The network for 'phosphatidylinositol metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

phosphatidylinositol metabolic process

The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.

NameDescriptionProbabilityFunc Analog Organism
GAA1Gaa1p0.914
GAB1Gab1p0.852
GPI17Gpi17p0.783
GPI8Gpi8p0.725
GLO3Glo3p0.681
LAS21Las21p0.670
GPI16Gpi16p0.513
RGD1Rgd1p0.460
FIG4Fig4p0.442
GUP1Gup1p0.334
PIK1Pik1p0.303
GCS1Gcs1p0.295
PER1Per1p0.277
SPF1Spf1p0.269
GOT1Got1p0.269
INP52Inp52p0.268
RSN1Rsn1p0.258
SLC1Slc1p0.257
ALG8Alg8p0.247
VPS15Vps15p0.230
HOC1Hoc1p0.229
TGL1Tgl1p0.219
SAC7Sac7p0.215
KCS1Kcs1p0.205
KRE5Kre5p0.197
ARV1Arv1p0.196
GDS1Gds1p0.194
YNL035Chypothetical protein0.186
PSD2Psd2p0.175
PMR1Pmr1p0.173
OSH7Osh7p0.171
INP53Inp53p0.166
MON2Mon2p0.164
YOR316C-Ahypothetical protein0.158
PIS1Pis1p0.157
BST1Bst1p0.154
SEY1Sey1p0.153
RFT1Rft1p0.150
ALG6Alg6p0.146
NMT1Nmt1p0.144
VPS38Vps38p0.138
GWT1Gwt1p0.138
SEC59Sec59p0.137
LSB5Lsb5p0.136
KKQ8Kkq8p0.131
STT4Stt4p0.131
PTC7Ptc7p0.126
ERD2Erd2p0.124
CNE1Cne1p0.124
GGA1Gga1p0.121
MDL1Mdl1p0.119
YOL087Chypothetical protein0.118
PST2Pst2p0.117
YGR205Whypothetical protein0.114
GPI13Gpi13p0.113
FAR11Far11p0.109
YHR177Whypothetical protein0.109
PHS1Phs1p0.109
SAM2Sam2p0.109
ARF3Arf3p0.108
WSC3Wsc3p0.107
TRS130Trs130p0.107
YFR016Chypothetical protein0.106
TCB3Tcb3p0.105
SEC61Sec61p0.104
IRS4Irs4p0.103
VPS13Vps13p0.098
YJR015Whypothetical protein0.094
GPI1Gpi1p0.094
SFB3Sfb3p0.091
AGE1Age1p0.090
ROT2Rot2p0.088
MNN2Mnn2p0.087
STV1Stv1p0.086
CBK1Cbk1p0.086
TSC11Tsc11p0.085
PFY1Pfy1p0.084
VPH2Vph2p0.082
KAP120Kap120p0.082
EDE1Ede1p0.081
SEC63Sec63p0.081
PDR17Pdr17p0.081
FRA1Fra1p0.079
GMH1Gmh1p0.078
YNL108Chypothetical protein0.078
CWH43Cwh43p0.078
LAG1Lag1p0.076
YJR012Chypothetical protein0.076
KES1Kes1p0.076
CSR1Csr1p0.075
RCE1Rce1p0.074
RTT105Rtt105p0.073
TPT1Tpt1p0.073
YPL066Whypothetical protein0.072
PFA4Pfa4p0.071
HSV2Hsv2p0.069
FPR3Fpr3p0.069
SCJ1Scj1p0.067
ARL1Arl1p0.067
MNN5Mnn5p0.067
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gdf6agrowth differentiation factor 6a0.062
disp1dispatched homolog 1 (Drosophila)0.026
cyfip2cytoplasmic FMR1 interacting protein 20.018
ptch1patched 10.015
drd2bdopamine receptor D2b0.012
syt11asynaptotagmin XIa0.011
pmelapremelanosome protein a0.011
acvr2aactivin receptor IIa0.011
prox2prospero homeobox 20.011
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.011
slc26a5solute carrier family 26, member 50.011
zgc:112359zgc:1123590.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
RalaRas-related protein0.015
CG3004CG3004 gene product from transcript CG3004-RA0.013
brpbruchpilot0.012
oa2octopamine receptor 20.010
TbhTyramine beta hydroxylase0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.999
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.994
FGFR2fibroblast growth factor receptor 20.987
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.973
FGFR1fibroblast growth factor receptor 10.966
NRP1neuropilin 10.925
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.891
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.884
EGFRepidermal growth factor receptor0.852
PLCG1phospholipase C, gamma 10.849
LATlinker for activation of T cells0.744
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.737
IRS1insulin receptor substrate 10.633
SHC1SHC (Src homology 2 domain containing) transforming protein 10.548
FGF1fibroblast growth factor 1 (acidic)0.538
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.531
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.503
MTMR12myotubularin related protein 120.500
MTM1myotubularin 10.481
MPDZmultiple PDZ domain protein0.462
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.431
VEGFAvascular endothelial growth factor A0.423
SHC2SHC (Src homology 2 domain containing) transforming protein 20.389
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.362
SOS1son of sevenless homolog 1 (Drosophila)0.344
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.306
PTPN11protein tyrosine phosphatase, non-receptor type 110.230
ADORA2Aadenosine A2a receptor0.229
PDGFAplatelet-derived growth factor alpha polypeptide0.213
UPF1UPF1 regulator of nonsense transcripts homolog (yeast)0.196
SNAP25synaptosomal-associated protein, 25kDa0.185
GRB7growth factor receptor-bound protein 70.179
MTMR6myotubularin related protein 60.177
BECN1beclin 1, autophagy related0.144
VAC14Vac14 homolog (S. cerevisiae)0.143
NOS1nitric oxide synthase 1 (neuronal)0.142
RAB5ARAB5A, member RAS oncogene family0.139
CD81CD81 molecule0.139
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.135
GAB1GRB2-associated binding protein 10.132
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.132
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.126
SH3GL2SH3-domain GRB2-like 20.122
PIK3CBphosphoinositide-3-kinase, catalytic, beta polypeptide0.120
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.119
PIKFYVEphosphoinositide kinase, FYVE finger containing0.118
MTMR9myotubularin related protein 90.113
INSRinsulin receptor0.113
CD9CD9 molecule0.101
SMAD9SMAD family member 90.100
SYKspleen tyrosine kinase0.097
PTPRBprotein tyrosine phosphatase, receptor type, B0.096
AMPHamphiphysin0.094
C17orf28chromosome 17 open reading frame 280.091
SOS2son of sevenless homolog 2 (Drosophila)0.087
GRB10growth factor receptor-bound protein 100.086
PGFplacental growth factor0.085
ATG14ATG14 autophagy related 14 homolog (S. cerevisiae)0.083
FGF10fibroblast growth factor 100.082
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.080
FGF2fibroblast growth factor 2 (basic)0.078
ITSN1intersectin 1 (SH3 domain protein)0.075
SPAG9sperm associated antigen 90.074
GRB2growth factor receptor-bound protein 20.069
FGF7fibroblast growth factor 70.066
RNF6ring finger protein (C3H2C3 type) 60.062
TMEM173transmembrane protein 1730.061
PDGFCplatelet derived growth factor C0.060
SPOPspeckle-type POZ protein0.060
BLNKB-cell linker0.059
GMFBglia maturation factor, beta0.058
DNM1dynamin 10.057
CD63CD63 molecule0.056
VAV3vav 3 guanine nucleotide exchange factor0.056
ARRDC3arrestin domain containing 30.055
ACBD3acyl-CoA binding domain containing 30.055
UVRAGUV radiation resistance associated gene0.054
GAB2GRB2-associated binding protein 20.053
FRS2fibroblast growth factor receptor substrate 20.053
NEDD4neural precursor cell expressed, developmentally down-regulated 40.050
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.047
VAPAVAMP (vesicle-associated membrane protein)-associated protein A, 33kDa0.044
SFNstratifin0.043
DCTN1dynactin 10.043
PTPRJprotein tyrosine phosphatase, receptor type, J0.043
SLASrc-like-adaptor0.042
PIGSphosphatidylinositol glycan anchor biosynthesis, class S0.041
BAI1brain-specific angiogenesis inhibitor 10.041
TP53BP1tumor protein p53 binding protein 10.041
OSBPL9oxysterol binding protein-like 90.040
PRKACBprotein kinase, cAMP-dependent, catalytic, beta0.039
RAB6ARAB6A, member RAS oncogene family0.039
BTBD1BTB (POZ) domain containing 10.039
C19orf61chromosome 19 open reading frame 610.038
TSPAN4tetraspanin 40.037
PIGTphosphatidylinositol glycan anchor biosynthesis, class T0.036
UPF3AUPF3 regulator of nonsense transcripts homolog A (yeast)0.036
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.036
SH3BP2SH3-domain binding protein 20.036
HIPK3homeodomain interacting protein kinase 30.035
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Kdrkinase insert domain protein receptor0.810
Nos3nitric oxide synthase 3, endothelial cell0.789
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.684
Trp53transformation related protein 530.649
Shc1src homology 2 domain-containing transforming protein C10.643
CblCasitas B-lineage lymphoma0.603
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.548
Inpp5dinositol polyphosphate-5-phosphatase D0.514
Plcg1phospholipase C, gamma 10.433
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.402
Ednrbendothelin receptor type B0.352
Flt4FMS-like tyrosine kinase 40.336
Flt1FMS-like tyrosine kinase 10.306
Lig4ligase IV, DNA, ATP-dependent0.285
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.285
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.275
Vegfavascular endothelial growth factor A0.261
Lama5laminin, alpha 50.224
Col1a1collagen, type I, alpha 10.210
Leprleptin receptor0.183
Ighimmunoglobulin heavy chain complex0.180
FynFyn proto-oncogene0.178
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.174
Csf1colony stimulating factor 1 (macrophage)0.161
Myo6myosin VI0.151
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.147
Itsn1intersectin 1 (SH3 domain protein 1A)0.137
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.135
Bcl6B-cell leukemia/lymphoma 60.133
BlnkB-cell linker0.124
Rb1retinoblastoma 10.119
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.115
Ctnnb1catenin (cadherin associated protein), beta 10.110
Tgfbr1transforming growth factor, beta receptor I0.108
Gab1growth factor receptor bound protein 2-associated protein 10.108
Becn1beclin 1, autophagy related0.107
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.105
Pdgfbplatelet derived growth factor, B polypeptide0.102
Plxnd1plexin D10.101
Mapk9mitogen-activated protein kinase 90.099
Cd22CD22 antigen0.095
Cdh5cadherin 50.094
Ptch1patched homolog 10.094
Apcadenomatosis polyposis coli0.088
Ap2b1adaptor-related protein complex 2, beta 1 subunit0.086
Engendoglin0.084
Agrpagouti related protein0.083
Sirpasignal-regulatory protein alpha0.080
Efr3aEFR3 homolog A (S. cerevisiae)0.079
Ptprbprotein tyrosine phosphatase, receptor type, B0.079
Pik3cgphosphoinositide-3-kinase, catalytic, gamma polypeptide0.075
SrcRous sarcoma oncogene0.073
Sorbs3sorbin and SH3 domain containing 30.069
Lystlysosomal trafficking regulator0.066
Notch2Notch gene homolog 2 (Drosophila)0.066
Tmem204transmembrane protein 2040.065
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.065
Tekendothelial-specific receptor tyrosine kinase0.062
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.060
Homer1homer homolog 1 (Drosophila)0.058
Prkcbprotein kinase C, beta0.056
Jag2jagged 20.056
Kcnab3potassium voltage-gated channel, shaker-related subfamily, beta member 30.055
Crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.054
Pik3r6phosphoinositide-3-kinase, regulatory subunit 60.054
Metmet proto-oncogene0.053
Sstsomatostatin0.053
Tgfbr2transforming growth factor, beta receptor II0.052
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.051
Eps15epidermal growth factor receptor pathway substrate 150.051
Ptenphosphatase and tensin homolog0.050
Esr1estrogen receptor 1 (alpha)0.050
Plcb3phospholipase C, beta 30.050
Nbnnibrin0.049
Slc27a1solute carrier family 27 (fatty acid transporter), member 10.049
Stat5bsignal transducer and activator of transcription 5B0.048
Idsiduronate 2-sulfatase0.048
Cdkn1bcyclin-dependent kinase inhibitor 1B0.048
Epb4.1l2erythrocyte protein band 4.1-like 20.048
Parvgparvin, gamma0.047
Rasgrp1RAS guanyl releasing protein 10.047
Cxcl14chemokine (C-X-C motif) ligand 140.047
Bcar1breast cancer anti-estrogen resistance 10.046
GnptabN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits0.046
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.045
Kifc3kinesin family member C30.045
Snx13sorting nexin 130.044
Scn1bsodium channel, voltage-gated, type I, beta0.044
Sh3gl2SH3-domain GRB2-like 20.044
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.044
Ate1arginyltransferase 10.043
BrafBraf transforming gene0.043
Spry2sprouty homolog 2 (Drosophila)0.042
Prkchprotein kinase C, eta0.042
Dok3docking protein 30.042
Acvrl1activin A receptor, type II-like 10.042
Elavl2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)0.041
Ap2a1adaptor protein complex AP-2, alpha 1 subunit0.041
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.041
Nrp1neuropilin 10.041
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Slc16a8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.013
Amphamphiphysin0.013
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.012
Grm1glutamate receptor, metabotropic 10.012
Olr1500olfactory receptor 15000.011
Gad1glutamate decarboxylase 10.011
Ip6k1inositol hexakisphosphate kinase 10.011
Dlg4discs, large homolog 4 (Drosophila)0.011
Grik1glutamate receptor, ionotropic, kainate 10.010
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.010