The network for 'negative regulation of metaphase anaphase transition of cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of metaphase anaphase transition of cell cycle

Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of cell cycle.

NameDescriptionProbabilityFunc Analog Organism
PPH21Pph21p0.952
MTW1Mtw1p0.910
CDC20Cdc20p0.902
DSN1Dsn1p0.894
SLK19Slk19p0.871
NSL1Nsl1p0.858
BUB1Bub1p0.800
PPH22Pph22p0.782
CSE4Cse4p0.780
TID3Tid3p0.762
IML3Iml3p0.757
AME1Ame1p0.728
CHL4Chl4p0.619
SLI15Sli15p0.559
HHF2Hhf2p0.543
SMC4Smc4p0.536
CDC55Cdc55p0.520
PPZ1Ppz1p0.500
MIF2Mif2p0.496
HHT1Hht1p0.476
MCM21Mcm21p0.466
YPI1Ypi1p0.453
MAD1Mad1p0.447
CTF13Ctf13p0.436
MAD2Mad2p0.420
KIP1Kip1p0.349
SPC24Spc24p0.348
IPL1Ipl1p0.273
YBP2Ybp2p0.247
RTS1Rts1p0.245
DAM1Dam1p0.215
MAD3Mad3p0.213
GIP2Gip2p0.212
SPC105Spc105p0.207
OKP1Okp1p0.203
BUB3Bub3p0.183
ASE1Ase1p0.177
MCM22Mcm22p0.170
NUF2Nuf2p0.167
BIR1Bir1p0.166
PIG2Pig2p0.154
CTF3Ctf3p0.135
NNF1Nnf1p0.130
FMP48Fmp48p0.125
SDS22Sds22p0.124
MPS1Mps1p0.119
CBF2Cbf2p0.106
CIN8Cin8p0.084
SMC5Smc5p0.073
CAB3Cab3p0.069
BRN1Brn1p0.063
GLG1Glg1p0.058
SMC2Smc2p0.057
SPC25Spc25p0.056
PDS1Pds1p0.055
ZDS1Zds1p0.054
SMC6Smc6p0.054
CBF1Cbf1p0.048
GAC1Gac1p0.047
NBL1Nbl1p0.045
VHS2Vhs2p0.040
VHS3Vhs3p0.040
ECO1Eco1p0.040
YIL151Chypothetical protein0.039
CRP1Crp1p0.038
PTI1Pti1p0.038
SMC3Smc3p0.037
BFA1Bfa1p0.036
SCM3Scm3p0.035
NTO1Nto1p0.035
PSH1Psh1p0.035
PCL10Pcl10p0.034
ZDS2Zds2p0.033
SPO12Spo12p0.033
SRD1Srd1p0.032
FIN1Fin1p0.032
SPC110Spc110p0.031
YLR162Whypothetical protein0.028
JLP2Jlp2p0.028
CSM1Csm1p0.028
HIT1Hit1p0.028
YLR264C-Ahypothetical protein0.028
CIN1Cin1p0.027
CHL1Chl1p0.027
MMS21Mms21p0.027
SCC2Scc2p0.027
PSY4Psy4p0.027
YOL038C-Ahypothetical protein0.027
LEU2Leu2p0.026
STU1Stu1p0.025
ESP1Esp1p0.025
NDD1Ndd1p0.024
YNL144Chypothetical protein0.024
PDR15Pdr15p0.023
TIP41Tip41p0.023
MER1Mer1p0.023
PLC1Plc1p0.023
SPC97Spc97p0.022
ARG8Arg8p0.022
YML053Chypothetical protein0.022
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
rnr-1Protein RNR-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
IswiImitation SWI0.204
CycBCyclin B0.109
BubR1Bub1-related kinase0.096
ncdnon-claret disjunctional0.084
CycB3Cyclin B30.055
fzyfizzy0.041
SAKSak kinase0.039
aslasterless0.037
CycACyclin A0.036
flflfalafel0.036
Cks30ACyclin-dependent kinase subunit 30A0.034
cavcaravaggio0.030
poloCG12306 gene product from transcript CG12306-RA0.029
gwlgreatwall0.028
bambag of marbles0.024
Nup153Nucleoporin 1530.024
tumtumbleweed0.022
cnncentrosomin0.022
pavpavarotti0.022
cmetCENP-meta0.020
Cap-GCG34438 gene product from transcript CG34438-RF0.020
ruxroughex0.019
dupdouble parked0.018
Klp61FKinesin-like protein at 61F0.018
nbsCG6754 gene product from transcript CG6754-RC0.015
SMC2CG10212 gene product from transcript CG10212-RA0.015
pimpimples0.015
Cdc37CG12019 gene product from transcript CG12019-RA0.015
nodno distributive disjunction0.015
mus301mutagen-sensitive 3010.014
IncenpInner centromere protein0.013
thrthree rows0.013
DrefDNA replication-related element factor0.012
Klp3AKinesin-like protein at 3A0.012
aspabnormal spindle0.012
alphaTub67Calpha-Tubulin at 67C0.011
spn-Dspindle D0.011
CG6439CG6439 gene product from transcript CG6439-RA0.010
DNApol-alpha60DNA polymerase alpha 60kD0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDC27cell division cycle 27 homolog (S. cerevisiae)0.734
CDK2cyclin-dependent kinase 20.638
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.536
MDC1mediator of DNA-damage checkpoint 10.421
CCNA2cyclin A20.334
ANAPC7anaphase promoting complex subunit 70.314
CDC20cell division cycle 20 homolog (S. cerevisiae)0.300
CCT8chaperonin containing TCP1, subunit 8 (theta)0.285
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.238
CCNB1cyclin B10.145
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.131
ANAPC4anaphase promoting complex subunit 40.078
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.074
SKA1spindle and kinetochore associated complex subunit 10.064
BRCA2breast cancer 2, early onset0.059
NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.057
FBXO5F-box protein 50.052
SKP2S-phase kinase-associated protein 2 (p45)0.049
UHRF1ubiquitin-like with PHD and ring finger domains 10.049
SPC24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.040
SKA3spindle and kinetochore associated complex subunit 30.039
ZNF207zinc finger protein 2070.036
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.033
ANAPC11anaphase promoting complex subunit 110.033
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.030
CHAF1Achromatin assembly factor 1, subunit A (p150)0.030
CBX5chromobox homolog 50.027
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.026
TINF2TERF1 (TRF1)-interacting nuclear factor 20.026
SMC3structural maintenance of chromosomes 30.025
C13orf34chromosome 13 open reading frame 340.024
CASC5cancer susceptibility candidate 50.023
UHRF2ubiquitin-like with PHD and ring finger domains 20.023
SKA2spindle and kinetochore associated complex subunit 20.022
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.022
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.022
AURKBaurora kinase B0.022
TP53BP1tumor protein p53 binding protein 10.022
ATMINATM interactor0.021
CCNE1cyclin E10.021
KIF18Akinesin family member 18A0.021
FXR2fragile X mental retardation, autosomal homolog 20.019
TERF2IPtelomeric repeat binding factor 2, interacting protein0.019
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.019
CDKN3cyclin-dependent kinase inhibitor 30.018
CKS1BCDC28 protein kinase regulatory subunit 1B0.018
MYST1MYST histone acetyltransferase 10.018
HERC2hect domain and RLD 20.018
MAD2L1BPMAD2L1 binding protein0.018
UBE2Cubiquitin-conjugating enzyme E2C0.017
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.017
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.017
NEK2NIMA (never in mitosis gene a)-related kinase 20.017
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.017
PPME1protein phosphatase methylesterase 10.016
RB1retinoblastoma 10.016
INCENPinner centromere protein antigens 135/155kDa0.016
ZC3HAV1zinc finger CCCH-type, antiviral 10.016
CDC26cell division cycle 26 homolog (S. cerevisiae)0.015
PPP6R2protein phosphatase 6, regulatory subunit 20.015
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.015
CDT1chromatin licensing and DNA replication factor 10.015
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.015
HIST1H4Ahistone cluster 1, H4a0.014
CCND1cyclin D10.014
SMC4structural maintenance of chromosomes 40.014
RAD52RAD52 homolog (S. cerevisiae)0.014
CDC6cell division cycle 6 homolog (S. cerevisiae)0.014
SYVN1synovial apoptosis inhibitor 1, synoviolin0.013
CDC23cell division cycle 23 homolog (S. cerevisiae)0.013
PRC1protein regulator of cytokinesis 10.013
KDM4Alysine (K)-specific demethylase 4A0.013
PARP3poly (ADP-ribose) polymerase family, member 30.013
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.013
BRCA1breast cancer 1, early onset0.013
CCNB2cyclin B20.013
PAXIP1PAX interacting (with transcription-activation domain) protein 10.012
CDC25Ccell division cycle 25 homolog C (S. pombe)0.012
CENPEcentromere protein E, 312kDa0.012
PRNPprion protein0.012
HIST1H4Fhistone cluster 1, H4f0.012
NUF2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.012
RAD51L1RAD51-like 1 (S. cerevisiae)0.012
PPP2R5Dprotein phosphatase 2, regulatory subunit B', delta0.011
SGOL1shugoshin-like 1 (S. pombe)0.011
ANKRD52ankyrin repeat domain 520.011
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.011
ERCC6Lexcision repair cross-complementing rodent repair deficiency, complementation group 6-like0.011
ZSWIM7zinc finger, SWIM-type containing 70.011
HIST1H1Ehistone cluster 1, H1e0.011
PLK1polo-like kinase 10.010
FANCD2Fanconi anemia, complementation group D20.010
DCLRE1CDNA cross-link repair 1C0.010
MAD1L1MAD1 mitotic arrest deficient-like 1 (yeast)0.010
HIST1H1Bhistone cluster 1, H1b0.010
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.010
TTKTTK protein kinase0.010
DLGAP5discs, large (Drosophila) homolog-associated protein 50.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.113
Prc1protein regulator of cytokinesis 10.108
Brca1breast cancer 10.060
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.046
Ccnb1cyclin B10.043
Cdk1cyclin-dependent kinase 10.042
Brca2breast cancer 20.033
C330027C09RikRIKEN cDNA C330027C09 gene0.032
Ooepoocyte expressed protein homolog (dog)0.031
Ccna2cyclin A20.031
Kif22kinesin family member 220.028
Birc5baculoviral IAP repeat-containing 50.025
Trim59tripartite motif-containing 590.025
Ect2ect2 oncogene0.022
Ccnb2cyclin B20.021
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.021
Cdk2cyclin-dependent kinase 20.020
Kif20akinesin family member 20A0.020
Trip13thyroid hormone receptor interactor 130.019
Sgol1shugoshin-like 1 (S. pombe)0.018
Mis18bp1MIS18 binding protein 10.018
Mki67antigen identified by monoclonal antibody Ki 670.017
Aurkaaurora kinase A0.015
Cdkn1bcyclin-dependent kinase inhibitor 1B0.014
Smc4structural maintenance of chromosomes 40.014
Ezh2enhancer of zeste homolog 2 (Drosophila)0.014
Cdca8cell division cycle associated 80.014
Kif2ckinesin family member 2C0.012
Gsg2germ cell-specific gene 20.012
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.012
Hmmrhyaluronan mediated motility receptor (RHAMM)0.012
Ccnfcyclin F0.012
Chek1checkpoint kinase 1 homolog (S. pombe)0.012
Wdhd1WD repeat and HMG-box DNA binding protein 10.011
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.011
Sgol2shugoshin-like 2 (S. pombe)0.011
Melkmaternal embryonic leucine zipper kinase0.011
Kif23kinesin family member 230.010
Kif11kinesin family member 110.010
Spag5sperm associated antigen 50.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism