The network for 'negative regulation of cellular biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cellular biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

NameDescriptionProbabilityFunc Analog Organism
RPD3Rpd3p0.997
RLF2Rlf2p0.988
RAP1Rap1p0.986
HHT1Hht1p0.986
SIN3Sin3p0.982
SUM1Sum1p0.979
HDA1Hda1p0.973
SIR4Sir4p0.955
HOG1Hog1p0.944
CYC8Cyc8p0.936
SNF1Snf1p0.930
RXT2Rxt2p0.908
HHF1Hhf1p0.907
CTI6Cti6p0.902
ORC5Orc5p0.890
GLC7Glc7p0.890
RIM101Rim101p0.888
UME1Ume1p0.880
RTT106Rtt106p0.875
SIN4Sin4p0.869
DHH1Dhh1p0.868
HMO1Hmo1p0.864
PAP2Pap2p0.862
SIR2Sir2p0.857
RTF1Rtf1p0.844
YTA7Yta7p0.838
YAK1Yak1p0.817
RPN4Rpn4p0.812
SET1Set1p0.802
SWI4Swi4p0.794
MRC1Mrc1p0.782
ASF1Asf1p0.780
ADR1Adr1p0.779
SAS2Sas2p0.755
BDF1Bdf1p0.753
NRG1Nrg1p0.744
CTK1Ctk1p0.742
ORC3Orc3p0.738
FHL1Fhl1p0.735
ITC1Itc1p0.735
SAP30Sap30p0.734
SDS3Sds3p0.733
PSY2Psy2p0.731
ISW2Isw2p0.728
RCO1Rco1p0.722
HAT1Hat1p0.719
ORC2Orc2p0.704
GAL11Gal11p0.695
PAT1Pat1p0.693
SPT16Spt16p0.679
REG1Reg1p0.678
RIF1Rif1p0.670
DED1Ded1p0.659
CTF18Ctf18p0.654
SLX5Slx5p0.649
RSC2Rsc2p0.647
SNF5Snf5p0.646
MED2Med2p0.634
GLN3Gln3p0.628
SCH9Sch9p0.627
HHO1Hho1p0.618
GCR2Gcr2p0.615
SET2Set2p0.611
PHO23Pho23p0.607
MCM2Mcm2p0.595
IFH1Ifh1p0.591
UBP8Ubp8p0.585
CDC14Cdc14p0.566
SNT1Snt1p0.563
VID30Vid30p0.562
TUP1Tup1p0.557
RSP5Rsp5p0.549
ORC1Orc1p0.546
EAF3Eaf3p0.544
HCM1Hcm1p0.542
RGR1Rgr1p0.537
CSE2Cse2p0.536
CDC6Cdc6p0.529
HAT2Hat2p0.528
SLX8Slx8p0.525
HFI1Hfi1p0.521
HDA2Hda2p0.520
NUP157Nup157p0.515
MMS22Mms22p0.515
CCR4Ccr4p0.515
TIF4632Tif4632p0.514
VID24Vid24p0.512
SUI3Sui3p0.509
FOB1Fob1p0.508
HIR1Hir1p0.506
RIA1Ria1p0.504
EAF1Eaf1p0.501
HHF2Hhf2p0.499
RAD9Rad9p0.496
SPT21Spt21p0.494
STH1Sth1p0.493
SRM1Srm1p0.492
NTO1Nto1p0.491
MED7Med7p0.487
NUT1Nut1p0.485
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.985
pha-4Protein PHA-40.675
elt-6Protein ELT-60.477
mix-1Protein MIX-10.394
lin-53Protein LIN-530.383
his-64Protein HIS-640.357
nhr-2Protein NHR-20.352
plk-3Protein PLK-30.349
his-16Protein HIS-160.343
wrm-1Protein WRM-10.338
mab-5Protein MAB-50.317
his-1Protein HIS-10.311
mcm-7Protein MCM-70.274
daf-4Protein DAF-40.253
hbl-1Protein HBL-10.247
his-61Protein HIS-610.237
mcm-2Protein MCM-20.232
tbx-8Protein TBX-80.229
hda-1Protein HDA-10.219
unc-62Protein UNC-620.216
eor-1Protein EOR-10.201
mes-4Protein MES-40.198
tam-1Protein TAM-10.194
let-502Protein LET-5020.190
CELE_C12D8.1Protein C12D8.10.188
flt-1Protein FLT-10.186
nhr-67Protein NHR-670.181
unc-37Protein UNC-370.181
pry-1Protein PRY-10.176
rsp-1Protein RSP-10.167
CELE_Y41E3.11Protein Y41E3.110.164
his-31Protein HIS-310.161
egl-13Protein EGL-130.159
hlh-2Protein HLH-20.155
egl-46Protein EGL-460.146
cnd-1Protein CND-10.143
lin-35Protein LIN-350.143
nhr-25Protein NHR-250.141
top-2Protein TOP-20.139
cpb-3Protein CPB-30.139
pop-1Protein POP-10.137
mex-5Protein MEX-50.134
CELE_F19F10.9Protein F19F10.90.132
his-3Protein HIS-30.131
eya-1Protein EYA-10.129
lsy-22Protein LSY-220.125
his-4Protein HIS-40.125
egl-27Protein EGL-270.123
daf-1Protein DAF-10.123
rskn-2Protein RSKN-20.120
CELE_F54D5.5Protein F54D5.50.120
egg-6Protein EGG-60.120
zip-7Protein ZIP-70.118
puf-3Protein PUF-30.118
atg-2Protein ATG-20.118
his-5Protein HIS-50.115
fkh-2Protein FKH-20.112
ceh-27Protein CEH-270.111
rad-26Protein RAD-260.111
daf-12Protein DAF-120.110
hil-2Protein HIL-20.110
his-24Protein HIS-240.105
eftu-2Protein EFTU-20.104
pdr-1Protein PDR-10.103
dcn-1Protein DCN-10.103
lin-17Protein LIN-170.102
T28C6.7Protein T28C6.70.102
xpo-1Protein XPO-10.098
lin-66Protein LIN-660.098
his-38Protein HIS-380.096
pos-1Protein POS-10.096
attf-2Protein ATTF-20.095
CELE_C17E4.6Protein C17E4.60.095
T28F4.1Protein T28F4.10.094
Y7A9D.1Protein Y7A9D.10.094
spd-5Protein SPD-50.094
CELE_C23G10.8Protein C23G10.80.093
mom-2Protein MOM-20.093
F26B1.2Protein F26B1.20.093
hlh-1Protein HLH-10.093
cdc-25.1Protein CDC-25.10.091
tag-319Protein TAG-3190.091
bed-3Protein BED-30.091
Y82E9BR.13Protein Y82E9BR.130.090
skp-1Protein SKP-10.089
ptr-6Protein PTR-60.088
mls-2Protein MLS-20.088
C27F2.8Protein C27F2.80.088
hmg-1.1Protein HMG-1.10.088
his-46Protein HIS-460.086
atn-1Protein ATN-10.084
patr-1Protein PATR-10.081
D1081.8Protein D1081.80.081
his-51Protein HIS-510.081
his-48Protein HIS-480.080
CELE_C24H12.5Protein C24H12.50.079
lin-29Protein LIN-290.079
his-42Protein HIS-420.079
aak-2Protein AAK-20.079
cdt-2Protein CDT-20.079
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
foxi1forkhead box I10.956
ndr2nodal-related 20.929
pcnaproliferating cell nuclear antigen0.898
fgf3fibroblast growth factor 30.850
jag2jagged 20.796
pax6apaired box gene 6a0.743
snai1bsnail homolog 1b (Drosophila)0.709
whsc1Wolf-Hirschhorn syndrome candidate 10.633
nkx2.3NK2 transcription factor related 30.631
her15.1hairy and enhancer of split-related 15.10.616
fezf2FEZ family zinc finger 20.613
notch1anotch homolog 1a0.600
lft2lefty20.587
gli1GLI-Kruppel family member 10.584
sox9bSRY-box containing gene 9b0.583
lmx1b.1LIM homeobox transcription factor 1, beta 10.564
zic2bzic family member 2 (odd-paired homolog, Drosophila) b0.513
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.495
gata6GATA-binding protein 60.489
gro1groucho 10.477
nkx2.5NK2 transcription factor related 50.475
fgf8afibroblast growth factor 8 a0.473
tbx2aT-box gene 2a0.473
prdm1aPR domain containing 1a, with ZNF domain0.469
hnf1baHNF1 homeobox Ba0.455
tfap2atranscription factor AP-2 alpha0.454
twist3twist30.440
disp1dispatched homolog 1 (Drosophila)0.438
mab21l2mab-21-like 20.433
jam3bjunctional adhesion molecule 3b0.416
prmt1protein arginine methyltransferase 10.412
sox2SRY-box containing gene 20.401
her8ahairy-related 8a0.396
lhx1aLIM homeobox 1a0.393
sox1aSRY-box containing gene 1a0.390
sox19aSRY-box containing gene 19a0.384
bmp2bbone morphogenetic protein 2b0.367
eng2aengrailed 2a0.356
lft1lefty10.347
hmx1H6 homeo box 10.346
dlx5adistal-less homeobox gene 5a0.346
tac1tachykinin 10.335
otx1borthodenticle homolog 1b0.325
hey1hairy/enhancer-of-split related with YRPW motif 10.320
ascl1bachaete-scute complex-like 1b (Drosophila)0.315
chdchordin0.312
dlx2adistal-less homeobox gene 2a0.310
etv5bets variant 5b0.294
traf4atnf receptor-associated factor 4a0.292
tardbpTAR DNA binding protein0.285
pcdh18bprotocadherin 18b0.282
dlcdeltaC0.280
her12hairy-related 120.276
mycamyelocytomatosis oncogene a0.275
otx2orthodenticle homolog 20.271
rxrgaretinoid x receptor, gamma a0.266
six3asine oculis homeobox homolog 3a0.264
bmp4bone morphogenetic protein 40.261
pax8paired box gene 80.259
klf4Kruppel-like factor 40.257
dlx1adistal-less homeobox gene 1a0.257
ripply1ripply10.256
emx1empty spiracles homeobox 10.255
fgf19fibroblast growth factor 190.250
tagln2transgelin 20.248
vsx1visual system homeobox 1 homolog, chx10-like0.248
dlx3bdistal-less homeobox gene 3b0.245
six3bsine oculis homeobox homolog 3b0.244
tbx6T-box gene 60.239
etv2ets variant gene 20.239
emx3empty spiracles homeobox 30.237
eomesaeomesodermin homolog a0.236
bocbrother of CDO0.233
ube2iubiquitin-conjugating enzyme E2I0.229
her11hairy-related 110.228
irx4biroquois homeobox protein 4b0.228
foxa3forkhead box A30.228
cyp1b1cytochrome P450, family 1, subfamily B, polypeptide 10.227
hhexhematopoietically expressed homeobox0.224
msxcmuscle segment homeobox C0.221
six2asine oculis-related homeobox 2a0.221
pitx2paired-like homeodomain transcription factor 20.219
vsx2visual system homeobox 20.217
plekhg4pleckstrin homology domain containing, family G (with RhoGef domain) member 40.216
rx2retinal homeobox gene 20.216
hmga1ahigh mobility group AT-hook 1a0.214
hoxa3ahomeo box A3a0.213
hoxb8ahomeo box B8a0.210
tal1T-cell acute lymphocytic leukemia 10.210
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.207
six4bsine oculis homeobox homolog 4b0.207
dladeltaA0.205
hoxd4ahomeo box D4a0.204
tgif1TGFB-induced factor homeobox 10.199
dctdopachrome tautomerase0.199
ptf1apancreas specific transcription factor, 1a0.198
rargaretinoic acid receptor gamma a0.193
foxc1aforkhead box C1a0.192
her1hairy-related 10.192
atoh1aatonal homolog 1a0.190
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
kaykayak1.000
CTCFCG8591 gene product from transcript CG8591-RA0.999
fufused0.998
E(spl)Enhancer of split0.998
IswiImitation SWI0.998
MadMothers against dpp0.998
Snr1Snf5-related 10.997
smt3CG4494 gene product from transcript CG4494-RA0.997
atoatonal0.997
PclPolycomblike0.997
slmbsupernumerary limbs0.997
shnschnurri0.997
Sir2CG5216 gene product from transcript CG5216-RA0.996
SceSex combs extra0.993
brkbrinker0.993
sdscalloped0.990
PcPolycomb0.989
TrlTrithorax-like0.989
InRInsulin-like receptor0.988
ash1absent, small, or homeotic discs 10.988
lwrlesswright0.987
cicubitus interruptus0.986
dcodiscs overgrown0.986
p53CG33336 gene product from transcript CG33336-RB0.977
dppdecapentaplegic0.970
eygeyegone0.968
Pka-C1cAMP-dependent protein kinase 10.967
pr-set7CG3307 gene product from transcript CG3307-RC0.965
ScmSex comb on midleg0.962
Nf-YCNuclear factor Y-box C0.960
Pp1-87BProtein phosphatase 1 at 87B0.959
CtBPC-terminal Binding Protein0.957
nmonemo0.954
ykiyorkie0.951
escextra sexcombs0.950
emsempty spiracles0.950
His2AvHistone H2A variant0.949
ctcut0.947
D1D1 chromosomal protein0.947
phylphyllopod0.947
hephemipterous0.943
dsxdoublesex0.942
lidlittle imaginal discs0.939
mammastermind0.939
E(var)3-9Enhancer of variegation 3-90.938
Su(var)205Suppressor of variegation 2050.936
GdiGDP dissociation inhibitor0.933
E(z)Enhancer of zeste0.932
PcafCG4107 gene product from transcript CG4107-RA0.931
crolcrooked legs0.928
BEAF-32Boundary element-associated factor of 32kD0.922
araaraucan0.917
wgwingless0.916
mormoira0.914
SuURSuppressor of Under-Replication0.907
eyeyeless0.904
knknot0.902
Tip60CG6121 gene product from transcript CG6121-RA0.895
barrbarren0.894
Fmr1CG6203 gene product from transcript CG6203-RC0.891
mus209mutagen-sensitive 2090.889
tintinman0.887
tshteashirt0.882
stysprouty0.881
eggeggless0.880
UbxUltrabithorax0.874
e(y)3enhancer of yellow 30.874
Rpd3CG7471 gene product from transcript CG7471-RA0.870
bratbrain tumor0.866
RgaRegena0.857
Trf2TATA box binding protein-related factor 20.856
Cap-GCG34438 gene product from transcript CG34438-RF0.854
SerSerrate0.854
mrnmarionette0.854
dallydivision abnormally delayed0.853
slislit0.851
howheld out wings0.844
nabCG33545 gene product from transcript CG33545-RC0.843
zpgzero population growth0.837
ph-ppolyhomeotic proximal0.836
grogroucho0.828
panpangolin0.822
snasnail0.813
rinrasputin0.813
hipkhomeodomain interacting protein kinase0.811
SoxNSoxNeuro0.810
slp1sloppy paired 10.805
HLHm7E(spl) region transcript m70.804
E2f2E2F transcription factor 20.800
poloCG12306 gene product from transcript CG12306-RA0.799
eyaeyes absent0.798
osoutstretched0.797
RpII215RNA polymerase II 215kD subunit0.795
abd-Aabdominal A0.788
gsbgooseberry0.788
esgescargot0.787
hbhunchback0.782
cnccap-n-collar0.779
SmrSmrter0.777
enengrailed0.775
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Junbjun B proto-oncogene0.824
Tgfbr2transforming growth factor, beta receptor II0.727
JunJun oncogene0.726
Dusp1dual specificity phosphatase 10.659
Tcfe2atranscription factor E2a0.641
Nr4a1nuclear receptor subfamily 4, group A, member 10.534
Nfibnuclear factor I/B0.531
Ier2immediate early response 20.517
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.505
FosFBJ osteosarcoma oncogene0.474
Nek9NIMA (never in mitosis gene a)- related kinase 90.447
Hes1hairy and enhancer of split 1 (Drosophila)0.443
Cdc42cell division cycle 42 (GTP binding protein)0.432
Fgfr1Fibroblast growth factor receptor 10.427
Egr1early growth response 10.420
DbpD site of albumin promoter (albumin D-box) binding protein0.405
Lzts2leucine zipper, putative tumor suppressor 20.377
Nedd4neural precursor cell expressed, developmentally down-regulated 40.372
Klf4Kruppel-like factor 4 (gut)0.369
Btg2BTG family, member 20.359
Shox2short stature homeobox 20.349
Arf6ADP-ribosylation factor 60.320
Stat5bsignal transducer and activator of transcription 5B0.312
S100a6S100 calcium binding protein A60.308
Pspnpersephin0.304
Zfp36zinc finger protein 360.304
Dchs1dachsous 1 (Drosophila)0.302
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.297
Klf2Kruppel-like factor 2 (lung)0.292
Fgfr2fibroblast growth factor receptor 20.290
Nfianuclear factor I/A0.286
Errfi1ERBB receptor feedback inhibitor 10.271
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.271
Rhobras homolog gene family, member B0.271
Gcm1glial cells missing homolog 1 (Drosophila)0.262
Kcnt1potassium channel, subfamily T, member 10.257
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.251
Hoxc4homeo box C40.248
Hmgb2high mobility group box 20.246
RGD1565591similar to Ski protein0.244
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.242
Egr2early growth response 20.238
Mybl2myeloblastosis oncogene-like 20.236
Pcnaproliferating cell nuclear antigen0.229
RorbRAR-related orphan receptor B0.225
Cd40lgCD40 ligand0.224
LOC100362814hypothetical protein LOC1003628140.223
Foxd1forkhead box D10.223
Smad6SMAD family member 60.222
Grk1G protein-coupled receptor kinase 10.222
Casp2caspase 20.219
Il12binterleukin 12B0.219
Sp1Sp1 transcription factor0.216
Rap1bRAP1B, member of RAS oncogene family0.215
Gja1gap junction protein, alpha 10.213
Sox18SRY (sex determining region Y)-box 180.211
Lphn1latrophilin 10.210
Barhl2BarH-like homeobox 20.209
FynFYN oncogene related to SRC, FGR, YES0.208
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.207
Ahraryl hydrocarbon receptor0.207
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.205
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.203
Gata4GATA binding protein 40.202
Dusp6dual specificity phosphatase 60.201
Smad7SMAD family member 70.199
S100a8S100 calcium binding protein A80.196
Pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.196
Ncanneurocan0.195
RestRE1-silencing transcription factor0.193
S100a9S100 calcium binding protein A90.193
Metmet proto-oncogene0.190
Lhx5LIM homeobox 50.190
Nfyanuclear transcription factor-Y alpha0.188
Nr3c1nuclear receptor subfamily 3, group C, member 10.182
Hmgb1high mobility group box 10.181
Siah1aseven in absentia 1A0.179
Gfi1growth factor independent 1 transcription repressor0.178
Hmgn2high mobility group nucleosomal binding domain 20.178
Flt1FMS-related tyrosine kinase 10.178
Cgaglycoprotein hormones, alpha polypeptide0.177
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.175
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.174
S100a4S100 calcium-binding protein A40.172
Ptgfrprostaglandin F receptor0.171
St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.170
Nr2f2nuclear receptor subfamily 2, group F, member 20.170
Klf6Kruppel-like factor 60.168
Grm8glutamate receptor, metabotropic 80.168
Nr4a3nuclear receptor subfamily 4, group A, member 30.166
Pax9paired box 90.166
Capn5calpain 50.163
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.163
Kdm6blysine (K)-specific demethylase 6B0.160
Vax2ventral anterior homeobox 20.158
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.157
Nononon-POU domain containing, octamer-binding0.156
Socs3suppressor of cytokine signaling 30.155
Tcf4transcription factor 40.154
Anxa2annexin A20.152