The network for 'regulation of actin filament polymerization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of actin filament polymerization

Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.

NameDescriptionProbabilityFunc Analog Organism
MYO5Myo5p0.992
CAP2Cap2p0.973
ABP1Abp1p0.969
LAS17Las17p0.942
ARP2Arp2p0.783
SRV2Srv2p0.742
ARC19Arc19p0.709
BBC1Bbc1p0.635
ACT1Act1p0.632
ARC35Arc35p0.605
ARC15Arc15p0.594
ARC40Arc40p0.580
LSB1Lsb1p0.499
ARP3Arp3p0.497
RVS167Rvs167p0.497
SAC6Sac6p0.363
SLA2Sla2p0.307
TPM1Tpm1p0.191
RHO1Rho1p0.171
VRP1Vrp1p0.159
CDC24Cdc24p0.137
PFY1Pfy1p0.103
CDC55Cdc55p0.091
GYL1Gyl1p0.090
AIP1Aip1p0.076
TWF1Twf1p0.071
BEM3Bem3p0.060
YPK1Ypk1p0.060
ARC18Arc18p0.051
COF1Cof1p0.050
CAP1Cap1p0.042
BOI1Boi1p0.038
SCP1Scp1p0.033
TCO89Tco89p0.032
BNI1Bni1p0.031
AVO1Avo1p0.028
SLA1Sla1p0.028
YSC84Ysc84p0.027
BEM1Bem1p0.026
BEM4Bem4p0.024
STE5Ste5p0.022
INP52Inp52p0.022
PAN1Pan1p0.022
BMH1Bmh1p0.021
FIR1Fir1p0.021
PRS2Prs2p0.020
BZZ1Bzz1p0.020
TSC11Tsc11p0.019
NBP2Nbp2p0.019
SRD1Srd1p0.019
YER134Chypothetical protein0.018
YPR1Ypr1p0.018
SKT5Skt5p0.018
TPD3Tpd3p0.017
APP1App1p0.017
PRP28Prp28p0.017
YLR162Whypothetical protein0.017
LEU2Leu2p0.017
YOL038C-Ahypothetical protein0.017
YMR315Whypothetical protein0.017
CRN1Crn1p0.016
KOG1Kog1p0.016
CMD1Cmd1p0.016
YLR264C-Ahypothetical protein0.016
URA3Ura3p0.016
ADH2Adh2p0.016
YIL151Chypothetical protein0.015
SRO77Sro77p0.015
ZDS1Zds1p0.015
CLC1Clc1p0.015
ARG8Arg8p0.015
CLA4Cla4p0.015
SKM1Skm1p0.015
MER1Mer1p0.015
YKR075Chypothetical protein0.015
ARP10Arp10p0.014
RDI1Rdi1p0.014
SPL2Spl2p0.014
EDE1Ede1p0.014
TOR2Tor2p0.014
ENT3Ent3p0.014
HXT3Hxt3p0.014
UBP7Ubp7p0.014
ARE2Are2p0.014
EHT1Eht1p0.013
YIR035Chypothetical protein0.013
AIM7Aim7p0.013
RIB4Rib4p0.013
BUD2Bud2p0.013
ARO10Aro10p0.013
RGD1Rgd1p0.013
YLR042Chypothetical protein0.013
ZPS1Zps1p0.013
BUL1Bul1p0.013
YAR068Whypothetical protein0.013
TOR1Tor1p0.013
ATP6Atp6p0.012
YPL014Whypothetical protein0.012
YBR013Chypothetical protein0.012
CPD1Cpd1p0.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cdc-42Protein CDC-420.058
ifp-1Protein IFP-10.034
ifb-2Protein IFB-20.032
goa-1Protein GOA-10.031
unc-16Protein UNC-160.029
B0511.12Protein B0511.120.025
vps-32.1Protein VPS-32.10.023
mig-38Protein MIG-380.021
cap-1Protein CAP-10.020
unc-9Protein UNC-90.019
sorb-1Protein SORB-10.018
sax-7Protein SAX-70.018
T16G1.9Protein T16G1.90.018
CELE_Y67A10A.9Protein Y67A10A.90.017
ina-1Protein INA-10.017
CELE_B0238.10Protein B0238.100.016
C11E4.6Protein C11E4.60.016
praf-3Protein PRAF-30.016
deb-1Protein DEB-10.016
cam-1Protein CAM-10.015
T12B3.4Protein T12B3.40.015
gfi-2Protein GFI-20.015
unc-32Protein UNC-320.014
spk-1Protein SPK-10.013
unc-15Protein UNC-150.013
gsp-1Protein GSP-10.013
emb-9Protein EMB-90.013
K06A9.1Protein K06A9.10.013
paqr-2Protein PAQR-20.013
afd-1Protein AFD-10.013
arx-1Protein ARX-10.012
myo-3Protein MYO-30.012
ced-10Protein CED-100.012
CELE_T05E11.3Protein T05E11.30.012
tes-1Protein TES-10.012
clic-1Protein CLIC-10.011
CELE_Y45F10B.13Protein Y45F10B.130.011
CELE_F52E1.13Protein F52E1.130.011
pac-1Protein PAC-10.011
F33H2.2Protein F33H2.20.011
ntl-4Protein NTL-40.011
chc-1Protein CHC-10.011
kin-4Protein KIN-40.010
gly-7Protein GLY-70.010
lat-1Protein LAT-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
chicchickadee0.996
Arc-p34CG10954 gene product from transcript CG10954-RA0.979
Rac1CG2248 gene product from transcript CG2248-RA0.928
p120ctnAdherens junction protein p1200.921
Vrp1Verprolin 10.912
HemHEM-protein0.900
Arp66BActin-related protein 66B0.893
Cdc42CG12530 gene product from transcript CG12530-RA0.810
mbcmyoblast city0.810
enaenabled0.766
bifbifocal0.711
Arf51FADP ribosylation factor 51F0.710
katanin-60katanin 600.705
RalaRas-related protein0.697
ctaconcertina0.659
par-1CG8201 gene product from transcript CG8201-RA0.649
WASpCG1520 gene product from transcript CG1520-RA0.646
twftwinfilin0.633
Rho1CG8416 gene product from transcript CG8416-RB0.627
slssallimus0.624
msnmisshapen0.587
bazbazooka0.551
flwflapwing0.541
Sra-1specifically Rac1-associated protein 10.532
roboroundabout0.512
Rab11Rab-protein 110.472
CortactinCG3637 gene product from transcript CG3637-RA0.468
trctricornered0.465
dockdreadlocks0.440
par-6CG5884 gene product from transcript CG5884-RA0.438
cpbcapping protein beta0.435
Akt1CG4006 gene product from transcript CG4006-RA0.416
cindrCIN85 and CD2AP orthologue0.401
S6kRPS6-p70-protein kinase0.386
zipzipper0.385
rokRho-kinase0.378
PakPAK-kinase0.377
spirspire0.368
Arp14DActin-related protein 14D0.363
Btk29ABtk family kinase at 29A0.344
CkIIbetaCasein kinase II beta subunit0.315
Sop2Suppressor of profilin 20.300
Cip4CG15015 gene product from transcript CG15015-RA0.282
rapretina aberrant in pattern0.253
cpacapping protein alpha0.221
giggigas0.215
shgshotgun0.212
MtlMig-2-like0.183
DadDaughters against dpp0.179
ChcClathrin heavy chain0.153
sqhspaghetti squash0.152
MicalMolecule interacting with CasL0.149
dshdishevelled0.143
Src64BSrc oncogene at 64B0.139
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.134
snssticks and stones0.123
cazcabeza0.121
didumdilute class unconventional myosin0.117
ttktramtrack0.117
plexAplexin A0.116
eghegghead0.112
savsalvador0.108
numbCG3779 gene product from transcript CG3779-RB0.105
flrflare0.101
CG8578CG8578 gene product from transcript CG8578-RA0.100
wdbwiderborst0.097
spasspastin0.092
vavCG7893 gene product from transcript CG7893-RB0.092
Mlc-cMyosin light chain cytoplasmic0.092
htshu li tai shao0.091
Ptp69DProtein tyrosine phosphatase 69D0.091
kuzkuzbanian0.088
kelkelch0.086
SosSon of sevenless0.084
trioCG18214 gene product from transcript CG18214-RA0.083
RhoGEF2CG9635 gene product from transcript CG9635-RF0.082
BicDBicaudal D0.081
Actnalpha actinin0.079
eglegalitarian0.079
DlicDynein light intermediate chain0.077
Tao-1CG14217 gene product from transcript CG14217-RF0.077
capucappuccino0.077
ShcSHC-adaptor protein0.075
AbiAbelson interacting protein0.075
rstroughest0.074
Mob2CG11711 gene product from transcript CG11711-RC0.071
EphrinCG1862 gene product from transcript CG1862-RA0.071
staistathmin0.068
dosdaughter of sevenless0.068
laceCG4162 gene product from transcript CG4162-RA0.068
PebProtein ejaculatory bulb0.067
Pak3CG14895 gene product from transcript CG14895-RA0.066
rinrasputin0.066
hbshibris0.066
kirrekin of irre0.065
uspultraspiracle0.063
G-oalpha47AG protein oalpha 47A0.061
stanstarry night0.060
bchsblue cheese0.060
Mlc2Myosin light chain 20.059
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDC42cell division cycle 42 (GTP binding protein, 25kDa)1.000
GRB2growth factor receptor-bound protein 21.000
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)1.000
IQGAP1IQ motif containing GTPase activating protein 11.000
GAS7growth arrest-specific 70.999
ARPC1Bactin related protein 2/3 complex, subunit 1B, 41kDa0.998
TPM4tropomyosin 40.997
ABI1abl-interactor 10.997
WASLWiskott-Aldrich syndrome-like0.996
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.996
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.996
BAIAP2BAI1-associated protein 20.994
FLNAfilamin A, alpha0.991
ARPC4actin related protein 2/3 complex, subunit 4, 20kDa0.991
ARPC2actin related protein 2/3 complex, subunit 2, 34kDa0.990
FYNFYN oncogene related to SRC, FGR, YES0.983
ACTR3ARP3 actin-related protein 3 homolog (yeast)0.981
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.976
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.974
ZYXzyxin0.972
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.972
ITSN1intersectin 1 (SH3 domain protein)0.962
MYH9myosin, heavy chain 9, non-muscle0.959
TRIP10thyroid hormone receptor interactor 100.953
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.950
NCKAP1NCK-associated protein 10.949
WIPF1WAS/WASL interacting protein family, member 10.936
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)0.935
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.932
ARPC3actin related protein 2/3 complex, subunit 3, 21kDa0.915
VAV1vav 1 guanine nucleotide exchange factor0.909
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.883
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.860
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.856
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.842
FNBP1Lformin binding protein 1-like0.828
PFN1profilin 10.821
SH2D4ASH2 domain containing 4A0.819
TNK2tyrosine kinase, non-receptor, 20.816
CORO1Ccoronin, actin binding protein, 1C0.799
PDLIM7PDZ and LIM domain 7 (enigma)0.782
CCR5chemokine (C-C motif) receptor 50.765
DAAM1dishevelled associated activator of morphogenesis 10.760
RHOAras homolog gene family, member A0.733
BCAR1breast cancer anti-estrogen resistance 10.730
ACTN1actinin, alpha 10.722
SH3KBP1SH3-domain kinase binding protein 10.701
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.691
PAK4p21 protein (Cdc42/Rac)-activated kinase 40.676
CCL4chemokine (C-C motif) ligand 40.676
ARRB1arrestin, beta 10.672
FKBP1AFK506 binding protein 1A, 12kDa0.607
TJP1tight junction protein 1 (zona occludens 1)0.592
CFL1cofilin 1 (non-muscle)0.592
HCKhemopoietic cell kinase0.569
CD2APCD2-associated protein0.567
ACTBactin, beta0.561
SOS1son of sevenless homolog 1 (Drosophila)0.511
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.498
RPTORregulatory associated protein of MTOR, complex 10.487
CAPZBcapping protein (actin filament) muscle Z-line, beta0.487
MTORmechanistic target of rapamycin (serine/threonine kinase)0.482
MAP3K11mitogen-activated protein kinase kinase kinase 110.455
CAPNS1calpain, small subunit 10.453
PRKCAprotein kinase C, alpha0.446
PACSIN1protein kinase C and casein kinase substrate in neurons 10.440
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.439
CTTNcortactin0.437
TPM1tropomyosin 1 (alpha)0.437
SH3BGRL3SH3 domain binding glutamic acid-rich protein like 30.419
HTThuntingtin0.410
NCF2neutrophil cytosolic factor 20.403
NCK1NCK adaptor protein 10.395
TRIM63tripartite motif containing 630.374
HIPK2homeodomain interacting protein kinase 20.360
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.358
WASF1WAS protein family, member 10.356
ADAM19ADAM metallopeptidase domain 190.353
WDR1WD repeat domain 10.353
TPM2tropomyosin 2 (beta)0.337
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.335
ARHGAP1Rho GTPase activating protein 10.333
LASP1LIM and SH3 protein 10.332
SFNstratifin0.326
PRKAR2Aprotein kinase, cAMP-dependent, regulatory, type II, alpha0.325
SPAG9sperm associated antigen 90.317
TAGLN2transgelin 20.313
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.311
ABI2abl-interactor 20.308
PRR5proline rich 5 (renal)0.306
PAK7p21 protein (Cdc42/Rac)-activated kinase 70.298
PLECplectin0.282
ACTA1actin, alpha 1, skeletal muscle0.282
SNX9sorting nexin 90.277
ARFIP2ADP-ribosylation factor interacting protein 20.276
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.270
PRKCIprotein kinase C, iota0.269
ARRB2arrestin, beta 20.265
NCKIPSDNCK interacting protein with SH3 domain0.258
SPRR2Asmall proline-rich protein 2A0.257
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
Vaspvasodilator-stimulated phosphoprotein0.999
Wdr1WD repeat domain 10.999
Capzbcapping protein (actin filament) muscle Z-line, beta0.998
Arpc4actin related protein 2/3 complex, subunit 40.997
Actr3ARP3 actin-related protein 3 homolog (yeast)0.992
Rac1RAS-related C3 botulinum substrate 10.992
Msnmoesin0.991
Cttncortactin0.984
Akt1thymoma viral proto-oncogene 10.981
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.979
Ldb3LIM domain binding 30.973
BlnkB-cell linker0.938
Actbactin, beta0.924
Mtormechanistic target of rapamycin (serine/threonine kinase)0.914
Cfl1cofilin 1, non-muscle0.910
Gnb2guanine nucleotide binding protein (G protein), beta 20.908
Rhogras homolog gene family, member G0.858
Dnm1dynamin 10.854
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.847
Prkceprotein kinase C, epsilon0.844
Abi1abl-interactor 10.843
Arhgap1Rho GTPase activating protein 10.833
Dok1docking protein 10.828
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.814
Arpc2actin related protein 2/3 complex, subunit 20.792
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.790
Dbnldrebrin-like0.783
Pfn1profilin 10.779
Actg1actin, gamma, cytoplasmic 10.776
Mapkap1mitogen-activated protein kinase associated protein 10.761
Pfn2profilin 20.729
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.699
Cnn2calponin 20.684
Cdc42se1CDC42 small effector 10.675
Map4k1mitogen-activated protein kinase kinase kinase kinase 10.635
Efnb2ephrin B20.634
Rhoaras homolog gene family, member A0.621
Wipf1WAS/WASL interacting protein family, member 10.609
Enahenabled homolog (Drosophila)0.576
Cotl1coactosin-like 1 (Dictyostelium)0.567
Ilkintegrin linked kinase0.567
Rgs14regulator of G-protein signaling 140.561
Tagln2transgelin 20.552
Sh3gl2SH3-domain GRB2-like 20.526
Tpm4tropomyosin 40.525
Myh9myosin, heavy polypeptide 9, non-muscle0.520
Shisa5shisa homolog 5 (Xenopus laevis)0.493
Csrp1cysteine and glycine-rich protein 10.485
Actr2ARP2 actin-related protein 2 homolog (yeast)0.478
Cltcclathrin, heavy polypeptide (Hc)0.449
FynFyn proto-oncogene0.445
Iqgap1IQ motif containing GTPase activating protein 10.432
Actn1actinin, alpha 10.423
Lrrk2leucine-rich repeat kinase 20.417
Clic1chloride intracellular channel 10.409
Mtpnmyotrophin0.398
Rod1ROD1 regulator of differentiation 1 (S. pombe)0.381
Arhgap9Rho GTPase activating protein 90.371
Nckap1NCK-associated protein 10.366
Bcl10B-cell leukemia/lymphoma 100.362
CblCasitas B-lineage lymphoma0.354
Actn4actinin alpha 40.352
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.351
Arrb2arrestin, beta 20.343
Kctd10potassium channel tetramerisation domain containing 100.342
Sept9septin 90.338
Robo1roundabout homolog 1 (Drosophila)0.337
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.323
ArhgdibRho, GDP dissociation inhibitor (GDI) beta0.320
Slit3slit homolog 3 (Drosophila)0.308
SrcRous sarcoma oncogene0.307
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.300
Prkcbprotein kinase C, beta0.292
Grb2growth factor receptor bound protein 20.290
Apbb1ipamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.285
Prkccprotein kinase C, gamma0.283
Tubb5tubulin, beta 50.263
Arf1ADP-ribosylation factor 10.251
Ptpreprotein tyrosine phosphatase, receptor type, E0.242
Cd44CD44 antigen0.239
Lmnb1lamin B10.222
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.219
Fermt3fermitin family homolog 3 (Drosophila)0.216
Gnb1guanine nucleotide binding protein (G protein), beta 10.202
Coro1acoronin, actin binding protein 1A0.200
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.194
Zap70zeta-chain (TCR) associated protein kinase0.192
RictorRPTOR independent companion of MTOR, complex 20.189
Calm1calmodulin 10.185
Coro1ccoronin, actin binding protein 1C0.185
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.180
Rap1bRAS related protein 1b0.173
Hif1ahypoxia inducible factor 1, alpha subunit0.167
Lcp1lymphocyte cytosolic protein 10.166
Klf6Kruppel-like factor 60.165
Sh3kbp1SH3-domain kinase binding protein 10.164
Trpv2transient receptor potential cation channel, subfamily V, member 20.164
Robo2roundabout homolog 2 (Drosophila)0.163
Tmod3tropomodulin 30.161
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism