The network for 'endosome transport via multivesicular body sorting pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endosome transport via multivesicular body sorting pathway

The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.

NameDescriptionProbabilityFunc Analog Organism
DID2Did2p0.823
VPS4Vps4p0.751
VPS21Vps21p0.600
YPT52Ypt52p0.455
MRS6Mrs6p0.428
SNF7Snf7p0.405
VPS60Vps60p0.394
PEP1Pep1p0.386
IST1Ist1p0.332
VPS24Vps24p0.315
GDI1Gdi1p0.261
YIP4Yip4p0.181
DID4Did4p0.177
YPT10Ypt10p0.160
VTA1Vta1p0.154
SRN2Srn2p0.152
VPS55Vps55p0.125
VPS68Vps68p0.110
CRZ1Crz1p0.106
YPT1Ypt1p0.100
YMR086Whypothetical protein0.077
PEP8Pep8p0.077
NYV1Nyv1p0.072
VTI1Vti1p0.071
VPS28Vps28p0.069
YIP5Yip5p0.059
YOR111Whypothetical protein0.059
BRO1Bro1p0.058
COG8Cog8p0.054
YPT6Ypt6p0.054
CSR2Csr2p0.051
SEC26Sec26p0.051
VPS17Vps17p0.051
VPS36Vps36p0.051
VPS3Vps3p0.049
RET3Ret3p0.045
APS1Aps1p0.044
ALY1Aly1p0.042
HAL5Hal5p0.039
RIM13Rim13p0.039
YER128Whypothetical protein0.038
APM2Apm2p0.037
PKH2Pkh2p0.036
YKL023Whypothetical protein0.035
SYN8Syn8p0.034
YMR258Chypothetical protein0.033
TVP18Tvp18p0.033
HUR1Hur1p0.032
VPS27Vps27p0.031
END3End3p0.031
AZF1Azf1p0.031
PEP3Pep3p0.030
SNF8Snf8p0.029
SRD1Srd1p0.029
AOS1Aos1p0.028
LEU2Leu2p0.028
ALY2Aly2p0.028
YLR162Whypothetical protein0.027
COP1Cop1p0.027
YOL038C-Ahypothetical protein0.027
YLR264C-Ahypothetical protein0.027
TOK1Tok1p0.027
CAD1Cad1p0.026
RAV2Rav2p0.025
SAP30Sap30p0.025
PAM1Pam1p0.024
MER1Mer1p0.024
YPL150Whypothetical protein0.024
MDH2Mdh2p0.024
MVP1Mvp1p0.024
ARP10Arp10p0.024
PAR32Par32p0.024
SSP1Ssp1p0.023
YPR091Chypothetical protein0.023
PGM3Pgm3p0.023
YJL055Whypothetical protein0.023
DAP1Dap1p0.023
PCL9Pcl9p0.023
RIM20Rim20p0.023
CUP1-1Cup1-1p0.022
EMP47Emp47p0.022
ARG8Arg8p0.022
YLR042Chypothetical protein0.022
YAR068Whypothetical protein0.022
HDA2Hda2p0.021
HPF1Hpf1p0.021
ADE16Ade16p0.021
YIR035Chypothetical protein0.021
YMR087Whypothetical protein0.021
YTA6Yta6p0.021
TGL1Tgl1p0.021
CAM1Cam1p0.021
ATP6Atp6p0.021
PTI1Pti1p0.021
OPT2Opt2p0.021
EAR1Ear1p0.021
PUF2Puf2p0.021
URA3Ura3p0.020
ZPS1Zps1p0.020
EIS1Eis1p0.020
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rab7Rab-protein 70.994
Vps25Vacuolar protein sorting 250.991
lsnlarsen0.975
vps24Charged multivesicular body protein 30.906
Rab5Rab-protein 50.849
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.798
vps2CG14542 gene product from transcript CG14542-RA0.590
Vps36Vacuolar protein sorting 360.564
TSG101tumor suppressor protein 1010.324
Vps20Vacuolar protein sorting 200.307
RhoLrho-like0.297
CG10103CG10103 gene product from transcript CG10103-RA0.242
CHMP2BCharged multivesicular body protein 2b0.190
Sop2Suppressor of profilin 20.174
Vps28Vacuolar protein sorting 280.167
Pi3K59FPhosphotidylinositol 3 kinase 59F0.159
slikSterile20-like kinase0.142
Vps4Vacuolar protein sorting 40.080
PHGPxCG12013 gene product from transcript CG12013-RC0.067
Xbp1X box binding protein-10.058
betaCopbeta-coatomer protein0.058
Chmp1CG4108 gene product from transcript CG4108-RA0.043
shrbshrub0.043
Syx7Syntaxin 70.042
rheaCG6831 gene product from transcript CG6831-RA0.037
CG1572CG1572 gene product from transcript CG1572-RA0.030
Xrp1CG17836 gene product from transcript CG17836-RB0.030
CG10277CG10277 gene product from transcript CG10277-RB0.028
CG6259CG6259 gene product from transcript CG6259-RA0.023
StamSignal transducing adaptor molecule0.021
lqfliquid facets0.021
RhebCG1081 gene product from transcript CG1081-RA0.020
CG4699CG4699 gene product from transcript CG4699-RJ0.020
atlatlastin0.019
DlicDynein light intermediate chain0.018
fab1CG6355 gene product from transcript CG6355-RA0.017
CG11009CG11009 gene product from transcript CG11009-RB0.017
CG8839CG8839 gene product from transcript CG8839-RA0.015
alphaCopalpha-coatomer protein0.014
CG13117CG13117 gene product from transcript CG13117-RA0.014
eIF-1AEukaryotic initiation factor 1A0.013
Atg8aAutophagy-specific gene 8a0.013
PsnPresenilin0.012
Rab2Rab-protein 20.012
Prp38pre-mRNA processing factor 380.011
Rab14Rab-protein 140.011
CycGCyclin G0.011
skdskuld0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PDCD6IPprogrammed cell death 6 interacting protein0.996
SMURF2SMAD specific E3 ubiquitin protein ligase 20.979
RNF11ring finger protein 110.955
GGA1golgi-associated, gamma adaptin ear containing, ARF binding protein 10.940
TSG101tumor susceptibility gene 1010.927
GGA2golgi-associated, gamma adaptin ear containing, ARF binding protein 20.917
NEDD4neural precursor cell expressed, developmentally down-regulated 40.837
ARCN1archain 10.832
ROCK1Rho-associated, coiled-coil containing protein kinase 10.729
CALCOCO2calcium binding and coiled-coil domain 20.673
SMURF1SMAD specific E3 ubiquitin protein ligase 10.645
CHMP4Bchromatin modifying protein 4B0.610
SYNRGsynergin, gamma0.554
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.553
STAMBPSTAM binding protein0.518
SMAD1SMAD family member 10.515
WWP2WW domain containing E3 ubiquitin protein ligase 20.479
SMAD4SMAD family member 40.477
CHMP1Achromatin modifying protein 1A0.466
ZFYVE9zinc finger, FYVE domain containing 90.457
SH3GL2SH3-domain GRB2-like 20.378
SMAD5SMAD family member 50.355
SH3KBP1SH3-domain kinase binding protein 10.345
FBXL15F-box and leucine-rich repeat protein 150.294
SORT1sortilin 10.292
COPB1coatomer protein complex, subunit beta 10.291
ANKRD13Aankyrin repeat domain 13A0.277
CD2APCD2-associated protein0.263
SORL1sortilin-related receptor, L(DLR class) A repeats containing0.263
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.259
RABEP1rabaptin, RAB GTPase binding effector protein 10.255
TAX1BP1Tax1 (human T-cell leukemia virus type I) binding protein 10.253
VPS28vacuolar protein sorting 28 homolog (S. cerevisiae)0.237
PDCD6programmed cell death 60.230
RHOAras homolog gene family, member A0.184
WWP1WW domain containing E3 ubiquitin protein ligase 10.153
LRSAM1leucine rich repeat and sterile alpha motif containing 10.143
NBR1neighbor of BRCA1 gene 10.134
EEA1early endosome antigen 10.131
SNX9sorting nexin 90.131
LRRK2leucine-rich repeat kinase 20.127
STAM2signal transducing adaptor molecule (SH3 domain and ITAM motif) 20.113
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.113
GGA3golgi-associated, gamma adaptin ear containing, ARF binding protein 30.112
IGF2Rinsulin-like growth factor 2 receptor0.111
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.107
SPG20spastic paraplegia 20 (Troyer syndrome)0.093
SMAD7SMAD family member 70.092
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.088
NEDD9neural precursor cell expressed, developmentally down-regulated 90.084
C1orf93chromosome 1 open reading frame 930.080
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.078
RAB6ARAB6A, member RAS oncogene family0.077
DNM2dynamin 20.076
CXXC5CXXC finger protein 50.074
HGShepatocyte growth factor-regulated tyrosine kinase substrate0.070
PTPN23protein tyrosine phosphatase, non-receptor type 230.068
ELLelongation factor RNA polymerase II0.067
DAZAP2DAZ associated protein 20.058
ING2inhibitor of growth family, member 20.057
EPS15epidermal growth factor receptor pathway substrate 150.056
RAB22ARAB22A, member RAS oncogene family0.055
OCRLoculocerebrorenal syndrome of Lowe0.050
SGK3serum/glucocorticoid regulated kinase family, member 30.048
TOM1L1target of myb1 (chicken)-like 10.045
APIPAPAF1 interacting protein0.044
RAB5ARAB5A, member RAS oncogene family0.044
PPFIBP2PTPRF interacting protein, binding protein 2 (liprin beta 2)0.042
PLEKHO1pleckstrin homology domain containing, family O member 10.041
CARD11caspase recruitment domain family, member 110.041
POU5F1POU class 5 homeobox 10.038
TRAF4TNF receptor-associated factor 40.038
VPS24vacuolar protein sorting 24 homolog (S. cerevisiae)0.037
CHMP6chromatin modifying protein 60.037
MED15mediator complex subunit 150.036
SCNN1Asodium channel, nonvoltage-gated 1 alpha0.035
DTX1deltex homolog 1 (Drosophila)0.034
COPAcoatomer protein complex, subunit alpha0.033
ZRANB1zinc finger, RAN-binding domain containing 10.033
SMAD6SMAD family member 60.031
GOLGA5golgin A50.031
NDFIP2Nedd4 family interacting protein 20.031
ADRBK1adrenergic, beta, receptor kinase 10.031
KRT15keratin 150.030
KLF5Kruppel-like factor 5 (intestinal)0.029
UBQLN2ubiquilin 20.029
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.029
YAP1Yes-associated protein 10.029
EIF1Beukaryotic translation initiation factor 1B0.028
CCDC127coiled-coil domain containing 1270.028
EXOC7exocyst complex component 70.027
WNK1WNK lysine deficient protein kinase 10.027
ZFAND5zinc finger, AN1-type domain 50.027
CLTCclathrin, heavy chain (Hc)0.026
ARRDC3arrestin domain containing 30.026
APPL1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.026
SBF1SET binding factor 10.025
ATP6V1E1ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E10.025
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.025
CBLCCas-Br-M (murine) ecotropic retroviral transforming sequence c0.025
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism