The network for 'actin filament depolymerization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

actin filament depolymerization

Disassembly of actin filaments by the removal of actin monomers from a filament.

Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
MYO5Myo5p0.687
CAP2Cap2p0.671
ABP1Abp1p0.570
SRV2Srv2p0.477
LAS17Las17p0.168
PFY1Pfy1p0.118
ARC40Arc40p0.104
BOI1Boi1p0.082
ARP3Arp3p0.064
AIP1Aip1p0.060
ARC15Arc15p0.049
BBC1Bbc1p0.040
SAC6Sac6p0.039
AQY2Aqy2p0.036
LSB1Lsb1p0.033
UBP7Ubp7p0.032
SLA2Sla2p0.032
CDC24Cdc24p0.031
CAP1Cap1p0.031
ACT1Act1p0.030
ARC35Arc35p0.028
PAN1Pan1p0.028
ARP2Arp2p0.025
GYL1Gyl1p0.024
AIM21Aim21p0.023
YPR1Ypr1p0.022
TPM1Tpm1p0.021
BNA3Bna3p0.021
YIL151Chypothetical protein0.020
SRD1Srd1p0.020
STE5Ste5p0.020
AIM6Aim6p0.018
ARP10Arp10p0.018
YFR016Chypothetical protein0.018
YAR068Whypothetical protein0.018
BEM3Bem3p0.017
YOL038C-Ahypothetical protein0.017
SCP1Scp1p0.017
LEU2Leu2p0.016
TWF1Twf1p0.016
YLR162Whypothetical protein0.016
ARE2Are2p0.015
YLR264C-Ahypothetical protein0.015
SPR6Spr6p0.015
BSP1Bsp1p0.014
YGL015Chypothetical protein0.014
MER1Mer1p0.014
HXT3Hxt3p0.013
YAR066Whypothetical protein0.013
SUT1Sut1p0.013
DUG1Dug1p0.013
ARG8Arg8p0.012
CUP1-1Cup1-1p0.012
YPL066Whypothetical protein0.012
ATP6Atp6p0.012
HPF1Hpf1p0.012
ERG9Erg9p0.012
ZPS1Zps1p0.012
YBR013Chypothetical protein0.012
SPP41Spp41p0.011
YPR157Whypothetical protein0.011
SPL2Spl2p0.011
AUA1Aua1p0.011
YKR075Chypothetical protein0.011
YLR042Chypothetical protein0.011
NUS1Nus1p0.011
UPS3Ups3p0.011
TYE7Tye7p0.011
OPT2Opt2p0.011
CPD1Cpd1p0.011
ENT3Ent3p0.010
FMT1Fmt1p0.010
CHA1Cha1p0.010
TIP1Tip1p0.010
IZH4Izh4p0.010
CRP1Crp1p0.010
YPL216Whypothetical protein0.010
HOHop0.010
YOL013W-Ahypothetical protein0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
TER94CG2331 gene product from transcript CG2331-RA0.731
flrflare0.609
Arp66BActin-related protein 66B0.278
Zasp66Z band alternatively spliced PDZ-motif protein 660.188
cpbcapping protein beta0.171
miminus0.160
CG11299CG11299 gene product from transcript CG11299-RA0.153
Act5CActin 5C0.104
snsinged0.085
cpacapping protein alpha0.085
Mlc2Myosin light chain 20.083
slssallimus0.082
Sop2Suppressor of profilin 20.075
CortactinCG3637 gene product from transcript CG3637-RA0.070
upupheld0.068
CanB2Calcineurin B20.060
tsrtwinstar0.041
Act88FActin 88F0.040
Arc-p34CG10954 gene product from transcript CG10954-RA0.039
Arp14DActin-related protein 14D0.039
sqhspaghetti squash0.038
Rbsn-5Rabenosyn-50.033
sharkSrc homology 2, ankyrin repeat, tyrosine kinase0.031
Dcr-2Dicer-20.031
SH3PX1CG6757 gene product from transcript CG6757-RA0.030
RalaRas-related protein0.030
Cf2Chorion factor 20.030
Tom34Translocase of outer membrane 340.030
uspultraspiracle0.029
tmodtropomodulin0.028
KhcKinesin heavy chain0.026
laceCG4162 gene product from transcript CG4162-RA0.025
wun2wunen-20.022
LaspCG3849 gene product from transcript CG3849-RB0.022
wupAwings up A0.022
ifcinfertile crescent0.020
wdbwiderborst0.020
spasspastin0.020
sec6CG5341 gene product from transcript CG5341-RA0.020
flwflapwing0.019
IlkIntegrin linked kinase0.017
Vrp1Verprolin 10.016
GmdGDP-mannose 4,6-dehydratase0.016
Kap-alpha3karyopherin alpha30.015
HemHEM-protein0.015
AmphAmphiphysin0.014
CG8578CG8578 gene product from transcript CG8578-RA0.013
salssarcomere length short0.013
CG12042CG12042 gene product from transcript CG12042-RA0.013
CG12007CG12007 gene product from transcript CG12007-RA0.011
zpgzero population growth0.011
CG8443CG8443 gene product from transcript CG8443-RA0.011
Sh3betaCG8582 gene product from transcript CG8582-RD0.011
sds22CG5851 gene product from transcript CG5851-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ACTBactin, beta0.358
ACTG1actin, gamma 10.270
MYH9myosin, heavy chain 9, non-muscle0.076
ZYXzyxin0.054
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.054
ACTN1actinin, alpha 10.041
FLNAfilamin A, alpha0.038
TPM1tropomyosin 1 (alpha)0.037
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.026
TTNtitin0.025
CORO1Ccoronin, actin binding protein, 1C0.024
TPM4tropomyosin 40.023
PDLIM7PDZ and LIM domain 7 (enigma)0.018
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.017
CAPZBcapping protein (actin filament) muscle Z-line, beta0.017
TPM2tropomyosin 2 (beta)0.016
SCP2sterol carrier protein 20.014
ACTR3ARP3 actin-related protein 3 homolog (yeast)0.010
SOS1son of sevenless homolog 1 (Drosophila)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Capzbcapping protein (actin filament) muscle Z-line, beta0.990
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.984
Actr3ARP3 actin-related protein 3 homolog (yeast)0.984
Arpc4actin related protein 2/3 complex, subunit 40.981
Wdr1WD repeat domain 10.951
Msnmoesin0.869
Rac1RAS-related C3 botulinum substrate 10.728
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.646
Rap1bRAS related protein 1b0.612
Csrp1cysteine and glycine-rich protein 10.570
Pfn1profilin 10.508
Cltcclathrin, heavy polypeptide (Hc)0.481
Akt1thymoma viral proto-oncogene 10.424
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.401
Gnb1guanine nucleotide binding protein (G protein), beta 10.401
Tpm4tropomyosin 40.395
Rhoaras homolog gene family, member A0.356
Actg1actin, gamma, cytoplasmic 10.355
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.336
Pdlim5PDZ and LIM domain 50.317
Dbnldrebrin-like0.289
Vaspvasodilator-stimulated phosphoprotein0.287
Slc25a24solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 240.286
Tmod3tropomodulin 30.246
Actr2ARP2 actin-related protein 2 homolog (yeast)0.235
Actn1actinin, alpha 10.222
Gnb2guanine nucleotide binding protein (G protein), beta 20.201
Arhgap1Rho GTPase activating protein 10.199
Actbactin, beta0.187
Cnn2calponin 20.186
Bcl10B-cell leukemia/lymphoma 100.185
Lrrk2leucine-rich repeat kinase 20.179
Cttncortactin0.169
Mapre1microtubule-associated protein, RP/EB family, member 10.161
Bzw1basic leucine zipper and W2 domains 10.147
Rod1ROD1 regulator of differentiation 1 (S. pombe)0.147
Tubb5tubulin, beta 50.137
Myl9myosin, light polypeptide 9, regulatory0.130
Abi1abl-interactor 10.126
Arpc2actin related protein 2/3 complex, subunit 20.114
Acot9acyl-CoA thioesterase 90.107
Ilkintegrin linked kinase0.098
Actn4actinin alpha 40.095
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.092
Ap2m1adaptor protein complex AP-2, mu10.090
Coro1ccoronin, actin binding protein 1C0.086
Lims1LIM and senescent cell antigen-like domains 10.079
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.078
Mtpnmyotrophin0.075
Arf1ADP-ribosylation factor 10.073
Coro1acoronin, actin binding protein 1A0.070
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.069
Capza2capping protein (actin filament) muscle Z-line, alpha 20.064
Myh9myosin, heavy polypeptide 9, non-muscle0.063
Sept7septin 70.062
Tpm1tropomyosin 1, alpha0.058
UgcgUDP-glucose ceramide glucosyltransferase0.058
UgdhUDP-glucose dehydrogenase0.056
Srisorcin0.055
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.054
Stx7syntaxin 70.053
Sdcbpsyndecan binding protein0.053
Gipc1GIPC PDZ domain containing family, member 10.052
Sept9septin 90.051
Glipr2GLI pathogenesis-related 20.049
Gng12guanine nucleotide binding protein (G protein), gamma 120.049
Rap2cRAP2C, member of RAS oncogene family0.048
Calm1calmodulin 10.047
Cdc42se1CDC42 small effector 10.045
Acot10acyl-CoA thioesterase 100.044
Plekho1pleckstrin homology domain containing, family O member 10.044
Rgs19regulator of G-protein signaling 190.040
Actc1actin, alpha, cardiac muscle 10.039
Vclvinculin0.039
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.039
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.038
Arrb2arrestin, beta 20.037
Arf4ADP-ribosylation factor 40.037
Ptp4a2protein tyrosine phosphatase 4a20.036
Snx6sorting nexin 60.036
Ctnnd1catenin (cadherin associated protein), delta 10.036
Tmsb10thymosin, beta 100.035
Arpc3actin related protein 2/3 complex, subunit 30.035
Clic1chloride intracellular channel 10.034
Pkm2pyruvate kinase, muscle0.034
Tagln2transgelin 20.034
Tmprss2transmembrane protease, serine 20.033
Flnafilamin, alpha0.033
Tpm3tropomyosin 3, gamma0.033
Acbd3acyl-Coenzyme A binding domain containing 30.033
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.032
Hn1hematological and neurological expressed sequence 10.031
LitafLPS-induced TN factor0.029
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.029
Cfl1cofilin 1, non-muscle0.028
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.028
Ckap4cytoskeleton-associated protein 40.028
Itga3integrin alpha 30.027
Nipa2non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)0.027
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.027
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tpm4tropomyosin 40.749
Tpm3tropomyosin 3, gamma0.577
Taglntransgelin0.557
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.503
Acta2smooth muscle alpha-actin0.341
Myl9myosin, light chain 9, regulatory0.284
Actr3ARP3 actin-related protein 3 homolog (yeast)0.283
Gnai3guanine nucleotide binding protein (G protein), alpha inhibiting 30.240
Arpc2actin related protein 2/3 complex, subunit 20.182
Sept2septin 20.169
Wdr1WD repeat domain 10.130
Emp1epithelial membrane protein 10.125
Efhd2EF-hand domain family, member D20.113
Actbactin, beta0.112
Rac1ras-related C3 botulinum toxin substrate 10.106
Actg1actin, gamma 10.092
Myh9myosin, heavy chain 9, non-muscle0.092
Pfn1profilin 10.082
Mapre1microtubule-associated protein, RP/EB family, member 10.074
Actg2actin, gamma 2, smooth muscle, enteric0.073
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.070
Arf6ADP-ribosylation factor 60.067
Rhoaras homolog gene family, member A0.060
Bnip2BCL2/adenovirus E1B interacting protein 20.057
Cd44Cd44 molecule0.056
Coro1acoronin, actin binding protein 1A0.053
Tubb5tubulin, beta 50.051
Pitpnaphosphatidylinositol transfer protein, alpha0.042
Sec62SEC62 homolog (S. cerevisiae)0.042
Rap1bRAP1B, member of RAS oncogene family0.041
Elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.041
Itgb1integrin, beta 10.037
Tagln2transgelin 20.037
Txnrd1thioredoxin reductase 10.036
Olr1500olfactory receptor 15000.034
Cnn1calponin 1, basic, smooth muscle0.034
Flnafilamin A, alpha0.032
Timp3TIMP metallopeptidase inhibitor 30.032
Ptmaprothymosin alpha0.031
Msnmoesin0.031
Clic4chloride intracellular channel 40.031
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.030
Cttnbp2nlCTTNBP2 N-terminal like0.030
Iqgap1IQ motif containing GTPase activating protein 10.029
Srisorcin0.029
Slc31a1solute carrier family 31 (copper transporters), member 10.028
Laptm4alysosomal protein transmembrane 4 alpha0.027
Sept11septin 110.026
Myh11myosin, heavy chain 11, smooth muscle0.026
Lbrlamin B receptor0.025
BidBH3 interacting domain death agonist0.025
Acta1actin, alpha 1, skeletal muscle0.025
Stk17bserine/threonine kinase 17b0.025
Castcalpastatin0.024
Csrp1cysteine and glycine-rich protein 10.024
A3galt2alpha 1,3-galactosyltransferase 20.023
Avparginine vasopressin0.023
Caprin1cell cycle associated protein 10.023
Srgnserglycin0.022
Rhocras homolog gene family, member C0.022
Cnn3calponin 3, acidic0.021
Cd82Cd82 molecule0.020
Arf1ADP-ribosylation factor 10.020
Cttncortactin0.020
Cald1caldesmon 10.019
Arpc4actin related protein 2/3 complex, subunit 40.019
Anxa4annexin A40.019
Snx6sorting nexin 60.019
Mcammelanoma cell adhesion molecule0.019
Id2inhibitor of DNA binding 20.019
Pax4paired box 40.018
Grk4G protein-coupled receptor kinase 40.018
Cfl1cofilin 1, non-muscle0.018
Igf2insulin-like growth factor 20.018
Pkm2pyruvate kinase, muscle0.018
Mgat3mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase0.018
Ehfets homologous factor0.017
Tjp2tight junction protein 20.017
Seltselenoprotein T0.017
Ucnurocortin0.017
Rin1Ras and Rab interactor 10.017
Scnn1gsodium channel, nonvoltage-gated 1, gamma0.017
Itga6integrin, alpha 60.017
Myadmmyeloid-associated differentiation marker0.017
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.016
Tmed2transmembrane emp24 domain trafficking protein 20.016
Stc1stanniocalcin 10.016
Prkd3protein kinase D30.016
Cav1caveolin 1, caveolae protein0.016
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.016
Ap2m1adaptor-related protein complex 2, mu 1 subunit0.015
Olr287olfactory receptor 2870.015
Sisucrase-isomaltase (alpha-glucosidase)0.015
Rnf13ring finger protein 130.015
Uba1ubiquitin-like modifier activating enzyme 10.015
Magt1magnesium transporter 10.015
Adra2badrenergic, alpha-2B-, receptor0.015
Atxn1ataxin 10.015
Cldn7claudin 70.015
Mylkmyosin light chain kinase0.015