The network for 'negative regulation of protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

NameDescriptionProbabilityFunc Analog Organism
CDC55Cdc55p0.670
CDC20Cdc20p0.661
PPH22Pph22p0.616
PPH21Pph21p0.586
MAD2Mad2p0.526
HHF2Hhf2p0.511
CSE4Cse4p0.446
RTS1Rts1p0.312
CTF13Ctf13p0.257
PPZ1Ppz1p0.254
SLK19Slk19p0.237
MAD3Mad3p0.215
CHL4Chl4p0.214
MAD1Mad1p0.200
MTW1Mtw1p0.150
KIP1Kip1p0.149
ZDS1Zds1p0.125
MLC1Mlc1p0.120
NBL1Nbl1p0.119
YPI1Ypi1p0.116
IML3Iml3p0.110
BUB3Bub3p0.108
SLI15Sli15p0.098
CTF3Ctf3p0.094
BUB1Bub1p0.093
SDS22Sds22p0.083
NSL1Nsl1p0.079
MCM21Mcm21p0.077
HTA1Hta1p0.050
EAF1Eaf1p0.050
TIP41Tip41p0.045
STE4Ste4p0.045
HTB1Htb1p0.042
DAM1Dam1p0.042
SPC24Spc24p0.041
VIK1Vik1p0.040
PIG2Pig2p0.039
UFD2Ufd2p0.039
RFA1Rfa1p0.038
YIL151Chypothetical protein0.038
IPL1Ipl1p0.037
SPO12Spo12p0.035
ASE1Ase1p0.034
FMP48Fmp48p0.034
KIN1Kin1p0.034
NTO1Nto1p0.033
YBP2Ybp2p0.033
YKL075Chypothetical protein0.032
CTF8Ctf8p0.031
SLG1Slg1p0.030
CDC28Cdc28p0.030
GLG1Glg1p0.029
PCL10Pcl10p0.029
SPC110Spc110p0.029
CIN1Cin1p0.029
PKC1Pkc1p0.029
PTI1Pti1p0.028
SET2Set2p0.027
YML053Chypothetical protein0.027
GIP2Gip2p0.027
BET5Bet5p0.027
SPC105Spc105p0.026
SRD1Srd1p0.026
YGL010Whypothetical protein0.026
HHT1Hht1p0.025
YNL144Chypothetical protein0.025
JLP2Jlp2p0.025
ATG27Atg27p0.024
PDR15Pdr15p0.024
STD1Std1p0.024
DSN1Dsn1p0.024
SMC5Smc5p0.024
TRA1Tra1p0.024
YOL038C-Ahypothetical protein0.024
PLC1Plc1p0.024
YLR162Whypothetical protein0.024
RMD5Rmd5p0.023
LEU2Leu2p0.023
SWC4Swc4p0.023
SAP4Sap4p0.023
YLR264C-Ahypothetical protein0.023
SMC4Smc4p0.023
VHS2Vhs2p0.023
CBF1Cbf1p0.022
CAB3Cab3p0.022
STU1Stu1p0.022
CAR1Car1p0.022
MER1Mer1p0.022
HST3Hst3p0.022
ARG8Arg8p0.021
HIT1Hit1p0.021
MEC1Mec1p0.021
YDL206Whypothetical protein0.021
SWC7Swc7p0.021
GLC7Glc7p0.021
TAF11Taf11p0.021
FRA2Fra2p0.021
SFI1Sfi1p0.021
YNR014Whypothetical protein0.021
CIN8Cin8p0.021
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
gpr-2Protein GPR-20.013
abl-1Protein ABL-10.012
his-42Protein HIS-420.012
imb-2Protein IMB-20.011
his-45Protein HIS-450.011
pri-2Protein PRI-20.011
rsd-6Protein RSD-60.011
asd-1Protein ASD-10.011
goa-1Protein GOA-10.010
sma-6Protein SMA-60.010
bli-1Protein BLI-10.010
C49H3.9Protein C49H3.90.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CycBCyclin B0.083
CSN5COP9 complex homolog subunit 50.064
Pp1-87BProtein phosphatase 1 at 87B0.038
Su(var)205Suppressor of variegation 2050.036
MEP-1CG1244 gene product from transcript CG1244-RG0.034
IswiImitation SWI0.033
ncdnon-claret disjunctional0.033
alphaTub67Calpha-Tubulin at 67C0.030
fzyfizzy0.029
Bap55Brahma associated protein 55kD0.027
Nup153Nucleoporin 1530.026
brmbrahma0.024
rinrasputin0.024
AblAbl tyrosine kinase0.023
pr-set7CG3307 gene product from transcript CG3307-RC0.021
IncenpInner centromere protein0.020
KP78bCG17216 gene product from transcript CG17216-RB0.020
CycB3Cyclin B30.019
cdc2CG5363 gene product from transcript CG5363-RA0.019
aslasterless0.019
Ras85DRas oncogene at 85D0.019
nctnicastrin0.018
Mmp1Matrix metalloproteinase 10.018
tefutelomere fusion0.018
hhhedgehog0.018
EgfrEpidermal growth factor receptor0.017
CycTCyclin T0.017
ruxroughex0.016
vasvasa0.016
borrborealin-related0.016
Sep2Septin-20.015
RpS20Ribosomal protein S200.015
htshu li tai shao0.015
hydhyperplastic discs0.014
rtettetracycline resistance0.014
Taf2TBP-associated factor 20.014
Psf2CG18013 gene product from transcript CG18013-RA0.014
captcapulet0.014
B52CG10851 gene product from transcript CG10851-RB0.014
fwdfour wheel drive0.013
sglsugarless0.013
CG2926CG2926 gene product from transcript CG2926-RA0.013
CSN6COP9 complex homolog subunit 60.013
imdimmune deficiency0.012
Syx13Syntaxin 130.012
spn-Dspindle D0.012
CG4771CG4771 gene product from transcript CG4771-RA0.012
cdc16CG6759 gene product from transcript CG6759-RA0.012
locolocomotion defects0.012
Gef26CG9491 gene product from transcript CG9491-RB0.012
NELF-BCG32721 gene product from transcript CG32721-RA0.012
FBX011FBX011 ortholog0.012
DNApol-alpha60DNA polymerase alpha 60kD0.012
Cdc37CG12019 gene product from transcript CG12019-RA0.011
Cap-GCG34438 gene product from transcript CG34438-RF0.011
Cks30ACyclin-dependent kinase subunit 30A0.011
Spn77BaSerpin 77Ba0.011
mus301mutagen-sensitive 3010.011
thrthree rows0.011
Syt4Synaptotagmin 40.010
CG2224CG2224 gene product from transcript CG2224-RA0.010
Cenp-CCG31258 gene product from transcript CG31258-RA0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMAD3SMAD family member 30.984
TRAF6TNF receptor-associated factor 60.869
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.813
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.539
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.532
SQSTM1sequestosome 10.520
DLG4discs, large homolog 4 (Drosophila)0.462
PRKCZprotein kinase C, zeta0.446
TP53tumor protein p530.383
PMLpromyelocytic leukemia0.382
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.363
IRAK2interleukin-1 receptor-associated kinase 20.354
SMAD2SMAD family member 20.343
TRIM39tripartite motif containing 390.301
SMAD1SMAD family member 10.294
DAXXdeath-domain associated protein0.285
CCT4chaperonin containing TCP1, subunit 4 (delta)0.262
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.241
MYD88myeloid differentiation primary response gene (88)0.213
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.205
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.169
TRIM43tripartite motif containing 430.168
AGAP5ArfGAP with GTPase domain, ankyrin repeat and PH domain 50.160
CCT8chaperonin containing TCP1, subunit 8 (theta)0.153
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.141
AGAP7ArfGAP with GTPase domain, ankyrin repeat and PH domain 70.141
GABARAPL2GABA(A) receptor-associated protein-like 20.140
MMP14matrix metallopeptidase 14 (membrane-inserted)0.135
SMURF2SMAD specific E3 ubiquitin protein ligase 20.131
FLNBfilamin B, beta0.131
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.110
LMNAlamin A/C0.110
PXNpaxillin0.102
GABARAPL1GABA(A) receptor-associated protein like 10.094
FASFas (TNF receptor superfamily, member 6)0.093
GABARAPGABA(A) receptor-associated protein0.092
ARIH2ariadne homolog 2 (Drosophila)0.091
VCPvalosin containing protein0.082
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.081
PLK1polo-like kinase 10.078
KPNA3karyopherin alpha 3 (importin alpha 4)0.078
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.076
FLNAfilamin A, alpha0.073
CCNA2cyclin A20.072
IL22RA2interleukin 22 receptor, alpha 20.071
RB1retinoblastoma 10.071
FBXW7F-box and WD repeat domain containing 70.070
APPamyloid beta (A4) precursor protein0.070
NOXA1NADPH oxidase activator 10.069
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.068
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.067
DLGAP1discs, large (Drosophila) homolog-associated protein 10.066
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.066
VHLvon Hippel-Lindau tumor suppressor0.065
UHRF2ubiquitin-like with PHD and ring finger domains 20.065
MAP3K5mitogen-activated protein kinase kinase kinase 50.064
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.063
COPS2COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)0.063
ADRBK1adrenergic, beta, receptor kinase 10.063
TPBGtrophoblast glycoprotein0.061
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.061
ATMataxia telangiectasia mutated0.061
GHRgrowth hormone receptor0.061
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.060
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.059
HDAC6histone deacetylase 60.059
ZNF263zinc finger protein 2630.058
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.058
TRIM32tripartite motif containing 320.057
ASF1AASF1 anti-silencing function 1 homolog A (S. cerevisiae)0.056
NBR1neighbor of BRCA1 gene 10.056
CDC27cell division cycle 27 homolog (S. cerevisiae)0.056
KAT5K(lysine) acetyltransferase 50.054
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.054
S100A4S100 calcium binding protein A40.052
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.051
TERF1telomeric repeat binding factor (NIMA-interacting) 10.050
CDCP1CUB domain containing protein 10.050
MBIPMAP3K12 binding inhibitory protein 10.049
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.048
COPS8COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)0.047
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.047
MED15mediator complex subunit 150.046
CCND1cyclin D10.046
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.046
DLG1discs, large homolog 1 (Drosophila)0.046
CD81CD81 molecule0.045
FOXM1forkhead box M10.045
IRAK3interleukin-1 receptor-associated kinase 30.044
SPRR2Asmall proline-rich protein 2A0.044
SKA2spindle and kinetochore associated complex subunit 20.044
CUL3cullin 30.044
CBX5chromobox homolog 50.044
CASC5cancer susceptibility candidate 50.043
SKP2S-phase kinase-associated protein 2 (p45)0.043
ITGB1BP3integrin beta 1 binding protein 30.043
TERF2IPtelomeric repeat binding factor 2, interacting protein0.042
SKA3spindle and kinetochore associated complex subunit 30.042
CIB1calcium and integrin binding 1 (calmyrin)0.042
COPS6COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)0.042
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.996
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.986
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.831
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.809
Mdm2transformed mouse 3T3 cell double minute 20.651
Traf6TNF receptor-associated factor 60.524
Ptenphosphatase and tensin homolog0.430
Dlg4discs, large homolog 4 (Drosophila)0.357
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.336
Ctnnb1catenin (cadherin associated protein), beta 10.332
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.330
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.299
Ighimmunoglobulin heavy chain complex0.249
Appamyloid beta (A4) precursor protein0.184
Tnftumor necrosis factor0.176
Il2rginterleukin 2 receptor, gamma chain0.157
Cd19CD19 antigen0.151
Thbs1thrombospondin 10.142
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.130
Notch2Notch gene homolog 2 (Drosophila)0.127
Esr1estrogen receptor 1 (alpha)0.126
Apcadenomatosis polyposis coli0.125
Amhr2anti-Mullerian hormone type 2 receptor0.119
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.117
Sap18Sin3-associated polypeptide 180.115
Lhx1LIM homeobox protein 10.113
Notch1Notch gene homolog 1 (Drosophila)0.112
Myd88myeloid differentiation primary response gene 880.106
Socs1suppressor of cytokine signaling 10.105
SkilSKI-like0.100
CblCasitas B-lineage lymphoma0.094
Cd40CD40 antigen0.090
Emx1empty spiracles homolog 1 (Drosophila)0.089
Lin9lin-9 homolog (C. elegans)0.087
FasFas (TNF receptor superfamily member 6)0.086
Stat3signal transducer and activator of transcription 30.085
Pax2paired box gene 20.082
Vdrvitamin D receptor0.081
DaxxFas death domain-associated protein0.081
Citcitron0.078
Sgol2shugoshin-like 2 (S. pombe)0.077
Aireautoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)0.076
Wnt10bwingless related MMTV integration site 10b0.073
Bcl3B-cell leukemia/lymphoma 30.073
Pgrprogesterone receptor0.071
Pcsk5proprotein convertase subtilisin/kexin type 50.071
Ikzf1IKAROS family zinc finger 10.068
Ptk2bPTK2 protein tyrosine kinase 2 beta0.066
Psen1presenilin 10.065
Hmmrhyaluronan mediated motility receptor (RHAMM)0.065
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.065
Tnfaip3tumor necrosis factor, alpha-induced protein 30.063
Dlgap1discs, large (Drosophila) homolog-associated protein 10.062
Plcg2phospholipase C, gamma 20.060
Shank2SH3/ankyrin domain gene 20.060
Nos1nitric oxide synthase 1, neuronal0.059
Sgol1shugoshin-like 1 (S. pombe)0.058
Brca1breast cancer 10.057
Axin1axin 10.054
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.053
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.052
Ncoa3nuclear receptor coactivator 30.051
Ooepoocyte expressed protein homolog (dog)0.050
Spag5sperm associated antigen 50.050
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.050
Trp73transformation related protein 730.050
Dlg2discs, large homolog 2 (Drosophila)0.049
Retret proto-oncogene0.049
Brca2breast cancer 20.048
Foxn1forkhead box N10.048
Cdk1cyclin-dependent kinase 10.048
Dkk1dickkopf homolog 1 (Xenopus laevis)0.047
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.046
Arid1aAT rich interactive domain 1A (SWI-like)0.045
Ptk2PTK2 protein tyrosine kinase 20.045
Tbrachyury0.045
Ccna2cyclin A20.043
Cdca8cell division cycle associated 80.043
Wnt7awingless-related MMTV integration site 7A0.042
Plcg1phospholipase C, gamma 10.042
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.042
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.042
Prkceprotein kinase C, epsilon0.041
WasWiskott-Aldrich syndrome homolog (human)0.041
Nbnnibrin0.041
Ccnb1cyclin B10.041
Bdnfbrain derived neurotrophic factor0.041
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.041
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.040
Gdnfglial cell line derived neurotrophic factor0.040
Cops4COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)0.040
Scube1signal peptide, CUB domain, EGF-like 10.040
Cep55centrosomal protein 550.039
Mdm4transformed mouse 3T3 cell double minute 40.039
Ncapg2non-SMC condensin II complex, subunit G20.039
Ncstnnicastrin0.039
Glrx3glutaredoxin 30.037
AxlAXL receptor tyrosine kinase0.037
Csf1colony stimulating factor 1 (macrophage)0.036
Pax8paired box gene 80.035
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism