The network for 'leukocyte homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

leukocyte homeostasis

The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dnttdeoxynucleotidyltransferase, terminal0.601
tgfb3transforming growth factor, beta 30.479
anxa1bannexin A1b0.356
ikzf1IKAROS family zinc finger 1 (Ikaros)0.349
il7rinterleukin 7 receptor0.313
pycardPYD and CARD domain containing0.237
ptpn6protein tyrosine phosphatase, non-receptor type 60.209
rag1recombination activating gene 10.191
mef2camyocyte enhancer factor 2ca0.168
jam2ajunctional adhesion molecule 2a0.159
terttelomerase reverse transcriptase0.142
cldneclaudin e0.128
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.120
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.108
cbfbcore-binding factor, beta subunit0.092
krt4keratin 40.090
csf1racolony stimulating factor 1 receptor, a0.083
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.075
tnfrsf18tumor necrosis factor receptor superfamily, member 180.073
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.073
crb2acrumbs homolog 2a0.072
tmem2transmembrane protein 20.071
ptprcprotein tyrosine phosphatase, receptor type, C0.071
arpc1bactin related protein 2/3 complex, subunit 1B0.068
lrrc33leucine rich repeat containing 330.064
thy1Thy-1 cell surface antigen0.064
ighzimmunoglobulin heavy constant zeta0.064
icn2ictacalcin 20.062
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.061
bnip3lbBCL2/adenovirus E1B interacting protein 3-like b0.061
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.060
anxa2aannexin A2a0.060
atpif1ATPase inhibitory factor 10.059
ncf1neutrophil cytosolic factor 10.058
anxa1aannexin A1a0.057
cdc42lcell division cycle 42, like0.056
rpl7aribosomal protein L7a0.055
lppLIM domain containing preferred translocation partner in lipoma0.055
mef2cbmyocyte enhancer factor 2cb0.053
csnk1a1casein kinase 1, alpha 10.053
dlx5adistal-less homeobox gene 5a0.052
ryr1bryanodine receptor 1b (skeletal)0.052
cmybtranscription factor cmyb0.052
LOC569128hypothetical protein LOC5691280.052
aurkbaurora kinase B0.051
disc1disrupted in schizophrenia 10.051
stc1lstanniocalcin 1, like0.050
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.048
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.048
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.047
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.046
mef2amyocyte enhancer factor 2a0.046
ints6integrator complex subunit 60.045
mbnl2muscleblind-like 2 (Drosophila)0.045
rad21RAD21 homolog (S. pombe)0.045
jag1bjagged 1b0.044
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.043
capns1bcalpain, small subunit 1 b0.043
col1a2collagen, type I, alpha 20.042
tnfsf18tumor necrosis factor (ligand) superfamily, member 180.042
jak1Janus kinase 10.042
alas2aminolevulinate, delta-, synthetase 20.042
tbx1T-box 10.041
yrkYes-related kinase0.040
mmp13amatrix metalloproteinase 13a0.040
mfn2mitofusin 20.040
LOC553366hypothetical protein LOC5533660.039
ednraendothelin receptor type A0.039
anxa1cannexin A1c0.038
emilin2belastin microfibril interfacer 2b0.038
gna12guanine nucleotide binding protein (G protein) alpha 120.037
cdc42cell division cycle 420.037
runx3runt-related transcription factor 30.036
tcf21transcription factor 210.036
ck2a2acasein kinase 2 alpha 2a0.036
scinlascinderin like a0.036
appl1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.036
tbx5bT-box 5b0.036
og9xOG9 homeobox gene0.036
gnb2l1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 10.036
fgf20afibroblast growth factor 20a0.035
thsd7athrombospondin, type I, domain containing 7A0.035
rps3ribosomal protein S30.034
gmfgglia maturation factor, gamma0.034
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.034
mpxmyeloid-specific peroxidase0.033
ppialpeptidylprolyl isomerase A, like0.033
stat5.1signal transducer and activator of transcription 5.10.033
psen1presenilin 10.032
hand2heart and neural crest derivatives expressed transcript 20.032
tbx22T-box 220.031
cxcr3.2chemokine (C-X-C motif) receptor 3.20.031
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.302
BCL2L1BCL2-like 10.234
SYKspleen tyrosine kinase0.196
BCL2L11BCL2-like 11 (apoptosis facilitator)0.111
CASP8caspase 8, apoptosis-related cysteine peptidase0.109
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.091
BIDBH3 interacting domain death agonist0.090
BCL2B-cell CLL/lymphoma 20.064
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.061
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.045
BAXBCL2-associated X protein0.044
LATlinker for activation of T cells0.031
EGFRepidermal growth factor receptor0.030
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.029
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.026
MDM2Mdm2 p53 binding protein homolog (mouse)0.024
BAK1BCL2-antagonist/killer 10.023
S100A10S100 calcium binding protein A100.020
CARD11caspase recruitment domain family, member 110.020
CASP9caspase 9, apoptosis-related cysteine peptidase0.019
DLG1discs, large homolog 1 (Drosophila)0.019
CXCR4chemokine (C-X-C motif) receptor 40.018
LCKlymphocyte-specific protein tyrosine kinase0.017
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.017
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.016
PLCG1phospholipase C, gamma 10.015
FASFas (TNF receptor superfamily, member 6)0.015
IL8interleukin 80.014
INSRinsulin receptor0.013
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.012
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.012
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.012
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.012
NCF1neutrophil cytosolic factor 10.012
NOXA1NADPH oxidase activator 10.011
PTPN6protein tyrosine phosphatase, non-receptor type 60.011
IL2RBinterleukin 2 receptor, beta0.011
APAF1apoptotic peptidase activating factor 10.011
EP300E1A binding protein p3000.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Inpp5dinositol polyphosphate-5-phosphatase D0.996
Il2rginterleukin 2 receptor, gamma chain0.990
Lyz2lysozyme 20.972
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.957
Map3k7mitogen-activated protein kinase kinase kinase 70.936
Il6stinterleukin 6 signal transducer0.931
Ikzf1IKAROS family zinc finger 10.905
TcraT-cell receptor alpha chain0.880
Stat3signal transducer and activator of transcription 30.874
Ptgs2prostaglandin-endoperoxide synthase 20.858
Stat5bsignal transducer and activator of transcription 5B0.834
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.831
Ptprcprotein tyrosine phosphatase, receptor type, C0.819
Rc3h1RING CCCH (C3H) domains 10.796
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.783
Ptenphosphatase and tensin homolog0.772
FasFas (TNF receptor superfamily member 6)0.764
BaxBCL2-associated X protein0.758
CblCasitas B-lineage lymphoma0.729
Nfe2l2nuclear factor, erythroid derived 2, like 20.690
Stat5asignal transducer and activator of transcription 5A0.687
Mmp9matrix metallopeptidase 90.680
Prf1perforin 1 (pore forming protein)0.680
Hif1ahypoxia inducible factor 1, alpha subunit0.656
Hdac5histone deacetylase 50.649
Cxcl2chemokine (C-X-C motif) ligand 20.624
Latlinker for activation of T cells0.617
Il2interleukin 20.615
Csf1colony stimulating factor 1 (macrophage)0.613
Adam17a disintegrin and metallopeptidase domain 170.610
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.599
Lcklymphocyte protein tyrosine kinase0.589
Trp53transformation related protein 530.564
Smad4MAD homolog 4 (Drosophila)0.559
Tgfbr2transforming growth factor, beta receptor II0.557
Cdk1cyclin-dependent kinase 10.551
Nr3c1nuclear receptor subfamily 3, group C, member 10.551
Vegfavascular endothelial growth factor A0.550
Ighimmunoglobulin heavy chain complex0.549
Ccr1chemokine (C-C motif) receptor 10.539
Cd19CD19 antigen0.502
Il6interleukin 60.484
Foxp3forkhead box P30.458
Myd88myeloid differentiation primary response gene 880.457
Tnftumor necrosis factor0.456
Rxraretinoid X receptor alpha0.456
Stat6signal transducer and activator of transcription 60.435
Kitkit oncogene0.420
Nckap1lNCK associated protein 1 like0.411
Il10interleukin 100.377
Ttc7tetratricopeptide repeat domain 70.372
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.362
Pick1protein interacting with C kinase 10.346
Socs1suppressor of cytokine signaling 10.332
Tnfaip3tumor necrosis factor, alpha-induced protein 30.326
Tlr4toll-like receptor 40.323
Lystlysosomal trafficking regulator0.321
Ifnginterferon gamma0.316
Mcl1myeloid cell leukemia sequence 10.313
Cyldcylindromatosis (turban tumor syndrome)0.307
Hdac7histone deacetylase 70.303
Jak3Janus kinase 30.300
Arntaryl hydrocarbon receptor nuclear translocator0.299
Foxc2forkhead box C20.291
Anxa1annexin A10.291
Cd247CD247 antigen0.290
Selpselectin, platelet0.288
Grb2growth factor receptor bound protein 20.288
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.279
Il1ainterleukin 1 alpha0.274
Ly6dlymphocyte antigen 6 complex, locus D0.274
Cd40CD40 antigen0.273
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.269
H2-Aahistocompatibility 2, class II antigen A, alpha0.267
Flt4FMS-like tyrosine kinase 40.266
Rag2recombination activating gene 20.248
Dok1docking protein 10.240
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.237
Batfbasic leucine zipper transcription factor, ATF-like0.237
Jak2Janus kinase 20.233
Cd14CD14 antigen0.226
Tgfb1transforming growth factor, beta 10.225
WasWiskott-Aldrich syndrome homolog (human)0.225
Egln1EGL nine homolog 1 (C. elegans)0.219
Irf9interferon regulatory factor 90.217
TcrdT-cell receptor delta chain0.215
Ikbkginhibitor of kappaB kinase gamma0.213
Ncf1neutrophil cytosolic factor 10.213
Spna1spectrin alpha 10.210
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.210
FaddFas (TNFRSF6)-associated via death domain0.206
Map3k8mitogen-activated protein kinase kinase kinase 80.204
Wdr1WD repeat domain 10.204
Kdrkinase insert domain protein receptor0.200
Pou2f2POU domain, class 2, transcription factor 20.199
Hbb-b1hemoglobin, beta adult major chain0.187
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.186
Birc5baculoviral IAP repeat-containing 50.186
Apaf1apoptotic peptidase activating factor 10.184
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd53Cd53 molecule0.291
Lcp1lymphocyte cytosolic protein 10.226
Hckhemopoietic cell kinase0.194
Slfn2schlafen 20.192
Il8rbinterleukin 8 receptor, beta0.142
Sellselectin L0.131
Aif1allograft inflammatory factor 10.130
Tgfbr3transforming growth factor, beta receptor III0.123
Tp53tumor protein p530.104
Flt1FMS-related tyrosine kinase 10.097
Limd2LIM domain containing 20.092
Ptprcprotein tyrosine phosphatase, receptor type, C0.088
Lyz2lysozyme 20.086
Il1r1interleukin 1 receptor, type I0.082
Prrx1paired related homeobox 10.070
Cd37CD37 molecule0.070
Cd4Cd4 molecule0.069
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.066
Laptm5lysosomal protein transmembrane 50.062
RT1-BaRT1 class II, locus Ba0.058
Icam1intercellular adhesion molecule 10.057
S1pr2sphingosine-1-phosphate receptor 20.056
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.055
Cd14CD14 molecule0.048
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.046
Leprleptin receptor0.046
Arpc1bactin related protein 2/3 complex, subunit 1B0.039
Cd247Cd247 molecule0.037
Fcer1gFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.035
Ptpn6protein tyrosine phosphatase, non-receptor type 60.035
Aebp1AE binding protein 10.034
Creb1cAMP responsive element binding protein 10.033
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.030
Sh2b3SH2B adaptor protein 30.027
Inpp5dinositol polyphosphate-5-phosphatase D0.026
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.026
Pecam1platelet/endothelial cell adhesion molecule 10.025
Fgfr2fibroblast growth factor receptor 20.024
Cxcr4chemokine (C-X-C motif) receptor 40.023
Plauplasminogen activator, urokinase0.023
Cd38CD38 molecule0.022
Il1binterleukin 1 beta0.022
Rac2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.022
Nos3nitric oxide synthase 3, endothelial cell0.022
Dctn4dynactin 40.021
Cd2Cd2 molecule0.021
Ptch1patched homolog 1 (Drosophila)0.020
Tgfb1transforming growth factor, beta 10.019
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.019
TyrobpTyro protein tyrosine kinase binding protein0.019
Il2rginterleukin 2 receptor, gamma0.018
Casp1caspase 10.018
Arntaryl hydrocarbon receptor nuclear translocator0.018
Prkchprotein kinase C, eta0.017
Sh3bgrl3SH3 domain binding glutamic acid-rich protein-like 30.017
Il2rbinterleukin 2 receptor, beta0.016
Cd48Cd48 molecule0.016
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.016
Marcksmyristoylated alanine rich protein kinase C substrate0.015
TcrbT-cell receptor beta chain0.015
Alox5aparachidonate 5-lipoxygenase activating protein0.015
Arrb2arrestin, beta 20.015
Ddx54DEAD (Asp-Glu-Ala-Asp) box polypeptide 540.015
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.015
Cd5Cd5 molecule0.015
Metmet proto-oncogene0.014
Cdh5cadherin 50.014
Jak2Janus kinase 20.014
Mrc1mannose receptor, C type 10.013
Trhr2thyrotropin releasing hormone receptor 20.013
Adam7ADAM metallopeptidase domain 70.013
Ncf1neutrophil cytosolic factor 10.013
Gucy2dguanylate cyclase 2d0.013
Ciitaclass II, major histocompatibility complex, transactivator0.013
Lamc1laminin, gamma 10.013
Fn1fibronectin 10.012
Fgf7fibroblast growth factor 70.012
Cdh17cadherin 170.012
Itpr2inositol 1,4,5-triphosphate receptor, type 20.012
Cd44Cd44 molecule0.012
Sirpasignal-regulatory protein alpha0.012
Zbp1Z-DNA binding protein 10.011
Bat3HLA-B-associated transcript 30.011
Ms4a6bmembrane-spanning 4-domains, subfamily A, member 6B0.010
Crygfcrystallin, gamma F0.010
Phkg1phosphorylase kinase, gamma 10.010
Gzmkgranzyme K0.010
Tln1talin 10.010
RT1-DMbRT1 class II, locus DMb0.010
Selpselectin P0.010
LOC100361571keratin associated protein 1-3-like0.010