The network for 'mitochondrion degradation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitochondrion degradation

The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions.

NameDescriptionProbabilityFunc Analog Organism
ATG1Atg1p0.989
ATG12Atg12p0.987
ATG8Atg8p0.981
ATG29Atg29p0.978
ATG4Atg4p0.943
ATG11Atg11p0.938
ATG3Atg3p0.937
ATG7Atg7p0.935
ATG21Atg21p0.925
ATG16Atg16p0.915
ATG13Atg13p0.902
ATG5Atg5p0.848
SNX4Snx4p0.777
ATG2Atg2p0.673
ATG9Atg9p0.638
ATG23Atg23p0.624
CIS1Cis1p0.563
ATG17Atg17p0.532
ATG14Atg14p0.313
STP2Stp2p0.269
ATG10Atg10p0.256
HSV2Hsv2p0.139
LAT1Lat1p0.127
YIL165Chypothetical protein0.097
UBX3Ubx3p0.095
SPG3Spg3p0.093
ATG20Atg20p0.084
HIT1Hit1p0.079
ATG18Atg18p0.071
ATG32Atg32p0.060
YLR031Whypothetical protein0.059
PPM1Ppm1p0.059
RRD1Rrd1p0.058
PCL5Pcl5p0.053
VPS41Vps41p0.047
MFM1Mfm1p0.046
MDM10Mdm10p0.046
YLR211Chypothetical protein0.045
NGL2Ngl2p0.045
ABM1Abm1p0.041
GSH1Gsh1p0.040
VPS30Vps30p0.039
PSR1Psr1p0.038
ATG26Atg26p0.035
SLG1Slg1p0.034
NFT1Nft1p0.033
DNM1Dnm1p0.033
PTC6Ptc6p0.033
MUB1Mub1p0.032
SRD1Srd1p0.032
MPT5Mpt5p0.031
APN2Apn2p0.031
ARP10Arp10p0.031
KGD1Kgd1p0.030
YLR407Whypothetical protein0.029
HSP60Hsp60p0.028
CRP1Crp1p0.027
YLR264C-Ahypothetical protein0.026
MER1Mer1p0.026
UPS3Ups3p0.026
SCW4Scw4p0.026
YLR162Whypothetical protein0.026
SSP1Ssp1p0.025
PRM9Prm9p0.025
LEU2Leu2p0.025
YBR296C-Ahypothetical protein0.025
HXT3Hxt3p0.025
ALT2Alt2p0.025
SWC7Swc7p0.024
MKS1Mks1p0.024
ICS2Ics2p0.024
YNL190Whypothetical protein0.024
YOL038C-Ahypothetical protein0.023
DOA4Doa4p0.023
KRE1Kre1p0.023
CHA1Cha1p0.023
AZF1Azf1p0.022
SPL2Spl2p0.022
YHR140Whypothetical protein0.022
VPS36Vps36p0.022
CYT2Cyt2p0.022
FMP23Fmp23p0.021
PHD1Phd1p0.021
HSP31Hsp31p0.021
TYE7Tye7p0.021
PEP4Pep4p0.021
ACH1Ach1p0.020
YLR042Chypothetical protein0.020
YJL185Chypothetical protein0.020
TIP1Tip1p0.020
CUP1-1Cup1-1p0.020
ARG82Arg82p0.020
YAP1Yap1p0.020
YBR013Chypothetical protein0.020
REV1Rev1p0.020
OPT2Opt2p0.020
MOD5Mod5p0.019
REE1Ree1p0.019
CCW14Ccw14p0.019
STB3Stb3p0.019
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MarfMitochondrial assembly regulatory factor0.630
parkparkin0.568
Pink1PTEN-induced putative kinase 10.420
CG8443CG8443 gene product from transcript CG8443-RA0.148
porinCG6647 gene product from transcript CG6647-RA0.133
p38bCG7393 gene product from transcript CG7393-RA0.130
Dcr-2Dicer-20.076
LaspCG3849 gene product from transcript CG3849-RB0.059
TazTafazzin0.058
opa1-likeoptic atrophy 1-like0.056
Atg9Autophagy-specific gene 90.047
trpmltransient receptor potential mucolipin0.035
Tom34Translocase of outer membrane 340.034
RhebCG1081 gene product from transcript CG1081-RA0.032
Cul-5Cullin-50.031
srasarah0.030
MiroMitochondrial Rho0.030
SNF1ASNF1A/AMP-activated protein kinase0.029
pixpixie0.026
Drp1Dynamin related protein 10.024
LrrkLeucine-rich repeat kinase0.023
Pi3K59FPhosphotidylinositol 3 kinase 59F0.021
maf-SCG9954 gene product from transcript CG9954-RA0.021
Atg18Autophagy-specific gene 180.021
ref(2)Prefractory to sigma P0.020
Atg7Autophagy-specific gene 70.020
SdhBSuccinate dehydrogenase B0.019
drddrop dead0.019
rho-7rhomboid-70.018
dmdiminutive0.018
twinCG31137 gene product from transcript CG31137-RB0.018
mei-41meiotic 410.016
pelopelota0.016
DreddDeath related ced-3/Nedd2-like protein0.016
chicoCG5686 gene product from transcript CG5686-RB0.015
PHGPxCG12013 gene product from transcript CG12013-RC0.015
vasvasa0.014
Syx17Syntaxin 170.014
Ptp61FProtein tyrosine phosphatase 61F0.014
HtrA2CG8464 gene product from transcript CG8464-RA0.013
Atg8aAutophagy-specific gene 8a0.013
Ppat-DpckBifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase0.013
borbelphegor0.013
bdgbedraggled0.012
cmetCENP-meta0.012
CG31033CG31033 gene product from transcript CG31033-RC0.012
alphaTub84Balpha-Tubulin at 84B0.011
Letm1CG4589 gene product from transcript CG4589-RB0.011
porporcupine0.011
CG31133CG31133 gene product from transcript CG31133-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.917
GABARAPGABA(A) receptor-associated protein0.785
NBR1neighbor of BRCA1 gene 10.697
PINK1PTEN induced putative kinase 10.626
GABARAPL2GABA(A) receptor-associated protein-like 20.382
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.105
GABARAPL1GABA(A) receptor-associated protein like 10.062
FBXO7F-box protein 70.061
ZNF746zinc finger protein 7460.043
SQSTM1sequestosome 10.042
ATG5ATG5 autophagy related 5 homolog (S. cerevisiae)0.039
ATG7ATG7 autophagy related 7 homolog (S. cerevisiae)0.035
ARL15ADP-ribosylation factor-like 150.030
ULK1unc-51-like kinase 1 (C. elegans)0.028
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.025
NSFN-ethylmaleimide-sensitive factor0.025
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.021
OPTNoptineurin0.017
UBR1ubiquitin protein ligase E3 component n-recognin 10.012
ATG10ATG10 autophagy related 10 homolog (S. cerevisiae)0.010
PRDX6peroxiredoxin 60.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.959
Atg12autophagy-related 12 (yeast)0.927
Ptenphosphatase and tensin homolog0.901
Mdm2transformed mouse 3T3 cell double minute 20.599
Emx1empty spiracles homolog 1 (Drosophila)0.297
Hspd1heat shock protein 1 (chaperonin)0.292
Mdm4transformed mouse 3T3 cell double minute 40.278
Trp53inp2transformation related protein 53 inducible nuclear protein 20.271
Trp73transformation related protein 730.268
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.247
Rararetinoic acid receptor, alpha0.196
Mapre3microtubule-associated protein, RP/EB family, member 30.178
Dnaja3DnaJ (Hsp40) homolog, subfamily A, member 30.135
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.116
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.108
Sqstm1sequestosome 10.107
Cycscytochrome c, somatic0.102
Kitkit oncogene0.102
Trp63transformation related protein 630.084
Hrhairless0.083
Eif4a2eukaryotic translation initiation factor 4A20.077
Mfn2mitofusin 20.068
WwoxWW domain-containing oxidoreductase0.061
Hif1anhypoxia-inducible factor 1, alpha subunit inhibitor0.061
Ubxn6UBX domain protein 60.060
Atg5autophagy-related 5 (yeast)0.056
Ypel3yippee-like 3 (Drosophila)0.054
Sfnstratifin0.052
Yipf4Yip1 domain family, member 40.050
Tprgltransformation related protein 63 regulated like0.050
Yap1yes-associated protein 10.048
Haghhydroxyacyl glutathione hydrolase0.047
Dnajb2DnaJ (Hsp40) homolog, subfamily B, member 20.046
Criptcysteine-rich PDZ-binding protein0.046
Fam103a1family with sequence similarity 103, member A10.045
Atp6v1dATPase, H+ transporting, lysosomal V1 subunit D0.045
Brp44brain protein 440.042
Hhathedgehog acyltransferase0.041
Wdr45WD repeat domain 450.041
Rab28RAB28, member RAS oncogene family0.041
Irf6interferon regulatory factor 60.040
Ghitmgrowth hormone inducible transmembrane protein0.039
Paip2polyadenylate-binding protein-interacting protein 20.039
Csde1cold shock domain containing E1, RNA binding0.039
Lrpprcleucine-rich PPR-motif containing0.039
Atg7autophagy-related 7 (yeast)0.038
Map3k7mitogen-activated protein kinase kinase kinase 70.038
Rb1retinoblastoma 10.038
Apcadenomatosis polyposis coli0.036
2310061I04RikRIKEN cDNA 2310061I04 gene0.034
Rab18RAB18, member RAS oncogene family0.034
Trpc2transient receptor potential cation channel, subfamily C, member 20.034
Gabarapl1gamma-aminobutyric acid (GABA) A receptor-associated protein-like 10.033
Htatip2HIV-1 tat interactive protein 2, homolog (human)0.033
Aifm1apoptosis-inducing factor, mitochondrion-associated 10.033
Isca1iron-sulfur cluster assembly 1 homolog (S. cerevisiae)0.033
TctaT-cell leukemia translocation altered gene0.031
Maf1MAF1 homolog (S. cerevisiae)0.031
Ndufaf4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 40.031
March5membrane-associated ring finger (C3HC4) 50.030
Nudt9nudix (nucleoside diphosphate linked moiety X)-type motif 90.030
Foxo3forkhead box O30.030
Tmem70transmembrane protein 700.030
Pdk2pyruvate dehydrogenase kinase, isoenzyme 20.030
Ahraryl-hydrocarbon receptor0.029
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.029
Slmo2slowmo homolog 2 (Drosophila)0.029
Mgllmonoglyceride lipase0.029
Afg3l2AFG3(ATPase family gene 3)-like 2 (yeast)0.028
Gfm1G elongation factor, mitochondrial 10.027
Sucla2succinate-Coenzyme A ligase, ADP-forming, beta subunit0.027
Huwe1HECT, UBA and WWE domain containing 10.027
Mapk14mitogen-activated protein kinase 140.026
Liaslipoic acid synthetase0.026
Ctnnb1catenin (cadherin associated protein), beta 10.026
Rab11aRAB11a, member RAS oncogene family0.025
Polbpolymerase (DNA directed), beta0.025
Lamc2laminin, gamma 20.025
BrafBraf transforming gene0.025
Macrod1MACRO domain containing 10.025
Dmddystrophin, muscular dystrophy0.024
Gm3244predicted pseudogene 32440.024
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.024
Gde1glycerophosphodiester phosphodiesterase 10.024
Abtb1ankyrin repeat and BTB (POZ) domain containing 10.024
Slc25a33solute carrier family 25, member 330.024
Sgcbsarcoglycan, beta (dystrophin-associated glycoprotein)0.024
Brca1breast cancer 10.024
Optnoptineurin0.024
Lap3leucine aminopeptidase 30.024
Hsbp1heat shock factor binding protein 10.023
Reep5receptor accessory protein 50.023
Hspa8heat shock protein 80.023
Ubcubiquitin C0.022
Dctn2dynactin 20.022
Chchd7coiled-coil-helix-coiled-coil-helix domain containing 70.022
Hprthypoxanthine guanine phosphoribosyl transferase0.022
Rint1RAD50 interactor 10.022
Tmem66transmembrane protein 660.022
Cables1CDK5 and Abl enzyme substrate 10.022
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism