The network for 'dna unwinding involved in dna replication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna unwinding involved in dna replication

The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.

NameDescriptionProbabilityFunc Analog Organism
RFA1Rfa1p0.981
MCM4Mcm4p0.806
MCM5Mcm5p0.704
SLD5Sld5p0.563
MCM3Mcm3p0.481
RFA2Rfa2p0.476
SMC4Smc4p0.472
MCM2Mcm2p0.449
RAD53Rad53p0.432
MCM6Mcm6p0.395
SLD2Sld2p0.256
RFA3Rfa3p0.255
CDC6Cdc6p0.251
TOF1Tof1p0.217
MEC1Mec1p0.189
MCM10Mcm10p0.179
MCM7Mcm7p0.156
BRN1Brn1p0.136
PSF2Psf2p0.087
CDC45Cdc45p0.070
YDL156Whypothetical protein0.062
CSM3Csm3p0.060
MRC1Mrc1p0.059
ACM1Acm1p0.057
MSH6Msh6p0.051
HST3Hst3p0.048
POL1Pol1p0.045
TOP3Top3p0.042
DNA2Dna2p0.042
SMC3Smc3p0.040
SPC97Spc97p0.036
LEU2Leu2p0.034
POB3Pob3p0.033
SRD1Srd1p0.033
YCG1Ycg1p0.032
YLR264C-Ahypothetical protein0.030
MER1Mer1p0.028
CUP1-1Cup1-1p0.028
DBF4Dbf4p0.027
YLR162Whypothetical protein0.027
TAH11Tah11p0.026
YOL038C-Ahypothetical protein0.025
POL2Pol2p0.025
YIR035Chypothetical protein0.023
YAR068Whypothetical protein0.022
COS12Cos12p0.022
HXT3Hxt3p0.022
YLR042Chypothetical protein0.021
SPL2Spl2p0.020
ATP6Atp6p0.020
YPR157Whypothetical protein0.020
ZPS1Zps1p0.020
ARG8Arg8p0.020
AUA1Aua1p0.020
SRS2Srs2p0.020
HTA2Hta2p0.019
HOHop0.019
HHT2Hht2p0.019
YBR013Chypothetical protein0.018
ARP10Arp10p0.018
OPT2Opt2p0.018
HPF1Hpf1p0.018
ALG14Alg14p0.018
YJL181Whypothetical protein0.017
RAD52Rad52p0.017
IRC8Irc8p0.017
CDC9Cdc9p0.016
CTF4Ctf4p0.016
BSC1Bsc1p0.016
YOL013W-Ahypothetical protein0.016
CDC8Cdc8p0.016
FMT1Fmt1p0.016
SCM4Scm4p0.016
PRI2Pri2p0.016
MF(ALPHA)2Mf(alpha)2p0.015
PTR2Ptr2p0.015
BIO2Bio2p0.015
YPR096Chypothetical protein0.015
RAD55Rad55p0.015
IZH4Izh4p0.015
DIC1Dic1p0.015
ADH2Adh2p0.015
ALT2Alt2p0.015
REE1Ree1p0.014
SMC6Smc6p0.014
RNP1Rnp1p0.014
PRS2Prs2p0.014
SPT16Spt16p0.014
CPD1Cpd1p0.014
SPS4Sps4p0.014
YLR040Chypothetical protein0.014
MSA2Msa2p0.014
YAL037C-Ahypothetical protein0.014
UPS3Ups3p0.014
YBL029Whypothetical protein0.014
YPR027Chypothetical protein0.014
MET8Met8p0.013
YPL067Chypothetical protein0.013
YKR075Chypothetical protein0.013
YAL064Whypothetical protein0.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RPA1replication protein A1, 70kDa0.986
MCM6minichromosome maintenance complex component 60.948
MCM2minichromosome maintenance complex component 20.914
ORC1origin recognition complex, subunit 10.615
NCAPD2non-SMC condensin I complex, subunit D20.562
MCM5minichromosome maintenance complex component 50.477
MCM3minichromosome maintenance complex component 30.367
RPA3replication protein A3, 14kDa0.342
BRCA2breast cancer 2, early onset0.193
SSRP1structure specific recognition protein 10.125
RPA2replication protein A2, 32kDa0.114
PARP1poly (ADP-ribose) polymerase 10.103
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.098
UNGuracil-DNA glycosylase0.066
RAD21RAD21 homolog (S. pombe)0.052
NCAPGnon-SMC condensin I complex, subunit G0.043
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.041
MCMBPminichromosome maintenance complex binding protein0.030
BLMBloom syndrome, RecQ helicase-like0.029
CSNK2A1casein kinase 2, alpha 1 polypeptide0.027
RFC2replication factor C (activator 1) 2, 40kDa0.024
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.022
MCM8minichromosome maintenance complex component 80.022
MCM10minichromosome maintenance complex component 100.020
MCM7minichromosome maintenance complex component 70.016
CDC45cell division cycle 45 homolog (S. cerevisiae)0.014
SMC2structural maintenance of chromosomes 20.013
TK1thymidine kinase 1, soluble0.013
LMNB1lamin B10.013
WRNWerner syndrome, RecQ helicase-like0.013
MDC1mediator of DNA-damage checkpoint 10.012
DTLdenticleless homolog (Drosophila)0.012
HDGFhepatoma-derived growth factor0.011
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.011
CUX1cut-like homeobox 10.011
CENPMcentromere protein M0.011
E2F3E2F transcription factor 30.010
SMC1Astructural maintenance of chromosomes 1A0.010
ORC6origin recognition complex, subunit 60.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.975
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.975
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.942
Cdt1chromatin licensing and DNA replication factor 10.926
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.480
Timelesstimeless homolog (Drosophila)0.446
Lig1ligase I, DNA, ATP-dependent0.427
Nup85nucleoporin 850.352
Rrm1ribonucleotide reductase M10.249
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.176
Dnmt1DNA methyltransferase (cytosine-5) 10.163
Rfc2replication factor C (activator 1) 20.133
Rpa1replication protein A10.099
Polepolymerase (DNA directed), epsilon0.096
Rfc5replication factor C (activator 1) 50.096
Rrm2ribonucleotide reductase M20.080
Prim1DNA primase, p49 subunit0.075
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.058
Mcm6minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)0.053
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.051
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.042
Smc2structural maintenance of chromosomes 20.030
Wdhd1WD repeat and HMG-box DNA binding protein 10.030
Cdca8cell division cycle associated 80.029
Ezh2enhancer of zeste homolog 2 (Drosophila)0.027
Prim2DNA primase, p58 subunit0.026
Fen1flap structure specific endonuclease 10.026
Eftud2elongation factor Tu GTP binding domain containing 20.024
Hellshelicase, lymphoid specific0.023
Tk1thymidine kinase 10.023
Brca2breast cancer 20.022
Ssrp1structure specific recognition protein 10.021
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.021
Cdca5cell division cycle associated 50.020
Pold2polymerase (DNA directed), delta 2, regulatory subunit0.019
Rfc3replication factor C (activator 1) 30.018
Nup107nucleoporin 1070.018
Dnajc9DnaJ (Hsp40) homolog, subfamily C, member 90.017
Nup93nucleoporin 930.016
Tcf12transcription factor 120.015
Kif22kinesin family member 220.014
Rad51RAD51 homolog (S. cerevisiae)0.012
Cdca7cell division cycle associated 70.012
Trim28tripartite motif-containing 280.011
Aaasachalasia, adrenocortical insufficiency, alacrimia0.010
Ncaphnon-SMC condensin I complex, subunit H0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism