The network for 'negative regulation of catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.

NameDescriptionProbabilityFunc Analog Organism
CDC55Cdc55p0.841
MAD2Mad2p0.598
CDC20Cdc20p0.533
TOR1Tor1p0.476
GLC7Glc7p0.440
PPH21Pph21p0.392
SLK19Slk19p0.327
HHT1Hht1p0.314
CTF13Ctf13p0.309
MAD1Mad1p0.308
RTS1Rts1p0.293
PPH22Pph22p0.245
SIT4Sit4p0.244
BUB3Bub3p0.237
TPK1Tpk1p0.210
CHL4Chl4p0.202
MLC1Mlc1p0.201
YPL260Whypothetical protein0.185
IML3Iml3p0.183
STE4Ste4p0.182
FUS3Fus3p0.175
BUB1Bub1p0.167
SGV1Sgv1p0.155
YPI1Ypi1p0.153
CDC28Cdc28p0.143
CIN8Cin8p0.142
NSL1Nsl1p0.135
GIP2Gip2p0.134
TCO89Tco89p0.122
HHF2Hhf2p0.119
PIG2Pig2p0.119
SDS22Sds22p0.115
HDA2Hda2p0.115
SUR1Sur1p0.111
CTK2Ctk2p0.108
FMP48Fmp48p0.104
SUI3Sui3p0.103
REG1Reg1p0.099
SNF4Snf4p0.096
MDS3Mds3p0.095
CHL1Chl1p0.095
PSP1Psp1p0.093
KIN1Kin1p0.093
MAD3Mad3p0.091
KIP1Kip1p0.090
SAP185Sap185p0.088
SHP1Shp1p0.085
BBC1Bbc1p0.079
CTK1Ctk1p0.079
RTS3Rts3p0.078
KSP1Ksp1p0.076
WWM1Wwm1p0.076
CIN1Cin1p0.073
IML1Iml1p0.072
PPZ1Ppz1p0.071
CDC4Cdc4p0.070
TPD3Tpd3p0.070
SUS1Sus1p0.070
BMH1Bmh1p0.069
SEF1Sef1p0.066
MCM21Mcm21p0.065
MTW1Mtw1p0.064
HAA1Haa1p0.063
STD1Std1p0.062
HYM1Hym1p0.061
GBP2Gbp2p0.061
ERV25Erv25p0.061
GAL83Gal83p0.061
ZDS1Zds1p0.061
MBF1Mbf1p0.059
GPH1Gph1p0.056
CDC6Cdc6p0.055
LRS4Lrs4p0.055
ECO1Eco1p0.055
LCB4Lcb4p0.055
ADR1Adr1p0.055
HAL5Hal5p0.055
BEM3Bem3p0.054
RAD53Rad53p0.053
YIL151Chypothetical protein0.052
NIP7Nip7p0.051
YGR250Chypothetical protein0.051
SEC62Sec62p0.051
NBL1Nbl1p0.051
NAB3Nab3p0.050
CRN1Crn1p0.050
YGR130Chypothetical protein0.049
SIC1Sic1p0.049
PTK2Ptk2p0.047
PBP4Pbp4p0.047
SUI1Sui1p0.047
SAP4Sap4p0.046
GPI11Gpi11p0.046
GIS1Gis1p0.046
SPC24Spc24p0.046
SPO12Spo12p0.045
SKO1Sko1p0.044
ACH1Ach1p0.044
SAR1Sar1p0.044
YLR177Whypothetical protein0.044
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cye-1Protein CYE-10.085
goa-1Protein GOA-10.083
gpr-1Protein GPR-10.076
his-45Protein HIS-450.069
gpr-2Protein GPR-20.053
his-6Protein HIS-60.051
sac-1Protein SAC-10.041
chc-1Protein CHC-10.041
uaf-1Protein UAF-10.039
prg-2Protein PRG-20.037
his-42Protein HIS-420.036
pkg-1Protein PKG-10.026
T22C1.1Protein T22C1.10.025
tps-1Protein TPS-10.024
ani-1Protein ANI-10.022
sem-5Protein SEM-50.022
sma-6Protein SMA-60.022
egl-15Protein EGL-150.021
chd-7Protein CHD-70.020
cec-4Protein CEC-40.020
pabp-2Protein PABP-20.019
mon-2Protein MON-20.018
his-32Protein HIS-320.017
CELE_Y69A2AR.28Protein Y69A2AR.280.017
mlt-10Protein MLT-100.017
imb-2Protein IMB-20.016
pqn-44Protein PQN-440.016
air-1Protein AIR-10.015
bar-1Protein BAR-10.015
CELE_C10C6.6Protein C10C6.60.015
zer-1Protein ZER-10.014
miz-1Protein MIZ-10.014
rab-5Protein RAB-50.014
C53C9.2Protein C53C9.20.014
daf-5Protein DAF-50.014
lpd-3Protein LPD-30.014
lag-1Protein LAG-10.014
teg-1Protein TEG-10.013
spdl-1Protein SPDL-10.013
mex-5Protein MEX-50.013
pqn-47Protein PQN-470.013
let-60Protein LET-600.013
ntl-4Protein NTL-40.012
mig-15Protein MIG-150.012
ZK507.6Protein ZK507.60.012
cks-1Protein CKS-10.012
ykt-6Protein YKT-60.011
T23F11.1Protein T23F11.10.011
smc-3Protein SMC-30.011
abts-1Protein ABTS-10.011
sli-1Protein SLI-10.011
Y55F3BR.8Protein Y55F3BR.80.011
daf-16Protein DAF-160.011
scd-1Protein SCD-10.011
smk-1Protein SMK-10.011
npp-11Protein NPP-110.011
crm-1Protein CRM-10.010
daf-3Protein DAF-30.010
vpr-1Protein VPR-10.010
hpo-10Protein HPO-100.010
pld-1Protein PLD-10.010
F52F10.2Protein F52F10.20.010
tfg-1Protein TFG-10.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.557
igf1rbinsulin-like growth factor 1b receptor0.330
il6rinterleukin 6 receptor0.212
si:ch211-69g19.2si:ch211-69g19.20.200
dbx1adeveloping brain homeobox 1a0.190
elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.180
snai1asnail homolog 1a (Drosophila)0.170
mapk3mitogen-activated protein kinase 30.165
tacc3transforming, acidic coiled-coil containing protein 30.160
gins3GINS complex subunit 30.154
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.153
stc1lstanniocalcin 1, like0.142
ripk2receptor-interacting serine-threonine kinase 20.139
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.133
plk1polo-like kinase 1 (Drosophila)0.126
fgf20afibroblast growth factor 20a0.123
aurkbaurora kinase B0.121
cdca8cell division cycle associated 80.119
kif23kinesin family member 230.119
dlx4adistal-less homeobox gene 4a0.118
gro2groucho 20.117
LOC100535549cytoplasmic polyadenylation element-binding protein 4-like0.116
mpzmyelin protein zero0.116
tmed10transmembrane emp24-like trafficking protein 10 (yeast)0.115
ef1aelongation factor 1-alpha0.115
rxrbaretinoid x receptor, beta a0.114
sp2sp2 transcription factor0.112
kpna2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.111
fgf8afibroblast growth factor 8 a0.111
cdc20cell division cycle 20 homolog0.110
gro1groucho 10.110
ccna2cyclin A20.109
s1pr2sphingosine-1-phosphate receptor 20.106
mxi1max interacting protein0.103
bactin2bactin20.102
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.102
akt2v-akt murine thymoma viral oncogene homolog 20.100
furinafurin (paired basic amino acid cleaving enzyme) a0.099
hmx4H6 family homeobox 40.096
polr2bpolymerase (RNA) II (DNA directed) polypeptide B0.093
smad5MAD homolog 5 (Drosophila)0.091
rpl4ribosomal protein L40.090
wu:fc31g04wu:fc31g040.088
slc35b2solute carrier family 35, member B20.088
insrbinsulin receptor b0.086
tia1lcytotoxic granule-associated RNA binding protein 1, like0.085
ptch2patched 20.085
fgf3fibroblast growth factor 30.085
gpr126G protein-coupled receptor 1260.083
derl1Der1-like domain family, member 10.082
arcn1archain 10.082
tax1bp1bTax1 (human T-cell leukemia virus type I) binding protein 1b0.082
ube4bubiquitination factor E4B, UFD2 homolog (S. cerevisiae)0.079
wnt9awingless-type MMTV integration site family, member 9A0.077
zgc:64114zgc:641140.075
mfn2mitofusin 20.074
tm9sf2transmembrane 9 superfamily member 20.074
fcho2FCH domain only 20.074
zgc:56200zgc:562000.073
tfe3atranscription factor binding to IGHM enhancer 3a0.073
abcc1ATP-binding cassette, sub-family C, member 10.073
cdt1chromatin licensing and DNA replication factor 10.073
tnfatumor necrosis factor a (TNF superfamily, member 2)0.073
map2k4amitogen-activated protein kinase kinase 4a0.072
ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.072
mapk1mitogen-activated protein kinase 10.072
kif11kinesin family member 110.071
hspa5heat shock protein 50.070
si:dkey-11e23.5si:dkey-11e23.50.069
zgc:66100zgc:661000.069
dkk1bdickkopf 1b0.069
nortnotch-regulated transcript0.069
pcsk7proprotein convertase subtilisin/kexin type 70.068
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.067
nf1aneurofibromin 1a0.067
mapk14amitogen-activated protein kinase 14a0.066
jhdm1dajumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae)0.065
furinbfurin (paired basic amino acid cleaving enzyme) b0.065
birc5abaculoviral IAP repeat-containing 5a0.064
ccnb1cyclin B10.064
copz2zeta2-cop0.064
puf60apoly-U binding splicing factor a0.063
ldb2bLIM-domain binding factor 2b0.063
nusap1nucleolar and spindle associated protein 10.062
tnikbTRAF2 and NCK interacting kinase b0.062
trpm7transient receptor potential cation channel, subfamily M, member 70.062
dclk2doublecortin-like kinase 20.062
uxs1UDP-glucuronic acid decarboxylase 10.061
polepolymerase (DNA directed), epsilon0.061
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.061
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.061
usp5ubiquitin specific protease 50.060
smc4structural maintenance of chromosomes 40.060
ca8carbonic anhydrase VIII0.060
cdh1cadherin 1, epithelial0.060
zgc:56538zgc:565380.058
tm9sf4transmembrane 9 superfamily protein member 40.058
cdk1cyclin-dependent kinase 10.058
tgfb1atransforming growth factor, beta 1a0.058
si:ch211-244o22.2si:ch211-244o22.20.058
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.946
EgfrEpidermal growth factor receptor0.594
DrefDNA replication-related element factor0.506
EcREcdysone receptor0.473
saxsaxophone0.371
Akt1CG4006 gene product from transcript CG4006-RA0.307
SmoxSmad on X0.265
MadMothers against dpp0.237
rhorhomboid0.216
CSN5COP9 complex homolog subunit 50.153
CycACyclin A0.149
flwflapwing0.147
fzyfizzy0.141
MntCG13316 gene product from transcript CG13316-RD0.136
tsrtwinstar0.122
NNotch0.119
dmdiminutive0.110
rlrolled0.110
tkvthickveins0.102
pontpontin0.098
norpAno receptor potential A0.087
drkdownstream of receptor kinase0.077
Pi3K92ECG4141 gene product from transcript CG4141-RB0.076
flflfalafel0.075
effeffete0.072
phlpole hole0.071
CG11486CG11486 gene product from transcript CG11486-RG0.070
Gp150CG5820 gene product from transcript CG5820-RA0.064
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.064
miminus0.062
smosmoothened0.062
AlyCG1101 gene product from transcript CG1101-RA0.059
Xbp1X box binding protein-10.057
Drep-2DNA fragmentation factor-related protein 20.052
ttktramtrack0.051
htshu li tai shao0.051
Cdc37CG12019 gene product from transcript CG12019-RA0.050
tefutelomere fusion0.049
CdsACDP diglyceride synthetase0.048
RanGapRan GTPase activating protein0.047
stgstring0.047
DabDisabled0.046
invinvected0.045
CG7967CG7967 gene product from transcript CG7967-RA0.044
Taf1TBP-associated factor 10.044
Bap55Brahma associated protein 55kD0.043
scylscylla0.043
chicchickadee0.043
Cdc42CG12530 gene product from transcript CG12530-RA0.042
jebjelly belly0.042
Rho1CG8416 gene product from transcript CG8416-RB0.041
pntpointed0.041
Rpd3CG7471 gene product from transcript CG7471-RA0.041
ogreoptic ganglion reduced0.041
smt3CG4494 gene product from transcript CG4494-RA0.039
UbqnUbiquilin0.038
S6kRPS6-p70-protein kinase0.038
ash2absent, small, or homeotic discs 20.037
bambag of marbles0.037
alphaTub67Calpha-Tubulin at 67C0.037
drprdraper0.037
FhosCG42610 gene product from transcript CG42610-RC0.036
RpS20Ribosomal protein S200.036
betaTub60Dbeta-Tubulin at 60D0.033
Snr1Snf5-related 10.032
Vap-33-1CG5014 gene product from transcript CG5014-RB0.031
klgklingon0.031
dppdecapentaplegic0.031
Elp3Elongator complex protein 30.030
G-oalpha47AG protein oalpha 47A0.030
Sep2Septin-20.030
Top1Topoisomerase 10.030
mgemaggie0.030
bazbazooka0.029
ActbetaActivin-beta0.029
eIF-4BEukaryotic initiation factor 4B0.028
SNF1ASNF1A/AMP-activated protein kinase0.027
trptransient receptor potential0.027
Mkp3Mitogen-activated protein kinase phosphatase 30.026
eastenhanced adult sensory threshold0.026
ImpL2Ecdysone-inducible gene L20.026
babobaboon0.026
myoglianinCG1838 gene product from transcript CG1838-RD0.025
ranCG1404 gene product from transcript CG1404-RB0.025
Psf2CG18013 gene product from transcript CG18013-RA0.025
tldtolloid0.025
RanBPMRan-binding protein M0.025
CG9986CG9986 gene product from transcript CG9986-RA0.024
CycBCyclin B0.024
DlDelta0.024
ththread0.024
Mcm10Sensitized chromosome inheritance modifier 190.024
InRInsulin-like receptor0.023
Mcm7Minichromosome maintenance 70.023
sar1CG7073 gene product from transcript CG7073-RB0.023
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.023
panpangolin0.023
Gef26CG9491 gene product from transcript CG9491-RB0.023
Pabp2CG2163 gene product from transcript CG2163-RA0.023
stysprouty0.023
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.904
SMAD3SMAD family member 30.836
DLG4discs, large homolog 4 (Drosophila)0.733
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.667
YAP1Yes-associated protein 10.644
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.619
TRAF6TNF receptor-associated factor 60.594
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.588
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.585
CALM1calmodulin 1 (phosphorylase kinase, delta)0.530
SMAD1SMAD family member 10.520
IL1R1interleukin 1 receptor, type I0.498
APOA1apolipoprotein A-I0.489
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.462
FKBP1AFK506 binding protein 1A, 12kDa0.448
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.439
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.421
TNNC1troponin C type 1 (slow)0.413
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.385
EGFRepidermal growth factor receptor0.383
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.382
CCT8chaperonin containing TCP1, subunit 8 (theta)0.377
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.366
CDC27cell division cycle 27 homolog (S. cerevisiae)0.357
PMLpromyelocytic leukemia0.355
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.354
SH3KBP1SH3-domain kinase binding protein 10.345
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.327
MAP3K5mitogen-activated protein kinase kinase kinase 50.322
TP53tumor protein p530.315
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.306
MAPRE1microtubule-associated protein, RP/EB family, member 10.303
TCP1t-complex 10.297
MYD88myeloid differentiation primary response gene (88)0.296
MAPK1mitogen-activated protein kinase 10.284
UHRF1ubiquitin-like with PHD and ring finger domains 10.282
SQSTM1sequestosome 10.278
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.273
CCT4chaperonin containing TCP1, subunit 4 (delta)0.272
CDC20cell division cycle 20 homolog (S. cerevisiae)0.257
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.237
DLG1discs, large homolog 1 (Drosophila)0.227
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.222
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)0.221
KIF5Bkinesin family member 5B0.221
APOEapolipoprotein E0.203
PSEN1presenilin 10.202
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 110.193
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.182
RND1Rho family GTPase 10.179
ALBalbumin0.176
HDAC6histone deacetylase 60.173
TRADDTNFRSF1A-associated via death domain0.172
TRIM63tripartite motif containing 630.169
ATRXalpha thalassemia/mental retardation syndrome X-linked0.168
SEMA4Asema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A0.163
APPamyloid beta (A4) precursor protein0.156
MPDZmultiple PDZ domain protein0.155
HMOX2heme oxygenase (decycling) 20.155
CD14CD14 molecule0.153
RNF11ring finger protein 110.151
PRNPprion protein0.150
MDM2Mdm2 p53 binding protein homolog (mouse)0.148
SMAD2SMAD family member 20.148
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.148
AGAP7ArfGAP with GTPase domain, ankyrin repeat and PH domain 70.147
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.147
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.146
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.145
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.142
FLNBfilamin B, beta0.140
SKILSKI-like oncogene0.140
GHRgrowth hormone receptor0.135
PARP1poly (ADP-ribose) polymerase 10.134
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.134
VHLvon Hippel-Lindau tumor suppressor0.131
PPARGperoxisome proliferator-activated receptor gamma0.128
HAP1huntingtin-associated protein 10.126
TOR1Atorsin family 1, member A (torsin A)0.126
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.125
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.122
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.122
ITGB1BP3integrin beta 1 binding protein 30.118
CCT3chaperonin containing TCP1, subunit 3 (gamma)0.117
EPAS1endothelial PAS domain protein 10.115
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.113
TFRCtransferrin receptor (p90, CD71)0.113
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.112
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.110
SRIsorcin0.109
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.107
SMURF2SMAD specific E3 ubiquitin protein ligase 20.105
SPRR2Asmall proline-rich protein 2A0.105
CDK17cyclin-dependent kinase 170.104
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.104
MAP2K1mitogen-activated protein kinase kinase 10.104
DAXXdeath-domain associated protein0.102
IRAK2interleukin-1 receptor-associated kinase 20.102
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.101
CPEB4cytoplasmic polyadenylation element binding protein 40.101
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism