprss4btransmembrane protease, serine 4b0.011
hspb6heat shock protein, alpha-crystallin-related, b60.011
efna2ephrin A20.011
slc46a1solute carrier family 46, member 10.010
atp6v1e1bATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b0.010
atxn7l2aataxin 7-like 2a0.010
vamp4vesicle-associated membrane protein 40.010
mitd1MIT, microtubule interacting and transport, domain containing 10.010
tas2r200.1taste receptor, type 2, member 200.10.010
crb2acrumbs homolog 2a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.960
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.811
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.623
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.486
GPAA1glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)0.483
FGFR2fibroblast growth factor receptor 20.469
FGFR1fibroblast growth factor receptor 10.381
NOS1nitric oxide synthase 1 (neuronal)0.297
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.266
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.207
IRS1insulin receptor substrate 10.187
PLCG1phospholipase C, gamma 10.183
PIGTphosphatidylinositol glycan anchor biosynthesis, class T0.181
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.163
CMIPc-Maf-inducing protein0.130
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.101
NRP1neuropilin 10.067
FGF10fibroblast growth factor 100.062
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.059
CD9CD9 molecule0.056
SPAG9sperm associated antigen 90.051
VKORC1vitamin K epoxide reductase complex, subunit 10.047
NEDD4neural precursor cell expressed, developmentally down-regulated 40.047
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.045
POLR2Kpolymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa0.044
CD81CD81 molecule0.044
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.037
SHC1SHC (Src homology 2 domain containing) transforming protein 10.035
CD63CD63 molecule0.034
SYKspleen tyrosine kinase0.033
DVL3dishevelled, dsh homolog 3 (Drosophila)0.031
PTPN1protein tyrosine phosphatase, non-receptor type 10.030
GAB1GRB2-associated binding protein 10.030
PIKFYVEphosphoinositide kinase, FYVE finger containing0.029
TSPAN4tetraspanin 40.028
PTPRBprotein tyrosine phosphatase, receptor type, B0.027
BLNKB-cell linker0.024
HSPG2heparan sulfate proteoglycan 20.024
SORBS1sorbin and SH3 domain containing 10.023
THBS1thrombospondin 10.022
ATMINATM interactor0.022
NDUFA3NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa0.022
PDGFAplatelet-derived growth factor alpha polypeptide0.022
LATlinker for activation of T cells0.022
FGF2fibroblast growth factor 2 (basic)0.022
PDGFCplatelet derived growth factor C0.022
FGF1fibroblast growth factor 1 (acidic)0.021
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.021
GRB7growth factor receptor-bound protein 70.020
VAV2vav 2 guanine nucleotide exchange factor0.020
VAV3vav 3 guanine nucleotide exchange factor0.019
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.019
FGF7fibroblast growth factor 70.019
GAB2GRB2-associated binding protein 20.019
UVRAGUV radiation resistance associated gene0.019
PIGSphosphatidylinositol glycan anchor biosynthesis, class S0.019
COL6A1collagen, type VI, alpha 10.018
TLR3toll-like receptor 30.018
SCAND1SCAN domain containing 10.018
DLG5discs, large homolog 5 (Drosophila)0.018
CUTAcutA divalent cation tolerance homolog (E. coli)0.018
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.017
IPO11importin 110.017
MMP14matrix metallopeptidase 14 (membrane-inserted)0.017
C1DC1D nuclear receptor corepressor0.016
HPS6Hermansky-Pudlak syndrome 60.016
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.016
AXLAXL receptor tyrosine kinase0.016
CHMP2Bchromatin modifying protein 2B0.016
ALAS1aminolevulinate, delta-, synthase 10.016
PSMC6proteasome (prosome, macropain) 26S subunit, ATPase, 60.016
GSSglutathione synthetase0.015
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.015
SH3KBP1SH3-domain kinase binding protein 10.015
SEP1515 kDa selenoprotein0.014
FIG4FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)0.014
FRS2fibroblast growth factor receptor substrate 20.014
DSCAML1Down syndrome cell adhesion molecule like 10.014
PFDN4prefoldin subunit 40.014
PTK6PTK6 protein tyrosine kinase 60.014
BAI1brain-specific angiogenesis inhibitor 10.014
ARRDC3arrestin domain containing 30.013
PIK3R3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)0.013
INSRinsulin receptor0.013
PIK3R4phosphoinositide-3-kinase, regulatory subunit 40.013
SORBS3sorbin and SH3 domain containing 30.012
USP16ubiquitin specific peptidase 160.012
INO80BINO80 complex subunit B0.012
C1orf9chromosome 1 open reading frame 90.012
COL5A1collagen, type V, alpha 10.012
SLMO2slowmo homolog 2 (Drosophila)0.012
ROCK1Rho-associated, coiled-coil containing protein kinase 10.012
NOSTRINnitric oxide synthase trafficker0.012
G6PC3glucose 6 phosphatase, catalytic, 30.012
CD99CD99 molecule0.012
NME3non-metastatic cells 3, protein expressed in0.012
BCAS2breast carcinoma amplified sequence 20.012
ERRFI1ERBB receptor feedback inhibitor 10.012
CD28CD28 molecule0.012
SNRNP27small nuclear ribonucleoprotein 27kDa (U4/U6.U5)0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.949
Gab1growth factor receptor bound protein 2-associated protein 10.491
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.444
BtkBruton agammaglobulinemia tyrosine kinase0.347
Dok1docking protein 10.281
CblCasitas B-lineage lymphoma0.242
Ptenphosphatase and tensin homolog0.223
Grb2growth factor receptor bound protein 20.214
Itsn1intersectin 1 (SH3 domain protein 1A)0.202
Mdm2transformed mouse 3T3 cell double minute 20.183
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.174
FynFyn proto-oncogene0.140
Irs1insulin receptor substrate 10.129
Ep300E1A binding protein p3000.116
Ighimmunoglobulin heavy chain complex0.109
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.105
Lig4ligase IV, DNA, ATP-dependent0.090
Cd40CD40 antigen0.079
Shc1src homology 2 domain-containing transforming protein C10.075
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.068
Tgfbr1transforming growth factor, beta receptor I0.066
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.066
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.056
TcrdT-cell receptor delta chain0.053
Bcl6B-cell leukemia/lymphoma 60.050
Notch2Notch gene homolog 2 (Drosophila)0.040
Parvgparvin, gamma0.039
Nbnnibrin0.037
Fcgr2bFc receptor, IgG, low affinity IIb0.032
BlnkB-cell linker0.031
Gab2growth factor receptor bound protein 2-associated protein 20.029
D15Ertd621eDNA segment, Chr 15, ERATO Doi 621, expressed0.027
Ikzf1IKAROS family zinc finger 10.027
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.026
Phlda3pleckstrin homology-like domain, family A, member 30.026
Kifc3kinesin family member C30.024
5730494N06RikRIKEN cDNA 5730494N06 gene0.023
Ptprcprotein tyrosine phosphatase, receptor type, C0.023
Kdelr1KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 10.023
Crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.022
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.021
Tnfsf15tumor necrosis factor (ligand) superfamily, member 150.021
B230308N11RikRIKEN cDNA B230308N11 gene0.020
Dok2docking protein 20.020
Anapc7anaphase promoting complex subunit 70.019
Pdpk13-phosphoinositide dependent protein kinase 10.019
Polr3kpolymerase (RNA) III (DNA directed) polypeptide K0.019
Slc33a1solute carrier family 33 (acetyl-CoA transporter), member 10.019
Rc3h1RING CCCH (C3H) domains 10.018
Brca2breast cancer 20.018
Slc27a1solute carrier family 27 (fatty acid transporter), member 10.017
Fbxw7F-box and WD-40 domain protein 70.017
Dynlt1bdynein light chain Tctex-type 1D0.017
Aplp2amyloid beta (A4) precursor-like protein 20.017
Metmet proto-oncogene0.017
St6galnac6ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 60.016
Hook2hook homolog 2 (Drosophila)0.016
Ptpn6protein tyrosine phosphatase, non-receptor type 60.016
Dok3docking protein 30.016
Pdgfcplatelet-derived growth factor, C polypeptide0.015
Pdk2pyruvate dehydrogenase kinase, isoenzyme 20.015
Dnajb5DnaJ (Hsp40) homolog, subfamily B, member 50.015
2310044H10RikRIKEN cDNA 2310044H10 gene0.015
Plcg1phospholipase C, gamma 10.015
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.015
Zp2zona pellucida glycoprotein 20.015
Ptgs2prostaglandin-endoperoxide synthase 20.015
Prkceprotein kinase C, epsilon0.015
Slamf1signaling lymphocytic activation molecule family member 10.015
9430031J16RikRIKEN cDNA 9430031J16 gene0.014
Gas6growth arrest specific 60.014
Epas1endothelial PAS domain protein 10.014
Etaa1Ewing's tumor-associated antigen 10.014
Brca1breast cancer 10.014
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.014
Kitkit oncogene0.013
Atp11cATPase, class VI, type 11C0.013
Mapk3mitogen-activated protein kinase 30.013
Sh3kbp1SH3-domain kinase binding protein 10.013
WrnWerner syndrome homolog (human)0.013
Sorbs3sorbin and SH3 domain containing 30.013
Gaaglucosidase, alpha, acid0.013
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.013
Fbxo32F-box protein 320.013
Nr3c1nuclear receptor subfamily 3, group C, member 10.013
Rock2Rho-associated coiled-coil containing protein kinase 20.013
Cd22CD22 antigen0.012
Zfp148zinc finger protein 1480.012
Vegfbvascular endothelial growth factor B0.012
Fntafarnesyltransferase, CAAX box, alpha0.012
0610007C21RikRIKEN cDNA 0610007C21 gene0.012
Akap9A kinase (PRKA) anchor protein (yotiao) 90.012
Pde7aphosphodiesterase 7A0.012
Man2c1mannosidase, alpha, class 2C, member 10.012
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.012
Aplnapelin0.012
Atp5sATP synthase, H+ transporting, mitochondrial F0 complex, subunit s0.012
Spry4sprouty homolog 4 (Drosophila)0.011
Acvr2aactivin receptor IIA0.011
Prf1perforin 1 (pore forming protein)0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism