The network for 'regulation of chromatin silencing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of chromatin silencing

Any process that affects the rate, extent or location of chromatin silencing.

NameDescriptionProbabilityFunc Analog Organism
CTI6Cti6p0.791
RPD3Rpd3p0.752
SIN3Sin3p0.737
RTF1Rtf1p0.667
PHO23Pho23p0.592
NTO1Nto1p0.588
RXT2Rxt2p0.587
UME1Ume1p0.532
RNR2Rnr2p0.485
HOS4Hos4p0.447
HHT1Hht1p0.410
SIR2Sir2p0.381
CKA1Cka1p0.357
SDS3Sds3p0.357
SNT1Snt1p0.341
SET3Set3p0.316
SAP30Sap30p0.301
BDF1Bdf1p0.263
LEO1Leo1p0.257
CDC6Cdc6p0.236
ORC6Orc6p0.229
SIF2Sif2p0.220
YTA7Yta7p0.215
SIR4Sir4p0.205
YML081Whypothetical protein0.194
ORC3Orc3p0.191
HAL5Hal5p0.177
HST1Hst1p0.176
FKH1Fkh1p0.172
DEF1Def1p0.158
RPN4Rpn4p0.155
CTK1Ctk1p0.152
UME6Ume6p0.146
AFT1Aft1p0.137
RSC4Rsc4p0.124
ROX1Rox1p0.118
SNF5Snf5p0.117
HHO1Hho1p0.116
HOT1Hot1p0.113
IES2Ies2p0.113
IRC8Irc8p0.109
ORC4Orc4p0.108
NRG1Nrg1p0.106
ORC2Orc2p0.105
HDA2Hda2p0.105
CTK3Ctk3p0.099
CPR1Cpr1p0.097
YLR455Whypothetical protein0.097
MTR10Mtr10p0.095
MBR1Mbr1p0.094
RIM101Rim101p0.093
KIC1Kic1p0.092
CYC8Cyc8p0.092
EAF3Eaf3p0.092
MIG1Mig1p0.089
CHD1Chd1p0.088
EPL1Epl1p0.087
SGF29Sgf29p0.087
MCM3Mcm3p0.087
DIA2Dia2p0.086
ARP8Arp8p0.083
AGP2Agp2p0.082
YKR075Chypothetical protein0.081
RCO1Rco1p0.081
ABF1Abf1p0.079
SPT20Spt20p0.079
RAP1Rap1p0.078
ASF1Asf1p0.077
HHF2Hhf2p0.074
SPT8Spt8p0.074
MRS6Mrs6p0.074
GIS4Gis4p0.071
YLR278Chypothetical protein0.068
MOT2Mot2p0.065
URE2Ure2p0.064
CAT8Cat8p0.064
SPT3Spt3p0.063
CSR2Csr2p0.063
CLB1Clb1p0.061
GND2Gnd2p0.060
KAP95Kap95p0.059
FKH2Fkh2p0.059
RGS2Rgs2p0.059
CDC4Cdc4p0.058
HOS2Hos2p0.058
KIN3Kin3p0.058
CHL1Chl1p0.058
RXT3Rxt3p0.058
GAT2Gat2p0.057
PUB1Pub1p0.056
SPT10Spt10p0.056
SET2Set2p0.054
NUP1Nup1p0.053
YCL042Whypothetical protein0.053
VAC17Vac17p0.053
ASH1Ash1p0.052
RIM8Rim8p0.052
MET4Met4p0.051
CDC14Cdc14p0.050
HOS3Hos3p0.049
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mod(mdg4)modifier of mdg40.995
e(y)3enhancer of yellow 30.881
waplwings apart-like0.787
CTCFCG8591 gene product from transcript CG8591-RA0.785
lidlittle imaginal discs0.603
BEAF-32Boundary element-associated factor of 32kD0.546
msl-1male-specific lethal 10.506
Chd1Chromodomain-helicase-DNA-binding protein 10.479
His2AvHistone H2A variant0.408
ash1absent, small, or homeotic discs 10.359
Su(var)3-7Suppressor of variegation 3-70.296
E(var)3-9Enhancer of variegation 3-90.284
crmcramped0.235
DekCG5935 gene product from transcript CG5935-RA0.216
Su(var)2-10Suppressor of variegation 2-100.213
Jarid2CG3654 gene product from transcript CG3654-RD0.203
D1D1 chromosomal protein0.166
ChroChromator0.164
PscPosterior sex combs0.163
zzeste0.156
simjsimjang0.149
CG13474CG13474 gene product from transcript CG13474-RA0.142
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.136
cgcombgap0.131
Su(var)3-3Suppressor of variegation 3-30.117
rodrough deal0.117
Pp1-87BProtein phosphatase 1 at 87B0.114
CG3875CG3875 gene product from transcript CG3875-RA0.113
PcPolycomb0.108
CG14204CG14204 gene product from transcript CG14204-RA0.107
Nf-YCNuclear factor Y-box C0.107
Taf4TBP-associated factor 40.106
msl-2male-specific lethal 20.103
Grip84gamma-tubulin ring protein 840.102
ph-dpolyhomeotic distal0.101
TrlTrithorax-like0.100
vtdverthandi0.097
eIF4E-3CG8023 gene product from transcript CG8023-RA0.094
RgaRegena0.093
CG5017CG5017 gene product from transcript CG5017-RA0.088
ScmSex comb on midleg0.084
CycGCyclin G0.084
trxtrithorax0.080
Sir2CG5216 gene product from transcript CG5216-RA0.078
CG11504CG11504 gene product from transcript CG11504-RB0.074
SlbpStem-loop binding protein0.074
pr-set7CG3307 gene product from transcript CG3307-RC0.073
barrbarren0.073
msl-3male-specific lethal 30.071
HcfHost cell factor0.070
prodproliferation disrupter0.069
SuURSuppressor of Under-Replication0.069
gppgrappa0.067
Tsp96FTetraspanin 96F0.067
CG42709CG42709 gene product from transcript CG42709-RC0.067
HmgDHigh mobility group protein D0.067
CG6425CG6425 gene product from transcript CG6425-RA0.066
HP4Heterochromatin protein 40.063
Dp1Dodeca-satellite-binding protein 10.063
sxcsuper sex combs0.062
CG9363CG9363 gene product from transcript CG9363-RB0.060
CG8165CG8165 gene product from transcript CG8165-RA0.059
sinaseven in absentia0.058
otuovarian tumor0.058
bip2CG2009 gene product from transcript CG2009-RA0.057
Orc2Origin recognition complex subunit 20.056
Mst87FMale-specific RNA 87F0.055
ph-ppolyhomeotic proximal0.054
mofmales absent on the first0.053
Mi-2CG8103 gene product from transcript CG8103-RA0.051
scedscrambled0.050
CG2709CG2709 gene product from transcript CG2709-RA0.048
Hr4CG16902 gene product from transcript CG16902-RC0.048
MRG15CG6363 gene product from transcript CG6363-RA0.047
chmchameau0.046
pngpan gu0.045
U2af38U2 small nuclear riboprotein auxiliary factor 380.045
XNPCG4548 gene product from transcript CG4548-RA0.045
howheld out wings0.043
SosSon of sevenless0.042
msd1mitotic spindle density 10.042
CG10630CG10630 gene product from transcript CG10630-RA0.042
TbpTATA binding protein0.042
ImpIGF-II mRNA-binding protein0.042
CG42500CG42500 gene product from transcript CG42500-RA0.041
Acf1ATP-dependent chromatin assembly factor large subunit0.041
Su(var)205Suppressor of variegation 2050.041
InRInsulin-like receptor0.041
kelkelch0.039
crpcropped0.039
GmerGDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase0.039
sinahsina homologue0.039
CG4119CG4119 gene product from transcript CG4119-RA0.039
dalaoCG7055 gene product from transcript CG7055-RA0.039
dltdiscs lost0.039
CG11399CG11399 gene product from transcript CG11399-RB0.038
Nup58Nucleoporin 580.038
Cap-GCG34438 gene product from transcript CG34438-RF0.037
CG10164CG10164 gene product from transcript CG10164-RB0.037
enokenoki mushroom0.037
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HDAC1histone deacetylase 10.976
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.940
EP300E1A binding protein p3000.732
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.666
SP1Sp1 transcription factor0.625
HDAC2histone deacetylase 20.578
SIN3ASIN3 homolog A, transcription regulator (yeast)0.518
CBX5chromobox homolog 50.441
CREBBPCREB binding protein0.436
RB1retinoblastoma 10.299
ESR1estrogen receptor 10.201
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.173
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.164
PAX3paired box 30.157
MCM6minichromosome maintenance complex component 60.134
CSNK2A1casein kinase 2, alpha 1 polypeptide0.126
ORC6origin recognition complex, subunit 60.126
SMURF1SMAD specific E3 ubiquitin protein ligase 10.118
MCM4minichromosome maintenance complex component 40.113
HCFC1host cell factor C1 (VP16-accessory protein)0.112
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.107
BCORBCL6 corepressor0.098
ARID1AAT rich interactive domain 1A (SWI-like)0.091
CBX3chromobox homolog 30.089
DNMT1DNA (cytosine-5-)-methyltransferase 10.088
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.084
ADNPactivity-dependent neuroprotector homeobox0.068
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.066
RBBP4retinoblastoma binding protein 40.063
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.056
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.046
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.043
ORC2origin recognition complex, subunit 20.042
FOXD3forkhead box D30.041
WWP2WW domain containing E3 ubiquitin protein ligase 20.039
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.039
CDC7cell division cycle 7 homolog (S. cerevisiae)0.038
MCM2minichromosome maintenance complex component 20.037
MCM3minichromosome maintenance complex component 30.037
MAPK14mitogen-activated protein kinase 140.034
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.032
SMAD3SMAD family member 30.029
CHD4chromodomain helicase DNA binding protein 40.028
HTThuntingtin0.028
SAP30Sin3A-associated protein, 30kDa0.027
HIST1H3Bhistone cluster 1, H3b0.026
EEDembryonic ectoderm development0.026
MSL2male-specific lethal 2 homolog (Drosophila)0.026
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.025
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.023
NCOR2nuclear receptor corepressor 20.023
ORC3origin recognition complex, subunit 30.023
PCNAproliferating cell nuclear antigen0.021
POGZpogo transposable element with ZNF domain0.021
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.021
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.020
SETD7SET domain containing (lysine methyltransferase) 70.019
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.019
CDYLchromodomain protein, Y-like0.018
CBX1chromobox homolog 10.018
SMAD7SMAD family member 70.017
KAT2BK(lysine) acetyltransferase 2B0.017
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.017
PARP1poly (ADP-ribose) polymerase 10.017
ARID4BAT rich interactive domain 4B (RBP1-like)0.017
SOX2SRY (sex determining region Y)-box 20.015
NQO1NAD(P)H dehydrogenase, quinone 10.015
TALDO1transaldolase 10.014
ORC4origin recognition complex, subunit 40.014
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.014
RCOR1REST corepressor 10.014
HMGA1high mobility group AT-hook 10.014
NCOA3nuclear receptor coactivator 30.013
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.013
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.013
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.013
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.012
CDC6cell division cycle 6 homolog (S. cerevisiae)0.012
CHD3chromodomain helicase DNA binding protein 30.012
DBF4DBF4 homolog (S. cerevisiae)0.012
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.011
MBD1methyl-CpG binding domain protein 10.011
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.011
UHRF1ubiquitin-like with PHD and ring finger domains 10.011
MYST3MYST histone acetyltransferase (monocytic leukemia) 30.010
CHAF1Achromatin assembly factor 1, subunit A (p150)0.010
NCOA1nuclear receptor coactivator 10.010
SOCS1suppressor of cytokine signaling 10.010
RBBP7retinoblastoma binding protein 70.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Sall4sal-like 4 (Drosophila)0.997
NanogNanog homeobox0.996
Arid1aAT rich interactive domain 1A (SWI-like)0.995
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.984
Tcfcp2l1transcription factor CP2-like 10.982
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.949
Hdac1histone deacetylase 10.839
Sp1trans-acting transcription factor 10.771
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.699
Rnf2ring finger protein 20.515
Ncor1nuclear receptor co-repressor 10.485
Nr0b1nuclear receptor subfamily 0, group B, member 10.484
Sox2SRY-box containing gene 20.426
Sall1sal-like 1 (Drosophila)0.417
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.406
Esrrbestrogen related receptor, beta0.393
Ep300E1A binding protein p3000.380
Hdac2histone deacetylase 20.340
Sin3atranscriptional regulator, SIN3A (yeast)0.334
Rnf220ring finger protein 2200.294
Trim24tripartite motif-containing 240.269
Zfp292zinc finger protein 2920.226
Zmym5zinc finger, MYM-type 50.204
Arntlaryl hydrocarbon receptor nuclear translocator-like0.190
Msh2mutS homolog 2 (E. coli)0.188
Nacc1nucleus accumbens associated 1, BEN and BTB (POZ) domain containing0.184
Casp2caspase 20.162
Mll5myeloid/lymphoid or mixed-lineage leukemia 50.162
Kdm5blysine (K)-specific demethylase 5B0.160
Trp53transformation related protein 530.158
Hist1h2bchistone cluster 1, H2bc0.158
Chd4chromodomain helicase DNA binding protein 40.155
Ddx3yDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked0.153
Ccna2cyclin A20.146
Arid2AT rich interactive domain 2 (ARID, RFX-like)0.142
Mta1metastasis associated 10.124
Ep400E1A binding protein p4000.123
Sp3trans-acting transcription factor 30.115
Kiss1KiSS-1 metastasis-suppressor0.113
Erbb2ipErbb2 interacting protein0.113
Hcfc1host cell factor C10.111
Cnot2CCR4-NOT transcription complex, subunit 20.109
Cdk2cyclin-dependent kinase 20.108
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.108
Cdkn1bcyclin-dependent kinase inhibitor 1B0.104
Med23mediator complex subunit 230.103
Dbx1developing brain homeobox 10.101
Rb1retinoblastoma 10.101
Cry1cryptochrome 1 (photolyase-like)0.095
Kdm1alysine (K)-specific demethylase 1A0.086
Mta2metastasis-associated gene family, member 20.086
CrebbpCREB binding protein0.084
Gatad2bGATA zinc finger domain containing 2B0.083
RybpRING1 and YY1 binding protein0.082
Creb1cAMP responsive element binding protein 10.080
Arid1bAT rich interactive domain 1B (SWI-like)0.079
NipblNipped-B homolog (Drosophila)0.078
Mta3metastasis associated 30.077
Mbtd1mbt domain containing 10.073
Mecp2methyl CpG binding protein 20.071
Yy1YY1 transcription factor0.067
Ighimmunoglobulin heavy chain complex0.066
Hist3h2bb-pshistone cluster 3, H2bb, pseudogene0.066
Per2period homolog 2 (Drosophila)0.066
Supt16hsuppressor of Ty 16 homolog (S. cerevisiae)0.065
2210018M11RikRIKEN cDNA 2210018M11 gene0.064
Bod1lbiorientation of chromosomes in cell division 1-like0.063
L3mbtl2l(3)mbt-like 2 (Drosophila)0.062
Pias1protein inhibitor of activated STAT 10.062
Pou5f1POU domain, class 5, transcription factor 10.061
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.061
Zscan4bzinc finger and SCAN domain containing 4B0.060
Pou2f1POU domain, class 2, transcription factor 10.059
Tet1tet oncogene 10.059
Nfatc3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 30.056
Sall3sal-like 3 (Drosophila)0.055
Zmym2zinc finger, MYM-type 20.051
Prpf8pre-mRNA processing factor 80.050
Tet2tet oncogene family member 20.050
CtcfCCCTC-binding factor0.050
Atmataxia telangiectasia mutated homolog (human)0.050
Stag1stromal antigen 10.049
Clockcircadian locomotor output cycles kaput0.048
Rif1Rap1 interacting factor 1 homolog (yeast)0.048
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.047
Smc3structural maintenace of chromosomes 30.046
Cdk1cyclin-dependent kinase 10.046
Epc1enhancer of polycomb homolog 1 (Drosophila)0.046
Ctbp2C-terminal binding protein 20.045
RestRE1-silencing transcription factor0.045
Cenpecentromere protein E0.045
Ghrgrowth hormone receptor0.045
Pum2pumilio 2 (Drosophila)0.044
Foxp1forkhead box P10.044
MgaMAX gene associated0.043
Kdm3alysine (K)-specific demethylase 3A0.043
Dyrk1adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a0.042
Eif2s3yeukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked0.042
Rararetinoic acid receptor, alpha0.042
Foxo3forkhead box O30.042
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism