The network for 'estrogen metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

estrogen metabolic process

The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.511
hprt1hypoxanthine phosphoribosyltransferase 10.403
igf3insulin-like growth factor 30.343
mstnamyostatin a0.257
comtacatechol-O-methyltransferase a0.234
sult3st2sulfotransferase family 3, cytosolic sulfotransferase 20.162
sult2st2sulfotransferase family 2, cytosolic sulfotransferase 20.158
elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.128
trim71tripartite motif-containing 710.125
hsd17b3hydroxysteroid (17-beta) dehydrogenase 30.123
ripk2receptor-interacting serine-threonine kinase 20.118
casrlcalcium-sensing receptor, like0.117
tbpTATA box binding protein0.113
inhbabinhibin, beta Ab0.113
dio1deiodinase, iodothyronine, type I0.107
ocrloculocerebrorenal syndrome of Lowe0.104
slc4a2bsolute carrier family 4, anion exchanger, member 2b0.104
sgpp1sphingosine-1-phosphate phosphatase 10.103
epas1bendothelial PAS domain protein 1b0.098
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.098
sult2st3sulfotransferase family 2, cytosolic sulfotransferase 30.097
LOC794616chemokine CCL-C10b0.090
epas1aendothelial PAS domain protein 1a0.090
zp3zona pellucida glycoprotein 30.089
vtg1vitellogenin 10.087
cx32.3connexin 32.30.083
insl5binsulin-like 5b0.082
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.081
ndufs8aNADH dehydrogenase (ubiquinone) Fe-S protein 8a0.079
cyp4t8cytochrome P450, family 4, subfamily T, polypeptide 80.076
tob1atransducer of ERBB2, 1a0.075
tuba1tubulin, alpha 10.075
cnp2',3'-cyclic nucleotide 3' phosphodiesterase0.074
starsteroidogenic acute regulatory protein0.073
cyp2p6cytochrome P450, family 2, subfamily P, polypeptide 60.071
btg1B-cell translocation gene 10.071
ptgeslprostaglandin E synthase 2-like0.071
LOC567537chemokine CXCL-C5c0.068
amotl2aangiomotin like 2a0.067
nr3c2nuclear receptor subfamily 3, group C, member 20.064
piwil1piwi-like 1 (Drosophila)0.063
col5a3collagen, type V, alpha 30.062
sqrdlsulfide quinone reductase-like (yeast)0.061
cyp19a1acytochrome P450, family 19, subfamily A, polypeptide 1a0.061
tlr21toll-like receptor 210.060
cyp2ad2cytochrome P450, family 2, subfamily AD, polypeptide 20.060
LOC100150090sphingosine kinase 2-like0.058
ccl-c11bchemokine CCL-C11b0.057
slc34a2asolute carrier family 34 (sodium phosphate), member 2a0.056
vtg6vitellogenin 60.052
oclnboccludin b0.050
sdhasuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)0.050
wnt5awingless-type MMTV integration site family, member 5a0.050
inhbaainhibin, beta Aa0.049
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.048
slc2a9l1solute carrier family 2 (facilitated glucose transporter), member 9-like 10.047
amhanti-Mullerian hormone0.046
spg11spastic paraplegia 110.045
slc8a1bsolute carrier family 8 (sodium/calcium exchanger), member 1b0.044
cav1caveolin 10.044
grifingalectin related inter-fiber protein0.043
slc2a8solute carrier family 2 (facilitated glucose transporter), member 80.043
ogg18-oxoguanine DNA glycosylase0.043
pcsk7proprotein convertase subtilisin/kexin type 70.043
camk2n2calcium/calmodulin-dependent protein kinase II inhibitor 20.043
slc5a8lsolute carrier family 5 (iodide transporter), member 8-like0.042
slc26a6lsolute carrier family 26, member 6, like0.042
itga7integrin, alpha 70.042
cyp2k22cytochrome P450, family 2, subfamily K, polypeptide 220.041
LOC100002494relaxin/insulin-like family peptide receptor 3-like0.041
osbpl7oxysterol binding protein-like 70.041
slc10a2solute carrier family 10 (sodium/bile acid cotransporter family), member 20.040
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.040
sgk1serum/glucocorticoid regulated kinase 10.040
cyp2k16cytochrome P450, family 2, subfamily K, polypeptide160.038
ccl25bchemokine (C-C motif) ligand 25b0.038
pawrlPRKC, apoptosis, WT1, regulator like0.037
lhcgrluteinizing hormone/choriogonadotropin receptor0.037
cyp2y3cytochrome P450, family 2, subfamily Y, polypeptide 30.037
gstalglutathione S-transferase, alpha-like0.036
zp2zona pellucida glycoprotein 20.036
nod1nucleotide-binding oligomerization domain containing 10.035
or125-8odorant receptor, family E, subfamily 125, member 80.035
lgals1l1lectin, galactoside-binding, soluble, 1 (galectin 1)-like 10.034
lgsnlengsin, lens protein with glutamine synthetase domain0.034
hsd17b12bhydroxysteroid (17-beta) dehydrogenase 12b0.034
nr0b1nuclear receptor subfamily 0, group B, member 10.034
mapk8bmitogen-activated protein kinase 8b0.034
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG13310CG13310 gene product from transcript CG13310-RA0.740
Cyp6d5CG3050 gene product from transcript CG3050-RA0.368
JhI-26Juvenile hormone-inducible protein 260.326
Cyp6a21CG10247 gene product from transcript CG10247-RA0.259
CG10562CG10562 gene product from transcript CG10562-RA0.212
Cyp6d4CG12800 gene product from transcript CG12800-RA0.198
Ugt86DhCG4772 gene product from transcript CG4772-RA0.194
CG4302CG4302 gene product from transcript CG4302-RA0.177
CG5873CG5873 gene product from transcript CG5873-RA0.149
CG11149CG11149 gene product from transcript CG11149-RD0.126
CG1387CG1387 gene product from transcript CG1387-RA0.124
CG32379CG32379 gene product from transcript CG32379-RB0.104
CG17597CG17597 gene product from transcript CG17597-RA0.103
CG16898CG16898 gene product from transcript CG16898-RA0.094
Cyp6a13CG2397 gene product from transcript CG2397-RA0.092
CG14457CG14457 gene product from transcript CG14457-RA0.092
Jheh1Juvenile hormone epoxide hydrolase 10.092
Ugt86DjCG15902 gene product from transcript CG15902-RA0.092
CG13658CG13658 gene product from transcript CG13658-RB0.092
CG6465CG6465 gene product from transcript CG6465-RA0.086
CG5361CG5361 gene product from transcript CG5361-RA0.083
CG8292CG8292 gene product from transcript CG8292-RA0.081
CG13510CG13510 gene product from transcript CG13510-RA0.080
CG3702CG3702 gene product from transcript CG3702-RA0.079
Cyp12e1CG14680 gene product from transcript CG14680-RC0.079
Ugt36BaCG13270 gene product from transcript CG13270-RA0.077
Ugt35aUDP-glycosyltransferase 35a0.076
Ugt86DcCG4739 gene product from transcript CG4739-RA0.075
CG9360CG9360 gene product from transcript CG9360-RA0.074
Jheh3Juvenile hormone epoxide hydrolase 30.074
CG9509CG9509 gene product from transcript CG9509-RA0.068
CG13875CG13875 gene product from transcript CG13875-RA0.067
CG1941CG1941 gene product from transcript CG1941-RA0.066
CG16732CG16732 gene product from transcript CG16732-RB0.066
homerCG11324 gene product from transcript CG11324-RC0.063
CG2064CG2064 gene product from transcript CG2064-RA0.060
CG3649CG3649 gene product from transcript CG3649-RB0.058
CG12746CG12746 gene product from transcript CG12746-RD0.057
CG10560CG10560 gene product from transcript CG10560-RA0.056
CG6045CG6045 gene product from transcript CG6045-RA0.056
Syx4Syntaxin 40.053
Spn100ASerpin 100A0.053
CG9331CG9331 gene product from transcript CG9331-RF0.053
CG13258CG13258 gene product from transcript CG13258-RA0.052
GstE3Glutathione S transferase E30.052
CG6830CG6830 gene product from transcript CG6830-RA0.052
Cyp4d14CG3540 gene product from transcript CG3540-RA0.052
CG4462CG4462 gene product from transcript CG4462-RA0.051
CG6834CG6834 gene product from transcript CG6834-RA0.051
CG13189CG13189 gene product from transcript CG13189-RA0.050
CG4653CG4653 gene product from transcript CG4653-RA0.049
CG5167CG5167 gene product from transcript CG5167-RA0.049
CG31792CG31792 gene product from transcript CG31792-RA0.049
CG14655CG14655 gene product from transcript CG14655-RA0.048
CG31097CG31097 gene product from transcript CG31097-RB0.046
CG9512CG9512 gene product from transcript CG9512-RA0.046
CG8773CG8773 gene product from transcript CG8773-RB0.046
Cyp28a5CG8864 gene product from transcript CG8864-RA0.046
CG4324CG4324 gene product from transcript CG4324-RA0.045
CG10226CG10226 gene product from transcript CG10226-RA0.045
CG10550CG10550 gene product from transcript CG10550-RB0.044
CG17028CG17028 gene product from transcript CG17028-RA0.044
CG6178CG6178 gene product from transcript CG6178-RA0.044
CG32054CG32054 gene product from transcript CG32054-RA0.044
CG9527CG9527 gene product from transcript CG9527-RA0.044
CG5976CG5976 gene product from transcript CG5976-RB0.043
CG9416CG9416 gene product from transcript CG9416-RA0.042
CG15661CG15661 gene product from transcript CG15661-RA0.042
CG17109CG17109 gene product from transcript CG17109-RA0.042
mei-W68meiotic W680.042
CG14856CG14856 gene product from transcript CG14856-RA0.041
CG5724CG5724 gene product from transcript CG5724-RA0.041
CG33080CG33080 gene product from transcript CG33080-RA0.041
CG5999CG5999 gene product from transcript CG5999-RB0.041
CG7272CG7272 gene product from transcript CG7272-RA0.041
CG9396CG9396 gene product from transcript CG9396-RA0.040
CG10559CG10559 gene product from transcript CG10559-RB0.040
CG14125CG14125 gene product from transcript CG14125-RA0.040
CG12910CG12910 gene product from transcript CG12910-RA0.040
Acox57D-pacyl-Coenzyme A oxidase at 57D proximal0.040
CG31087CG31087 gene product from transcript CG31087-RA0.039
CG6439CG6439 gene product from transcript CG6439-RA0.039
CG4945CG4945 gene product from transcript CG4945-RA0.038
CG17026CG17026 gene product from transcript CG17026-RA0.038
Ugt86DaCG18578 gene product from transcript CG18578-RA0.038
CG9319CG9319 gene product from transcript CG9319-RA0.038
Cyp9f2CG11466 gene product from transcript CG11466-RB0.038
SansSans ortholog0.038
Hexo2Hexosaminidase 20.037
CG17928CG17928 gene product from transcript CG17928-RA0.037
CG13250CG13250 gene product from transcript CG13250-RA0.037
CG33514CG33514 gene product from transcript CG33514-RA0.036
Rh50CG7499 gene product from transcript CG7499-RA0.036
Ugt37b1UDP-glycosyltransferase 37b10.036
CG11438CG11438 gene product from transcript CG11438-RA0.036
CG18095CG18095 gene product from transcript CG18095-RB0.035
CG1942CG1942 gene product from transcript CG1942-RA0.035
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SULT1A2sulfotransferase family, cytosolic, 1A, phenol-preferring, member 21.000
SULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 11.000
SULT1A4sulfotransferase family, cytosolic, 1A, phenol-preferring, member 41.000
IL1R1interleukin 1 receptor, type I0.482
NF2neurofibromin 2 (merlin)0.407
MPDZmultiple PDZ domain protein0.306
PDGFCplatelet derived growth factor C0.267
ALS2CR12amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 120.235
PDGFAplatelet-derived growth factor alpha polypeptide0.104
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.079
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.063
IL1RAPinterleukin 1 receptor accessory protein0.055
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.052
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.037
SULT1E1sulfotransferase family 1E, estrogen-preferring, member 10.035
IL1RNinterleukin 1 receptor antagonist0.027
PLCG1phospholipase C, gamma 10.024
GABRA3gamma-aminobutyric acid (GABA) A receptor, alpha 30.022
IL8interleukin 80.021
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.019
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.018
MAPK8mitogen-activated protein kinase 80.016
PLAURplasminogen activator, urokinase receptor0.016
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.014
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.012
URODuroporphyrinogen decarboxylase0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.992
Sgpl1sphingosine phosphate lyase 10.890
Plekha1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.868
TiparpTCDD-inducible poly(ADP-ribose) polymerase0.800
Arid5bAT rich interactive domain 5B (MRF1-like)0.642
Kdrkinase insert domain protein receptor0.637
Schip1schwannomin interacting protein 10.166
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.124
Vegfavascular endothelial growth factor A0.082
Csf1colony stimulating factor 1 (macrophage)0.078
Runx2runt related transcription factor 20.076
Flt4FMS-like tyrosine kinase 40.045
Kitlkit ligand0.027
WwoxWW domain-containing oxidoreductase0.026
Cdh5cadherin 50.025
Vegfcvascular endothelial growth factor C0.022
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.022
Tgfbr2transforming growth factor, beta receptor II0.020
Hsd3b6hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 60.019
Gucy1b3guanylate cyclase 1, soluble, beta 30.019
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.018
Eci2enoyl-Coenzyme A delta isomerase 20.015
Nos3nitric oxide synthase 3, endothelial cell0.015
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.013
Acvr1activin A receptor, type 10.013
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.013
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.012
Acaa2acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)0.011
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.011
Ptch1patched homolog 10.011
Itgb1integrin beta 1 (fibronectin receptor beta)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.317
Mgst2microsomal glutathione S-transferase 20.227
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.151
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.126
LOC293989cytochrome P450-like0.122
LOC100361547Cytochrome P450, family 2, subfamily c, polypeptide 7-like0.103
Clca4chloride channel accessory 40.087
Otcornithine carbamoyltransferase0.071
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.070
Ugt1a5UDP glucuronosyltransferase 1 family, polypeptide A50.070
LOC494499LOC494499 protein0.069
Amy2amylase 2, pancreatic0.054
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.048
Zfp37zinc finger protein 370.042
Ugt1a3UDP glycosyltransferase 1 family, polypeptide A30.042
Abcc2ATP-binding cassette, subfamily C (CFTR/MRP), member 20.039
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.031
Cyp17a1cytochrome P450, family 17, subfamily a, polypeptide 10.029
Nr1h4nuclear receptor subfamily 1, group H, member 40.026
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.024
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.023
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.023
Nlrp6NLR family, pyrin domain containing 60.023
Ephx1epoxide hydrolase 1, microsomal0.022
Hao2hydroxyacid oxidase 2 (long chain)0.021
Sfrp4secreted frizzled-related protein 40.021
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.021
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.020
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.020
Prl8a7prolactin family 8, subfamily a, member 70.019
LOC100361864UDP-glucuronosyltransferase 2B3-like0.018
Cd14CD14 molecule0.017
Mug1murinoglobulin 10.017
Ces1ccarboxylesterase 1C0.017
Ugt2b37UDP-glucuronosyltransferase 2 family, member 370.017
Nr5a2nuclear receptor subfamily 5, group A, member 20.017
Sult2al1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring-like 10.017
Apobapolipoprotein B0.016
A1i3alpha-1-inhibitor III0.016
Slco1a1solute carrier organic anion transporter family, member 1a10.016
RGD1305347similar to RIKEN cDNA 2610528J110.015
Spink1serine peptidase inhibitor, Kazal type 10.015
Ptgs2prostaglandin-endoperoxide synthase 20.015
Akr1c18aldo-keto reductase family 1, member C180.015
Cyp2d1cytochrome P450, family 2, subfamily d, polypeptide 10.014
Akr1c14aldo-keto reductase family 1, member C140.014
Ddr2discoidin domain receptor tyrosine kinase 20.014
Zg16zymogen granule protein 160.014
Nat2N-acetyltransferase 20.013
RGD1564865similar to 20-alpha-hydroxysteroid dehydrogenase0.013
Slco1b3solute carrier organic anion transporter family, member 1b30.013
Acaa1bacetyl-Coenzyme A acyltransferase 1B0.013
Olr1697olfactory receptor 16970.013
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.013
Keg1kidney expressed gene 10.013
Mbl2mannose-binding lectin (protein C) 20.013
Decr12,4-dienoyl CoA reductase 1, mitochondrial0.013
Hmgcs23-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)0.012
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.012
Gsta5glutathione S-transferase Yc2 subunit0.012
Vom2r50vomeronasal 2 receptor, 500.012
Ugt1a8UDP glycosyltransferase 1 family, polypeptide A80.012
Mcpt3mast cell peptidase 30.012
Apohapolipoprotein H (beta-2-glycoprotein I)0.012
Tas2r105taste receptor, type 2, member 1050.012
Ugt1a1UDP glucuronosyltransferase 1 family, polypeptide A10.012
Fut1fucosyltransferase 10.012
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.012
Crygfcrystallin, gamma F0.012
Idh1isocitrate dehydrogenase 1 (NADP+), soluble0.012
Pigrpolymeric immunoglobulin receptor0.011
Scn11asodium channel, voltage-gated, type XI, alpha0.011
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.011
Rya3antimicrobial peptide RYA30.011
Fgbfibrinogen beta chain0.011
Slc9a3solute carrier family 9 (sodium/hydrogen exchanger), member 30.011
Ddx4DEAD (Asp-Glu-Ala-Asp) box polypeptide 40.011
Rup2urinary protein 20.011
Pdzk1PDZ domain containing 10.011
Akr1d1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)0.011
Acsm2acyl-CoA synthetase medium-chain family member 20.011
Aldh9a1aldehyde dehydrogenase 9 family, member A10.010
Tdo2tryptophan 2,3-dioxygenase0.010