The network for 'mesodermal cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mesodermal cell fate specification

The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
lin-12Protein LIN-120.976
elt-6Protein ELT-60.973
fkh-2Protein FKH-20.948
zip-7Protein ZIP-70.922
egl-46Protein EGL-460.921
pha-4Protein PHA-40.920
egl-18Protein EGL-180.897
cnd-1Protein CND-10.895
hnd-1Protein HND-10.815
pes-1Protein PES-10.788
nhr-67Protein NHR-670.773
hlh-2Protein HLH-20.758
hlh-1Protein HLH-10.714
hlh-14Protein HLH-140.689
pop-1Protein POP-10.590
mls-2Protein MLS-20.487
ten-1Protein TEN-10.360
egl-38Protein EGL-380.354
sdz-28Protein SDZ-280.328
ceh-13Protein CEH-130.268
eya-1Protein EYA-10.231
lin-17Protein LIN-170.224
unc-130Protein UNC-1300.195
T20D4.19Protein T20D4.190.188
odd-2Protein ODD-20.148
nhr-2Protein NHR-20.146
tbx-8Protein TBX-80.138
let-60Protein LET-600.107
egl-13Protein EGL-130.107
ztf-2Protein ZTF-20.105
bar-1Protein BAR-10.097
twk-25Protein TWK-250.094
unc-43Protein UNC-430.088
trim-9Protein TRIM-90.086
ceh-27Protein CEH-270.085
cwn-2Protein CWN-20.085
egl-36Protein EGL-360.083
flt-1Protein FLT-10.075
unc-86Protein UNC-860.071
egl-5Protein EGL-50.070
sem-2Protein SEM-20.070
ceh-34Protein CEH-340.062
egl-15Protein EGL-150.061
fbxb-40Protein FBXB-400.061
rig-5Protein RIG-50.058
bath-9Protein BATH-90.056
ref-2Protein REF-20.054
irx-1Protein IRX-10.052
sem-4Protein SEM-40.050
ceh-16Protein CEH-160.050
ceh-43Protein CEH-430.047
sma-6Protein SMA-60.046
sdz-4Protein SDZ-40.044
sdz-38Protein SDZ-380.042
F53G2.1Protein F53G2.10.042
CELE_W05H5.3Protein W05H5.30.040
CELE_C05B5.4Protein C05B5.40.040
F11D5.1Protein F11D5.10.038
sel-8Protein SEL-80.038
Y57A10B.6Protein Y57A10B.60.038
C40A11.6Protein C40A11.60.037
sel-7Protein SEL-70.036
magu-2Protein MAGU-20.036
ceh-36Protein CEH-360.036
Y54G2A.20Protein Y54G2A.200.036
klf-2Protein KLF-20.035
lin-32Protein LIN-320.035
fozi-1Protein FOZI-10.035
lag-2Protein LAG-20.035
ces-1Protein CES-10.030
pry-1Protein PRY-10.029
cwn-1Protein CWN-10.028
hlh-3Protein HLH-30.027
syd-2Protein SYD-20.027
unc-39Protein UNC-390.027
ccch-5Protein CCCH-50.027
C10A4.3Protein C10A4.30.026
end-3Protein END-30.026
F40G9.6Protein F40G9.60.025
vab-3Protein VAB-30.025
dmd-8Protein DMD-80.025
arl-13Protein ARL-130.024
fard-1Protein FARD-10.024
ahr-1Protein AHR-10.024
swsn-1Protein SWSN-10.024
let-381Protein LET-3810.023
K09E3.7Protein K09E3.70.023
ref-1Protein REF-10.023
ces-2Protein CES-20.023
egl-30Protein EGL-300.023
php-3Protein PHP-30.023
R173.3Protein R173.30.022
pax-3Protein PAX-30.022
CELE_C27D8.3Protein C27D8.30.021
CELE_Y105C5A.24Protein Y105C5A.240.021
tctn-1Protein TCTN-10.021
ceh-33Protein CEH-330.021
F56C9.8Protein F56C9.80.020
ric-19Protein RIC-190.020
C44H4.6Protein C44H4.60.020
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chdchordin0.992
foxi1forkhead box I10.944
hoxb3ahomeo box B3a0.937
pax2apaired box gene 2a0.857
six4bsine oculis homeobox homolog 4b0.834
gli1GLI-Kruppel family member 10.804
flhfloating head0.789
tbx1T-box 10.775
bmp4bone morphogenetic protein 40.726
pax8paired box gene 80.710
hoxa2bhomeo box A2b0.695
mibmind bomb0.691
shhasonic hedgehog a0.672
vedventrally expressed dharma/bozozok antagonist0.663
eya1eyes absent homolog 10.620
hnf1baHNF1 homeobox Ba0.605
ndr2nodal-related 20.588
msxcmuscle segment homeobox C0.579
tfap2atranscription factor AP-2 alpha0.556
dharmadharma0.544
hoxb2ahomeo box B2a0.506
pcdh8protocadherin 80.490
ventventral expressed homeobox0.446
hoxa11ahomeo box A11a0.442
tbx16T-box gene 160.422
her5hairy-related 50.396
oepone-eyed pinhead0.391
hmx4H6 family homeobox 40.379
hoxd4ahomeo box D4a0.377
foxg1aforkhead box G1a0.375
irx7iroquois homeobox protein 70.359
hoxb5ahomeo box B5a0.355
hoxa3ahomeo box A3a0.343
tll1tolloid-like 10.336
her7hairy and enhancer of split related-70.332
hoxb4ahomeo box B4a0.312
mab21l2mab-21-like 20.306
lhx5LIM homeobox 50.303
tbx6T-box gene 60.302
bmp7abone morphogenetic protein 7a0.277
flot2aflotillin 2a0.277
foxd5forkhead box D50.267
eng2bengrailed 2b0.260
fgf3fibroblast growth factor 30.254
tbx18T-box 180.254
bmp2bbone morphogenetic protein 2b0.246
epha7eph receptor A70.245
irx1airoquois homeobox protein 1, a0.237
voxventral homeobox0.236
lfnglunatic fringe homolog0.217
wnt5bwingless-type MMTV integration site family, member 5b0.216
gbx2gastrulation brain homeo box 20.204
hoxb1bhomeo box B1b0.204
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.204
sox3SRY-box containing gene 30.203
tbx2bT-box 2b0.201
gata3GATA-binding protein 30.198
irx5airoquois homeobox protein 5a0.190
neurod4neurogenic differentiation 40.186
dlx4bdistal-less homeobox gene 4b0.185
eve1even-skipped-like10.184
cdx4caudal type homeo box transcription factor 40.177
efnb3bephrin B3b0.174
sox1aSRY-box containing gene 1a0.169
msxemuscle segment homeobox E0.163
dlx3bdistal-less homeobox gene 3b0.160
hoxb5bhomeo box B5b0.160
sox2SRY-box containing gene 20.152
sall4sal-like 4 (Drosophila)0.151
notch1anotch homolog 1a0.147
mespamesoderm posterior a0.143
mespbmesoderm posterior b0.138
smosmoothened homolog (Drosophila)0.135
dbx1bdeveloping brain homeobox 1b0.131
hmx3homeo box (H6 family) 30.130
hey1hairy/enhancer-of-split related with YRPW motif 10.128
nkx2.2aNK2 transcription factor related 2a0.128
emx3empty spiracles homeobox 30.127
lhx1bLIM homeobox 1b0.126
vsx2visual system homeobox 20.125
fgf8bfibroblast growth factor 8 b0.123
epb4.1l4erythrocyte protein band 4.1-like 40.121
notch3notch homolog 30.120
admpanti-dorsalizing morphogenic protein0.119
isl1islet10.117
ephb4beph receptor B4b0.106
vax2ventral anterior homeobox 20.106
hbbe3hemoglobin beta embryonic-30.105
her6hairy-related 60.104
notch2notch homolog 20.098
hoxb8ahomeo box B8a0.097
fgf8afibroblast growth factor 8 a0.097
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.096
fgf10afibroblast growth factor 10a0.096
hoxc6ahomeo box C6a0.094
sp5lSp5 transcription factor-like0.091
foxb1.2forkhead box B1.20.089
gli2aGLI-Kruppel family member GLI2a0.089
irx1biroquois homeobox protein 1, b0.088
vangl2vang-like 2 (van gogh, Drosophila)0.087
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
wgwingless0.985
hhhedgehog0.963
Abd-BAbdominal B0.787
cicubitus interruptus0.782
tintinman0.717
stumpsCG31317 gene product from transcript CG31317-RC0.665
enengrailed0.586
salmspalt major0.530
dppdecapentaplegic0.497
AntpAntennapedia0.494
bnlbranchless0.435
brkbrinker0.415
HLH54FCG5005 gene product from transcript CG5005-RA0.350
SerSerrate0.313
tshteashirt0.291
binbiniou0.278
EgfrEpidermal growth factor receptor0.271
argosCG4531 gene product from transcript CG4531-RA0.270
bynbrachyenteron0.222
vgvestigial0.209
putpunt0.200
hkbhuckebein0.197
eyaeyes absent0.177
twitwist0.171
UbxUltrabithorax0.167
HHairless0.155
abd-Aabdominal A0.153
sogshort gastrulation0.139
dsxdoublesex0.127
CG14869CG14869 gene product from transcript CG14869-RB0.121
fkhfork head0.121
rhorhomboid0.120
DllDistal-less0.118
Mef2Myocyte enhancer factor 20.118
tlltailless0.118
gsbgooseberry0.118
ribribbon0.109
gcmglial cells missing0.106
ptcpatched0.105
pnrpannier0.104
TrhTryptophan hydroxylase0.100
ftzfushi tarazu0.096
esgescargot0.094
Doc2Dorsocross20.094
pntpointed0.091
PoxnPox neuro0.090
snssticks and stones0.089
slouslouch0.088
pyrpyramus0.086
E(spl)Enhancer of split0.084
eyeyeless0.083
srstripe0.080
wbwing blister0.076
htlheartless0.072
konkon-tiki0.072
lmdlame duck0.070
Wnt2Wnt oncogene analog 20.066
zfh1Zn finger homeodomain 10.064
LanB1CG7123 gene product from transcript CG7123-RA0.064
senssenseless0.057
HmgcrHMG Coenzyme A reductase0.050
rolsrolling pebbles0.049
slp1sloppy paired 10.047
DlDelta0.047
kniknirps0.039
fasfaint sausage0.037
HimHoles in muscle0.036
Lim1CG11354 gene product from transcript CG11354-RA0.036
slislit0.036
rorough0.035
amosabsent MD neurons and olfactory sensilla0.035
dydusky0.035
PclPolycomblike0.035
sinusinuous0.035
dmrt99Bdoublesex-Mab related 99B0.035
opaodd paired0.035
toytwin of eyeless0.035
sflsulfateless0.035
jebjelly belly0.034
lablabial0.034
pbproboscipedia0.033
kkvkrotzkopf verkehrt0.033
gtgiant0.032
rempAreduced mechanoreceptor potential A0.032
naunautilus0.031
mxcmulti sex combs0.031
discodisconnected0.030
hpohippo0.030
nocno ocelli0.030
aopanterior open0.030
Act42AActin 42A0.029
MsiMale-specific insect derived growth factor0.027
Btk29ABtk family kinase at 29A0.027
foifear-of-intimacy0.027
vavCG7893 gene product from transcript CG7893-RB0.026
alaristaless0.024
ifinflated0.024
btlbreathless0.023
rnrotund0.022
dshdishevelled0.022
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PBX1pre-B-cell leukemia homeobox 11.000
MEIS1Meis homeobox 11.000
MEIS2Meis homeobox 21.000
BMP2bone morphogenetic protein 20.997
JAG1jagged 10.995
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.989
SETD8SET domain containing (lysine methyltransferase) 80.988
NOTCH3notch 30.966
LRP6low density lipoprotein receptor-related protein 60.938
HOXA9homeobox A90.935
FGF2fibroblast growth factor 2 (basic)0.925
FGF1fibroblast growth factor 1 (acidic)0.867
NEDD4neural precursor cell expressed, developmentally down-regulated 40.803
MAML1mastermind-like 1 (Drosophila)0.686
FRS2fibroblast growth factor receptor substrate 20.579
HOXA10homeobox A100.562
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.477
PLCG1phospholipase C, gamma 10.465
NFIBnuclear factor I/B0.398
FGFR2fibroblast growth factor receptor 20.394
FSTL1follistatin-like 10.372
FZD1frizzled homolog 1 (Drosophila)0.261
MYH10myosin, heavy chain 10, non-muscle0.216
LATlinker for activation of T cells0.173
ATXN1Lataxin 1-like0.171
SMURF1SMAD specific E3 ubiquitin protein ligase 10.169
DLL1delta-like 1 (Drosophila)0.139
NOSTRINnitric oxide synthase trafficker0.132
ZFYVE9zinc finger, FYVE domain containing 90.129
NOTCH2notch 20.120
BBS1Bardet-Biedl syndrome 10.118
FOXC1forkhead box C10.107
LBX1ladybird homeobox 10.101
FZD8frizzled homolog 8 (Drosophila)0.099
HOXD13homeobox D130.098
BMP4bone morphogenetic protein 40.093
JAG2jagged 20.091
ZMYND11zinc finger, MYND-type containing 110.089
BMPR1Abone morphogenetic protein receptor, type IA0.087
SPENspen homolog, transcriptional regulator (Drosophila)0.087
SMAD1SMAD family member 10.082
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.075
HOXD9homeobox D90.073
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.064
FOXF2forkhead box F20.063
RHOBras homolog gene family, member B0.062
SIM2single-minded homolog 2 (Drosophila)0.061
HOXB7homeobox B70.060
SIX1SIX homeobox 10.059
COL2A1collagen, type II, alpha 10.058
HOXA13homeobox A130.058
HIC1hypermethylated in cancer 10.057
FOXL1forkhead box L10.057
GATA5GATA binding protein 50.056
FZD2frizzled homolog 2 (Drosophila)0.055
FOXE1forkhead box E1 (thyroid transcription factor 2)0.055
PAX8paired box 80.052
HES2hairy and enhancer of split 2 (Drosophila)0.051
HOXA5homeobox A50.051
WNT7Awingless-type MMTV integration site family, member 7A0.051
TLX2T-cell leukemia homeobox 20.050
UTF1undifferentiated embryonic cell transcription factor 10.050
MYOD1myogenic differentiation 10.049
PDX1pancreatic and duodenal homeobox 10.049
FGF3fibroblast growth factor 30.046
MXRA5matrix-remodelling associated 50.045
HOXC8homeobox C80.045
FGF8fibroblast growth factor 8 (androgen-induced)0.043
HOXB9homeobox B90.043
SMAD5SMAD family member 50.042
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.041
PAX7paired box 70.041
HOXA11homeobox A110.041
CDX2caudal type homeobox 20.041
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.040
PYYpeptide YY0.040
FOXD3forkhead box D30.040
HOXB13homeobox B130.039
INHBBinhibin, beta B0.038
NPAS1neuronal PAS domain protein 10.038
SFRP1secreted frizzled-related protein 10.037
WNT10Awingless-type MMTV integration site family, member 10A0.037
SMAD2SMAD family member 20.036
HOXB5homeobox B50.036
FZD7frizzled homolog 7 (Drosophila)0.034
FOXF1forkhead box F10.034
TBX1T-box 10.034
TP73tumor protein p730.033
GSK3Bglycogen synthase kinase 3 beta0.032
NOS3nitric oxide synthase 3 (endothelial cell)0.032
OTPorthopedia homeobox0.031
MSX1msh homeobox 10.031
CREBBPCREB binding protein0.031
HOXD1homeobox D10.030
RAXretina and anterior neural fold homeobox0.029
NKX2-1NK2 homeobox 10.029
KAL1Kallmann syndrome 1 sequence0.029
LHX5LIM homeobox 50.029
SFRP5secreted frizzled-related protein 50.029
WNT6wingless-type MMTV integration site family, member 60.029
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Bmp4bone morphogenetic protein 40.999
Gli3GLI-Kruppel family member GLI30.999
Foxc1forkhead box C10.991
Pax2paired box gene 20.988
Pitx2paired-like homeodomain transcription factor 20.986
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.982
Ctnnb1catenin (cadherin associated protein), beta 10.962
Pax3paired box gene 30.946
Tbx1T-box 10.944
Bmp7bone morphogenetic protein 70.933
Fgfr1fibroblast growth factor receptor 10.930
Pbx1pre B-cell leukemia transcription factor 10.917
Isl1ISL1 transcription factor, LIM/homeodomain0.907
Hoxa11homeobox A110.895
Hoxd13homeobox D130.894
Fgf8fibroblast growth factor 80.891
Vangl2vang-like 2 (van gogh, Drosophila)0.887
Hand1heart and neural crest derivatives expressed transcript 10.881
Sfrp2secreted frizzled-related protein 20.878
Eya1eyes absent 1 homolog (Drosophila)0.820
Foxc2forkhead box C20.815
Rargretinoic acid receptor, gamma0.777
Jag1jagged 10.767
Gdf5growth differentiation factor 50.728
Tgfbr2transforming growth factor, beta receptor II0.705
Hoxd11homeobox D110.613
Hand2heart and neural crest derivatives expressed transcript 20.604
Sox2SRY-box containing gene 20.602
Meox2mesenchyme homeobox 20.592
Sox9SRY-box containing gene 90.583
Hoxa13homeobox A130.580
Otx2orthodenticle homolog 2 (Drosophila)0.531
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.509
Gli2GLI-Kruppel family member GLI20.501
Hoxa3homeobox A30.496
Bmpr1abone morphogenetic protein receptor, type 1A0.494
Tcfap2atranscription factor AP-2, alpha0.487
Hoxa1homeobox A10.469
Tgfb2transforming growth factor, beta 20.466
Zeb1zinc finger E-box binding homeobox 10.441
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.416
Gas1growth arrest specific 10.397
Nodalnodal0.391
Engendoglin0.355
Alx4aristaless-like homeobox 40.354
Wnt3awingless-related MMTV integration site 3A0.345
Hes1hairy and enhancer of split 1 (Drosophila)0.339
Phox2bpaired-like homeobox 2b0.333
Gscgoosecoid homeobox0.330
Dlx5distal-less homeobox 50.319
Tbx15T-box 150.319
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.310
Fgf10fibroblast growth factor 100.297
Prrx1paired related homeobox 10.287
Ntf3neurotrophin 30.279
Smad6MAD homolog 6 (Drosophila)0.276
Msx2homeobox, msh-like 20.273
Msx1homeobox, msh-like 10.272
Gata4GATA binding protein 40.271
Smosmoothened homolog (Drosophila)0.270
Psen1presenilin 10.261
Ror2receptor tyrosine kinase-like orphan receptor 20.245
Ptenphosphatase and tensin homolog0.242
Sox4SRY-box containing gene 40.241
Hoxa9homeobox A90.238
Fgfr3fibroblast growth factor receptor 30.229
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.228
Dkk1dickkopf homolog 1 (Xenopus laevis)0.219
Nognoggin0.217
Meis2Meis homeobox 20.213
Six2sine oculis-related homeobox 2 homolog (Drosophila)0.211
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.188
Foxd2forkhead box D20.182
Hoxa5homeobox A50.178
Gata3GATA binding protein 30.174
Tbx2T-box 20.171
Vegfavascular endothelial growth factor A0.170
Cdh5cadherin 50.168
Efnb2ephrin B20.168
Prrx2paired related homeobox 20.165
Tbx6T-box 60.165
Barx1BarH-like homeobox 10.161
Sox11SRY-box containing gene 110.154
Apcadenomatosis polyposis coli0.141
Fgf3fibroblast growth factor 30.140
Lef1lymphoid enhancer binding factor 10.137
Rarbretinoic acid receptor, beta0.136
Nos3nitric oxide synthase 3, endothelial cell0.135
Ptpn11protein tyrosine phosphatase, non-receptor type 110.133
Smad3MAD homolog 3 (Drosophila)0.117
Hoxa2homeobox A20.115
Retret proto-oncogene0.107
Lhx1LIM homeobox protein 10.107
Lmx1aLIM homeobox transcription factor 1 alpha0.102
Gbx2gastrulation brain homeobox 20.092
Acvr1activin A receptor, type 10.088
Kif3akinesin family member 3A0.087
Tcf21transcription factor 210.084
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism