The network for 'multicellular organismal aging' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

multicellular organismal aging

An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
apy-1Protein APY-10.629
npl-4.2Protein NPL-4.20.577
rpt-3Protein RPT-30.563
eef-1A.1Protein EEF-1A.10.542
vit-6Protein VIT-60.517
vha-8Protein VHA-80.514
atp-5Protein ATP-50.491
cct-6Protein CCT-60.485
ucr-1Protein UCR-10.484
cts-1Protein CTS-10.473
col-17Protein COL-170.463
icd-1Protein ICD-10.460
hsp-1Protein HSP-10.459
gld-1Protein GLD-10.446
lys-1Protein LYS-10.444
npl-4.1Protein NPL-4.10.438
pas-6Protein PAS-60.432
hda-1Protein HDA-10.425
cul-3Protein CUL-30.421
egl-18Protein EGL-180.420
rpn-2Protein RPN-20.415
acs-4Protein ACS-40.413
ZK484.1Protein ZK484.10.411
gei-4Protein GEI-40.411
CELE_Y69A2AR.18Protein Y69A2AR.180.409
dph-1Protein DPH-10.407
K11H12.8Protein K11H12.80.406
F43D9.1Protein F43D9.10.405
col-73Protein COL-730.405
sqv-4Protein SQV-40.404
hlh-2Protein HLH-20.401
daf-11Protein DAF-110.396
pas-1Protein PAS-10.396
egal-1Protein EGAL-10.389
C23H3.3Protein C23H3.30.387
mom-4Protein MOM-40.387
idha-1Protein IDHA-10.383
R05G6.7Protein R05G6.70.381
daf-21Protein DAF-210.380
pqn-44Protein PQN-440.380
mel-26Protein MEL-260.380
dlat-1Protein DLAT-10.378
ubxn-2Protein UBXN-20.370
hpd-1Protein HPD-10.368
rpt-2Protein RPT-20.367
T11G6.8Protein T11G6.80.365
lin-36Protein LIN-360.364
sqt-1Protein SQT-10.363
dlc-1Protein DLC-10.362
tbb-2Protein TBB-20.361
dpy-4Protein DPY-40.361
nuo-4Protein NUO-40.360
rpn-12Protein RPN-120.358
gpd-3Protein GPD-30.355
peb-1Protein PEB-10.352
mes-4Protein MES-40.352
npp-15Protein NPP-150.351
hum-5Protein HUM-50.350
col-93Protein COL-930.347
F45H10.3Protein F45H10.30.345
sdhb-1Protein SDHB-10.345
rps-29Protein RPS-290.342
fln-2Protein FLN-20.340
atg-2Protein ATG-20.340
hsp-16.41Protein HSP-16.410.339
pkg-1Protein PKG-10.338
csn-4Protein CSN-40.337
acdh-3Protein ACDH-30.334
CELE_C08H9.2Protein C08H9.20.331
elo-1Protein ELO-10.330
Y44E3A.6Protein Y44E3A.60.329
rskn-2Protein RSKN-20.329
F44E5.4Protein F44E5.40.328
mdh-2Protein MDH-20.324
rap-1Protein RAP-10.324
ptr-4Protein PTR-40.323
CELE_F53C11.5Protein F53C11.50.323
rpl-5Protein RPL-50.322
T19D12.4Protein T19D12.40.322
vps-33.2Protein VPS-33.20.322
F13E6.1Protein F13E6.10.321
rpl-18Protein RPL-180.320
hsp-70Protein HSP-700.320
hda-3Protein HDA-30.320
T20H4.5Protein T20H4.50.319
par-5Protein PAR-50.319
dep-1Protein DEP-10.319
chc-1Protein CHC-10.318
nuo-2Protein NUO-20.318
ptr-14Protein PTR-140.317
abu-15Protein ABU-150.317
ugt-46Protein UGT-460.317
pmt-1Protein PMT-10.316
CELE_C46C2.2Protein C46C2.20.316
C06G3.6Protein C06G3.60.315
thn-2Protein THN-20.315
met-1Protein MET-10.314
mom-2Protein MOM-20.312
fkh-2Protein FKH-20.312
hrdl-1Protein HRDL-10.311
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
chicoCG5686 gene product from transcript CG5686-RB0.995
Atg1Autophagy-specific gene 10.971
Top2Topoisomerase 20.950
IndyI'm not dead yet0.928
Atg8aAutophagy-specific gene 8a0.918
Sod2Superoxide dismutase 2 (Mn)0.917
InRInsulin-like receptor0.907
SmoxSmad on X0.899
Pi3K92ECG4141 gene product from transcript CG4141-RB0.884
Hsp68Heat shock protein 680.853
ThorCG8846 gene product from transcript CG8846-RA0.822
CaMKIICalcium/calmodulin-dependent protein kinase II0.790
MadMothers against dpp0.786
tefutelomere fusion0.780
Hsp22Heat shock protein 220.749
Top1Topoisomerase 10.737
Mov34CG3416 gene product from transcript CG3416-RA0.710
PtenCG5671 gene product from transcript CG5671-RB0.707
GLazGlial Lazarillo0.688
CG9140CG9140 gene product from transcript CG9140-RA0.667
POSHPlenty of SH3s0.664
Myo31DFMyosin 31DF0.657
Rpn3Regulatory particle non-ATPase 30.656
Stat92ESignal-transducer and activator of transcription protein at 92E0.654
bratbrain tumor0.651
AtpalphaNa pump alpha subunit0.645
CG4769CG4769 gene product from transcript CG4769-RA0.633
Eps-15Epidermal growth factor receptor pathway substrate clone 150.632
Rpt4CG3455 gene product from transcript CG3455-RA0.601
foxoforkhead box, sub-group O0.590
GlyPGlycogen phosphorylase0.586
Hsp26Heat shock protein 260.586
Prx5Peroxiredoxin 50.575
alpha-Man-Ialpha Mannosidase I0.570
Rbp9RNA-binding protein 90.563
LnkCG17367 gene product from transcript CG17367-RC0.562
Vap-33-1CG5014 gene product from transcript CG5014-RB0.543
Ilp5Insulin-like peptide 50.543
Rpn2CG11888 gene product from transcript CG11888-RA0.537
Sin3ACG8815 gene product from transcript CG8815-RC0.532
Mekk1CG7717 gene product from transcript CG7717-RB0.531
ND42NADH:ubiquinone reductase 42kD subunit precursor0.510
Ilp2Insulin-like peptide 20.498
CG15531CG15531 gene product from transcript CG15531-RB0.492
M6CG7540 gene product from transcript CG7540-RA0.479
SodSuperoxide dismutase0.472
Rpt1CG1341 gene product from transcript CG1341-RA0.469
CG9350CG9350 gene product from transcript CG9350-RA0.459
Pros26Proteasome 26kD subunit0.449
dcodiscs overgrown0.447
CG16904CG16904 gene product from transcript CG16904-RA0.442
Rpt3CG16916 gene product from transcript CG16916-RA0.435
Hrb98DEHeterogeneous nuclear ribonucleoprotein at 98DE0.434
aspabnormal spindle0.426
TorTarget of rapamycin0.421
AcslAcyl-CoA synthetase long-chain0.383
Cct1CTP:phosphocholine cytidylyltransferase 10.382
dj-1betaCG1349 gene product from transcript CG1349-RA0.374
CG10664CG10664 gene product from transcript CG10664-RB0.371
CG8801CG8801 gene product from transcript CG8801-RA0.368
endoAendophilin A0.366
Trxr-1Thioredoxin reductase-10.363
RpL7ARibosomal protein L7A0.361
Mnn1Menin 10.356
Tbp-1Tat-binding protein-10.352
HsfHeat shock factor0.351
CG30008CG30008 gene product from transcript CG30008-RA0.350
Hsp27Heat shock protein 270.346
SpargelCG9809 gene product from transcript CG9809-RB0.345
Tsp2ATetraspanin 2A0.343
G-salpha60AG protein salpha 60A0.343
CG10219CG10219 gene product from transcript CG10219-RA0.342
CG13349CG13349 gene product from transcript CG13349-RA0.333
CG3192CG3192 gene product from transcript CG3192-RA0.330
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.999
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.992
TP53tumor protein p530.991
SMAD3SMAD family member 30.990
GABARAPL2GABA(A) receptor-associated protein-like 20.990
PSMA2proteasome (prosome, macropain) subunit, alpha type, 20.988
UQCRC2ubiquinol-cytochrome c reductase core protein II0.982
AKT1v-akt murine thymoma viral oncogene homolog 10.977
MAP3K7mitogen-activated protein kinase kinase kinase 70.977
MAPK8mitogen-activated protein kinase 80.975
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.974
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.973
YBX1Y box binding protein 10.970
ARRB1arrestin, beta 10.968
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.967
MAP3K1mitogen-activated protein kinase kinase kinase 10.967
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.966
PSMB1proteasome (prosome, macropain) subunit, beta type, 10.966
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.964
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.962
SMAD2SMAD family member 20.960
EIF3Keukaryotic translation initiation factor 3, subunit K0.956
MDM2Mdm2 p53 binding protein homolog (mouse)0.955
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.955
PSMB6proteasome (prosome, macropain) subunit, beta type, 60.953
SQSTM1sequestosome 10.951
SRSF2serine/arginine-rich splicing factor 20.949
MAP2K4mitogen-activated protein kinase kinase 40.945
BAG3BCL2-associated athanogene 30.942
YY1YY1 transcription factor0.940
MAPK14mitogen-activated protein kinase 140.936
PSMA7proteasome (prosome, macropain) subunit, alpha type, 70.932
WDR5WD repeat domain 50.931
SDHAsuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.930
PSMC3proteasome (prosome, macropain) 26S subunit, ATPase, 30.930
EIF4G1eukaryotic translation initiation factor 4 gamma, 10.929
SP1Sp1 transcription factor0.925
SIRT1sirtuin 10.924
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.923
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.922
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.915
PSMB3proteasome (prosome, macropain) subunit, beta type, 30.915
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.913
FLNAfilamin A, alpha0.911
NDUFS3NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)0.910
CALM1calmodulin 1 (phosphorylase kinase, delta)0.908
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.907
PSMC5proteasome (prosome, macropain) 26S subunit, ATPase, 50.906
ILKintegrin-linked kinase0.902
HSPA8heat shock 70kDa protein 80.901
HDAC2histone deacetylase 20.896
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.893
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.885
USP14ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)0.883
IRS1insulin receptor substrate 10.882
NBR1neighbor of BRCA1 gene 10.881
TH1LTH1-like (Drosophila)0.880
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.879
PSMC6proteasome (prosome, macropain) 26S subunit, ATPase, 60.878
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.872
PSMB7proteasome (prosome, macropain) subunit, beta type, 70.870
PSMD12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.865
PSMA6proteasome (prosome, macropain) subunit, alpha type, 60.863
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.863
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.860
OXA1Loxidase (cytochrome c) assembly 1-like0.860
ATP5G3ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)0.856
IGF1Rinsulin-like growth factor 1 receptor0.845
NDUFS2NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)0.844
JAG1jagged 10.842
ARRB2arrestin, beta 20.834
COX7Bcytochrome c oxidase subunit VIIb0.828
PSMB4proteasome (prosome, macropain) subunit, beta type, 40.825
VCPvalosin containing protein0.824
UQCRHubiquinol-cytochrome c reductase hinge protein0.823
HSF1heat shock transcription factor 10.816
HSPA9heat shock 70kDa protein 9 (mortalin)0.813
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.802
SYKspleen tyrosine kinase0.799
UQCRC1ubiquinol-cytochrome c reductase core protein I0.792
PBX1pre-B-cell leukemia homeobox 10.789
CSNK2Bcasein kinase 2, beta polypeptide0.787
CREBBPCREB binding protein0.784
RARAretinoic acid receptor, alpha0.784
HSPB1heat shock 27kDa protein 10.782
RB1CC1RB1-inducible coiled-coil 10.781
RPS3ribosomal protein S30.780
UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.775
PSMD8proteasome (prosome, macropain) 26S subunit, non-ATPase, 80.773
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.771
COX7A2cytochrome c oxidase subunit VIIa polypeptide 2 (liver)0.770
PSMA3proteasome (prosome, macropain) subunit, alpha type, 30.766
CRYABcrystallin, alpha B0.763
NDUFB5NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa0.762
UCHL5ubiquitin carboxyl-terminal hydrolase L50.758
RBM39RNA binding motif protein 390.753
TOP1topoisomerase (DNA) I0.739
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Psma1proteasome (prosome, macropain) subunit, alpha type 10.611
Ptenphosphatase and tensin homolog0.610
Hif1ahypoxia inducible factor 1, alpha subunit0.462
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.453
Mdm2transformed mouse 3T3 cell double minute 20.339
Hbb-b1hemoglobin, beta adult major chain0.309
Psmb7proteasome (prosome, macropain) subunit, beta type 70.304
Trp53transformation related protein 530.293
Mtormechanistic target of rapamycin (serine/threonine kinase)0.270
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.256
Ptpn11protein tyrosine phosphatase, non-receptor type 110.223
Insrinsulin receptor0.222
Iqcb1IQ calmodulin-binding motif containing 10.214
Eedembryonic ectoderm development0.209
Aldoaaldolase A, fructose-bisphosphate0.193
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.193
Hspa8heat shock protein 80.192
Mdh2malate dehydrogenase 2, NAD (mitochondrial)0.171
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.147
Nfe2l2nuclear factor, erythroid derived 2, like 20.143
RictorRPTOR independent companion of MTOR, complex 20.142
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.133
Rxraretinoid X receptor alpha0.129
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.128
Eif4a1eukaryotic translation initiation factor 4A10.126
Ilkintegrin linked kinase0.125
Rbbp4retinoblastoma binding protein 40.124
Ezh2enhancer of zeste homolog 2 (Drosophila)0.122
Sox2SRY-box containing gene 20.119
Apcadenomatosis polyposis coli0.119
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.118
Akt1thymoma viral proto-oncogene 10.110
Mknk2MAP kinase-interacting serine/threonine kinase 20.109
Prkceprotein kinase C, epsilon0.107
Tsc1tuberous sclerosis 10.105
Psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.103
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.102
Cxcr4chemokine (C-X-C motif) receptor 40.097
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.094
Inpp5dinositol polyphosphate-5-phosphatase D0.091
Rps15ribosomal protein S150.089
Mapk14mitogen-activated protein kinase 140.088
Atf2activating transcription factor 20.088
Rpl4ribosomal protein L40.088
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.085
Cftrcystic fibrosis transmembrane conductance regulator homolog0.082
Psmb4proteasome (prosome, macropain) subunit, beta type 40.082
Shc1src homology 2 domain-containing transforming protein C10.082
Hspa5heat shock protein 50.079
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.079
Ctsdcathepsin D0.078
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.075
Leprleptin receptor0.074
Nfibnuclear factor I/B0.074
Tlr4toll-like receptor 40.073
Ppp2caprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform0.072
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.070
Irs1insulin receptor substrate 10.069
Casp1caspase 10.065
Cyldcylindromatosis (turban tumor syndrome)0.065
Sqstm1sequestosome 10.065
Ppargperoxisome proliferator activated receptor gamma0.062
Hnrnpa2b1heterogeneous nuclear ribonucleoprotein A2/B10.061
Lmnb1lamin B10.060
Vegfavascular endothelial growth factor A0.060
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.058
Mapk8mitogen-activated protein kinase 80.058
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.057
Pdx1pancreatic and duodenal homeobox 10.057
Rbbp7retinoblastoma binding protein 70.056
Ftl1ferritin light chain 10.055
Apoeapolipoprotein E0.055
Psma7proteasome (prosome, macropain) subunit, alpha type 70.054
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.054
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.053
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.053
Cox5bcytochrome c oxidase, subunit Vb0.053
Hdac1histone deacetylase 10.053
Ep300E1A binding protein p3000.053
Emx1empty spiracles homolog 1 (Drosophila)0.052
Eif4g1eukaryotic translation initiation factor 4, gamma 10.052
Kitlkit ligand0.051
Krt14keratin 140.051
Esrrbestrogen related receptor, beta0.050
Foxo3forkhead box O30.049
Nos3nitric oxide synthase 3, endothelial cell0.049
Scd1stearoyl-Coenzyme A desaturase 10.048
Myh9myosin, heavy polypeptide 9, non-muscle0.048
Lims1LIM and senescent cell antigen-like domains 10.048
Lmnalamin A0.047
FosFBJ osteosarcoma oncogene0.047
Esr1estrogen receptor 1 (alpha)0.047
Ets1E26 avian leukemia oncogene 1, 5' domain0.046
Ctsbcathepsin B0.046
Lystlysosomal trafficking regulator0.045
Slc4a4solute carrier family 4 (anion exchanger), member 40.045
Cul3cullin 30.044
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ndufb10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 100.029
Uchl3ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)0.016
Tceb1transcription elongation factor B (SIII), polypeptide 10.015
LOC1003600566.8 kDa mitochondrial proteolipid0.014
Uqcr11ubiquinol-cytochrome c reductase, complex III subunit XI0.014
Mrps21mitochondrial ribosomal protein S210.014
Nop10NOP10 ribonucleoprotein homolog (yeast)0.012
Mrpl32mitochondrial ribosomal protein L320.012
Chchd1coiled-coil-helix-coiled-coil-helix domain containing 10.011
Ube2v2ubiquitin-conjugating enzyme E2 variant 20.010