The network for 'positive regulation of gene expression' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

NameDescriptionProbabilityFunc Analog Organism
SNF1Snf1p0.969
CHD1Chd1p0.963
GLN3Gln3p0.961
SWI6Swi6p0.958
YAP1Yap1p0.924
RPD3Rpd3p0.918
RTG3Rtg3p0.917
SPT15Spt15p0.912
RTF1Rtf1p0.911
CTR9Ctr9p0.897
HOG1Hog1p0.886
GAL11Gal11p0.869
SRB4Srb4p0.868
YAK1Yak1p0.863
ARP9Arp9p0.861
SNF6Snf6p0.852
UTP22Utp22p0.848
RGR1Rgr1p0.843
TAF14Taf14p0.825
MSN2Msn2p0.823
UBP6Ubp6p0.815
SWI1Swi1p0.809
SNF2Snf2p0.797
ADA2Ada2p0.780
RIM101Rim101p0.758
RPT6Rpt6p0.754
MOT2Mot2p0.734
CTK3Ctk3p0.730
MET4Met4p0.725
HAP5Hap5p0.725
SET2Set2p0.716
SNF5Snf5p0.712
CYC8Cyc8p0.709
HMO1Hmo1p0.707
MKS1Mks1p0.701
RXT2Rxt2p0.688
GAL4Gal4p0.684
CTK1Ctk1p0.681
SRB2Srb2p0.680
URE2Ure2p0.673
RIM1Rim1p0.669
LEU3Leu3p0.668
FKH1Fkh1p0.666
LSM1Lsm1p0.665
CDC39Cdc39p0.661
MSN4Msn4p0.660
ARG81Arg81p0.658
KSS1Kss1p0.651
HHT1Hht1p0.637
CLB5Clb5p0.629
MED6Med6p0.623
MED2Med2p0.620
CSE2Cse2p0.617
MIG1Mig1p0.613
MUM2Mum2p0.609
CDC28Cdc28p0.601
GIS1Gis1p0.598
SPT8Spt8p0.592
RAP1Rap1p0.590
HSP78Hsp78p0.589
RAD23Rad23p0.587
MSN1Msn1p0.586
SKN7Skn7p0.575
TUP1Tup1p0.572
SPT5Spt5p0.556
CKA2Cka2p0.554
PHO23Pho23p0.554
SAP185Sap185p0.553
GCN5Gcn5p0.544
NRG1Nrg1p0.544
PAF1Paf1p0.543
SRB5Srb5p0.536
SPT16Spt16p0.532
MED8Med8p0.529
HDA2Hda2p0.528
DCP2Dcp2p0.525
SDS3Sds3p0.520
MED1Med1p0.520
SIN3Sin3p0.519
ROX3Rox3p0.515
SWI3Swi3p0.512
SAP30Sap30p0.503
AFT1Aft1p0.494
NUT2Nut2p0.492
RTG1Rtg1p0.490
CRZ1Crz1p0.489
KCS1Kcs1p0.489
SGF73Sgf73p0.482
PGD1Pgd1p0.479
MDS3Mds3p0.478
PIP2Pip2p0.476
NOT5Not5p0.473
DEF1Def1p0.472
RPN4Rpn4p0.472
BTN2Btn2p0.471
PBS2Pbs2p0.468
HTA1Hta1p0.465
DOT6Dot6p0.465
MSG5Msg5p0.461
UGP1Ugp1p0.460
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
vab-3Protein VAB-30.997
pha-4Protein PHA-40.996
egl-18Protein EGL-180.996
elt-6Protein ELT-60.982
egl-13Protein EGL-130.976
zip-7Protein ZIP-70.920
nhr-67Protein NHR-670.919
fkh-2Protein FKH-20.908
hlh-2Protein HLH-20.862
eya-1Protein EYA-10.833
tag-298Protein TAG-2980.825
lst-3Protein LST-30.801
lin-36Protein LIN-360.790
unc-62Protein UNC-620.773
hbl-1Protein HBL-10.754
pry-1Protein PRY-10.746
soc-2Protein SOC-20.718
gei-4Protein GEI-40.705
egl-46Protein EGL-460.667
lin-17Protein LIN-170.664
cam-1Protein CAM-10.616
his-31Protein HIS-310.611
nhr-49Protein NHR-490.604
sas-5Protein SAS-50.599
his-1Protein HIS-10.598
alg-2Protein ALG-20.597
rad-26Protein RAD-260.587
tax-4Protein TAX-40.579
pbrm-1Protein PBRM-10.578
mat-3Protein MAT-30.548
bar-1Protein BAR-10.543
ceh-20Protein CEH-200.540
lin-12Protein LIN-120.516
unc-42Protein UNC-420.516
flt-1Protein FLT-10.500
sel-10Protein SEL-100.490
nhr-6Protein NHR-60.482
unc-40Protein UNC-400.472
apr-1Protein APR-10.444
swsn-4Protein SWSN-40.444
ced-9Protein CED-90.443
lsy-2Protein LSY-20.442
unc-86Protein UNC-860.435
cacn-1Protein CACN-10.433
T28F4.1Protein T28F4.10.421
zyg-1Protein ZYG-10.420
F33H1.4Protein F33H1.40.415
mig-5Protein MIG-50.415
attf-2Protein ATTF-20.403
ztf-2Protein ZTF-20.398
hrp-1Protein HRP-10.394
ten-1Protein TEN-10.393
daf-3Protein DAF-30.389
unc-73Protein UNC-730.386
his-5Protein HIS-50.381
cnd-1Protein CND-10.372
daf-1Protein DAF-10.370
abi-1Protein ABI-10.361
sax-3Protein SAX-30.360
mab-31Protein MAB-310.360
skp-1Protein SKP-10.359
hnd-1Protein HND-10.358
pop-1Protein POP-10.351
ain-1Protein AIN-10.347
mls-2Protein MLS-20.343
F53F10.2Protein F53F10.20.342
his-64Protein HIS-640.333
pdfr-1Protein PDFR-10.333
CELE_C17E4.6Protein C17E4.60.329
ceh-27Protein CEH-270.326
daf-12Protein DAF-120.326
set-16Protein SET-160.326
gon-4Protein GON-40.321
pac-1Protein PAC-10.320
vab-1Protein VAB-10.317
atgp-1Protein ATGP-10.313
his-46Protein HIS-460.305
pes-1Protein PES-10.304
cfim-2Protein CFIM-20.296
polq-1Protein POLQ-10.295
unc-26Protein UNC-260.290
aap-1Protein AAP-10.289
tag-124Protein TAG-1240.288
zfp-3Protein ZFP-30.286
egl-44Protein EGL-440.285
fox-1Protein FOX-10.285
kin-10Protein KIN-100.281
hif-1Protein HIF-10.279
sas-4Protein SAS-40.278
R11A8.7Protein R11A8.70.277
tbx-8Protein TBX-80.275
apl-1Protein APL-10.273
nhr-69Protein NHR-690.273
saeg-1Protein SAEG-10.262
thoc-1Protein THOC-10.261
mdt-8Protein MDT-80.260
lin-35Protein LIN-350.260
pax-3Protein PAX-30.260
rps-2Protein RPS-20.257
CELE_ZK337.2Protein ZK337.20.254
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
shhasonic hedgehog a0.998
nkx2.2aNK2 transcription factor related 2a0.984
tal1T-cell acute lymphocytic leukemia 10.981
hoxb1bhomeo box B1b0.950
dlx5adistal-less homeobox gene 5a0.932
isl1islet10.900
myod1myogenic differentiation 10.894
bmp2bbone morphogenetic protein 2b0.893
notch1anotch homolog 1a0.881
tbx20T-box 200.868
six3asine oculis homeobox homolog 3a0.866
fgf8afibroblast growth factor 8 a0.865
dlx3bdistal-less homeobox gene 3b0.860
pcnaproliferating cell nuclear antigen0.845
bmp4bone morphogenetic protein 40.839
etv2ets variant gene 20.835
crabp2acellular retinoic acid binding protein 2, a0.825
egr2bearly growth response 2b0.819
kdrlkinase insert domain receptor like0.817
fezf2FEZ family zinc finger 20.796
gli1GLI-Kruppel family member 10.779
runx2brunt-related transcription factor 2b0.776
pitx3paired-like homeodomain transcription factor 30.775
foxa2forkhead box A20.756
tbx1T-box 10.755
eya1eyes absent homolog 10.751
cmybtranscription factor cmyb0.740
dlx2adistal-less homeobox gene 2a0.716
pax8paired box gene 80.714
otpborthopedia homolog b0.694
pitx2paired-like homeodomain transcription factor 20.694
egr1early growth response 10.679
hey1hairy/enhancer-of-split related with YRPW motif 10.655
hnf1baHNF1 homeobox Ba0.655
dlcdeltaC0.653
lhx1aLIM homeobox 1a0.643
prlprolactin0.620
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.613
esr1estrogen receptor 10.613
spry4sprouty (Drosophila) homolog 40.611
flhfloating head0.595
mespbmesoderm posterior b0.593
evx1even-skipped homeobox 10.591
mapk1mitogen-activated protein kinase 10.588
pax2apaired box gene 2a0.586
foxi1forkhead box I10.581
sox2SRY-box containing gene 20.581
klf4Kruppel-like factor 40.577
irx4biroquois homeobox protein 4b0.577
lft1lefty10.564
hand2heart and neural crest derivatives expressed transcript 20.558
tbx16T-box gene 160.554
axin2axin 2 (conductin, axil)0.547
epha4aeph receptor A4a0.543
gata3GATA-binding protein 30.540
raraaretinoic acid receptor, alpha a0.534
pou3f2POU class 3 homeobox 20.534
col2a1acollagen type II, alpha-1a0.530
mespamesoderm posterior a0.525
fn1fibronectin 10.521
lmx1b.1LIM homeobox transcription factor 1, beta 10.506
foxp2forkhead box P20.488
jag2jagged 20.487
sox3SRY-box containing gene 30.485
lhx5LIM homeobox 50.481
osr1odd-skipped related 1 (Drosophila)0.475
tp53tumor protein p530.470
tll1tolloid-like 10.470
dladeltaA0.468
hoxb3ahomeo box B3a0.466
her7hairy and enhancer of split related-70.466
chdchordin0.461
pax7apaired box gene 7a0.460
wnt7bawingless-type MMTV integration site family, member 7Ba0.459
dlbdeltaB0.426
pcdh8protocadherin 80.421
myf5myogenic factor 50.417
eng1bengrailed 1b0.416
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.413
cdx4caudal type homeo box transcription factor 40.407
sox9bSRY-box containing gene 9b0.402
tfap2atranscription factor AP-2 alpha0.399
wt1awilms tumor 1a0.399
thrbthyroid hormone receptor beta0.395
sim2single-minded homolog 2 (Drosophila)0.391
foxn4forkhead box N40.390
ndr2nodal-related 20.390
sox7SRY-box containing gene 70.386
gbx2gastrulation brain homeo box 20.383
hmx3homeo box (H6 family) 30.381
hoxa9ahomeo box A9a0.377
barhl2BarH-like 20.377
meis3myeloid ecotropic viral integration site 30.376
hoxd13ahomeo box D13a0.373
irx7iroquois homeobox protein 70.372
fgfr2fibroblast growth factor receptor 20.365
twist1atwist1a0.365
nr5a2nuclear receptor subfamily 5, group A, member 20.353
tshbthyroid stimulating hormone, beta subunit0.352
otpaorthopedia homolog a0.349
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.997
InRInsulin-like receptor0.996
wgwingless0.996
cnccap-n-collar0.995
UbxUltrabithorax0.995
Snr1Snf5-related 10.994
Akt1CG4006 gene product from transcript CG4006-RA0.992
eygeyegone0.991
lolalongitudinals lacking0.990
slmbsupernumerary limbs0.990
MED15Mediator complex subunit 150.988
panpangolin0.983
MoeMoesin0.977
osaCG7467 gene product from transcript CG7467-RD0.975
AntpAntennapedia0.974
mormoira0.973
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.951
Fmr1CG6203 gene product from transcript CG6203-RC0.949
trxtrithorax0.946
sdscalloped0.941
pbproboscipedia0.938
eyaeyes absent0.933
slp1sloppy paired 10.931
dcodiscs overgrown0.930
SerSerrate0.929
hephemipterous0.925
CG4699CG4699 gene product from transcript CG4699-RJ0.922
kiskismet0.918
eIF-4aEukaryotic initiation factor 4a0.913
CtBPC-terminal Binding Protein0.906
hephhephaestus0.905
shnschnurri0.899
ash2absent, small, or homeotic discs 20.896
amosabsent MD neurons and olfactory sensilla0.895
Mef2Myocyte enhancer factor 20.893
dapdacapo0.891
salmspalt major0.889
TorTarget of rapamycin0.885
elavembryonic lethal abnormal vision0.881
NrgNeuroglian0.875
PcafCG4107 gene product from transcript CG4107-RA0.875
e(y)3enhancer of yellow 30.873
CkIIalphaCasein kinase II alpha subunit0.869
MedMedea0.867
belbelle0.865
ssspineless0.864
dshdishevelled0.861
brmbrahma0.857
aopanterior open0.853
traltrailer hitch0.853
frufruitless0.845
lwrlesswright0.845
kluklumpfuss0.842
jingCG9397 gene product from transcript CG9397-RI0.834
picpiccolo0.828
kaykayak0.824
mysmyospheroid0.824
runrunt0.823
eyeyeless0.820
bynbrachyenteron0.818
Rac1CG2248 gene product from transcript CG2248-RA0.818
SosSon of sevenless0.814
dsxdoublesex0.813
bcdbicoid0.811
ChiChip0.809
PcPolycomb0.808
Tak1TGF-beta activated kinase 10.806
Cp190Centrosomal protein 190kD0.806
nmonemo0.805
foxoforkhead box, sub-group O0.805
cactcactus0.800
eveeven skipped0.799
SoxNSoxNeuro0.786
tintinman0.785
TlToll0.783
TolloCG6890 gene product from transcript CG6890-RA0.783
hthhomothorax0.781
zzeste0.777
KrKruppel0.775
MadMothers against dpp0.775
CTCFCG8591 gene product from transcript CG8591-RA0.773
phlpole hole0.770
mib1mind bomb 10.768
hbhunchback0.764
svpseven up0.762
gsbgooseberry0.753
noinoisette0.749
eastenhanced adult sensory threshold0.745
HLHm7E(spl) region transcript m70.742
Pp2B-14DProtein phosphatase 2B at 14D0.741
fzfrizzled0.741
spensplit ends0.741
araaraucan0.736
binbiniou0.732
exdextradenticle0.724
slouslouch0.724
hkbhuckebein0.714
shotshort stop0.707
betaTub56Dbeta-Tubulin at 56D0.704
CG11347CG11347 gene product from transcript CG11347-RE0.702
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nfibnuclear factor I/B0.729
Tgfbr2transforming growth factor, beta receptor II0.686
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.658
Nedd4neural precursor cell expressed, developmentally down-regulated 40.633
Dusp1dual specificity phosphatase 10.618
Fgfr2fibroblast growth factor receptor 20.616
Hoxd3homeo box D30.578
Nr4a3nuclear receptor subfamily 4, group A, member 30.573
Fgfr1Fibroblast growth factor receptor 10.557
Junbjun B proto-oncogene0.526
Nek9NIMA (never in mitosis gene a)- related kinase 90.500
FosFBJ osteosarcoma oncogene0.467
Adam10ADAM metallopeptidase domain 100.446
Bmp6bone morphogenetic protein 60.425
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.417
Zfp36zinc finger protein 360.406
Hoxb7homeo box B70.402
Slit3slit homolog 3 (Drosophila)0.389
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.385
Shox2short stature homeobox 20.381
Ccdc49coiled-coil domain containing 490.374
Jak2Janus kinase 20.373
Tcfe2atranscription factor E2a0.357
Nkx2-1NK2 homeobox 10.353
Foxe3forkhead box E30.348
CrebbpCREB binding protein0.345
Aimp1aminoacyl tRNA synthetase complex-interacting multifunctional protein 10.339
Nr4a1nuclear receptor subfamily 4, group A, member 10.332
Phf12PHD finger protein 120.323
Map3k3mitogen activated protein kinase kinase kinase 30.321
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.316
Dll3delta-like 3 (Drosophila)0.315
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.313
Oxtroxytocin receptor0.313
Sox17SRY (sex determining region Y)-box 170.307
Metmet proto-oncogene0.305
Nr2f2nuclear receptor subfamily 2, group F, member 20.298
Hand2heart and neural crest derivatives expressed 20.297
Casp2caspase 20.296
Usf2upstream transcription factor 2, c-fos interacting0.295
Eef2eukaryotic translation elongation factor 20.293
Foxd3forkhead box D30.293
Ubtfupstream binding transcription factor, RNA polymerase I0.289
Chatcholine acetyltransferase0.280
Ptprkprotein tyrosine phosphatase, receptor type, K, extracellular region0.280
Akt1v-akt murine thymoma viral oncogene homolog 10.280
Foxi2forkhead box I20.279
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.276
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.274
Klf6Kruppel-like factor 60.274
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.271
Sorbs3sorbin and SH3 domain containing 30.270
Mll5myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)0.268
Mpripmyosin phosphatase Rho interacting protein0.267
Nr4a2nuclear receptor subfamily 4, group A, member 20.266
MrgprfMAS-related GPR, member F0.260
Csdacold shock domain protein A0.259
Tra2btransformer 2 beta homolog (Drosophila)0.256
Nr1d1nuclear receptor subfamily 1, group D, member 10.256
Gna12guanine nucleotide binding protein (G protein) alpha 120.255
Lgals2lectin, galactoside-binding, soluble, 20.254
Smad1SMAD family member 10.253
Hspa9heat shock protein 90.252
Col12a1collagen, type XII, alpha 10.251
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.250
Rxraretinoid X receptor alpha0.248
Socs3suppressor of cytokine signaling 30.248
Runx1runt-related transcription factor 10.246
Hmgb1high mobility group box 10.243
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.240
Jak1Janus kinase 10.237
Nup88nucleoporin 880.236
Atf3activating transcription factor 30.234
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.232
Aqp2aquaporin 2 (collecting duct)0.230
Plrg1pleiotropic regulator 1, PRL1 homolog (Arabidopsis)0.227
Creb1cAMP responsive element binding protein 10.225
Taok1TAO kinase 10.225
Btg2BTG family, member 20.225
LOC684996similar to chromosome 7 open reading frame 110.222
Homer3homer homolog 3 (Drosophila)0.220
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.220
Errfi1ERBB receptor feedback inhibitor 10.219
Fam38bfamily with sequence similarity 38, member B0.219
Mapk14mitogen activated protein kinase 140.215
Plcg2phospholipase C, gamma 20.215
Cdc2l6cell division cycle 2-like 6 (CDK8-like)0.214
Adra2badrenergic, alpha-2B-, receptor0.213
Smad2SMAD family member 20.212
Mef2dmyocyte enhancer factor 2D0.210
Pou3f2POU class 3 homeobox 20.209
Adora2aadenosine A2a receptor0.209
Ptmaprothymosin alpha0.208
Zyxzyxin0.208
Clcn7chloride channel 70.207
Vcpvalosin-containing protein0.204
Svs1seminal vesicle secretory protein 10.202
Msx2msh homeobox 20.202
Scnn1bsodium channel, nonvoltage-gated 1, beta0.201
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.201