The network for 'positive regulation of histone modification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of histone modification

Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone.

NameDescriptionProbabilityFunc Analog Organism
YLR264C-Ahypothetical protein0.011
YLR162Whypothetical protein0.011
YOL038C-Ahypothetical protein0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
rif1RAP1 interacting factor homolog (yeast)0.310
sephs1selenophosphate synthetase 10.166
pcnaproliferating cell nuclear antigen0.161
dnmt1DNA (cytosine-5-)-methyltransferase 10.115
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.113
mpxmyeloid-specific peroxidase0.106
hdac1histone deacetylase 10.102
tcea1transcription elongation factor A (SII), 10.101
znf703zinc finger protein 7030.100
ube2iubiquitin-conjugating enzyme E2I0.099
hirip3HIRA interacting protein 30.095
mapk1mitogen-activated protein kinase 10.093
naspnuclear autoantigenic sperm protein (histone-binding)0.089
csf3rcolony stimulating factor 3 receptor (granulocyte)0.087
apex1APEX nuclease (multifunctional DNA repair enzyme) 10.078
gins2GINS complex subunit 20.077
cse1lchromosome segregation 1-like (S. cerevisiae)0.071
pola2polymerase (DNA directed), alpha 20.068
wnk1WNK lysine deficient protein kinase 10.065
pold1polymerase (DNA directed), delta 1, catalytic subunit0.064
dnmt3DNA (cytosine-5-)-methyltransferase 30.064
orc5origin recognition complex, subunit 50.063
akap12bA kinase (PRKA) anchor protein (gravin) 12b0.062
rx1retinal homeobox gene 10.061
dnttdeoxynucleotidyltransferase, terminal0.060
ahctf1AT hook containing transcription factor 10.059
ilf3ainterleukin enhancer binding factor 3a0.058
agtr2angiotensin II receptor, type 20.054
aurkbaurora kinase B0.053
cbx1achromobox homolog 1a (HP1 beta homolog Drosophila)0.053
usp1ubiquitin specific protease 10.053
runx1runt-related transcription factor 10.051
stilTAL1 (SCL) interrupting locus0.050
rpa1replication protein A10.050
gata1aGATA binding protein 1a0.050
chek1CHK1 checkpoint homolog (S. pombe)0.050
rargaretinoic acid receptor gamma a0.050
rhagRhesus blood group-associated glycoprotein0.049
cdc23CDC23 (cell division cycle 23, yeast, homolog)0.048
srmspermidine synthase0.048
pax7apaired box gene 7a0.048
foxi2forkhead box I20.045
sema3aasemaphorin 3aa0.045
tra2btransformer 2 beta homolog (Drosophila)0.044
pnp4apurine nucleoside phosphorylase 4a0.044
snai1asnail homolog 1a (Drosophila)0.044
smosmoothened homolog (Drosophila)0.042
vps35vacuolar protein sorting 35 (yeast)0.042
ccnd1cyclin D10.042
msh2mutS homolog 2 (E. coli)0.042
rfc4replication factor C (activator 1) 40.042
ssrp1astructure specific recognition protein 1a0.042
kitakit receptor a0.041
prmt5protein arginine methyltransferase 50.041
pola1polymerase (DNA directed), alpha 10.041
eya2eyes absent homolog 2 (Drosophila)0.040
lmx1b.2LIM homeobox transcription factor 1, beta 20.040
cstf1cleavage stimulation factor, 3' pre-RNA, subunit 10.040
ash2lash2 (absent, small, or homeotic)-like (Drosophila)0.039
mtmr8myotubularin related protein 80.039
rpa3replication protein A30.039
myod1myogenic differentiation 10.038
pax3apaired box gene 3a0.037
foxe3forkhead box E30.036
sass6spindle assembly 6 homolog (C. elegans)0.036
chek2CHK2 checkpoint homolog (S. pombe)0.036
spc24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.035
ptpraprotein tyrosine phosphatase, receptor type, A0.034
efnb2aephrin B2a0.034
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.034
cbx5chromobox homolog 5 (HP1 alpha homolog, Drosophila)0.033
hellshelicase, lymphoid-specific0.033
ybeyybeY metallopeptidase0.033
adnp2bADNP homeobox 2b0.032
chp2calcineurin B homologous protein 20.032
fstafollistatin a0.032
myst2MYST histone acetyltransferase 20.032
mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.032
foxn1forkhead box N10.032
znf346zinc finger protein 3460.031
lppLIM domain containing preferred translocation partner in lipoma0.031
atoh8atonal homolog 80.031
ighzimmunoglobulin heavy constant zeta0.031
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.030
psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.030
nrp1bneuropilin 1b0.030
unguracil-DNA glycosylase0.030
cbx2chromobox homolog 2 (Drosophila Pc class)0.029
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
ChcClathrin heavy chain0.020
BicDBicaudal D0.013
Aats-ileIsoleucyl-tRNA synthetase0.013
mRpL33mitochondrial ribosomal protein L330.012
CG11583CG11583 gene product from transcript CG11583-RA0.012
CG11076CG11076 gene product from transcript CG11076-RB0.011
AbiAbelson interacting protein0.011
CkIIbetaCasein kinase II beta subunit0.010
AtpalphaNa pump alpha subunit0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.841
SIN3ASIN3 homolog A, transcription regulator (yeast)0.813
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.719
WDR5WD repeat domain 50.614
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.379
EEDembryonic ectoderm development0.300
DNMT1DNA (cytosine-5-)-methyltransferase 10.293
EZH2enhancer of zeste homolog 2 (Drosophila)0.282
UHRF1ubiquitin-like with PHD and ring finger domains 10.273
EP300E1A binding protein p3000.271
HDAC3histone deacetylase 30.267
HDAC2histone deacetylase 20.258
RB1retinoblastoma 10.241
PMLpromyelocytic leukemia0.234
NCOR2nuclear receptor corepressor 20.233
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.225
HIST1H3Bhistone cluster 1, H3b0.215
ZNF496zinc finger protein 4960.194
SUZ12suppressor of zeste 12 homolog (Drosophila)0.194
TGIF1TGFB-induced factor homeobox 10.191
RBBP5retinoblastoma binding protein 50.191
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.188
HCFC1host cell factor C1 (VP16-accessory protein)0.184
RBBP4retinoblastoma binding protein 40.179
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.178
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.161
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.133
PIAS4protein inhibitor of activated STAT, 40.127
HDAC1histone deacetylase 10.127
LIN9lin-9 homolog (C. elegans)0.125
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.116
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.112
TBL1XR1transducin (beta)-like 1 X-linked receptor 10.112
TSC22D1TSC22 domain family, member 10.111
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.101
HIPK2homeodomain interacting protein kinase 20.100
IRF2BP1interferon regulatory factor 2 binding protein 10.093
NR2E3nuclear receptor subfamily 2, group E, member 30.090
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.090
ADNPactivity-dependent neuroprotector homeobox0.088
EEF2Keukaryotic elongation factor-2 kinase0.088
PARP1poly (ADP-ribose) polymerase 10.088
GSK3Bglycogen synthase kinase 3 beta0.084
NRIP1nuclear receptor interacting protein 10.081
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.077
ATF3activating transcription factor 30.072
RBBP7retinoblastoma binding protein 70.065
STAG2stromal antigen 20.065
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.063
NCOR1nuclear receptor corepressor 10.062
HDAC7histone deacetylase 70.061
DUSP1dual specificity phosphatase 10.060
MBIPMAP3K12 binding inhibitory protein 10.059
CBX5chromobox homolog 50.058
NRP1neuropilin 10.058
MAP3K7mitogen-activated protein kinase kinase kinase 70.050
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.050
MAP2K4mitogen-activated protein kinase kinase 40.048
COASYCoA synthase0.047
NCOA6nuclear receptor coactivator 60.047
MED15mediator complex subunit 150.045
COL4A1collagen, type IV, alpha 10.042
HDGFhepatoma-derived growth factor0.041
BRCA1breast cancer 1, early onset0.040
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.038
CHD8chromodomain helicase DNA binding protein 80.037
CCNT1cyclin T10.037
JUNjun proto-oncogene0.037
MEN1multiple endocrine neoplasia I0.035
RAD51L1RAD51-like 1 (S. cerevisiae)0.035
HDAC9histone deacetylase 90.034
CUL4Acullin 4A0.034
CXXC1CXXC finger protein 10.033
JUBjub, ajuba homolog (Xenopus laevis)0.033
HIST2H3Chistone cluster 2, H3c0.032
CDCA4cell division cycle associated 40.032
CTBP2C-terminal binding protein 20.032
TONSLtonsoku-like, DNA repair protein0.031
MAPK3mitogen-activated protein kinase 30.031
TRIM28tripartite motif containing 280.031
MYST1MYST histone acetyltransferase 10.030
DUSP3dual specificity phosphatase 30.029
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.028
HEXIM1hexamethylene bis-acetamide inducible 10.028
TP53tumor protein p530.028
MAPK14mitogen-activated protein kinase 140.028
LIN54lin-54 homolog (C. elegans)0.028
RICTORRPTOR independent companion of MTOR, complex 20.027
HDAC5histone deacetylase 50.027
MYST3MYST histone acetyltransferase (monocytic leukemia) 30.027
HIST1H3Ahistone cluster 1, H3a0.026
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.026
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.025
CTBP1C-terminal binding protein 10.025
TLK1tousled-like kinase 10.025
STAG1stromal antigen 10.025
CREB1cAMP responsive element binding protein 10.025
VAMP2vesicle-associated membrane protein 2 (synaptobrevin 2)0.024
MAPK1mitogen-activated protein kinase 10.023
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ezh2enhancer of zeste homolog 2 (Drosophila)0.980
Trp53transformation related protein 530.879
Kdm2blysine (K)-specific demethylase 2B0.662
Jarid2jumonji, AT rich interactive domain 20.658
Suz12suppressor of zeste 12 homolog (Drosophila)0.535
Ptgs2prostaglandin-endoperoxide synthase 20.441
Hdac1histone deacetylase 10.437
Eedembryonic ectoderm development0.362
Trim28tripartite motif-containing 280.343
Il10interleukin 100.341
Dnmt3aDNA methyltransferase 3A0.334
Col1a1collagen, type I, alpha 10.304
Zeb1zinc finger E-box binding homeobox 10.298
Rb1retinoblastoma 10.287
Brca1breast cancer 10.275
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.274
Trim24tripartite motif-containing 240.263
JunJun oncogene0.242
Ppargperoxisome proliferator activated receptor gamma0.242
Cav1caveolin 1, caveolae protein0.226
Hist1h3ghistone cluster 1, H3g0.223
Tnftumor necrosis factor0.212
Esr1estrogen receptor 1 (alpha)0.206
Egr1early growth response 10.205
Runx1runt related transcription factor 10.193
Mdm2transformed mouse 3T3 cell double minute 20.173
Arrb2arrestin, beta 20.166
Sin3atranscriptional regulator, SIN3A (yeast)0.165
Plin1perilipin 10.161
CrebbpCREB binding protein0.150
Nos1nitric oxide synthase 1, neuronal0.140
Kdm1alysine (K)-specific demethylase 1A0.139
Pax3paired box gene 30.125
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.123
Ncoa6nuclear receptor coactivator 60.115
Vdrvitamin D receptor0.111
Atf3activating transcription factor 30.103
Stk38serine/threonine kinase 380.102
FosFBJ osteosarcoma oncogene0.099
Parp1poly (ADP-ribose) polymerase family, member 10.099
Rbbp4retinoblastoma binding protein 40.098
DaxxFas death domain-associated protein0.096
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.094
Pax7paired box gene 70.084
Mapk1mitogen-activated protein kinase 10.083
Fosl2fos-like antigen 20.079
Rararetinoic acid receptor, alpha0.079
Rxraretinoid X receptor alpha0.077
Cdkn2acyclin-dependent kinase inhibitor 2A0.076
Ptenphosphatase and tensin homolog0.075
Mdm4transformed mouse 3T3 cell double minute 40.073
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.073
Ptpn13protein tyrosine phosphatase, non-receptor type 130.072
Huwe1HECT, UBA and WWE domain containing 10.071
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.071
Ren1renin 1 structural0.070
Aebp2AE binding protein 20.069
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.068
JunbJun-B oncogene0.067
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.065
Brca2breast cancer 20.065
Nsfl1cNSFL1 (p97) cofactor (p47)0.064
Sp1trans-acting transcription factor 10.064
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.063
Trp73transformation related protein 730.063
Srfserum response factor0.063
Egr2early growth response 20.062
Gli2GLI-Kruppel family member GLI20.060
Brd4bromodomain containing 40.059
Nr4a1nuclear receptor subfamily 4, group A, member 10.059
Clk1CDC-like kinase 10.058
Ifnginterferon gamma0.056
Plaurplasminogen activator, urokinase receptor0.056
Ncor1nuclear receptor co-repressor 10.056
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.054
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.053
Rnf2ring finger protein 20.053
Ep300E1A binding protein p3000.052
Gli3GLI-Kruppel family member GLI30.052
E2f1E2F transcription factor 10.052
Cdk1cyclin-dependent kinase 10.049
Atmataxia telangiectasia mutated homolog (human)0.048
Arid2AT rich interactive domain 2 (ARID, RFX-like)0.048
Ruvbl1RuvB-like protein 10.048
Thbs1thrombospondin 10.048
Thoc2THO complex 20.047
Hdac7histone deacetylase 70.047
Kdm5alysine (K)-specific demethylase 5A0.046
H2afxH2A histone family, member X0.046
Kitlkit ligand0.046
Msx1homeobox, msh-like 10.045
Thrathyroid hormone receptor alpha0.044
Kitkit oncogene0.044
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.044
Cyr61cysteine rich protein 610.043
D4Wsu53eDNA segment, Chr 4, Wayne State University 53, expressed0.043
CtcfCCCTC-binding factor0.043
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism