The network for 'cellular response to xenobiotic stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to xenobiotic stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cyp1acytochrome P450, family 1, subfamily A0.649
cyp3a65cytochrome P450, family 3, subfamily A, polypeptide 650.559
idh1isocitrate dehydrogenase 1 (NADP+), soluble0.359
mbnl2muscleblind-like 2 (Drosophila)0.352
cyp3c1cytochrome P450, family 3, subfamily c, polypeptide 10.351
aqp1a.1aquaporin 1a, tandem duplicate 10.333
sult1st4sulfotransferase family 1, cytosolic sulfotransferase 40.297
cyp51cytochrome P450, family 510.297
ca2carbonic anhydrase II0.262
pla2g12bphospholipase A2, group XIIB0.245
epas1aendothelial PAS domain protein 1a0.240
maomonoamine oxidase0.200
slc9a3.2solute carrier family 9 (sodium/hydrogen exchanger), member 3.20.194
slc26a6lsolute carrier family 26, member 6, like0.176
cyp2y3cytochrome P450, family 2, subfamily Y, polypeptide 30.153
angptl6angiopoietin-like 60.137
aldobaldolase b, fructose-bisphosphate0.133
sult3st2sulfotransferase family 3, cytosolic sulfotransferase 20.130
slc40a1solute carrier family 40 (iron-regulated transporter), member 10.125
lgals2blectin, galactoside-binding, soluble, 2b0.125
atp6v1alATPase, H+ transporting, lysosomal V1 subunit A, like0.122
sparcsecreted acidic cysteine rich glycoprotein0.122
cacnb2acalcium channel, voltage-dependent, beta 2a0.121
znf711zinc finger protein 7110.121
apoa1apolipoprotein A-I0.119
chsy1chondroitin sulfate synthase 10.115
sepp1aselenoprotein P, plasma, 1a0.110
arandrogen receptor0.108
slc34a2asolute carrier family 34 (sodium phosphate), member 2a0.106
angptl3angiopoietin-like 30.096
ccl-c11bchemokine CCL-C11b0.093
mep1a.1meprin A, alpha.10.090
sult1st3sulfotransferase family 1, cytosolic sulfotransferase 30.089
klfdKruppel-like factor d0.085
gstt1bglutathione S-transferase theta 1b0.085
dio1deiodinase, iodothyronine, type I0.084
igfbp2ainsulin-like growth factor binding protein 2a0.084
cyp1d1cytochrome P450, family 1, subfamily D, polypeptide 10.083
slc16a12bsolute carrier family 16 (monocarboxylic acid transporters), member 12b0.081
sult6b1sulfotransferase family, cytosolic, 6b, member 10.080
acy3.2aspartoacylase (aminocyclase) 3.20.079
abca12ATP-binding cassette, sub-family A (ABC1), member 120.078
nfe2l2nuclear factor (erythroid-derived 2)-like 20.077
LOC790901glucose-dependent insulinotropic polypeptide0.076
cyp2aa1cytochrome P450, family 2, subfamily AA, polypeptide 10.074
nr3c2nuclear receptor subfamily 3, group C, member 20.074
ccl25bchemokine (C-C motif) ligand 25b0.073
ctsl.1cathepsin L.10.070
ptgdsprostaglandin D2 synthase0.069
card9caspase recruitment domain family, member 90.067
sult3st1sulfotransferase family 3, cytosolic sulfotransferase 10.066
fa2hfatty acid 2-hydroxylase0.066
cbr1lcarbonyl reductase 1-like0.065
rnf10ring finger protein 100.063
rnf11ring finger protein 110.062
igf3insulin-like growth factor 30.062
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.061
baxbbcl2-associated X protein, b0.061
slc26a3solute carrier family 26, member 30.061
comtacatechol-O-methyltransferase a0.060
rnasel3ribonuclease like 30.060
LOC568935ARF GTPase-activating protein GIT1-like0.060
myo18l2myosin XVIII-like 20.059
plekhg4pleckstrin homology domain containing, family G (with RhoGef domain) member 40.059
hoxc13bhomeo box C13b0.058
nt5e5'-nucleotidase, ecto (CD73)0.058
sqrdlsulfide quinone reductase-like (yeast)0.058
gstp1glutathione S-transferase pi0.058
aqp3aaquaporin 3a0.057
nod1nucleotide-binding oligomerization domain containing 10.055
sat1aspermidine/spermine N1-acetyltransferase 1a0.055
slc4a1bsolute carrier family 4, anion exchanger, member 1b0.055
ctsdcathepsin D0.054
spock3sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 30.054
keap1akelch-like ECH-associated protein 1a0.054
arhgap29bRho GTPase activating protein 29b0.053
kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.053
vasavasa homolog0.053
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.052
nadkaNAD kinase a0.050
igfbp1ainsulin-like growth factor binding protein 1a0.050
cyp4t8cytochrome P450, family 4, subfamily T, polypeptide 80.049
fbp1afructose-1,6-bisphosphatase 1a0.049
sox7SRY-box containing gene 70.048
LOC565839tumor necrosis factor alpha-induced protein 2-like0.048
lims1LIM and senescent cell antigen-like domains 10.048
apoa4apolipoprotein A-IV0.047
cx32.3connexin 32.30.046
ftr82finTRIM family, member 820.046
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ugt35aUDP-glycosyltransferase 35a0.495
Cyp6d5CG3050 gene product from transcript CG3050-RA0.175
JhI-26Juvenile hormone-inducible protein 260.174
Cyp6a21CG10247 gene product from transcript CG10247-RA0.139
Cyp28d1CG10833 gene product from transcript CG10833-RA0.099
Cyp6a23CG10242 gene product from transcript CG10242-RA0.073
UchUbiquitin carboxy-terminal hydrolase0.068
Prosbeta3Proteasome beta3 subunit0.059
Cyp6a9Cytochrome P450-6a90.057
Cyp12a4CG6042 gene product from transcript CG6042-RA0.035
CG10562CG10562 gene product from transcript CG10562-RA0.032
Cyp12a5CG11821 gene product from transcript CG11821-RA0.026
CG6830CG6830 gene product from transcript CG6830-RA0.026
Cyp12e1CG14680 gene product from transcript CG14680-RC0.023
LvpDLarval visceral protein D0.023
Cyp6a2Cytochrome P450-6a20.022
Jheh1Juvenile hormone epoxide hydrolase 10.019
Cyp6a13CG2397 gene product from transcript CG2397-RA0.019
Cyp28a5CG8864 gene product from transcript CG8864-RA0.019
GstE6Glutathione S transferase E60.017
Prosbeta7Proteasome beta7 subunit0.017
Cyp6a22CG10240 gene product from transcript CG10240-RA0.016
Acox57D-pacyl-Coenzyme A oxidase at 57D proximal0.016
CG9360CG9360 gene product from transcript CG9360-RA0.015
CG6834CG6834 gene product from transcript CG6834-RA0.014
Pros25Proteasome 25kD subunit0.014
Cyp6g1CG8453 gene product from transcript CG8453-RA0.013
Cyp4e2Cytochrome P450-4e20.013
Cyp6d4CG12800 gene product from transcript CG12800-RA0.012
CG2064CG2064 gene product from transcript CG2064-RA0.012
Cyp4p1Cytochrome P450-4p10.012
EpacCG34392 gene product from transcript CG34392-RC0.011
CG12672CG12672 gene product from transcript CG12672-RA0.010
Ugt86DaCG18578 gene product from transcript CG18578-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GSTM1glutathione S-transferase mu 10.999
GSTM2glutathione S-transferase mu 2 (muscle)0.999
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.997
S100BS100 calcium binding protein B0.990
RARAretinoic acid receptor, alpha0.969
UGT1A1UDP glucuronosyltransferase 1 family, polypeptide A10.965
SULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.952
UGT1A3UDP glucuronosyltransferase 1 family, polypeptide A30.951
S100A4S100 calcium binding protein A40.950
RXRAretinoid X receptor, alpha0.948
MDM2Mdm2 p53 binding protein homolog (mouse)0.941
SULT1A2sulfotransferase family, cytosolic, 1A, phenol-preferring, member 20.932
SULT1A4sulfotransferase family, cytosolic, 1A, phenol-preferring, member 40.913
S100A1S100 calcium binding protein A10.878
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.850
S100A16S100 calcium binding protein A160.840
S100A6S100 calcium binding protein A60.811
GSTM4glutathione S-transferase mu 40.799
ANXA2annexin A20.785
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.695
S100A14S100 calcium binding protein A140.659
NR0B1nuclear receptor subfamily 0, group B, member 10.559
MED25mediator complex subunit 250.556
CASP9caspase 9, apoptosis-related cysteine peptidase0.471
NCOR2nuclear receptor corepressor 20.417
CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 430.415
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.412
S100A11S100 calcium binding protein A110.385
CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 60.313
HRhairless homolog (mouse)0.289
XIAPX-linked inhibitor of apoptosis0.243
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.237
UGT1A9UDP glucuronosyltransferase 1 family, polypeptide A90.226
NCOA1nuclear receptor coactivator 10.223
ALS2CR12amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 120.219
C6complement component 60.205
CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 40.199
UGT2B15UDP glucuronosyltransferase 2 family, polypeptide B150.191
PLP2proteolipid protein 2 (colonic epithelium-enriched)0.178
GSTM3glutathione S-transferase mu 3 (brain)0.169
APAF1apoptotic peptidase activating factor 10.156
SPOPspeckle-type POZ protein0.154
CYP3A7cytochrome P450, family 3, subfamily A, polypeptide 70.146
NR0B2nuclear receptor subfamily 0, group B, member 20.130
A1CFAPOBEC1 complementation factor0.127
OTCornithine carbamoyltransferase0.127
HIPK2homeodomain interacting protein kinase 20.126
CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 190.124
AGERadvanced glycosylation end product-specific receptor0.123
FKBP4FK506 binding protein 4, 59kDa0.108
SULT1E1sulfotransferase family 1E, estrogen-preferring, member 10.103
TIMP2TIMP metallopeptidase inhibitor 20.102
MASP2mannan-binding lectin serine peptidase 20.097
UGT1A7UDP glucuronosyltransferase 1 family, polypeptide A70.096
SULT1B1sulfotransferase family, cytosolic, 1B, member 10.094
CYP2C18cytochrome P450, family 2, subfamily C, polypeptide 180.092
SLC2A2solute carrier family 2 (facilitated glucose transporter), member 20.081
HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)0.080
GSTM5glutathione S-transferase mu 50.075
KNG1kininogen 10.072
S100A2S100 calcium binding protein A20.071
FMO4flavin containing monooxygenase 40.071
HRGhistidine-rich glycoprotein0.071
ADH6alcohol dehydrogenase 6 (class V)0.068
FAM46Afamily with sequence similarity 46, member A0.067
UGT2B17UDP glucuronosyltransferase 2 family, polypeptide B170.063
LGALS3lectin, galactoside-binding, soluble, 30.063
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.062
F9coagulation factor IX0.062
ESR1estrogen receptor 10.062
LGALS1lectin, galactoside-binding, soluble, 10.061
TMSB10thymosin beta 100.060
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.059
NAT2N-acetyltransferase 2 (arylamine N-acetyltransferase)0.059
NR1I2nuclear receptor subfamily 1, group I, member 20.058
SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.057
S100A8S100 calcium binding protein A80.054
XDHxanthine dehydrogenase0.054
NPLOC4nuclear protein localization 4 homolog (S. cerevisiae)0.054
S100A9S100 calcium binding protein A90.054
C8Bcomplement component 8, beta polypeptide0.054
PROX1prospero homeobox 10.052
AADACarylacetamide deacetylase (esterase)0.051
NR1I3nuclear receptor subfamily 1, group I, member 30.051
PGRprogesterone receptor0.050
ALDOBaldolase B, fructose-bisphosphate0.050
CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 50.049
FTLferritin, light polypeptide0.049
PIK3C2Gphosphoinositide-3-kinase, class 2, gamma polypeptide0.047
CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 120.047
C8Acomplement component 8, alpha polypeptide0.046
GABRA3gamma-aminobutyric acid (GABA) A receptor, alpha 30.044
SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.043
HAO1hydroxyacid oxidase (glycolate oxidase) 10.042
BHMTbetaine--homocysteine S-methyltransferase0.041
NR1H4nuclear receptor subfamily 1, group H, member 40.040
SULT2B1sulfotransferase family, cytosolic, 2B, member 10.039
TM4SF4transmembrane 4 L six family member 40.039
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gstm1glutathione S-transferase, mu 10.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.983
Gstm1glutathione S-transferase mu 10.963
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.963
Ephx1epoxide hydrolase 1, microsomal0.948
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.933
Gsta3glutathione S-transferase A30.897
Mgst1microsomal glutathione S-transferase 10.825
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.804
Apobapolipoprotein B0.695
Ugt1a6UDP glucuronosyltransferase 1 family, polypeptide A60.547
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.510
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.488
Cyp2b2cytochrome P450, family 2, subfamily b, polypeptide 20.478
LOC293989cytochrome P450-like0.470
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.467
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.463
Ugt2b37UDP-glucuronosyltransferase 2 family, member 370.438
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.427
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.401
Mgst2microsomal glutathione S-transferase 20.370
Gsta5glutathione S-transferase Yc2 subunit0.294
Otcornithine carbamoyltransferase0.264
Gstm2glutathione S-transferase mu 20.248
Hsph1heat shock 105/110 protein 10.248
Gsta2glutathione S-transferase A20.246
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.236
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.227
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.221
Cyp1a1cytochrome P450, family 1, subfamily a, polypeptide 10.207
Cyb5acytochrome b5 type A (microsomal)0.197
Selenbp1selenium binding protein 10.182
LOC100361864UDP-glucuronosyltransferase 2B3-like0.171
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.152
Cyp4a2cytochrome P450, family 4, subfamily a, polypeptide 20.152
Akr1c14aldo-keto reductase family 1, member C140.152
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.149
Gstp1glutathione S-transferase pi 10.141
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.139
Gckrglucokinase (hexokinase 4) regulator0.134
Ces1fcarboxylesterase 1F0.131
Mettl7bmethyltransferase like 7B0.122
Ces1ecarboxylesterase 1E0.122
Crygfcrystallin, gamma F0.116
Cyp2f4cytochrome P450, family 2, subfamily f, polypeptide 40.109
Ugt1a1UDP glucuronosyltransferase 1 family, polypeptide A10.106
A1i3alpha-1-inhibitor III0.104
Gstt1glutathione S-transferase theta 10.102
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.101
Akr1c18aldo-keto reductase family 1, member C180.099
LOC100361547Cytochrome P450, family 2, subfamily c, polypeptide 7-like0.097
Cyp3a9cytochrome P450, family 3, subfamily a, polypeptide 90.096
Hpd4-hydroxyphenylpyruvate dioxygenase0.096
Cyp2b15cytochrome P450, family 2, subfamily b, polypeptide 150.094
Cyb5r3cytochrome b5 reductase 30.086
Abcc2ATP-binding cassette, subfamily C (CFTR/MRP), member 20.081
LOC494499LOC494499 protein0.080
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.078
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.071
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.069
Dhfrdihydrofolate reductase0.068
Hprt1hypoxanthine phosphoribosyltransferase 10.067
Nr5a2nuclear receptor subfamily 5, group A, member 20.064
Ugt1a3UDP glycosyltransferase 1 family, polypeptide A30.063
Aqp9aquaporin 90.061
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.060
Hsd17b6hydroxysteroid (17-beta) dehydrogenase 60.058
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.057
Azgp1alpha-2-glycoprotein 1, zinc-binding0.057
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.057
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.056
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.055
Tstthiosulfate sulfurtransferase0.055
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.054
Galnt5UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)0.052
Keg1kidney expressed gene 10.051
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.049
Dpyddihydropyrimidine dehydrogenase0.046
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.045
Cps1carbamoyl-phosphate synthetase 10.045
Cyp2c12cytochrome P450, family 2, subfamily c, polypeptide 120.044
Ces1ccarboxylesterase 1C0.044
Mbl2mannose-binding lectin (protein C) 20.044
Sult2al1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring-like 10.043
Cyp27a1cytochrome P450, family 27, subfamily a, polypeptide 10.042
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.041
Idh1isocitrate dehydrogenase 1 (NADP+), soluble0.041
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.040
Clrn3clarin 30.040
Hes2hairy and enhancer of split 2 (Drosophila)0.038
Klrc2killer cell lectin-like receptor subfamily C, member 20.038
Gsta4glutathione S-transferase alpha 40.037
Sult2a1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.037
Pparaperoxisome proliferator activated receptor alpha0.037
Ugt1a7cUDP glucuronosyltransferase 1 family, polypeptide A7C0.036
Slco1a1solute carrier organic anion transporter family, member 1a10.035
Fabp1fatty acid binding protein 1, liver0.035
Pigrpolymeric immunoglobulin receptor0.034