The network for 'positive regulation of cyclase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cyclase activity

Any process that activates or increases the activity of a cyclase.

NameDescriptionProbabilityFunc Analog Organism
RPA49Rpa49p0.033
GIS2Gis2p0.022
NOP1Nop1p0.021
RPF2Rpf2p0.017
LSG1Lsg1p0.017
UTP15Utp15p0.017
SSB2Ssb2p0.016
FEN1Fen1p0.016
RRP8Rrp8p0.016
UBI4Ubi4p0.015
DBP9Dbp9p0.014
PWP1Pwp1p0.014
PHO88Pho88p0.013
NCL1Ncl1p0.012
RIM11Rim11p0.012
SUP45Sup45p0.012
YVH1Yvh1p0.012
ELP2Elp2p0.012
RIX1Rix1p0.012
IPI3Ipi3p0.011
LIA1Lia1p0.011
YDL063Chypothetical protein0.011
MNN11Mnn11p0.011
ERB1Erb1p0.011
DIS3Dis3p0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nf1aneurofibromin 1a0.229
adrb2aadrenergic receptor, beta 2a0.153
gap43growth associated protein 430.111
nf1bneurofibromin 1b0.097
LOC559201similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3)0.079
paqr8progestin and adipoQ receptor family member VIII0.068
LOC555482tachykinin receptor 3-like0.064
sst3somatostatin 30.047
LOC569642hypothetical protein LOC5696420.037
calcrlacalcitonin receptor-like a0.031
LOC555504novel protocadherin protein0.031
adrb2badrenergic receptor, beta 2b0.029
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.029
sagaS-antigen; retina and pineal gland (arrestin) a0.026
si:dkey-228g21.4si:dkey-228g21.40.025
si:ch211-14k19.8si:ch211-14k19.80.023
grk7aG-protein-coupled receptor kinase 7a0.022
adcyap1aadenylate cyclase activating polypeptide 1a0.021
cldn2claudin 20.019
kiss1rbKISS1 receptor b0.019
trpc1transient receptor potential cation channel, subfamily C, member 10.019
flj13639flj136390.018
vwfvon Willebrand factor0.017
opn1lw1opsin 1 (cone pigments), long-wave-sensitive, 10.016
cldnkclaudin k0.016
plp1bproteolipid protein 1b0.016
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.015
lhbluteinizing hormone, beta polypeptide0.015
pdcaphosducin a0.015
si:dkey-27p23.3si:dkey-27p23.30.015
eno2enolase 20.014
rtn1areticulon 1a0.013
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.013
vegfabvascular endothelial growth factor Ab0.012
pyyapeptide YYa0.012
adipoqladiponectin, C1Q and collagen domain containing, like0.012
ptp4a1protein tyrosine phosphatase type IVA, member 10.012
hdchistidine decarboxylase0.011
npyneuropeptide Y0.011
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.011
calm1acalmodulin 1a0.010
penkaproenkephalin a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG13253CG13253 gene product from transcript CG13253-RB0.292
ShawShaker cognate w0.231
CG34400CG34400 gene product from transcript CG34400-RD0.198
VmatVesicular monoamine transporter0.160
RanBPMRan-binding protein M0.115
oa2octopamine receptor 20.072
fd85Eforkhead domain 85E0.071
Frq2Frequenin 20.065
5-HT1ASerotonin receptor 1A0.063
dnr1defense repressor 10.048
Atf-2Activating transcription factor-20.047
Octbeta2RCG33976 gene product from transcript CG33976-RA0.046
RicRas which interacts with Calmodulin0.045
tauCG31057 gene product from transcript CG31057-RA0.044
CG34139CG34139 gene product from transcript CG34139-RD0.034
DskDrosulfakinin0.033
Spf45CG17540 gene product from transcript CG17540-RB0.031
CG1970CG1970 gene product from transcript CG1970-RA0.030
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.028
CG6983CG6983 gene product from transcript CG6983-RA0.024
CG18437CG18437 gene product from transcript CG18437-RB0.023
PIP5K59BCG3682 gene product from transcript CG3682-RE0.023
CG3907CG3907 gene product from transcript CG3907-RB0.022
jebjelly belly0.020
mipleCG1221 gene product from transcript CG1221-RA0.019
CRMPCollapsin Response Mediator Protein0.019
Nmdar1NMDA receptor 10.017
perperiod0.017
CG3625CG3625 gene product from transcript CG3625-RC0.017
CG14989CG14989 gene product from transcript CG14989-RB0.017
HLH4CHelix loop helix protein 4C0.017
HmgZHMG protein Z0.016
timtimeless0.015
nannanchung0.015
Ank2Ankyrin 20.014
ScgdeltaSarcoglycan delta0.013
nordCG30418 gene product from transcript CG30418-RA0.013
neuroliginCG13772 gene product from transcript CG13772-RA0.013
CaMKIICalcium/calmodulin-dependent protein kinase II0.012
TbhTyramine beta hydroxylase0.012
unc79CG5237 gene product from transcript CG5237-RB0.012
CG11317CG11317 gene product from transcript CG11317-RA0.011
CG34353CG34353 gene product from transcript CG34353-RA0.011
RdlResistant to dieldrin0.011
CanA1Calcineurin A10.011
5-HT1BSerotonin receptor 1B0.010
DatDopamine N acetyltransferase0.010
GluClalphaCG7535 gene product from transcript CG7535-RG0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CALM1calmodulin 1 (phosphorylase kinase, delta)0.998
DRD2dopamine receptor D20.931
RALBP1ralA binding protein 10.673
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.582
NOSTRINnitric oxide synthase trafficker0.513
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.456
VAC14Vac14 homolog (S. cerevisiae)0.385
MPDZmultiple PDZ domain protein0.253
RASSF5Ras association (RalGDS/AF-6) domain family member 50.246
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.198
CRHcorticotropin releasing hormone0.190
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.178
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.112
NAMPTnicotinamide phosphoribosyltransferase0.103
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.093
RIN1Ras and Rab interactor 10.088
ADORA2Aadenosine A2a receptor0.077
DR1down-regulator of transcription 1, TBP-binding (negative cofactor 2)0.077
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.076
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.068
MEOX2mesenchyme homeobox 20.066
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.060
RALGDSral guanine nucleotide dissociation stimulator0.056
PTENphosphatase and tensin homolog0.043
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.042
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.040
KCNH1potassium voltage-gated channel, subfamily H (eag-related), member 10.040
ARRDC3arrestin domain containing 30.037
BZW1basic leucine zipper and W2 domains 10.033
FKBP8FK506 binding protein 8, 38kDa0.030
AKAP10A kinase (PRKA) anchor protein 100.027
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.027
DTX2deltex homolog 2 (Drosophila)0.025
OR2AG1olfactory receptor, family 2, subfamily AG, member 10.025
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.025
RAP2BRAP2B, member of RAS oncogene family0.025
PRKACBprotein kinase, cAMP-dependent, catalytic, beta0.025
CORO1Ccoronin, actin binding protein, 1C0.025
CLTBclathrin, light chain B0.024
GMFBglia maturation factor, beta0.024
RASSF1Ras association (RalGDS/AF-6) domain family member 10.023
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.023
ADORA1adenosine A1 receptor0.023
CP110CP110 protein0.022
NECAB2N-terminal EF-hand calcium binding protein 20.021
GNAI3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 30.020
SRIsorcin0.020
PAX3paired box 30.019
SSTR3somatostatin receptor 30.018
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.018
CALCAcalcitonin-related polypeptide alpha0.018
GHRHRgrowth hormone releasing hormone receptor0.018
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.016
SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.016
TMOD3tropomodulin 3 (ubiquitous)0.015
ODF1outer dense fiber of sperm tails 10.015
PAWRPRKC, apoptosis, WT1, regulator0.015
DRD1dopamine receptor D10.014
BMP8Abone morphogenetic protein 8a0.014
SOS1son of sevenless homolog 1 (Drosophila)0.014
ABL2v-abl Abelson murine leukemia viral oncogene homolog 20.014
DNM1dynamin 10.013
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.013
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.012
ELAVL3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.012
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.012
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.012
EMP3epithelial membrane protein 30.011
ARF6ADP-ribosylation factor 60.011
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.011
ROD1ROD1 regulator of differentiation 1 (S. pombe)0.011
PTGER3prostaglandin E receptor 3 (subtype EP3)0.011
PDE4DIPphosphodiesterase 4D interacting protein0.011
CAPZA2capping protein (actin filament) muscle Z-line, alpha 20.011
CALCRcalcitonin receptor0.010
DLGAP2discs, large (Drosophila) homolog-associated protein 20.010
GFAPglial fibrillary acidic protein0.010
HTR1D5-hydroxytryptamine (serotonin) receptor 1D0.010
ADRA2Badrenergic, alpha-2B-, receptor0.010
TBC1D10ATBC1 domain family, member 10A0.010
ARPP19cAMP-regulated phosphoprotein, 19kDa0.010
SMAD4SMAD family member 40.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Drd2dopamine receptor D20.745
Klklotho0.219
Ptenphosphatase and tensin homolog0.196
Pnpla2patatin-like phospholipase domain containing 20.117
Cckbrcholecystokinin B receptor0.113
Esr1estrogen receptor 1 (alpha)0.079
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.063
Pax8paired box gene 80.061
Ppargperoxisome proliferator activated receptor gamma0.059
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.053
Thrbthyroid hormone receptor beta0.049
Nrasneuroblastoma ras oncogene0.047
Sstr4somatostatin receptor 40.047
Adra2aadrenergic receptor, alpha 2a0.046
Hif1ahypoxia inducible factor 1, alpha subunit0.046
BrafBraf transforming gene0.040
Actr3ARP3 actin-related protein 3 homolog (yeast)0.039
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.037
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.037
Adrb1adrenergic receptor, beta 10.035
Slc16a8solute carrier family 16 (monocarboxylic acid transporters), member 80.035
Rhorhodopsin0.033
Tgfb1transforming growth factor, beta 10.033
Raf1v-raf-leukemia viral oncogene 10.032
Lhx6LIM homeobox protein 60.030
Trp53transformation related protein 530.030
Lhcgrluteinizing hormone/choriogonadotropin receptor0.029
Foxf2forkhead box F20.028
Mc5rmelanocortin 5 receptor0.028
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.028
Duox2dual oxidase 20.026
Arandrogen receptor0.025
Adrb2adrenergic receptor, beta 20.024
Tpothyroid peroxidase0.023
Grid1glutamate receptor, ionotropic, delta 10.023
Shc3src homology 2 domain-containing transforming protein C30.022
Itga2integrin alpha 20.022
Slc12a1solute carrier family 12, member 10.022
Kcnd1potassium voltage-gated channel, Shal-related family, member 10.022
Dlg4discs, large homolog 4 (Drosophila)0.022
Raxretina and anterior neural fold homeobox0.021
Chrm1cholinergic receptor, muscarinic 1, CNS0.021
Cryaacrystallin, alpha A0.021
Atp4aATPase, H+/K+ exchanging, gastric, alpha polypeptide0.021
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.021
Crhr1corticotropin releasing hormone receptor 10.021
Mdm2transformed mouse 3T3 cell double minute 20.020
Oprk1opioid receptor, kappa 10.020
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.020
ND6NADH dehydrogenase subunit 60.020
Adra2cadrenergic receptor, alpha 2c0.019
Krt86keratin 860.019
Pgrprogesterone receptor0.018
Sntb1syntrophin, basic 10.018
Gsx1GS homeobox 10.018
Nos3nitric oxide synthase 3, endothelial cell0.017
Ppyr1pancreatic polypeptide receptor 10.017
Mbmyoglobin0.017
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.017
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.017
Ikzf4IKAROS family zinc finger 40.016
Fgf23fibroblast growth factor 230.016
Cgaglycoprotein hormones, alpha subunit0.016
Gnrhrgonadotropin releasing hormone receptor0.016
Gpr27G protein-coupled receptor 270.016
Plxna1plexin A10.016
Pcsk2proprotein convertase subtilisin/kexin type 20.015
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.015
Htr75-hydroxytryptamine (serotonin) receptor 70.015
Hprthypoxanthine guanine phosphoribosyl transferase0.015
Adam17a disintegrin and metallopeptidase domain 170.015
Khdc1bKH domain containing 1B0.015
Gng4guanine nucleotide binding protein (G protein), gamma 40.015
Neurog3neurogenin 30.014
Ascl2achaete-scute complex homolog 2 (Drosophila)0.014
Trpm1transient receptor potential cation channel, subfamily M, member 10.014
Npy5rneuropeptide Y receptor Y50.014
Ghrgrowth hormone receptor0.014
Ptafrplatelet-activating factor receptor0.014
Cdkn1bcyclin-dependent kinase inhibitor 1B0.013
Rap2cRAP2C, member of RAS oncogene family0.013
Mtpnmyotrophin0.013
Klk4kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)0.013
Ncs1neuronal calcium sensor 10.012
Opn1swopsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)0.012
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.012
Pthlhparathyroid hormone-like peptide0.012
Slc12a5solute carrier family 12, member 50.012
Sstr1somatostatin receptor 10.012
Igf2insulin-like growth factor 20.012
Tll1tolloid-like0.012
Syn2synapsin II0.012
Tmod3tropomodulin 30.012
Mmp24matrix metallopeptidase 240.012
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.012
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.012
C1qtnf1C1q and tumor necrosis factor related protein 10.012
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.011
Icam5intercellular adhesion molecule 5, telencephalin0.011
Prkccprotein kinase C, gamma0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Kcnh3potassium voltage-gated channel, subfamily H (eag-related), member 30.136
Fgf14fibroblast growth factor 140.127
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.105
Rgs9regulator of G-protein signaling 90.105
Pde1bphosphodiesterase 1B, calmodulin-dependent0.104
Utrnutrophin0.084
Gpr176G protein-coupled receptor 1760.077
Sub1SUB1 homolog (S. cerevisiae)0.076
Calm1calmodulin 10.075
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.070
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.069
Teddm1transmembrane epididymal protein 10.067
Crhbpcorticotropin releasing hormone binding protein0.065
Nfascneurofascin0.063
Adra2cadrenergic, alpha-2C-, receptor0.060
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.057
Sdc3syndecan 30.056
Grin2cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.053
Gpr6G protein-coupled receptor 60.051
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.050
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.049
Ifitm3interferon induced transmembrane protein 30.048
Ptp4a2protein tyrosine phosphatase 4a20.048
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.047
Accn3amiloride-sensitive cation channel 30.046
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.045
Hpcahippocalcin0.044
Gad2glutamate decarboxylase 20.043
Adora2aadenosine A2a receptor0.043
Pdynprodynorphin0.041
Cx3cr1chemokine (C-X3-C motif) receptor 10.040
Ncanneurocan0.039
Pgpphosphoglycolate phosphatase0.039
Akp3alkaline phosphatase 3, intestine, not Mn requiring0.039
Adora1adenosine A1 receptor0.038
Dsppdentin sialophosphoprotein0.037
Mchr1melanin-concentrating hormone receptor 10.036
Rph3arabphilin 3A0.036
Grin3aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A0.036
Syt8synaptotagmin VIII0.035
Unc5aunc-5 homolog A (C. elegans)0.035
Ppp2r2cprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform0.035
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.035
Rin1Ras and Rab interactor 10.035
Il8rainterleukin 8 receptor, alpha0.034
Cysscystatin S0.034
Iappislet amyloid polypeptide0.033
Synposynaptopodin0.033
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.032
Pax6paired box 60.032
Actr2ARP2 actin-related protein 2 homolog (yeast)0.032
Lgals3lectin, galactoside-binding, soluble, 30.032
Pla2g2cphospholipase A2, group IIC0.032
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.032
Oxtroxytocin receptor0.031
Csf1colony stimulating factor 1 (macrophage)0.031
Acracrosin0.031
Cckbrcholecystokinin B receptor0.031
Calm2calmodulin 20.031
Avparginine vasopressin0.030
Necab2N-terminal EF-hand calcium binding protein 20.030
Hpcal4hippocalcin-like 40.030
Gabrdgamma-aminobutyric acid (GABA) A receptor, delta0.029
Pou6f1POU class 6 homeobox 10.029
Dynll1dynein light chain LC8-type 10.028
Olr416olfactory receptor 4160.028
Stmn1stathmin 10.028
Ube2d4ubiquitin-conjugating enzyme E2D 40.026
Dio2deiodinase, iodothyronine, type II0.026
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.026
Fgf2fibroblast growth factor 20.026
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.025
Grik3glutamate receptor, ionotropic, kainate 30.025
Rgs8regulator of G-protein signaling 80.025
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.025
Cckarcholecystokinin A receptor0.025
Nbl1neuroblastoma, suppression of tumorigenicity 10.025
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.024
Znf483zinc finger protein 4830.024
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.024
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.024
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.023
Epn2epsin 20.023
Bsnbassoon0.023
Ptprqprotein tyrosine phosphatase, receptor type, Q0.023
Rims1regulating synaptic membrane exocytosis 10.023
Adra1aadrenergic, alpha-1A-, receptor0.023
Gng7guanine nucleotide binding protein (G protein), gamma 70.022
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.022
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.022
Rgs12regulator of G-protein signaling 120.022
Cacng5calcium channel, voltage-dependent, gamma subunit 50.022
Vipr2vasoactive intestinal peptide receptor 20.021
Clstn3calsyntenin 30.021
Thbdthrombomodulin0.021
CartptCART prepropeptide0.021
Gabbr1gamma-aminobutyric acid (GABA) B receptor 10.021
Pou2f2POU class 2 homeobox 20.021
Tacr1tachykinin receptor 10.020
Sstr5somatostatin receptor 50.020