The network for 'mitotic spindle assembly checkpoint' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitotic spindle assembly checkpoint

A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.

NameDescriptionProbabilityFunc Analog Organism
MAD2Mad2p0.959
CDC20Cdc20p0.951
MTW1Mtw1p0.891
DSN1Dsn1p0.883
SLK19Slk19p0.880
BUB3Bub3p0.861
NSL1Nsl1p0.857
AME1Ame1p0.856
SLI15Sli15p0.837
CSE4Cse4p0.786
IML3Iml3p0.751
TID3Tid3p0.728
CDC55Cdc55p0.722
CHL4Chl4p0.630
PPH21Pph21p0.615
SMC4Smc4p0.507
MIF2Mif2p0.480
MAD3Mad3p0.462
MCM21Mcm21p0.454
HHF2Hhf2p0.444
CTF13Ctf13p0.441
PIG2Pig2p0.419
SPC105Spc105p0.391
KIP1Kip1p0.383
CTF3Ctf3p0.350
BUB1Bub1p0.324
IPL1Ipl1p0.300
SPC24Spc24p0.280
MAD1Mad1p0.276
YPI1Ypi1p0.269
GIP2Gip2p0.266
YBP2Ybp2p0.247
DAM1Dam1p0.236
OKP1Okp1p0.234
PPH22Pph22p0.202
MCM22Mcm22p0.199
RTS1Rts1p0.180
NUF2Nuf2p0.142
NNF1Nnf1p0.140
FMP48Fmp48p0.137
ASE1Ase1p0.136
CBF2Cbf2p0.132
CSM1Csm1p0.130
PPZ1Ppz1p0.122
CIN8Cin8p0.119
TIP41Tip41p0.098
SDS22Sds22p0.093
RDH54Rdh54p0.092
TPD3Tpd3p0.075
SCC2Scc2p0.075
GLG1Glg1p0.073
MPS1Mps1p0.073
PDS1Pds1p0.064
BRN1Brn1p0.062
SMC5Smc5p0.058
HTA1Hta1p0.057
BIR1Bir1p0.054
VIK1Vik1p0.053
SMC2Smc2p0.052
STU1Stu1p0.052
BIM1Bim1p0.052
CBF1Cbf1p0.049
GLC7Glc7p0.048
RAD53Rad53p0.048
SPC25Spc25p0.048
NBL1Nbl1p0.048
SMC6Smc6p0.046
CDC16Cdc16p0.045
NTO1Nto1p0.045
CAB3Cab3p0.044
PSY4Psy4p0.044
SKP1Skp1p0.044
PTI1Pti1p0.043
STB2Stb2p0.041
ECO1Eco1p0.041
SPC110Spc110p0.035
SPO12Spo12p0.035
VHS3Vhs3p0.035
SCM3Scm3p0.034
CTF18Ctf18p0.034
GAC1Gac1p0.034
RCO1Rco1p0.033
FIN1Fin1p0.032
SRD1Srd1p0.032
MMS21Mms21p0.032
SMC3Smc3p0.030
CIN1Cin1p0.029
SPL2Spl2p0.029
MCM16Mcm16p0.028
PCL10Pcl10p0.028
YLR264C-Ahypothetical protein0.028
YLR162Whypothetical protein0.027
YNL144Chypothetical protein0.027
YML053Chypothetical protein0.027
YOL038C-Ahypothetical protein0.027
CRP1Crp1p0.026
ESP1Esp1p0.026
LEU2Leu2p0.026
BDF2Bdf2p0.026
YIL151Chypothetical protein0.026
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
rnr-1Protein RNR-10.016
ZK507.6Protein ZK507.60.015
rsd-6Protein RSD-60.014
lmn-1Protein LMN-10.012
tba-2Protein TBA-20.012
gpr-2Protein GPR-20.012
bmk-1Protein BMK-10.011
his-45Protein HIS-450.011
htz-1Protein HTZ-10.011
F12F6.1Protein F12F6.10.010
npp-11Protein NPP-110.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
IswiImitation SWI0.451
CycBCyclin B0.232
ncdnon-claret disjunctional0.177
flflfalafel0.157
CycB3Cyclin B30.116
aslasterless0.074
cmetCENP-meta0.070
gwlgreatwall0.070
SAKSak kinase0.062
BubR1Bub1-related kinase0.061
poloCG12306 gene product from transcript CG12306-RA0.059
Klp61FKinesin-like protein at 61F0.057
Mcm10Sensitized chromosome inheritance modifier 190.053
Nup153Nucleoporin 1530.047
cnncentrosomin0.046
cavcaravaggio0.039
hydhyperplastic discs0.039
Cdc37CG12019 gene product from transcript CG12019-RA0.035
Cap-GCG34438 gene product from transcript CG34438-RF0.034
aspabnormal spindle0.033
Grip75CG6176 gene product from transcript CG6176-RA0.031
SMC2CG10212 gene product from transcript CG10212-RA0.030
dupdouble parked0.030
thrthree rows0.030
bambag of marbles0.028
nbsCG6754 gene product from transcript CG6754-RC0.025
alphaTub67Calpha-Tubulin at 67C0.025
CycACyclin A0.025
Cks30ACyclin-dependent kinase subunit 30A0.025
pimpimples0.022
Pp1-87BProtein phosphatase 1 at 87B0.022
Klp3AKinesin-like protein at 3A0.022
MybMyb oncogene-like0.021
nodno distributive disjunction0.021
mus301mutagen-sensitive 3010.020
pavpavarotti0.019
wispwispy0.017
ttvtout-velu0.017
ruxroughex0.016
Kap-alpha3karyopherin alpha30.016
ldslodestar0.016
msb1lCG10364 gene product from transcript CG10364-RA0.015
pluplutonium0.015
mus101mutagen-sensitive 1010.014
IncenpInner centromere protein0.014
Cenp-CCG31258 gene product from transcript CG31258-RA0.014
pngpan gu0.014
barrbarren0.014
DNApol-alpha60DNA polymerase alpha 60kD0.014
Mi-2CG8103 gene product from transcript CG8103-RA0.014
SseSeparase0.014
borrborealin-related0.013
mus304mutagen-sensitive 3040.012
Sgt1CG9617 gene product from transcript CG9617-RA0.012
mei-S332meiotic from via Salaria 3320.012
NiPp1Nuclear inhibitor of Protein phosphatase 10.012
mus209mutagen-sensitive 2090.011
vtdverthandi0.011
mus312mutagen-sensitive 3120.011
SRm160CG11274 gene product from transcript CG11274-RA0.011
Klp10ACG1453 gene product from transcript CG1453-RA0.011
mad2CG17498 gene product from transcript CG17498-RA0.010
PepProtein on ecdysone puffs0.010
Mcm7Minichromosome maintenance 70.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.979
ANAPC4anaphase promoting complex subunit 40.707
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.669
NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.540
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.520
CBX5chromobox homolog 50.493
CASC5cancer susceptibility candidate 50.278
CDC27cell division cycle 27 homolog (S. cerevisiae)0.260
ZWINTZW10 interactor0.125
NUF2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.084
CDC20cell division cycle 20 homolog (S. cerevisiae)0.064
CCT8chaperonin containing TCP1, subunit 8 (theta)0.062
NSL1NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)0.056
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.051
SPC24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.049
HDAC1histone deacetylase 10.047
SKA1spindle and kinetochore associated complex subunit 10.047
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.047
TP53BP1tumor protein p53 binding protein 10.040
SKA2spindle and kinetochore associated complex subunit 20.039
AURKBaurora kinase B0.034
SKA3spindle and kinetochore associated complex subunit 30.034
SGOL2shugoshin-like 2 (S. pombe)0.032
PPME1protein phosphatase methylesterase 10.029
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.028
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.027
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.026
PRNPprion protein0.025
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.023
H2AFXH2A histone family, member X0.022
CBX1chromobox homolog 10.022
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.022
DSN1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)0.022
SGOL1shugoshin-like 1 (S. pombe)0.021
SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.018
NBNnibrin0.018
MDC1mediator of DNA-damage checkpoint 10.018
SMC4structural maintenance of chromosomes 40.017
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.017
CENPEcentromere protein E, 312kDa0.016
UHRF1ubiquitin-like with PHD and ring finger domains 10.016
FXR2fragile X mental retardation, autosomal homolog 20.016
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.016
PARP3poly (ADP-ribose) polymerase family, member 30.016
TINF2TERF1 (TRF1)-interacting nuclear factor 20.015
APCadenomatous polyposis coli0.015
TERF2telomeric repeat binding factor 20.015
INCENPinner centromere protein antigens 135/155kDa0.015
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.014
ZW10ZW10, kinetochore associated, homolog (Drosophila)0.014
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.014
SMC6structural maintenance of chromosomes 60.013
LBRlamin B receptor0.013
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.012
PARP1poly (ADP-ribose) polymerase 10.012
BRCA2breast cancer 2, early onset0.012
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.012
ATRXalpha thalassemia/mental retardation syndrome X-linked0.012
WRNWerner syndrome, RecQ helicase-like0.012
ANAPC11anaphase promoting complex subunit 110.012
SMC3structural maintenance of chromosomes 30.012
HDAC2histone deacetylase 20.011
HMMRhyaluronan-mediated motility receptor (RHAMM)0.011
TOP2Atopoisomerase (DNA) II alpha 170kDa0.011
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.011
PPP2R5Dprotein phosphatase 2, regulatory subunit B', delta0.011
ATMINATM interactor0.010
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.933
Cdk1cyclin-dependent kinase 10.828
Ccnb1cyclin B10.815
Ccnb2cyclin B20.689
Prc1protein regulator of cytokinesis 10.585
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.565
Brca1breast cancer 10.521
Ccna2cyclin A20.481
Kif22kinesin family member 220.423
Kif20akinesin family member 20A0.344
Birc5baculoviral IAP repeat-containing 50.308
Cenpecentromere protein E0.303
Cdca8cell division cycle associated 80.212
Kif4kinesin family member 40.185
Sgol2shugoshin-like 2 (S. pombe)0.171
Brca2breast cancer 20.171
Cdc25ccell division cycle 25 homolog C (S. pombe)0.164
Hmmrhyaluronan mediated motility receptor (RHAMM)0.162
Spag5sperm associated antigen 50.158
Ckap2cytoskeleton associated protein 20.150
Kif2ckinesin family member 2C0.146
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.143
Aurkaaurora kinase A0.123
Aurkbaurora kinase B0.113
Ptenphosphatase and tensin homolog0.113
Kif11kinesin family member 110.112
Kif23kinesin family member 230.107
C330027C09RikRIKEN cDNA C330027C09 gene0.104
Ube2cubiquitin-conjugating enzyme E2C0.089
Mdm2transformed mouse 3T3 cell double minute 20.082
Dlgap5discs, large (Drosophila) homolog-associated protein 50.077
Ctnnb1catenin (cadherin associated protein), beta 10.076
Racgap1Rac GTPase-activating protein 10.074
Cdkn1bcyclin-dependent kinase inhibitor 1B0.071
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.071
Mki67antigen identified by monoclonal antibody Ki 670.069
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.069
Ccnfcyclin F0.064
Ooepoocyte expressed protein homolog (dog)0.052
Cep55centrosomal protein 550.046
Ncaphnon-SMC condensin I complex, subunit H0.044
Cenpncentromere protein N0.043
Mis18bp1MIS18 binding protein 10.042
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.042
Cdkn3cyclin-dependent kinase inhibitor 30.042
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.039
Rb1retinoblastoma 10.035
H2afxH2A histone family, member X0.034
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.033
Tacc3transforming, acidic coiled-coil containing protein 30.033
Ube2tubiquitin-conjugating enzyme E2T (putative)0.033
Cdca5cell division cycle associated 50.033
Gtse1G two S phase expressed protein 10.031
TtkTtk protein kinase0.030
Top2atopoisomerase (DNA) II alpha0.030
D2Ertd750eDNA segment, Chr 2, ERATO Doi 750, expressed0.028
Ncapgnon-SMC condensin I complex, subunit G0.028
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.026
Mdm4transformed mouse 3T3 cell double minute 40.026
Cks2CDC28 protein kinase regulatory subunit 20.025
Smc4structural maintenance of chromosomes 40.024
Plk4polo-like kinase 4 (Drosophila)0.024
Stk11serine/threonine kinase 110.024
Kiss1KiSS-1 metastasis-suppressor0.022
Ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.022
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.022
Trim59tripartite motif-containing 590.020
Smad4MAD homolog 4 (Drosophila)0.020
BrafBraf transforming gene0.020
Anlnanillin, actin binding protein0.020
Sgol1shugoshin-like 1 (S. pombe)0.020
Smad3MAD homolog 3 (Drosophila)0.019
Melkmaternal embryonic leucine zipper kinase0.019
Ckap2lcytoskeleton associated protein 2-like0.018
Ezh2enhancer of zeste homolog 2 (Drosophila)0.018
Cenpkcentromere protein K0.017
Gsg2germ cell-specific gene 20.016
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.015
6720463M24RikRIKEN cDNA 6720463M24 gene0.014
Ccdc99coiled-coil domain containing 990.014
Arandrogen receptor0.014
Fbxo5F-box protein 50.014
StilScl/Tal1 interrupting locus0.013
Nuf2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.013
Nf1neurofibromatosis 10.013
Kntc1kinetochore associated 10.012
Rad51ap1RAD51 associated protein 10.012
Cenpfcentromere protein F0.012
2810417H13RikRIKEN cDNA 2810417H13 gene0.012
Cenpacentromere protein A0.012
Hmgb1high mobility group box 10.011
Acdadrenocortical dysplasia0.011
Hist1h2bmhistone cluster 1, H2bm0.011
Lmnb1lamin B10.011
Incenpinner centromere protein0.011
BlmBloom syndrome, RecQ helicase-like0.011
Gsk3bglycogen synthase kinase 3 beta0.011
Trp63transformation related protein 630.011
Fam64afamily with sequence similarity 64, member A0.011
Esr2estrogen receptor 2 (beta)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism