The network for 'negative regulation of heart growth' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of heart growth

Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.

NameDescriptionProbabilityFunc Analog Organism
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.935
HDAC1histone deacetylase 10.903
STK3serine/threonine kinase 30.365
CABLES1Cdk5 and Abl enzyme substrate 10.345
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.272
KRT5keratin 50.265
MDM2Mdm2 p53 binding protein homolog (mouse)0.242
RASSF1Ras association (RalGDS/AF-6) domain family member 10.204
GATA4GATA binding protein 40.122
AXIN1axin 10.103
TP53tumor protein p530.090
SATB2SATB homeobox 20.081
TGFB1transforming growth factor, beta 10.079
YAP1Yes-associated protein 10.074
TGFB3transforming growth factor, beta 30.058
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.057
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.055
PTPN14protein tyrosine phosphatase, non-receptor type 140.053
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.051
SEC16ASEC16 homolog A (S. cerevisiae)0.039
RASSF3Ras association (RalGDS/AF-6) domain family member 30.037
DTX1deltex homolog 1 (Drosophila)0.030
BMP2bone morphogenetic protein 20.030
STK4serine/threonine kinase 40.030
TP73tumor protein p730.029
KRT6Ckeratin 6C0.029
TGFBR1transforming growth factor, beta receptor 10.024
SUZ12suppressor of zeste 12 homolog (Drosophila)0.024
S1PR5sphingosine-1-phosphate receptor 50.023
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.023
PPP1R13Bprotein phosphatase 1, regulatory (inhibitor) subunit 13B0.022
AMOTL1angiomotin like 10.022
SMAD7SMAD family member 70.021
TBX5T-box 50.021
TGFBR3transforming growth factor, beta receptor III0.020
FSTL1follistatin-like 10.020
TBX1T-box 10.020
ZNF676zinc finger protein 6760.019
CSNK1Ecasein kinase 1, epsilon0.018
CHD4chromodomain helicase DNA binding protein 40.018
NEDD9neural precursor cell expressed, developmentally down-regulated 90.018
NRP1neuropilin 10.017
SGK3serum/glucocorticoid regulated kinase family, member 30.015
TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor)0.014
KIR3DL2killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 20.014
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.014
AMOTL2angiomotin like 20.014
PYYpeptide YY0.014
FGF3fibroblast growth factor 30.013
AXIN2axin 20.013
GATA5GATA binding protein 50.013
RASSF5Ras association (RalGDS/AF-6) domain family member 50.013
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.013
RCOR1REST corepressor 10.013
SLC6A4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.013
TP53BP2tumor protein p53 binding protein, 20.012
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.012
LBX1ladybird homeobox 10.012
HDAC3histone deacetylase 30.011
SKIv-ski sarcoma viral oncogene homolog (avian)0.011
CDK2AP1cyclin-dependent kinase 2 associated protein 10.011
HNRNPCL1heterogeneous nuclear ribonucleoprotein C-like 10.011
CXCR3chemokine (C-X-C motif) receptor 30.011
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.011
BRD7bromodomain containing 70.011
CBLCCas-Br-M (murine) ecotropic retroviral transforming sequence c0.011
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.011
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.011
SCUBE1signal peptide, CUB domain, EGF-like 10.011
FOXE1forkhead box E1 (thyroid transcription factor 2)0.011
SIX2SIX homeobox 20.011
XRCC1X-ray repair complementing defective repair in Chinese hamster cells 10.010
ERN1endoplasmic reticulum to nucleus signaling 10.010
PAX5paired box 50.010
SAP30Sin3A-associated protein, 30kDa0.010
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.010
SMAD1SMAD family member 10.010
MT3metallothionein 30.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 10.882
Fgfr2fibroblast growth factor receptor 20.876
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.802
Shhsonic hedgehog0.575
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.570
Apcadenomatosis polyposis coli0.485
Sox9SRY-box containing gene 90.484
Bmp4bone morphogenetic protein 40.419
Ptpn11protein tyrosine phosphatase, non-receptor type 110.309
Hdac1histone deacetylase 10.289
Nos3nitric oxide synthase 3, endothelial cell0.286
Foxc2forkhead box C20.205
Tgfb2transforming growth factor, beta 20.201
Vegfavascular endothelial growth factor A0.190
Fgfr3fibroblast growth factor receptor 30.185
Trp53transformation related protein 530.172
Foxc1forkhead box C10.144
Sox2SRY-box containing gene 20.139
Hand2heart and neural crest derivatives expressed transcript 20.124
Axin1axin 10.122
Efnb2ephrin B20.113
Ptch1patched homolog 10.113
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.109
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.105
Meox2mesenchyme homeobox 20.097
Fbn1fibrillin 10.095
Tgfbr1transforming growth factor, beta receptor I0.093
Psen1presenilin 10.090
Ptenphosphatase and tensin homolog0.082
Rarbretinoic acid receptor, beta0.080
Egfrepidermal growth factor receptor0.080
Smad4MAD homolog 4 (Drosophila)0.077
Csf1colony stimulating factor 1 (macrophage)0.077
Bmp2bone morphogenetic protein 20.076
Cdh5cadherin 50.072
Tcfap2atranscription factor AP-2, alpha0.068
Itgb1integrin beta 1 (fibronectin receptor beta)0.065
Acvr1activin A receptor, type 10.064
Pax3paired box gene 30.063
Ror2receptor tyrosine kinase-like orphan receptor 20.057
Trp63transformation related protein 630.057
Sin3atranscriptional regulator, SIN3A (yeast)0.054
Hand1heart and neural crest derivatives expressed transcript 10.053
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.053
Mdm2transformed mouse 3T3 cell double minute 20.052
Tbx1T-box 10.052
Vangl2vang-like 2 (van gogh, Drosophila)0.051
Lrp6low density lipoprotein receptor-related protein 60.047
Bmpr1abone morphogenetic protein receptor, type 1A0.046
Tbx5T-box 50.043
Rxraretinoid X receptor alpha0.040
Smosmoothened homolog (Drosophila)0.039
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.038
Smad3MAD homolog 3 (Drosophila)0.037
Mta2metastasis-associated gene family, member 20.037
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.034
Runx2runt related transcription factor 20.032
BrafBraf transforming gene0.031
Tbx3T-box 30.031
Pitx2paired-like homeodomain transcription factor 20.029
Jag1jagged 10.029
Egfl7EGF-like domain 70.029
Rararetinoic acid receptor, alpha0.028
Gata4GATA binding protein 40.028
Atp7aATPase, Cu++ transporting, alpha polypeptide0.028
Hdac2histone deacetylase 20.026
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.026
Prrx1paired related homeobox 10.025
Gja1gap junction protein, alpha 10.024
Otx2orthodenticle homolog 2 (Drosophila)0.024
Cdx2caudal type homeobox 20.023
Ighmbp2immunoglobulin mu binding protein 20.022
Arid1aAT rich interactive domain 1A (SWI-like)0.022
Adam17a disintegrin and metallopeptidase domain 170.022
Fgf8fibroblast growth factor 80.021
Emx2empty spiracles homolog 2 (Drosophila)0.021
Fgfr1fibroblast growth factor receptor 10.021
Lmnalamin A0.020
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.019
Sall4sal-like 4 (Drosophila)0.019
Hey2hairy/enhancer-of-split related with YRPW motif 20.019
Loxlysyl oxidase0.018
Ccnd1cyclin D10.018
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.017
Zfp932zinc finger protein 9320.017
Emx1empty spiracles homolog 1 (Drosophila)0.016
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.016
Chd7chromodomain helicase DNA binding protein 70.014
Kif3akinesin family member 3A0.014
Gli3GLI-Kruppel family member GLI30.013
Hprthypoxanthine guanine phosphoribosyl transferase0.013
Alx1ALX homeobox 10.013
Bmp7bone morphogenetic protein 70.012
Hmgb1high mobility group box 10.012
Dot1lDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.011
Csdacold shock domain protein A0.011
Nkx2-1NK2 homeobox 10.011
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.011
Msx2homeobox, msh-like 20.010
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cav1caveolin 1, caveolae protein0.982
LOC100362824caveolin 2-like0.953
Cav2caveolin 20.891
Timp3TIMP metallopeptidase inhibitor 30.294
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.236
Emp1epithelial membrane protein 10.233
Nek9NIMA (never in mitosis gene a)- related kinase 90.188
Lamc1laminin, gamma 10.084
Dnah2dynein, axonemal, heavy chain 20.077
Smad7SMAD family member 70.069
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.066
Dusp7dual specificity phosphatase 70.065
Pecam1platelet/endothelial cell adhesion molecule 10.058
Olr857olfactory receptor 8570.053
Arntaryl hydrocarbon receptor nuclear translocator0.049
Nos3nitric oxide synthase 3, endothelial cell0.047
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.045
Rararetinoic acid receptor, alpha0.043
St3gal3ST3 beta-galactoside alpha-2,3-sialyltransferase 30.043
Mef2dmyocyte enhancer factor 2D0.041
Slc28a1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.041
Efnb1ephrin B10.040
Gja5gap junction protein, alpha 50.038
Fgfr1Fibroblast growth factor receptor 10.037
SnrkSNF related kinase0.037
Zfp37zinc finger protein 370.035
Myo1cmyosin IC0.035
Cox6a2cytochrome c oxidase, subunit VIa, polypeptide 20.032
Adam10ADAM metallopeptidase domain 100.032
Cd9CD9 molecule0.032
Sbk1SH3-binding domain kinase 10.032
Jak1Janus kinase 10.032
Vegfavascular endothelial growth factor A0.031
Dhrs7cdehydrogenase/reductase (SDR family) member 7C0.031
Arsbarylsulfatase B0.031
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.030
Camkk2calcium/calmodulin-dependent protein kinase kinase 2, beta0.028
Tcf12transcription factor 120.028
Rap1aRAP1A, member of RAS oncogene family0.028
Gja1gap junction protein, alpha 10.028
Stx2syntaxin 20.026
Rnase4ribonuclease, RNase A family 40.026
Esamendothelial cell adhesion molecule0.026
Dlc1deleted in liver cancer 10.026
Ppardperoxisome proliferator-activated receptor delta0.026
Lamb2laminin, beta 20.026
Fabp6fatty acid binding protein 6, ileal0.026
Slc4a4solute carrier family 4, sodium bicarbonate cotransporter, member 40.025
Socs2suppressor of cytokine signaling 20.025
Ehd2EH-domain containing 20.025
Myo1bmyosin Ib0.023
Notch2Notch homolog 2 (Drosophila)0.023
Fbln5fibulin 50.023
Nedd4neural precursor cell expressed, developmentally down-regulated 40.023
Defb1defensin beta 10.023
Epn2epsin 20.022
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.022
Strnstriatin, calmodulin binding protein0.022
Galnt1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)0.022
Gna12guanine nucleotide binding protein (G protein) alpha 120.022
Cald1caldesmon 10.022
Rab27aRAB27A, member RAS oncogene family0.021
Ppicpeptidylprolyl isomerase C0.021
KitlgKIT ligand0.021
Epcamepithelial cell adhesion molecule0.021
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.021
Olr1469olfactory receptor Olr14690.021
Col15a1collagen, type XV, alpha 10.021
Dlg4discs, large homolog 4 (Drosophila)0.021
Abcc2ATP-binding cassette, subfamily C (CFTR/MRP), member 20.021
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.021
Adam17ADAM metallopeptidase domain 170.020
Fgf17fibroblast growth factor 170.020
Gabrpgamma-aminobutyric acid (GABA-A) receptor, pi0.020
Sstr4somatostatin receptor 40.020
Icam2intercellular adhesion molecule 20.020
Ptpn12protein tyrosine phosphatase, non-receptor type 120.020
Sp1Sp1 transcription factor0.018
Arnt2aryl hydrocarbon receptor nuclear translocator 20.018
Slc6a20solute carrier family 6 (proline IMINO transporter), member 200.018
Zadh2zinc binding alcohol dehydrogenase, domain containing 20.018
Tubtubby homolog (mouse)0.018
Gpr4G protein-coupled receptor 40.018
Cox8bcytochrome c oxidase, subunit VIIIb0.018
Akt2v-akt murine thymoma viral oncogene homolog 20.017
Sdprserum deprivation response0.017
Asb2ankyrin repeat and SOCS box-containing 20.017
Lmcd1LIM and cysteine-rich domains 10.017
Nxph4neurexophilin 40.017
Prp15proline-rich protein 150.017
Cntfrciliary neurotrophic factor receptor0.016
Cyb5r3cytochrome b5 reductase 30.016
Aoc3amine oxidase, copper containing 3 (vascular adhesion protein 1)0.016
Eltd1EGF, latrophilin and seven transmembrane domain containing 10.016
Sept10septin 100.016
Fhl1four and a half LIM domains 10.016
Cntfciliary neurotrophic factor0.016
Efemp1EGF-containing fibulin-like extracellular matrix protein 10.016