The network for 'negative regulation of nucleocytoplasmic transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of nucleocytoplasmic transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
plk1polo-like kinase 1 (Drosophila)0.327
nf1aneurofibromin 1a0.305
LOC100535549cytoplasmic polyadenylation element-binding protein 4-like0.304
capns1acalpain, small subunit 1 a0.157
cdh1cadherin 1, epithelial0.145
akt2v-akt murine thymoma viral oncogene homolog 20.128
nf1bneurofibromin 1b0.116
cdc20cell division cycle 20 homolog0.100
ppp2r5dprotein phosphatase 2, regulatory subunit B', delta0.092
atp6ap2ATPase, H+ transporting, lysosomal accessory protein 20.092
fmr1fragile X mental retardation 10.092
gon4lgon-4-like (C.elegans)0.089
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.087
thraathyroid hormone receptor alpha a0.082
trpv4transient receptor potential cation channel, subfamily V, member 40.081
ptpraprotein tyrosine phosphatase, receptor type, A0.076
vgll4lvestigial like 4 like0.076
clasp2cytoplasmic linker associated protein 20.076
mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.073
gro2groucho 20.071
ncaphnon-SMC condensin I complex, subunit H0.070
kdm5clysine (K)-specific demethylase 5C0.070
nuf2NUF2, NDC80 kinetochore complex component, homolog0.069
polr2apolymerase (RNA) II (DNA directed) polypeptide A0.068
psmd11bproteasome (prosome, macropain) 216S subunit, non-ATPase, 11b0.066
lef1lymphocyte enhancer binding factor 10.063
sec24cSEC24 family, member C (S. cerevisiae)0.061
prps1bphosphoribosyl pyrophosphate synthetase 1B0.060
birc5abaculoviral IAP repeat-containing 5a0.060
ahcyl2S-adenosylhomocysteine hydrolase-like 20.060
lsm8LSM8 homolog, U6 small nuclear RNA associated0.058
kif23kinesin family member 230.058
tubg1tubulin, gamma 10.057
LOC567452G protein-coupled receptor kinase 5-like0.057
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.055
kpna2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.055
axin1axin 10.055
scn1labsodium channel, voltage-gated, type I like, alpha b0.054
mfn2mitofusin 20.053
ptpn11aprotein tyrosine phosphatase, non-receptor type 11, a0.052
acvr1bactivin A receptor, type IB0.052
ccr12.2chemokine (C-C motif) receptor 12.20.050
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.049
mapk12mitogen-activated protein kinase 120.048
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.047
atp6v1c1bATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1b0.047
hddc3HD domain containing 30.046
klhl11kelch-like 11 (Drosophila)0.046
ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.046
uspl1ubiquitin specific peptidase like 10.045
ppdpfbpancreatic progenitor cell differentiation and proliferation factor b0.045
ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.045
arfgef1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.044
sox11bSRY-box containing gene 11b0.043
birc2baculoviral IAP repeat-containing 20.043
pdlim1PDZ and LIM domain 1 (elfin)0.042
cyp1acytochrome P450, family 1, subfamily A0.042
tmem161btransmembrane protein 161B0.042
prdx5peroxiredoxin 50.042
snx27sorting nexin family member 270.041
anxa13annexin A130.041
warstryptophanyl-tRNA synthetase0.041
jag2jagged 20.040
tbeta-abeta thymosin-like protein 20.040
robo3roundabout homolog 30.040
ep300bE1A binding protein p300 b0.040
elovl1belongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b0.039
fbn2bfibrillin 2b0.039
LOC564872monocarboxylate transporter 7-like0.038
snrpb2small nuclear ribonucleoprotein polypeptide B20.038
apaf1apoptotic protease activating factor 10.038
rarabretinoic acid receptor, alpha b0.038
crsp7cofactor required for Sp1 transcriptional activation, subunit 70.038
ap2a1adaptor-related protein complex 2, alpha 1 subunit0.038
mapk6mitogen-activated protein kinase 60.038
lppLIM domain containing preferred translocation partner in lipoma0.038
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.037
smad9MAD homolog 9 (Drosophila)0.037
itm2bbintegral membrane protein 2Bb0.037
rsrc2arginine/serine-rich coiled-coil 20.037
ncoa2nuclear receptor coactivator 20.036
ap1m2adaptor-related protein complex 1, mu 2 subunit0.036
ddx3DEAD (Asp-Glu-Ala-Asp) box polypeptide 30.036
prpf40aPRP40 pre-mRNA processing factor 40 homolog A (yeast)0.036
atp2b4ATPase, Ca++ transporting, plasma membrane 40.036
clk4aCDC-like kinase 4a0.036
mkln1muskelin 1, intracellular mediator containing kelch motifs0.036
serinc2serine incorporator 20.035
nola1nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)0.035
litaflipopolysaccharide-induced TNF factor0.035
pdcd6ipprogrammed cell death 6 interacting protein0.035
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.655
GSK3Bglycogen synthase kinase 3 beta0.417
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.342
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.312
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.303
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.298
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.240
AXIN1axin 10.186
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.173
PAX3paired box 30.162
DTX3Ldeltex 3-like (Drosophila)0.158
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.140
PMLpromyelocytic leukemia0.130
CUL1cullin 10.128
MDM2Mdm2 p53 binding protein homolog (mouse)0.125
PRDX1peroxiredoxin 10.123
MMS22LMMS22-like, DNA repair protein0.112
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.111
PARP14poly (ADP-ribose) polymerase family, member 140.098
CHUKconserved helix-loop-helix ubiquitous kinase0.090
SP100SP100 nuclear antigen0.089
PKD2polycystic kidney disease 2 (autosomal dominant)0.088
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.088
SMAD7SMAD family member 70.087
PARP9poly (ADP-ribose) polymerase family, member 90.077
HIPK2homeodomain interacting protein kinase 20.069
CREBBPCREB binding protein0.068
DCAF7DDB1 and CUL4 associated factor 70.067
ZNF420zinc finger protein 4200.067
CKAP5cytoskeleton associated protein 50.065
APCadenomatous polyposis coli0.062
MAPK1mitogen-activated protein kinase 10.062
HIPK3homeodomain interacting protein kinase 30.061
C3orf15chromosome 3 open reading frame 150.061
PKD1polycystic kidney disease 1 (autosomal dominant)0.059
IRS1insulin receptor substrate 10.055
YAP1Yes-associated protein 10.055
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.054
CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.050
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.050
PRKAR2Aprotein kinase, cAMP-dependent, regulatory, type II, alpha0.049
BCL3B-cell CLL/lymphoma 30.048
RANBP3RAN binding protein 30.047
POU5F1POU class 5 homeobox 10.046
PROX1prospero homeobox 10.046
NXF1nuclear RNA export factor 10.046
MAP3K5mitogen-activated protein kinase kinase kinase 50.045
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.044
ERBB2IPerbb2 interacting protein0.040
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.040
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.040
FASFas (TNF receptor superfamily, member 6)0.039
RARAretinoic acid receptor, alpha0.039
MAP2K5mitogen-activated protein kinase kinase 50.039
ZNF84zinc finger protein 840.037
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.037
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.036
SOD1superoxide dismutase 1, soluble0.034
SKP1S-phase kinase-associated protein 10.033
PSMC5proteasome (prosome, macropain) 26S subunit, ATPase, 50.032
AXLAXL receptor tyrosine kinase0.032
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.032
DYRK2dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 20.032
MAP3K3mitogen-activated protein kinase kinase kinase 30.031
TEKTEK tyrosine kinase, endothelial0.031
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.030
ZNF585Azinc finger protein 585A0.029
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.029
SAMD9Lsterile alpha motif domain containing 9-like0.028
GLI1GLI family zinc finger 10.028
IFIH1interferon induced with helicase C domain 10.027
DYRK4dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 40.027
CASP8caspase 8, apoptosis-related cysteine peptidase0.026
NUP98nucleoporin 98kDa0.026
E2F3E2F transcription factor 30.026
SHFM1split hand/foot malformation (ectrodactyly) type 10.026
LMO4LIM domain only 40.026
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.026
POU3F2POU class 3 homeobox 20.025
MAPK14mitogen-activated protein kinase 140.025
KPNB1karyopherin (importin) beta 10.025
BTRCbeta-transducin repeat containing0.024
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.024
LZTS2leucine zipper, putative tumor suppressor 20.024
ZNF432zinc finger protein 4320.024
SNAI1snail homolog 1 (Drosophila)0.023
BIRC3baculoviral IAP repeat containing 30.023
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.023
FBXW11F-box and WD repeat domain containing 110.023
IRS2insulin receptor substrate 20.022
MAP3K1mitogen-activated protein kinase kinase kinase 10.022
BBS10Bardet-Biedl syndrome 100.022
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.022
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.022
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.022
DDAH2dimethylarginine dimethylaminohydrolase 20.021
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.021
FBXW7F-box and WD repeat domain containing 70.021
NUP50nucleoporin 50kDa0.020
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.020
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grb10growth factor receptor bound protein 100.430
Rararetinoic acid receptor, alpha0.406
Yap1yes-associated protein 10.382
Ctnnb1catenin (cadherin associated protein), beta 10.330
Trp63transformation related protein 630.242
Gbp2guanylate binding protein 20.230
Iigp1interferon inducible GTPase 10.222
Rargretinoic acid receptor, gamma0.187
Gbp7guanylate binding protein 70.166
Gli2GLI-Kruppel family member GLI20.143
Apcadenomatosis polyposis coli0.106
Fgfr2fibroblast growth factor receptor 20.103
Gbp3guanylate binding protein 30.088
Trp53transformation related protein 530.077
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.070
Rxraretinoid X receptor alpha0.065
Gopcgolgi associated PDZ and coiled-coil motif containing0.056
Bcl2B-cell leukemia/lymphoma 20.056
Irgm2immunity-related GTPase family M member 20.055
Gbp10guanylate-binding protein 100.053
Tgtp2T-cell specific GTPase 20.052
Gli3GLI-Kruppel family member GLI30.050
Kitlkit ligand0.050
Meox2mesenchyme homeobox 20.049
Igtpinterferon gamma induced GTPase0.049
Fzd8frizzled homolog 8 (Drosophila)0.046
Gbp6guanylate binding protein 60.045
Pax8paired box gene 80.043
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.042
Bcl3B-cell leukemia/lymphoma 30.042
Ikbkbinhibitor of kappaB kinase beta0.041
RictorRPTOR independent companion of MTOR, complex 20.041
Arandrogen receptor0.040
Ghrgrowth hormone receptor0.038
Pkd1polycystic kidney disease 1 homolog0.037
Ifi47interferon gamma inducible protein 470.035
Axin1axin 10.033
Dlg2discs, large homolog 2 (Drosophila)0.029
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.029
Ifi203interferon activated gene 2030.029
H2-Q7histocompatibility 2, Q region locus 70.028
Retret proto-oncogene0.028
Wnt5awingless-related MMTV integration site 5A0.028
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.027
Vegfavascular endothelial growth factor A0.027
Mapk3mitogen-activated protein kinase 30.026
Serpinb9serine (or cysteine) peptidase inhibitor, clade B, member 90.026
Hoxa3homeobox A30.026
Cdkn1bcyclin-dependent kinase inhibitor 1B0.025
Slc12a6solute carrier family 12, member 60.025
Dvl3dishevelled 3, dsh homolog (Drosophila)0.025
Duox2dual oxidase 20.025
Esr1estrogen receptor 1 (alpha)0.024
Fgfr1fibroblast growth factor receptor 10.024
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform0.024
Notch2Notch gene homolog 2 (Drosophila)0.024
Ifih1interferon induced with helicase C domain 10.024
Ptenphosphatase and tensin homolog0.023
Il6stinterleukin 6 signal transducer0.023
Smad3MAD homolog 3 (Drosophila)0.023
Coro1bcoronin, actin binding protein 1B0.023
Rnf115ring finger protein 1150.023
Mapkap1mitogen-activated protein kinase associated protein 10.023
Cuedc1CUE domain containing 10.022
Efnb1ephrin B10.022
Cav1caveolin 1, caveolae protein0.021
Rptorregulatory associated protein of MTOR, complex 10.021
Lrp5low density lipoprotein receptor-related protein 50.021
Dlg4discs, large homolog 4 (Drosophila)0.021
Flot2flotillin 20.021
Tbx3T-box 30.020
Oasl22'-5' oligoadenylate synthetase-like 20.020
F2rcoagulation factor II (thrombin) receptor0.020
Ifit3interferon-induced protein with tetratricopeptide repeats 30.019
Bcl6B-cell leukemia/lymphoma 60.019
Casp12caspase 120.019
Irgm1immunity-related GTPase family M member 10.019
Gimap4GTPase, IMAP family member 40.019
Ncoa3nuclear receptor coactivator 30.019
Trim30atripartite motif-containing 30A0.019
Tnfsf10tumor necrosis factor (ligand) superfamily, member 100.019
Parp14poly (ADP-ribose) polymerase family, member 140.018
Fzd1frizzled homolog 1 (Drosophila)0.018
Igbp1immunoglobulin (CD79A) binding protein 10.018
Kif1bkinesin family member 1B0.018
Aim2absent in melanoma 20.017
RrasHarvey rat sarcoma oncogene, subgroup R0.017
Ikbkginhibitor of kappaB kinase gamma0.017
Smosmoothened homolog (Drosophila)0.017
Bicc1bicaudal C homolog 1 (Drosophila)0.017
B2mbeta-2 microglobulin0.017
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.017
Pdgfbplatelet derived growth factor, B polypeptide0.017
Cys1cystin 10.017
Ap2m1adaptor protein complex AP-2, mu10.017
Ddr1discoidin domain receptor family, member 10.017
Irf1interferon regulatory factor 10.017
Ptpn11protein tyrosine phosphatase, non-receptor type 110.017
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism