The network for 'alpha amino acid biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

alpha amino acid biosynthetic process

The chemical reactions and pathways resulting in the formation of an alpha-amino acid.

NameDescriptionProbabilityFunc Analog Organism
ARO2Aro2p0.980
SER1Ser1p0.964
THR4Thr4p0.920
ASN1Asn1p0.914
LYS1Lys1p0.912
ARG1Arg1p0.911
TRP2Trp2p0.894
ARG4Arg4p0.892
ARG5,6Arg5,6p0.863
ARO8Aro8p0.829
TRP3Trp3p0.821
MET13Met13p0.787
HIS7His7p0.763
KRS1Krs1p0.742
HIS5His5p0.737
ARG2Arg2p0.660
LYS12Lys12p0.646
GGC1Ggc1p0.640
MET7Met7p0.604
TAE1Tae1p0.571
ARG3Arg3p0.547
ADE4Ade4p0.528
ILV6Ilv6p0.503
LSC2Lsc2p0.490
TRP5Trp5p0.464
MET6Met6p0.449
ALD5Ald5p0.435
ILV2Ilv2p0.408
ARO1Aro1p0.404
LYS21Lys21p0.399
ILV3Ilv3p0.395
MRI1Mri1p0.390
BAT1Bat1p0.387
LEU9Leu9p0.380
ENT3Ent3p0.366
FMP40Fmp40p0.360
ARO3Aro3p0.353
HIS4His4p0.341
HIS1His1p0.341
CPA2Cpa2p0.319
DUG1Dug1p0.311
SHM2Shm2p0.305
LYS2Lys2p0.304
OAC1Oac1p0.300
MET22Met22p0.295
YJR111Chypothetical protein0.294
ERV46Erv46p0.292
MIS1Mis1p0.286
HOM3Hom3p0.275
ASN2Asn2p0.271
NIF3Nif3p0.267
ARG81Arg81p0.262
ADE12Ade12p0.246
YLR179Chypothetical protein0.244
SAM1Sam1p0.243
ORT1Ort1p0.239
HOM2Hom2p0.235
ATR1Atr1p0.216
YMC2Ymc2p0.214
IDP1Idp1p0.212
TEA1Tea1p0.203
ILV1Ilv1p0.194
HIS2His2p0.194
MUP3Mup3p0.187
TRP4Trp4p0.184
ADE2Ade2p0.184
ADE3Ade3p0.181
BNA1Bna1p0.180
LYS9Lys9p0.177
STR2Str2p0.177
MET28Met28p0.176
FCY2Fcy2p0.173
HIS3His3p0.171
ARO4Aro4p0.164
LEU1Leu1p0.162
TRM9Trm9p0.160
ARG8Arg8p0.160
MET5Met5p0.158
REE1Ree1p0.157
DLD3Dld3p0.157
GND1Gnd1p0.156
YOR302Whypothetical protein0.156
FSF1Fsf1p0.156
YNG1Yng1p0.155
LAT1Lat1p0.154
CAR1Car1p0.153
HSP60Hsp60p0.151
CKB1Ckb1p0.151
ERG13Erg13p0.148
PMU1Pmu1p0.146
YGR001Chypothetical protein0.144
NAT5Nat5p0.143
SAM4Sam4p0.143
IDH1Idh1p0.142
SPE3Spe3p0.142
CPA1Cpa1p0.138
BAT2Bat2p0.137
SCC4Scc4p0.133
ODC2Odc2p0.133
ADE5,7Ade5,7p0.131
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
FdhFormaldehyde dehydrogenase0.074
EnoEnolase0.045
CG3011CG3011 gene product from transcript CG3011-RA0.031
Trxr-1Thioredoxin reductase-10.026
Got2Glutamate oxaloacetate transaminase 20.022
CG1240CG1240 gene product from transcript CG1240-RA0.022
seascheggia0.018
CG10576CG10576 gene product from transcript CG10576-RA0.017
CG8036CG8036 gene product from transcript CG8036-RB0.016
CG4365CG4365 gene product from transcript CG4365-RB0.014
l(1)G0334lethal (1) G03340.014
pugpugilist0.013
ade5CG3989 gene product from transcript CG3989-RA0.012
Cyp1Cyclophilin 10.012
CG3760CG3760 gene product from transcript CG3760-RB0.012
CG16704CG16704 gene product from transcript CG16704-RA0.012
Ance-4CG8196 gene product from transcript CG8196-RA0.011
CG11255CG11255 gene product from transcript CG11255-RA0.011
CG6415CG6415 gene product from transcript CG6415-RA0.010
CG5214CG5214 gene product from transcript CG5214-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IARSisoleucyl-tRNA synthetase0.332
GARSglycyl-tRNA synthetase0.316
RAB10RAB10, member RAS oncogene family0.226
XPOTexportin, tRNA (nuclear export receptor for tRNAs)0.187
SOD1superoxide dismutase 1, soluble0.181
ALDOBaldolase B, fructose-bisphosphate0.170
NARSasparaginyl-tRNA synthetase0.120
TOM1L1target of myb1 (chicken)-like 10.116
YARStyrosyl-tRNA synthetase0.115
SARSseryl-tRNA synthetase0.088
CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 10.068
FHfumarate hydratase0.066
MARSmethionyl-tRNA synthetase0.065
ALDOAaldolase A, fructose-bisphosphate0.056
GLUD1glutamate dehydrogenase 10.052
GLUD2glutamate dehydrogenase 20.051
MBNL1muscleblind-like (Drosophila)0.048
VDAC1voltage-dependent anion channel 10.042
EPRSglutamyl-prolyl-tRNA synthetase0.041
ECHS1enoyl CoA hydratase, short chain, 1, mitochondrial0.040
PRDX2peroxiredoxin 20.039
CDK2AP2cyclin-dependent kinase 2 associated protein 20.038
HPRT1hypoxanthine phosphoribosyltransferase 10.037
CALCAcalcitonin-related polypeptide alpha0.037
PDHA1pyruvate dehydrogenase (lipoamide) alpha 10.036
GCATglycine C-acetyltransferase0.033
DLG2discs, large homolog 2 (Drosophila)0.032
PSAT1phosphoserine aminotransferase 10.031
DNAJA3DnaJ (Hsp40) homolog, subfamily A, member 30.027
AIFM1apoptosis-inducing factor, mitochondrion-associated, 10.027
AARSalanyl-tRNA synthetase0.023
SLC25A10solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 100.022
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.021
VPS25vacuolar protein sorting 25 homolog (S. cerevisiae)0.021
HADHhydroxyacyl-CoA dehydrogenase0.021
C21orf33chromosome 21 open reading frame 330.020
SORDsorbitol dehydrogenase0.019
SLC37A4solute carrier family 37 (glucose-6-phosphate transporter), member 40.019
ATP5BATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.018
THOC7THO complex 7 homolog (Drosophila)0.018
DCXRdicarbonyl/L-xylulose reductase0.018
CARScysteinyl-tRNA synthetase0.018
NDUFS1NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)0.017
NIF3L1NIF3 NGG1 interacting factor 3-like 1 (S. pombe)0.017
DLG1discs, large homolog 1 (Drosophila)0.016
PEBP1phosphatidylethanolamine binding protein 10.016
PCK2phosphoenolpyruvate carboxykinase 2 (mitochondrial)0.016
TCTN3tectonic family member 30.016
SLC2A2solute carrier family 2 (facilitated glucose transporter), member 20.015
LNX1ligand of numb-protein X 10.015
SHMT2serine hydroxymethyltransferase 2 (mitochondrial)0.015
THOC5THO complex 50.015
GCDHglutaryl-CoA dehydrogenase0.015
DBTdihydrolipoamide branched chain transacylase E20.015
CYB5Bcytochrome b5 type B (outer mitochondrial membrane)0.015
RPS27ribosomal protein S270.014
PPP1R12Aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.014
NAT2N-acetyltransferase 2 (arylamine N-acetyltransferase)0.013
PHGDHphosphoglycerate dehydrogenase0.013
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)0.013
ATF2activating transcription factor 20.013
ATXN10ataxin 100.013
MTHFD2methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase0.012
KARSlysyl-tRNA synthetase0.012
ACLYATP citrate lyase0.012
HAAO3-hydroxyanthranilate 3,4-dioxygenase0.012
STT3ASTT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)0.012
GPT2glutamic pyruvate transaminase (alanine aminotransferase) 20.012
GRSF1G-rich RNA sequence binding factor 10.012
ARG1arginase, liver0.012
SEPT11septin 110.011
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.011
URODuroporphyrinogen decarboxylase0.011
OSBPL8oxysterol binding protein-like 80.011
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.011
MDH2malate dehydrogenase 2, NAD (mitochondrial)0.011
MAP3K1mitogen-activated protein kinase kinase kinase 10.011
ADAM17ADAM metallopeptidase domain 170.011
B4GALT2UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 20.011
MIPEPmitochondrial intermediate peptidase0.011
QDPRquinoid dihydropteridine reductase0.011
PON1paraoxonase 10.010
BAATbile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)0.010
DCTDdCMP deaminase0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dlg4discs, large homolog 4 (Drosophila)0.405
Dctpp1dCTP pyrophosphatase 10.379
Pgls6-phosphogluconolactonase0.278
Sardhsarcosine dehydrogenase0.271
Immtinner membrane protein, mitochondrial0.243
Eif5aeukaryotic translation initiation factor 5A0.242
Srebf2sterol regulatory element binding factor 20.199
Karslysyl-tRNA synthetase0.193
Scp2sterol carrier protein 2, liver0.123
Tspan12tetraspanin 120.104
Gcshglycine cleavage system protein H (aminomethyl carrier)0.100
Atad3aATPase family, AAA domain containing 3A0.096
F2coagulation factor II0.093
Mthfd1methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase0.087
Gnmtglycine N-methyltransferase0.082
Mdh1malate dehydrogenase 1, NAD (soluble)0.075
Qdprquinoid dihydropteridine reductase0.074
Hsd17b10hydroxysteroid (17-beta) dehydrogenase 100.074
Dmgdhdimethylglycine dehydrogenase precursor0.073
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 10.073
Dbidiazepam binding inhibitor0.068
Procprotein C0.067
Vdac1voltage-dependent anion channel 10.066
Got1glutamate oxaloacetate transaminase 1, soluble0.060
Shmt1serine hydroxymethyltransferase 1 (soluble)0.060
Shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.057
Pnliprp2pancreatic lipase-related protein 20.054
Ak3adenylate kinase 30.054
Arid3aAT rich interactive domain 3A (BRIGHT-like)0.054
Hsd17b4hydroxysteroid (17-beta) dehydrogenase 40.053
Aco1aconitase 10.052
Aldh18a1aldehyde dehydrogenase 18 family, member A10.052
C1qbpcomplement component 1, q subcomponent binding protein0.050
Campcathelicidin antimicrobial peptide0.049
Got2glutamate oxaloacetate transaminase 2, mitochondrial0.049
BC048355cDNA sequence BC0483550.049
Aldh9a1aldehyde dehydrogenase 9, subfamily A10.045
Adh5alcohol dehydrogenase 5 (class III), chi polypeptide0.044
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.044
Abcb1aATP-binding cassette, sub-family B (MDR/TAP), member 1A0.042
Elf1E74-like factor 10.042
Galk1galactokinase 10.041
Sfxn1sideroflexin 10.041
Pebp1phosphatidylethanolamine binding protein 10.040
Hccsholocytochrome c synthetase0.040
Gnrh1gonadotropin releasing hormone 10.040
Hgdhomogentisate 1, 2-dioxygenase0.040
Elovl2elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 20.039
Apobapolipoprotein B0.039
Mrpl2mitochondrial ribosomal protein L20.038
Mrpl13mitochondrial ribosomal protein L130.038
Asgr2asialoglycoprotein receptor 20.037
Acy1aminoacylase 10.037
Ciapin1cytokine induced apoptosis inhibitor 10.036
Eef1deukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)0.035
Fpgsfolylpolyglutamyl synthetase0.035
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.034
Stc2stanniocalcin 20.033
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.033
Ethe1ethylmalonic encephalopathy 10.032
Igfbp1insulin-like growth factor binding protein 10.032
Bhmt2betaine-homocysteine methyltransferase 20.032
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.032
Apoa2apolipoprotein A-II0.030
Slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.030
Ugp2UDP-glucose pyrophosphorylase 20.030
Trap1TNF receptor-associated protein 10.030
Cyb5cytochrome b-50.029
Hspd1heat shock protein 1 (chaperonin)0.029
Acadsacyl-Coenzyme A dehydrogenase, short chain0.029
Sox15SRY-box containing gene 150.029
Gtf3ageneral transcription factor III A0.029
Gjb1gap junction protein, beta 10.028
Col11a2collagen, type XI, alpha 20.028
Lonp1lon peptidase 1, mitochondrial0.028
Rgs14regulator of G-protein signaling 140.028
Slc38a3solute carrier family 38, member 30.028
Apofapolipoprotein F0.027
Tmem150atransmembrane protein 150A0.027
Bsnbassoon0.027
AhcyS-adenosylhomocysteine hydrolase0.027
Dhcr2424-dehydrocholesterol reductase0.026
1300001I01RikRIKEN cDNA 1300001I01 gene0.026
Sypsynaptophysin0.026
Aldobaldolase B, fructose-bisphosphate0.025
Fbp1fructose bisphosphatase 10.025
Phb2prohibitin 20.025
Tulp2tubby-like protein 20.025
Acat2acetyl-Coenzyme A acetyltransferase 20.024
Lap3leucine aminopeptidase 30.024
Ahsgalpha-2-HS-glycoprotein0.024
Agxtalanine-glyoxylate aminotransferase0.024
Slc19a1solute carrier family 19 (sodium/hydrogen exchanger), member 10.024
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.024
NadkNAD kinase0.024
Gcgroup specific component0.024
Ass1argininosuccinate synthetase 10.023
Six5sine oculis-related homeobox 5 homolog (Drosophila)0.023
Grin2cglutamate receptor, ionotropic, NMDA2C (epsilon 3)0.023
Faahfatty acid amide hydrolase0.023
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Aldh18a1aldehyde dehydrogenase 18 family, member A10.447
Dhfrdihydrofolate reductase0.397
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.340
Fbp1fructose-1,6-bisphosphatase 10.315
Gcgroup specific component0.312
Pahphenylalanine hydroxylase0.267
Ass1argininosuccinate synthetase 10.258
Tstthiosulfate sulfurtransferase0.217
Tattyrosine aminotransferase0.214
Aadataminoadipate aminotransferase0.208
Asnsasparagine synthetase0.203
Sdsserine dehydratase0.196
Carscysteinyl-tRNA synthetase0.186
Cbscystathionine beta synthase0.153
Shmt1serine hydroxymethyltransferase 1 (soluble)0.150
Slc7a1solute carrier family 7 (cationic amino acid transporter, y+ system), member 10.144
Sardhsarcosine dehydrogenase0.142
Mthfd2methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase0.138
Nr1h4nuclear receptor subfamily 1, group H, member 40.116
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.111
Acy1aminoacylase 10.107
Nolc1nucleolar and coiled-body phosphoprotein 10.106
Garsglycyl-tRNA synthetase0.106
Khkketohexokinase0.102
Ahcyadenosylhomocysteinase0.099
Dpysdihydropyrimidinase0.098
Glsglutaminase0.097
Echs1enoyl Coenzyme A hydratase, short chain, 1, mitochondrial0.096
Il1rninterleukin 1 receptor antagonist0.093
Mpstmercaptopyruvate sulfurtransferase0.091
Apoa1apolipoprotein A-I0.089
Slc3a2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 20.086
Tk1thymidine kinase 1, soluble0.078
Slc7a5solute carrier family 7 (cationic amino acid transporter, y+ system), member 50.077
Marsmethionine-tRNA synthetase0.075
Rdh2retinol dehydrogenase 20.074
Sfxn1sideroflexin 10.071
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.070
Gys2glycogen synthase 20.070
Pklrpyruvate kinase, liver and RBC0.069
Cyp2c12cytochrome P450, family 2, subfamily c, polypeptide 120.066
Mbl2mannose-binding lectin (protein C) 20.063
Gcshglycine cleavage system protein H (aminomethyl carrier)0.063
FanccFanconi anemia, complementation group C0.061
Fabp1fatty acid binding protein 1, liver0.060
Got2glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)0.059
Trap1TNF receptor-associated protein 10.059
Ftcdformiminotransferase cyclodeaminase0.058
Nr5a2nuclear receptor subfamily 5, group A, member 20.058
Gldcglycine dehydrogenase (decarboxylating)0.057
Fkbp11FK506 binding protein 110.056
Akr7a2aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)0.055
Anxa7annexin A70.055
Ppifpeptidylprolyl isomerase F0.054
Alg2asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)0.053
Glud1glutamate dehydrogenase 10.052
Pccapropionyl-coenzyme A carboxylase, alpha polypeptide0.051
Piglphosphatidylinositol glycan anchor biosynthesis, class L0.050
Sf3b3splicing factor 3b, subunit 30.049
Mthfd1methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase0.048
AuhAU RNA binding protein/enoyl-coenzyme A hydratase0.045
Got1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)0.044
Dph1DPH1 homolog (S. cerevisiae)0.044
Lipclipase, hepatic0.044
Slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.043
Selenbp1selenium binding protein 10.042
Bbox1butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 10.042
Serpina3mserine (or cysteine) proteinase inhibitor, clade A, member 3M0.042
KlKlotho0.041
Qprtquinolinate phosphoribosyltransferase0.041
Bmp7bone morphogenetic protein 70.041
Tdo2tryptophan 2,3-dioxygenase0.040
Acsm2acyl-CoA synthetase medium-chain family member 20.039
Ndrg2N-myc downstream regulated gene 20.039
Eif3beukaryotic translation initiation factor 3, subunit B0.039
Suclg2succinate-CoA ligase, GDP-forming, beta subunit0.038
Hpd4-hydroxyphenylpyruvate dioxygenase0.038
Sult1a1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.038
Cdh17cadherin 170.037
Nntnicotinamide nucleotide transhydrogenase0.036
Pptc7PTC7 protein phosphatase homolog (S. cerevisiae)0.036
Qarsglutaminyl-tRNA synthetase0.036
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.035
Hn1lhematological and neurological expressed 1-like0.035
Pfkfb16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.034
Aldh7a1aldehyde dehydrogenase 7 family, member A10.033
Mipepmitochondrial intermediate peptidase0.032
Kynukynureninase (L-kynurenine hydrolase)0.031
Nsun4NOL1/NOP2/Sun domain family, member 40.030
Rcl1RNA terminal phosphate cyclase-like 10.030
Pex1peroxisomal biogenesis factor 10.030
Gja5gap junction protein, alpha 50.030
RGD1307222similar to mKIAA0664 protein0.030
Gipgastric inhibitory polypeptide0.030
Hsd17b13hydroxysteroid (17-beta) dehydrogenase 130.030
Dmgdhdimethylglycine dehydrogenase0.030
Ppa2pyrophosphatase (inorganic) 20.029
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.029
Chac1ChaC, cation transport regulator homolog 1 (E. coli)0.029
Fabp2fatty acid binding protein 2, intestinal0.029