The network for 'negative regulation of response to stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of response to stimulus

Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

NameDescriptionProbabilityFunc Analog Organism
TPK1Tpk1p0.840
SCH9Sch9p0.502
ROM2Rom2p0.481
PPH21Pph21p0.461
YOL087Chypothetical protein0.444
BOI1Boi1p0.426
BCK1Bck1p0.382
KSP1Ksp1p0.378
TIP41Tip41p0.353
GIS1Gis1p0.340
FUS3Fus3p0.293
VPS36Vps36p0.290
VPS33Vps33p0.282
PBS2Pbs2p0.268
TOR1Tor1p0.254
REG1Reg1p0.234
RIM101Rim101p0.227
STE20Ste20p0.221
TPK2Tpk2p0.209
KSS1Kss1p0.161
SIZ1Siz1p0.152
MSN4Msn4p0.148
RHO1Rho1p0.147
PEP5Pep5p0.145
SLX5Slx5p0.142
TGL4Tgl4p0.140
RPN4Rpn4p0.133
DID2Did2p0.132
PRR2Prr2p0.129
CYC8Cyc8p0.129
BEM1Bem1p0.128
VMA13Vma13p0.128
KOG1Kog1p0.128
URN1Urn1p0.121
GSC2Gsc2p0.117
SIP1Sip1p0.116
STI1Sti1p0.113
MKK1Mkk1p0.112
FPK1Fpk1p0.112
POG1Pog1p0.110
PPH3Pph3p0.109
MON2Mon2p0.108
SSN8Ssn8p0.106
HKR1Hkr1p0.106
VPS27Vps27p0.105
LEU5Leu5p0.104
CCR4Ccr4p0.103
MDS3Mds3p0.101
PDE2Pde2p0.099
DOT6Dot6p0.099
YAK1Yak1p0.096
RLM1Rlm1p0.094
PKH2Pkh2p0.090
IRA1Ira1p0.089
LHS1Lhs1p0.089
RSC6Rsc6p0.088
SLG1Slg1p0.088
YKR015Chypothetical protein0.084
BEM3Bem3p0.084
BEM4Bem4p0.082
NBP2Nbp2p0.080
CRZ1Crz1p0.080
HOG1Hog1p0.079
SUV3Suv3p0.078
MSN1Msn1p0.076
GBP2Gbp2p0.076
UBC4Ubc4p0.074
GSY2Gsy2p0.074
MSG5Msg5p0.073
SNF4Snf4p0.072
VTA1Vta1p0.071
TPD3Tpd3p0.070
SRN2Srn2p0.068
SKO1Sko1p0.068
STP2Stp2p0.066
NOP1Nop1p0.066
BBC1Bbc1p0.066
GPR1Gpr1p0.064
RTS1Rts1p0.063
PSY2Psy2p0.062
MNR2Mnr2p0.062
MSN5Msn5p0.061
CKA2Cka2p0.061
STE7Ste7p0.060
SWI1Swi1p0.060
HSV2Hsv2p0.060
TPK3Tpk3p0.060
CSR2Csr2p0.060
VPS24Vps24p0.060
VAC7Vac7p0.056
GLC7Glc7p0.056
CMK1Cmk1p0.056
CYR1Cyr1p0.056
PIL1Pil1p0.055
SEF1Sef1p0.055
NTO1Nto1p0.054
VPS4Vps4p0.053
NRG1Nrg1p0.052
ESS1Ess1p0.052
GLN3Gln3p0.052
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
vab-3Protein VAB-30.709
odr-3Protein ODR-30.639
egl-18Protein EGL-180.481
pat-12Protein PAT-120.306
mec-2Protein MEC-20.270
K10D6.4Protein K10D6.40.268
pry-1Protein PRY-10.264
glp-1Protein GLP-10.259
ida-1Protein IDA-10.227
eat-4Protein EAT-40.212
unc-7Protein UNC-70.207
unc-9Protein UNC-90.196
unc-40Protein UNC-400.190
lin-25Protein LIN-250.172
eps-8Protein EPS-80.153
akt-1Protein AKT-10.147
peb-1Protein PEB-10.144
eya-1Protein EYA-10.130
egl-30Protein EGL-300.127
pkg-1Protein PKG-10.125
nhr-67Protein NHR-670.123
syg-1Protein SYG-10.116
sur-2Protein SUR-20.114
rbr-2Protein RBR-20.111
cam-1Protein CAM-10.110
sup-12Protein SUP-120.109
bar-1Protein BAR-10.109
eor-1Protein EOR-10.108
ceh-20Protein CEH-200.107
let-60Protein LET-600.105
egl-8Protein EGL-80.104
sma-6Protein SMA-60.100
eor-2Protein EOR-20.099
sec-31Protein SEC-310.094
che-2Protein CHE-20.092
inx-13Protein INX-130.091
ceh-44Protein CEH-440.090
mpz-2Protein MPZ-20.089
CELE_Y43D4A.3Protein Y43D4A.30.089
vang-1Protein VANG-10.084
gad-1Protein GAD-10.081
F11E6.8Protein F11E6.80.081
unc-62Protein UNC-620.080
flt-1Protein FLT-10.080
zyg-8Protein ZYG-80.079
cki-1Protein CKI-10.079
egg-6Protein EGG-60.079
ttyh-1Protein TTYH-10.078
smp-1Protein SMP-10.077
atn-1Protein ATN-10.076
ima-3Protein IMA-30.076
dlk-1Protein DLK-10.075
egl-5Protein EGL-50.074
ham-1Protein HAM-10.069
grk-2Protein GRK-20.068
ceh-18Protein CEH-180.068
rpy-1Protein RPY-10.067
skn-1Protein SKN-10.067
F14B8.6Protein F14B8.60.067
bath-42Protein BATH-420.067
T23F4.2Protein T23F4.20.067
R90.1Protein R90.10.066
lag-1Protein LAG-10.066
magi-1Protein MAGI-10.065
hum-5Protein HUM-50.065
egl-46Protein EGL-460.064
daf-21Protein DAF-210.064
sax-3Protein SAX-30.063
che-3Protein CHE-30.062
rme-4Protein RME-40.061
daf-5Protein DAF-50.061
sel-2Protein SEL-20.060
cls-3Protein CLS-30.059
hmg-1.2Protein HMG-1.20.059
unc-52Protein UNC-520.059
tbc-2Protein TBC-20.058
mig-5Protein MIG-50.058
unc-70Protein UNC-700.058
hmp-2Protein HMP-20.058
F31C3.2Protein F31C3.20.057
eef-1A.1Protein EEF-1A.10.056
daf-12Protein DAF-120.056
vha-5Protein VHA-50.056
goa-1Protein GOA-10.056
unc-71Protein UNC-710.055
klp-3Protein KLP-30.055
akt-2Protein AKT-20.054
lin-11Protein LIN-110.053
lin-5Protein LIN-50.053
ifa-1Protein IFA-10.053
alx-1Protein ALX-10.053
mrg-1Protein MRG-10.053
inx-3Protein INX-30.052
lam-3Protein LAM-30.052
pde-4Protein PDE-40.051
pdfr-1Protein PDFR-10.051
pqn-18Protein PQN-180.051
sax-7Protein SAX-70.051
ant-1.1Protein ANT-1.10.051
sgt-1Protein SGT-10.050
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.986
chdchordin0.981
cdh1cadherin 1, epithelial0.953
fgf3fibroblast growth factor 30.952
bmp2bbone morphogenetic protein 2b0.884
ndr2nodal-related 20.812
nog1noggin 10.795
egr1early growth response 10.758
rarabretinoic acid receptor, alpha b0.734
cxcr4bchemokine (C-X-C motif), receptor 4b0.702
ptgs2aprostaglandin-endoperoxide synthase 2a0.693
wnt5bwingless-type MMTV integration site family, member 5b0.692
sema3aasemaphorin 3aa0.683
wnt2bbwingless-type MMTV integration site family, member 2Bb0.683
sox9bSRY-box containing gene 9b0.674
wnt10awingless-type MMTV integration site family, member 10a0.634
snai1asnail homolog 1a (Drosophila)0.626
pcdh18bprotocadherin 18b0.620
fzd7bfrizzled homolog 7b0.620
flhfloating head0.601
fzd5frizzled homolog 50.600
robo3roundabout homolog 30.595
bmp2abone morphogenetic protein 2a0.594
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.578
fzd7afrizzled homolog 7a0.577
dlddeltaD0.557
nrp1aneuropilin 1a0.542
mapk3mitogen-activated protein kinase 30.534
pea3ETS-domain transcription factor pea30.516
tll1tolloid-like 10.509
grem2gremlin 2, cysteine knot superfamily0.509
nkx2.5NK2 transcription factor related 50.500
per3period homolog 3 (Drosophila)0.493
gli1GLI-Kruppel family member 10.483
irx3airoquois homeobox protein 3a0.476
bocbrother of CDO0.474
fras1Fraser syndrome 10.462
ntlano tail a0.460
ptgs1prostaglandin-endoperoxide synthase 10.459
jag1bjagged 1b0.456
shhasonic hedgehog a0.455
tbx6T-box gene 60.447
il17rdinterleukin 17 receptor D0.446
zbtb4zinc finger and BTB domain containing 40.446
lft1lefty10.441
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.437
bcl2l1bcl2-like 10.434
otpaorthopedia homolog a0.432
restRE1-silencing transcription factor0.432
sox17SRY-box containing gene 170.427
efna5aephrin A5a0.427
kirrel3lkin of IRRE like 3 like0.425
axin1axin 10.424
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.422
dab1adisabled homolog 1a (Drosophila)0.417
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.412
dusp6dual specificity phosphatase 60.404
bmperBMP binding endothelial regulator0.401
gro1groucho 10.391
fgf8afibroblast growth factor 8 a0.381
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.381
itgb1b.2integrin, beta 1b.20.379
igf1rbinsulin-like growth factor 1b receptor0.372
sox9aSRY-box containing gene 9a0.370
epha4aeph receptor A4a0.366
slc17a6bsolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b0.365
vimvimentin0.359
znf703zinc finger protein 7030.352
wnt11wingless-type MMTV integration site family, member 110.341
lef1lymphocyte enhancer binding factor 10.340
aldh1a2aldehyde dehydrogenase 1 family, member A20.332
lhx1aLIM homeobox 1a0.329
ip6k2inositol hexaphosphate kinase 20.322
tbx16T-box gene 160.317
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.316
frzbfrizzled-related protein0.315
mapk1mitogen-activated protein kinase 10.291
pax8paired box gene 80.290
sox2SRY-box containing gene 20.289
irx5airoquois homeobox protein 5a0.287
epb41l5erythrocyte membrane protein band 4.1 like 50.282
sema3dsemaphorin 3d0.281
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.281
anxa1aannexin A1a0.278
wlswntless homolog (Drosophila)0.275
spry4sprouty (Drosophila) homolog 40.274
kal1aKallmann syndrome 1a sequence0.272
lama5laminin, alpha 50.272
maomonoamine oxidase0.270
krt18keratin 180.269
bmp4bone morphogenetic protein 40.269
fzd2frizzled homolog 20.268
fn1fibronectin 10.263
tp63tumor protein p630.263
tnfrsfatumor necrosis factor receptor superfamily, member a0.262
wnt3wingless-type MMTV integration site family, member 30.260
si:dkeyp-104h9.6si:dkeyp-104h9.60.255
rargaretinoic acid receptor gamma a0.254
pcnaproliferating cell nuclear antigen0.252
foxa2forkhead box A20.252
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
rlrolled0.998
MadMothers against dpp0.993
Akt1CG4006 gene product from transcript CG4006-RA0.992
dallydivision abnormally delayed0.985
pucpuckered0.981
BEAF-32Boundary element-associated factor of 32kD0.973
Pi3K92ECG4141 gene product from transcript CG4141-RB0.966
Sulf1Sulfated0.957
dmdiminutive0.955
wtswarts0.948
tkvthickveins0.940
dxdeltex0.931
InRInsulin-like receptor0.930
krzkurtz0.923
giggigas0.922
MoeMoesin0.921
drkdownstream of receptor kinase0.918
dcodiscs overgrown0.909
panpangolin0.905
smosmoothened0.887
hephemipterous0.886
C3GCG42328 gene product from transcript CG42328-RC0.884
PtenCG5671 gene product from transcript CG5671-RB0.869
shishibire0.865
shnschnurri0.858
dncdunce0.848
aopanterior open0.829
cicubitus interruptus0.823
PvrPDGF- and VEGF-receptor related0.819
slmbsupernumerary limbs0.816
Cul-3Cullin-30.811
p38bCG7393 gene product from transcript CG7393-RA0.798
ykiyorkie0.798
sggshaggy0.787
SdcSyndecan0.787
babobaboon0.785
jarjaguar0.767
Rho1CG8416 gene product from transcript CG8416-RB0.762
wgwingless0.762
Socs36ESuppressor of cytokine signaling at 36E0.751
dshdishevelled0.749
chicoCG5686 gene product from transcript CG5686-RB0.748
Atg1Autophagy-specific gene 10.745
MntCG13316 gene product from transcript CG13316-RD0.742
rutrutabaga0.740
apapterous0.739
tshteashirt0.725
nejnejire0.722
RelRelish0.714
EgfrEpidermal growth factor receptor0.710
fjfour-jointed0.705
Hsp27Heat shock protein 270.705
foxoforkhead box, sub-group O0.693
skpACG16983 gene product from transcript CG16983-RD0.688
LanALaminin A0.681
Unc-76CG3981 gene product from transcript CG3981-RB0.674
Dsor1Downstream of raf10.668
cindrCIN85 and CD2AP orthologue0.667
agoarchipelago0.662
sbbscribbler0.659
Tsc1CG6147 gene product from transcript CG6147-RA0.654
Myo31DFMyosin 31DF0.650
MetMethoprene-tolerant0.641
EndoGIEndonuclease G inhibitor0.640
trioCG18214 gene product from transcript CG18214-RA0.632
SoxNSoxNeuro0.628
Dcr-1Dicer-10.614
LLobe0.614
Atg13Autophagy-specific gene 130.613
kiskismet0.611
UbxUltrabithorax0.608
SfmbtScm-related gene containing four mbt domains0.602
bsblistered0.599
S6kRPS6-p70-protein kinase0.596
stysprouty0.595
CG9425CG9425 gene product from transcript CG9425-RB0.595
Rac2CG8556 gene product from transcript CG8556-RA0.592
Rab5Rab-protein 50.592
cutletCG33122 gene product from transcript CG33122-RA0.580
coscosta0.579
PakPAK-kinase0.576
frufruitless0.574
mbcmyoblast city0.571
chicchickadee0.568
E(z)Enhancer of zeste0.551
hipkhomeodomain interacting protein kinase0.549
ciccapicua0.548
elavembryonic lethal abnormal vision0.546
CkIIalphaCasein kinase II alpha subunit0.539
rokRho-kinase0.532
Dcr-2Dicer-20.524
Mpk2CG5475 gene product from transcript CG5475-RB0.523
Pka-C1cAMP-dependent protein kinase 10.518
hpohippo0.515
mewmultiple edematous wings0.514
DAAMDishevelled Associated Activator of Morphogenesis0.510
edechinoid0.503
Sema-1aCG18405 gene product from transcript CG18405-RD0.503
CG8155CG8155 gene product from transcript CG8155-RA0.502
HsfHeat shock factor0.502
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Pzppregnancy-zone protein0.598
Nos3nitric oxide synthase 3, endothelial cell0.454
Icam1intercellular adhesion molecule 10.447
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.432
Lyz2lysozyme 20.428
Calcrlcalcitonin receptor-like0.418
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.393
Adora2aadenosine A2a receptor0.380
Rararetinoic acid receptor, alpha0.377
Syt8synaptotagmin VIII0.315
Ddr1discoidin domain receptor tyrosine kinase 10.314
Prdm2PR domain containing 2, with ZNF domain0.312
Iappislet amyloid polypeptide0.311
Csf3colony stimulating factor 3 (granulocyte)0.302
Anxa2annexin A20.295
Phkg1phosphorylase kinase, gamma 10.285
Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha0.278
Gria1glutamate receptor, ionotropic, AMPA 10.267
Mef2dmyocyte enhancer factor 2D0.266
RorbRAR-related orphan receptor B0.260
Nudt3nudix (nucleoside diphosphate linked moiety X)-type motif 30.251
Znf483zinc finger protein 4830.249
Ptprcprotein tyrosine phosphatase, receptor type, C0.247
Sf1splicing factor 10.246
Ccl2chemokine (C-C motif) ligand 20.245
RhagRh-associated glycoprotein0.244
Adora3adenosine A3 receptor0.242
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.239
Crhr1corticotropin releasing hormone receptor 10.238
Cxcl10chemokine (C-X-C motif) ligand 100.237
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.237
JunJun oncogene0.233
Pdynprodynorphin0.233
Anxa5annexin A50.229
Jak2Janus kinase 20.229
Crip2cysteine-rich protein 20.228
Eef2eukaryotic translation elongation factor 20.227
Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.223
Arl11ADP-ribosylation factor-like 110.222
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.219
Lnpepleucyl/cystinyl aminopeptidase0.218
Pde3aphosphodiesterase 3A, cGMP inhibited0.216
Scn10asodium channel, voltage-gated, type X, alpha subunit0.214
Celcarboxyl ester lipase0.213
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.211
Bcanbrevican0.211
Myo1bmyosin Ib0.211
Crybb2crystallin, beta B20.210
Flt1FMS-related tyrosine kinase 10.209
Gpr20G protein-coupled receptor 200.202
Itgamintegrin, alpha M0.200
Agtr1aangiotensin II receptor, type 1a0.199
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.195
Fgf1fibroblast growth factor 10.194
Cx3cr1chemokine (C-X3-C motif) receptor 10.192
Arf6ADP-ribosylation factor 60.191
Ccr2chemokine (C-C motif) receptor 20.190
Fgfr2fibroblast growth factor receptor 20.189
Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 10.187
Ptk2bPTK2B protein tyrosine kinase 2 beta0.187
Pgrprogesterone receptor0.185
Ptafrplatelet-activating factor receptor0.184
Lyve1lymphatic vessel endothelial hyaluronan receptor 10.183
Ralgdsral guanine nucleotide dissociation stimulator0.182
Ncr1natural cytotoxicity triggering receptor 10.178
Tp53tumor protein p530.178
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.178
Cntfrciliary neurotrophic factor receptor0.175
Grm5glutamate receptor, metabotropic 50.173
Npy5rneuropeptide Y receptor Y50.171
Gzmbgranzyme B0.171
Map2microtubule-associated protein 20.171
Akt1v-akt murine thymoma viral oncogene homolog 10.170
Mgat5mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase0.169
Apohapolipoprotein H (beta-2-glycoprotein I)0.169
Il18interleukin 180.168
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.167
Fgbfibrinogen beta chain0.167
Cugbp2CUG triplet repeat, RNA binding protein 20.167
Ptpn14protein tyrosine phosphatase, non-receptor type 140.167
LOC100362824caveolin 2-like0.165
Tacr1tachykinin receptor 10.165
Reg3aregenerating islet-derived 3 alpha0.162
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.162
Lgals3lectin, galactoside-binding, soluble, 30.161
Prdx1peroxiredoxin 10.161
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.160
Fgf14fibroblast growth factor 140.160
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.160
Casp1caspase 10.159
Aspgasparaginase homolog (S. cerevisiae)0.159
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.158
Dlg1discs, large homolog 1 (Drosophila)0.157
Jdp2Jun dimerization protein 20.157
Apcsamyloid P component, serum0.157
Tubb5tubulin, beta 50.155
Rhobras homolog gene family, member B0.153
Spp1secreted phosphoprotein 10.151
Krtap1-5keratin associated protein 1-50.151
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.151