The network for 'trna aminoacylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

trna aminoacylation

The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.

NameDescriptionProbabilityFunc Analog Organism
GUS1Gus1p0.999
VAS1Vas1p0.965
CDC60Cdc60p0.961
ILS1Ils1p0.960
SES1Ses1p0.951
DYS1Dys1p0.949
SLM5Slm5p0.940
THS1Ths1p0.938
FRS2Frs2p0.915
DED81Ded81p0.882
MSE1Mse1p0.858
YHR020Whypothetical protein0.843
KRS1Krs1p0.811
GRS1Grs1p0.803
MES1Mes1p0.730
TYS1Tys1p0.669
HTS1Hts1p0.654
IFM1Ifm1p0.617
MSD1Msd1p0.582
ASN2Asn2p0.512
ALA1Ala1p0.504
MSF1Msf1p0.501
GLN4Gln4p0.417
MRF1Mrf1p0.336
MSY1Msy1p0.300
KAP104Kap104p0.294
ISM1Ism1p0.270
PET112Pet112p0.244
YNL247Whypothetical protein0.240
YDR341Chypothetical protein0.234
GUA1Gua1p0.225
AIM10Aim10p0.223
RRF1Rrf1p0.216
MST1Mst1p0.203
FRS1Frs1p0.180
SUP35Sup35p0.164
GYL1Gyl1p0.163
TCM62Tcm62p0.138
CYM1Cym1p0.137
ISA2Isa2p0.133
IMD2Imd2p0.131
IBA57Iba57p0.127
ART10Art10p0.126
COQ1Coq1p0.122
DPS1Dps1p0.121
YFH7Yfh7p0.117
GCN20Gcn20p0.105
ADE6Ade6p0.101
GUF1Guf1p0.095
KEL3Kel3p0.093
DBP5Dbp5p0.086
NAM2Nam2p0.083
SUB2Sub2p0.077
OLA1Ola1p0.073
PRO2Pro2p0.072
AIM32Aim32p0.070
CTM1Ctm1p0.067
FMP30Fmp30p0.061
AGC1Agc1p0.051
LYS21Lys21p0.050
YLR264C-Ahypothetical protein0.050
URA4Ura4p0.050
CYT2Cyt2p0.049
RPS20Rps20p0.048
DIA4Dia4p0.048
MDM34Mdm34p0.048
SRD1Srd1p0.047
MSR1Msr1p0.047
YNR040Whypothetical protein0.046
MRP20Mrp20p0.046
YOL038C-Ahypothetical protein0.044
MEF2Mef2p0.044
ARP10Arp10p0.043
MDN1Mdn1p0.040
YLR162Whypothetical protein0.040
LEU2Leu2p0.039
PET494Pet494p0.037
YRB1Yrb1p0.037
MAP2Map2p0.036
GCN1Gcn1p0.036
MER1Mer1p0.035
CUP1-1Cup1-1p0.034
AAP1Aap1p0.032
ATP6Atp6p0.032
DPH5Dph5p0.032
ILV3Ilv3p0.032
ATP25Atp25p0.032
OPT2Opt2p0.032
YAR068Whypothetical protein0.031
AEP3Aep3p0.031
YPR157Whypothetical protein0.030
ASN1Asn1p0.030
SHM1Shm1p0.030
AIM33Aim33p0.030
ICP55Icp55p0.029
PRS2Prs2p0.029
ABP140Abp140p0.028
ZPS1Zps1p0.028
CPD1Cpd1p0.028
URA3Ura3p0.028
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Aats-tyrTyrosyl-tRNA synthetase0.977
Srp68CG5064 gene product from transcript CG5064-RA0.641
Aats-thrThreonyl-tRNA synthetase0.540
Aats-leuLeucyl-tRNA synthetase0.528
CG1703CG1703 gene product from transcript CG1703-RA0.409
CG17259CG17259 gene product from transcript CG17259-RA0.372
Aats-ileIsoleucyl-tRNA synthetase0.281
Aats-trpTryptophanyl-tRNA synthetase0.269
Srp54kSignal recognition particle protein 54k0.261
Hsc70-5Heat shock protein cognate 50.259
Aats-aspAspartyl-tRNA synthetase0.258
Drp1Dynamin related protein 10.166
Aats-asnAsparaginyl-tRNA synthetase0.143
Aats-gluproGlutamyl-prolyl-tRNA synthetase0.134
beta'Copbeta'-coatomer protein0.116
CG33123CG33123 gene product from transcript CG33123-RA0.109
Aats-alaAlanyl-tRNA synthetase0.082
Gcn2CG1609 gene product from transcript CG1609-RA0.078
CG11771CG11771 gene product from transcript CG11771-RA0.058
l(2)k01209lethal (2) k012090.056
CG8545CG8545 gene product from transcript CG8545-RA0.047
Aats-metMethionyl-tRNA synthetase0.033
Aats-valValyl-tRNA synthetase0.032
JhI-21CG12317 gene product from transcript CG12317-RB0.032
T-cp1Tcp1-like0.031
Aats-argArginyl-tRNA synthetase0.031
l(2)03709lethal (2) 037090.030
SrpRbetaSignal recognition particle receptor beta0.027
Aats-proProlyl-tRNA synthetase0.027
CG8417CG8417 gene product from transcript CG8417-RA0.027
HmgsHMG Coenzyme A synthase0.025
l(2)37Cclethal (2) 37Cc0.021
CG7456CG7456 gene product from transcript CG7456-RA0.021
RFeSPRieske iron-sulfur protein0.019
CG4610CG4610 gene product from transcript CG4610-RA0.019
CG11418CG11418 gene product from transcript CG11418-RA0.019
eIF2B-epsilonCG3806 gene product from transcript CG3806-RB0.018
CG7277CG7277 gene product from transcript CG7277-RA0.017
CG4679CG4679 gene product from transcript CG4679-RA0.017
CG5205CG5205 gene product from transcript CG5205-RA0.014
CG7556CG7556 gene product from transcript CG7556-RA0.014
eIF4Geukaryotic translation initiation factor 4G0.014
Xbp1X box binding protein-10.013
CG3267CG3267 gene product from transcript CG3267-RA0.013
CG7791CG7791 gene product from transcript CG7791-RA0.012
CG42630CG42630 gene product from transcript CG42630-RA0.012
Aats-cysCysteinyl-tRNA synthetase0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IARSisoleucyl-tRNA synthetase1.000
EPRSglutamyl-prolyl-tRNA synthetase1.000
GARSglycyl-tRNA synthetase1.000
ASNSasparagine synthetase (glutamine-hydrolyzing)0.991
MARSmethionyl-tRNA synthetase0.989
AARSalanyl-tRNA synthetase0.982
AIMP2aminoacyl tRNA synthetase complex-interacting multifunctional protein 20.975
NARSasparaginyl-tRNA synthetase0.932
YARStyrosyl-tRNA synthetase0.931
KARSlysyl-tRNA synthetase0.842
RARSarginyl-tRNA synthetase0.788
CARScysteinyl-tRNA synthetase0.696
LARSleucyl-tRNA synthetase0.685
SHMT2serine hydroxymethyltransferase 2 (mitochondrial)0.476
SARSseryl-tRNA synthetase0.464
BCS1LBCS1-like (S. cerevisiae)0.193
TARSthreonyl-tRNA synthetase0.162
XPOTexportin, tRNA (nuclear export receptor for tRNAs)0.137
MTHFD2methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase0.129
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase0.119
AIMP1aminoacyl tRNA synthetase complex-interacting multifunctional protein 10.088
GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.078
OTUD5OTU domain containing 50.053
GARTphosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase0.052
XPO5exportin 50.044
DARSaspartyl-tRNA synthetase0.041
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.039
LRPPRCleucine-rich PPR-motif containing0.036
BOP1block of proliferation 10.035
WDR46WD repeat domain 460.031
MRPS27mitochondrial ribosomal protein S270.027
MINAMYC induced nuclear antigen0.026
EIF3CLeukaryotic translation initiation factor 3, subunit C-like0.023
CADcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.023
EIF2B3eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa0.023
EIF2S2eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa0.023
BMS1BMS1 homolog, ribosome assembly protein (yeast)0.022
LARS2leucyl-tRNA synthetase 2, mitochondrial0.021
PUS1pseudouridylate synthase 10.021
PSAT1phosphoserine aminotransferase 10.020
OGFOD12-oxoglutarate and iron-dependent oxygenase domain containing 10.020
ECSITECSIT homolog (Drosophila)0.019
CNOcappuccino homolog (mouse)0.019
KRT8keratin 80.019
DNAJA3DnaJ (Hsp40) homolog, subfamily A, member 30.018
EEF1E1eukaryotic translation elongation factor 1 epsilon 10.018
METTL13methyltransferase like 130.017
ARMC6armadillo repeat containing 60.016
LIASlipoic acid synthetase0.015
FKBP4FK506 binding protein 4, 59kDa0.014
DAP3death associated protein 30.014
TSEN2tRNA splicing endonuclease 2 homolog (S. cerevisiae)0.014
FARSBphenylalanyl-tRNA synthetase, beta subunit0.013
EIF2B2eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa0.013
UBA5ubiquitin-like modifier activating enzyme 50.013
SKIV2L2superkiller viralicidic activity 2-like 2 (S. cerevisiae)0.013
GEMIN5gem (nuclear organelle) associated protein 50.012
VARSvalyl-tRNA synthetase0.012
THG1LtRNA-histidine guanylyltransferase 1-like (S. cerevisiae)0.012
PSME1proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)0.012
METTL17methyltransferase like 170.012
C12orf44chromosome 12 open reading frame 440.012
POLR1Apolymerase (RNA) I polypeptide A, 194kDa0.011
RTN4IP1reticulon 4 interacting protein 10.011
FUBP1far upstream element (FUSE) binding protein 10.011
MRRFmitochondrial ribosome recycling factor0.010
MRPS9mitochondrial ribosomal protein S90.010
NAT10N-acetyltransferase 10 (GCN5-related)0.010
APEX1APEX nuclease (multifunctional DNA repair enzyme) 10.010
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Garsglycyl-tRNA synthetase0.993
Narsasparaginyl-tRNA synthetase0.847
Tarsthreonyl-tRNA synthetase0.726
Larsleucyl-tRNA synthetase0.634
Eprsglutamyl-prolyl-tRNA synthetase0.438
Rarsarginyl-tRNA synthetase0.379
Yarstyrosyl-tRNA synthetase0.316
Farsbphenylalanyl-tRNA synthetase, beta subunit0.259
Iarsisoleucine-tRNA synthetase0.256
Marsmethionine-tRNA synthetase0.151
Lrpprcleucine-rich PPR-motif containing0.151
Eif3ceukaryotic translation initiation factor 3, subunit C0.087
Aarsalanyl-tRNA synthetase0.073
Lonp1lon peptidase 1, mitochondrial0.068
Hspa9heat shock protein 90.066
Ddx1DEAD (Asp-Glu-Ala-Asp) box polypeptide 10.061
Asnsasparagine synthetase0.057
Immtinner membrane protein, mitochondrial0.052
Xpotexportin, tRNA (nuclear export receptor for tRNAs)0.052
Adsladenylosuccinate lyase0.046
Fam98afamily with sequence similarity 98, member A0.039
Fastkd2FAST kinase domains 20.035
Dus1ldihydrouridine synthase 1-like (S. cerevisiae)0.033
Aifm1apoptosis-inducing factor, mitochondrion-associated 10.029
1110002N22RikRIKEN cDNA 1110002N22 gene0.027
Rpn1ribophorin I0.027
Eif2b4eukaryotic translation initiation factor 2B, subunit 4 delta0.025
Abce1ATP-binding cassette, sub-family E (OABP), member 10.023
Rrp12ribosomal RNA processing 12 homolog (S. cerevisiae)0.023
Mettl5methyltransferase like 50.022
Orc5origin recognition complex, subunit 50.022
Psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.021
Ppp1r7protein phosphatase 1, regulatory (inhibitor) subunit 70.020
Carscysteinyl-tRNA synthetase0.019
Arl6ip4ADP-ribosylation factor-like 6 interacting protein 40.019
Mtif2mitochondrial translational initiation factor 20.019
Polr2bpolymerase (RNA) II (DNA directed) polypeptide B0.017
Tcp1t-complex protein 10.017
Xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.016
Ndufs1NADH dehydrogenase (ubiquinone) Fe-S protein 10.015
BccipBRCA2 and CDKN1A interacting protein0.015
Ndufaf1NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 10.015
Mrpl37mitochondrial ribosomal protein L370.014
Srp68signal recognition particle 680.014
Wdr36WD repeat domain 360.014
Mthfd2methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase0.014
Psmc5protease (prosome, macropain) 26S subunit, ATPase 50.013
Rai12retinoic acid induced 120.013
Bms1BMS1 homolog, ribosome assembly protein (yeast)0.013
RabggtbRAB geranylgeranyl transferase, b subunit0.013
Sarsseryl-aminoacyl-tRNA synthetase0.013
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.013
Lap3leucine aminopeptidase 30.013
Atf4activating transcription factor 40.012
Spcs3signal peptidase complex subunit 3 homolog (S. cerevisiae)0.012
Eif2b3eukaryotic translation initiation factor 2B, subunit 30.011
Cse1lchromosome segregation 1-like (S. cerevisiae)0.011
Las1lLAS1-like (S. cerevisiae)0.011
Xrcc6X-ray repair complementing defective repair in Chinese hamster cells 60.011
Liaslipoic acid synthetase0.011
Ptcd3pentatricopeptide repeat domain 30.011
Gfm1G elongation factor, mitochondrial 10.011
Ccnhcyclin H0.011
Tbrg4transforming growth factor beta regulated gene 40.011
Wbscr22Williams Beuren syndrome chromosome region 220.011
Cct5chaperonin containing Tcp1, subunit 5 (epsilon)0.010
Cdc123cell division cycle 123 homolog (S. cerevisiae)0.010
H2-Ke2H2-K region expressed gene 20.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Yarstyrosyl-tRNA synthetase0.929
Marsmethionine-tRNA synthetase0.727
Tarsthreonyl-tRNA synthetase0.661
Vcpvalosin-containing protein0.598
Eif3ceukaryotic translation initiation factor 3, subunit C0.483
Eif3beukaryotic translation initiation factor 3, subunit B0.406
Carscysteinyl-tRNA synthetase0.403
Aarsalanyl-tRNA synthetase0.379
Garsglycyl-tRNA synthetase0.344
Eif3deukaryotic translation initiation factor 3, subunit D0.270
Sarsseryl-tRNA synthetase0.245
Cpsf3cleavage and polyadenylation specificity factor 30.135
Nmt1N-myristoyltransferase 10.101
Ubxn4UBX domain protein 40.089
Eif2deukaryotic translation initiation factor 2D0.069
Tcp1t-complex 10.068
Psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.056
Psmc3proteasome (prosome, macropain) 26S subunit, ATPase 30.036
Larsleucyl-tRNA synthetase0.031
Farsbphenylalanyl-tRNA synthetase, beta subunit0.030
Aatfapoptosis antagonizing transcription factor0.029
LOC100362155cysteine and histidine rich 10.028
Mrps18bmitochondrial ribosomal protein S18B0.028
Abce1ATP-binding cassette, subfamily E (OABP), member 10.025
Karslysyl-tRNA synthetase0.022
LOC362855P550.022
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.022
Abcf1ATP-binding cassette, subfamily F (GCN20), member 10.020
Nsfl1cNSFL1 (p97) cofactor (p47)0.020
Iarsisoleucyl-tRNA synthetase0.019
LOC100360406rCG34104-like0.018
Cct3chaperonin containing Tcp1, subunit 3 (gamma)0.017
Ddx1DEAD (Asp-Glu-Ala-Asp) box polypeptide 10.015
Asnsasparagine synthetase0.015
Rpl28ribosomal protein L280.015
Utp3UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)0.015
Taldo1transaldolase 10.014
Faf1Fas (TNFRSF6) associated factor 10.013
Trap1TNF receptor-associated protein 10.013
Tmem69transmembrane protein 690.013
Strapserine/threonine kinase receptor associated protein0.012
Warstryptophanyl-tRNA synthetase0.012
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.012
Psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.011
Dusp19dual specificity phosphatase 190.011
Eprsglutamyl-prolyl-tRNA synthetase0.010
Pno1partner of NOB1 homolog (S. cerevisiae)0.010
Cirh1acirrhosis, autosomal recessive 1A (cirhin)0.010