The network for 'telomere maintenance via telomerase' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

telomere maintenance via telomerase

The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.

NameDescriptionProbabilityFunc Analog Organism
RFA2Rfa2p0.966
EST2Est2p0.924
RFA1Rfa1p0.854
MEC1Mec1p0.632
SGS1Sgs1p0.401
DNA2Dna2p0.383
CDC13Cdc13p0.354
RAD53Rad53p0.319
TEL1Tel1p0.310
POL12Pol12p0.256
STN1Stn1p0.245
TEN1Ten1p0.230
STI1Sti1p0.227
MSH6Msh6p0.186
NOP10Nop10p0.163
RIF1Rif1p0.161
POL1Pol1p0.160
RMI1Rmi1p0.150
SMC6Smc6p0.137
PIF1Pif1p0.120
RFA3Rfa3p0.099
RAD5Rad5p0.096
YDL156Whypothetical protein0.079
DUN1Dun1p0.073
EST1Est1p0.065
VAC17Vac17p0.056
YKU80Yku80p0.052
TTI2Tti2p0.052
SWM2Swm2p0.051
CSM2Csm2p0.047
PRI1Pri1p0.047
YLR162Whypothetical protein0.045
EBS1Ebs1p0.041
IRC5Irc5p0.040
POL2Pol2p0.038
HHO1Hho1p0.038
RNH201Rnh201p0.036
RIO1Rio1p0.034
PRS2Prs2p0.033
YLR363W-Ahypothetical protein0.033
SRD1Srd1p0.031
URA3Ura3p0.031
YLR264C-Ahypothetical protein0.030
RTT105Rtt105p0.029
SPT15Spt15p0.028
THG1Thg1p0.028
MER1Mer1p0.027
ARP10Arp10p0.027
LEU2Leu2p0.027
YOL038C-Ahypothetical protein0.026
DED1Ded1p0.026
YMR147Whypothetical protein0.026
YOR390Whypothetical protein0.026
SEN54Sen54p0.025
MMS1Mms1p0.025
CDC9Cdc9p0.025
YGR071Chypothetical protein0.025
RAP1Rap1p0.024
RTT107Rtt107p0.024
FHL1Fhl1p0.024
RAD51Rad51p0.023
FYV7Fyv7p0.023
ARG8Arg8p0.023
FAF1Faf1p0.023
MGS1Mgs1p0.022
ADH2Adh2p0.022
SIR4Sir4p0.022
FCP1Fcp1p0.022
SAE2Sae2p0.022
EXO1Exo1p0.022
YAR068Whypothetical protein0.021
SGT2Sgt2p0.021
MSH3Msh3p0.021
POL32Pol32p0.021
SIR3Sir3p0.021
HOHop0.021
PDS1Pds1p0.021
SFT1Sft1p0.021
YIL151Chypothetical protein0.020
YLR042Chypothetical protein0.020
YPR157Whypothetical protein0.020
HCH1Hch1p0.020
ATP6Atp6p0.020
CUP1-1Cup1-1p0.020
YER186Chypothetical protein0.020
OGG1Ogg1p0.020
YNR071Chypothetical protein0.019
YBR013Chypothetical protein0.019
HHT2Hht2p0.019
MET8Met8p0.019
BSC1Bsc1p0.019
MF(ALPHA)2Mf(alpha)2p0.019
HPF1Hpf1p0.019
SSP1Ssp1p0.019
CHA1Cha1p0.019
HXT3Hxt3p0.019
FMT1Fmt1p0.019
RAD9Rad9p0.019
YOR342Chypothetical protein0.019
CAB4Cab4p0.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RPA1replication protein A1, 70kDa0.999
PINX1PIN2/TERF1 interacting, telomerase inhibitor 10.951
TERF2IPtelomeric repeat binding factor 2, interacting protein0.782
RPA2replication protein A2, 32kDa0.759
TERF1telomeric repeat binding factor (NIMA-interacting) 10.649
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.565
RPA3replication protein A3, 14kDa0.465
NBNnibrin0.413
HIF1ANhypoxia inducible factor 1, alpha subunit inhibitor0.412
TINF2TERF1 (TRF1)-interacting nuclear factor 20.343
WRNWerner syndrome, RecQ helicase-like0.311
TOP3Atopoisomerase (DNA) III alpha0.289
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.262
POT1protection of telomeres 1 homolog (S. pombe)0.243
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.200
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.152
RFC1replication factor C (activator 1) 1, 145kDa0.127
BLMBloom syndrome, RecQ helicase-like0.095
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.089
MSH3mutS homolog 3 (E. coli)0.076
DAXXdeath-domain associated protein0.059
FNBP1formin binding protein 10.059
HUS1HUS1 checkpoint homolog (S. pombe)0.055
ATMataxia telangiectasia mutated0.044
MSH6mutS homolog 6 (E. coli)0.038
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.037
ORC2origin recognition complex, subunit 20.034
BANPBTG3 associated nuclear protein0.032
ACDadrenocortical dysplasia homolog (mouse)0.029
TGIF1TGFB-induced factor homeobox 10.025
AXIN1axin 10.024
UPF1UPF1 regulator of nonsense transcripts homolog (yeast)0.024
MAPK7mitogen-activated protein kinase 70.023
RAD17RAD17 homolog (S. pombe)0.021
ATRXalpha thalassemia/mental retardation syndrome X-linked0.019
MDM4Mdm4 p53 binding protein homolog (mouse)0.016
TERF2telomeric repeat binding factor 20.016
MDC1mediator of DNA-damage checkpoint 10.015
MDM2Mdm2 p53 binding protein homolog (mouse)0.014
RUNX1runt-related transcription factor 10.014
STAG1stromal antigen 10.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.936
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.828
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.235
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.204
Msh2mutS homolog 2 (E. coli)0.198
Ighimmunoglobulin heavy chain complex0.182
Hspa8heat shock protein 80.166
Tipintimeless interacting protein0.147
WrnWerner syndrome homolog (human)0.115
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.108
SkilSKI-like0.104
Iqcb1IQ calmodulin-binding motif containing 10.098
Terf1telomeric repeat binding factor 10.098
Stip1stress-induced phosphoprotein 10.093
Hsph1heat shock 105kDa/110kDa protein 10.087
Rfc1replication factor C (activator 1) 10.081
Smn1survival motor neuron 10.071
Rpgrip1lRpgrip1-like0.069
DaxxFas death domain-associated protein0.064
Ptpn11protein tyrosine phosphatase, non-receptor type 110.064
Rrm1ribonucleotide reductase M10.064
Dnajc9DnaJ (Hsp40) homolog, subfamily C, member 90.055
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.052
Ahi1Abelson helper integration site 10.050
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.047
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.046
Dkc1dyskeratosis congenita 1, dyskerin homolog (human)0.044
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.039
Pot1aprotection of telomeres 1A0.039
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.037
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.037
Tubgcp2tubulin, gamma complex associated protein 20.035
Prim1DNA primase, p49 subunit0.032
Mdm4transformed mouse 3T3 cell double minute 40.030
Mre11ameiotic recombination 11 homolog A (S. cerevisiae)0.029
Sae1SUMO1 activating enzyme subunit 10.029
Acdadrenocortical dysplasia0.028
Rnaseh2aribonuclease H2, large subunit0.028
Tdp1tyrosyl-DNA phosphodiesterase 10.028
Parp1poly (ADP-ribose) polymerase family, member 10.025
Mdm2transformed mouse 3T3 cell double minute 20.022
H2afxH2A histone family, member X0.021
Timelesstimeless homolog (Drosophila)0.021
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.020
Tuba1btubulin, alpha 1B0.019
Exosc7exosome component 70.019
Fgf2fibroblast growth factor 20.019
Vcpvalosin containing protein0.019
Fkbp4FK506 binding protein 40.019
Nde1nuclear distribution gene E homolog 1 (A nidulans)0.018
Gins4GINS complex subunit 4 (Sld5 homolog)0.017
Cdk4cyclin-dependent kinase 40.016
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.016
Pold3polymerase (DNA-directed), delta 3, accessory subunit0.016
Dmddystrophin, muscular dystrophy0.016
Mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.016
Rfc2replication factor C (activator 1) 20.015
Ttntitin0.015
Invsinversin0.015
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.015
Itgb1bp2integrin beta 1 binding protein 20.015
Prpsap2phosphoribosyl pyrophosphate synthetase-associated protein 20.015
Prim2DNA primase, p58 subunit0.015
Rfc3replication factor C (activator 1) 30.015
Stat1signal transducer and activator of transcription 10.014
Sf3a3splicing factor 3a, subunit 30.014
Dtymkdeoxythymidylate kinase0.014
Mlh1mutL homolog 1 (E. coli)0.014
Lmnalamin A0.014
Siva1SIVA1, apoptosis-inducing factor0.014
Nup93nucleoporin 930.014
Gja1gap junction protein, alpha 10.013
Pms2postmeiotic segregation increased 2 (S. cerevisiae)0.013
Mcm8minichromosome maintenance deficient 8 (S. cerevisiae)0.013
Huwe1HECT, UBA and WWE domain containing 10.013
Tubb5tubulin, beta 50.013
Tcf3transcription factor 30.012
Eftud2elongation factor Tu GTP binding domain containing 20.012
Rttnrotatin0.012
Lsm2LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.012
Cdkn2aipnlCDKN2A interacting protein N-terminal like0.011
Cdc23CDC23 (cell division cycle 23, yeast, homolog)0.011
Gpn3GPN-loop GTPase 30.011
Nup85nucleoporin 850.011
Fam83hfamily with sequence similarity 83, member H0.011
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.011
Ints9integrator complex subunit 90.010
Nup107nucleoporin 1070.010
Rbl1retinoblastoma-like 1 (p107)0.010
Hspd1heat shock protein 1 (chaperonin)0.010
Lin9lin-9 homolog (C. elegans)0.010
Dna2DNA replication helicase 2 homolog (yeast)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism