The network for 'negative regulation of mitotic sister chromatid segregation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of mitotic sister chromatid segregation

Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis.

NameDescriptionProbabilityFunc Analog Organism
MAD2Mad2p0.885
SLI15Sli15p0.835
CDC20Cdc20p0.815
MTW1Mtw1p0.781
DSN1Dsn1p0.776
PPH22Pph22p0.745
CDC55Cdc55p0.723
NSL1Nsl1p0.713
HHF2Hhf2p0.654
SLK19Slk19p0.612
TID3Tid3p0.602
PPH21Pph21p0.576
CSE4Cse4p0.536
IML3Iml3p0.505
MAD3Mad3p0.476
CTF13Ctf13p0.439
DAM1Dam1p0.433
MCM21Mcm21p0.433
HHT1Hht1p0.424
SPC105Spc105p0.414
CTF3Ctf3p0.368
SMC4Smc4p0.366
MAD1Mad1p0.357
AME1Ame1p0.339
RTS1Rts1p0.237
SPC24Spc24p0.227
KIP1Kip1p0.219
MIF2Mif2p0.198
MCM22Mcm22p0.183
IPL1Ipl1p0.169
MPS1Mps1p0.169
YBP2Ybp2p0.150
NUF2Nuf2p0.148
OKP1Okp1p0.143
PPZ1Ppz1p0.135
NNF1Nnf1p0.130
FMP48Fmp48p0.106
BUB3Bub3p0.106
SDS22Sds22p0.093
ECO1Eco1p0.085
GIP2Gip2p0.083
HTA1Hta1p0.078
CIN8Cin8p0.077
CBF2Cbf2p0.073
CSM1Csm1p0.069
CHL4Chl4p0.069
BUB1Bub1p0.066
PIG2Pig2p0.065
YPI1Ypi1p0.055
SPC25Spc25p0.049
BRN1Brn1p0.049
SMC5Smc5p0.048
BIM1Bim1p0.048
PKC1Pkc1p0.046
ZDS1Zds1p0.046
KIC1Kic1p0.042
NBL1Nbl1p0.041
STU1Stu1p0.039
SPO12Spo12p0.039
PCL10Pcl10p0.037
VIK1Vik1p0.036
HST3Hst3p0.035
RAD53Rad53p0.034
CAB3Cab3p0.034
PDS1Pds1p0.034
SCC2Scc2p0.034
TIP41Tip41p0.034
GLG1Glg1p0.033
BFA1Bfa1p0.032
JLP2Jlp2p0.031
CBF1Cbf1p0.031
SMC2Smc2p0.031
SRD1Srd1p0.031
PSP1Psp1p0.029
YNL144Chypothetical protein0.029
GLC7Glc7p0.028
MCM16Mcm16p0.028
SMC3Smc3p0.027
PLC1Plc1p0.027
CRP1Crp1p0.027
YLR264C-Ahypothetical protein0.027
YLR162Whypothetical protein0.026
CIN1Cin1p0.026
SPC110Spc110p0.026
YOL038C-Ahypothetical protein0.026
SCM3Scm3p0.026
IML1Iml1p0.026
LEU2Leu2p0.026
ESP1Esp1p0.025
YML053Chypothetical protein0.025
PDR15Pdr15p0.025
PSY4Psy4p0.025
SAP4Sap4p0.024
YKL075Chypothetical protein0.024
ARG8Arg8p0.024
TOF2Tof2p0.024
ASE1Ase1p0.024
TGL2Tgl2p0.024
PTI1Pti1p0.023
VHS2Vhs2p0.023
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
ZK507.6Protein ZK507.60.050
cec-5Protein CEC-50.046
rnr-1Protein RNR-10.036
lmn-1Protein LMN-10.036
npp-11Protein NPP-110.029
math-33Protein MATH-330.028
his-42Protein HIS-420.025
knl-1Protein KNL-10.023
spdl-1Protein SPDL-10.023
gpr-2Protein GPR-20.022
ani-1Protein ANI-10.022
cdl-1Protein CDL-10.021
mcm-5Protein MCM-50.021
let-502Protein LET-5020.019
mcm-2Protein MCM-20.019
pri-2Protein PRI-20.018
scc-1Protein SCC-10.017
bmk-1Protein BMK-10.017
hcp-1Protein HCP-10.017
CELE_C24H12.5Protein C24H12.50.017
tba-2Protein TBA-20.015
his-45Protein HIS-450.015
F12F6.1Protein F12F6.10.015
aipl-1Protein AIPL-10.015
rsd-6Protein RSD-60.014
teg-4Protein TEG-40.014
attf-2Protein ATTF-20.013
gpr-1Protein GPR-10.013
cin-4Protein CIN-40.013
npp-1Protein NPP-10.012
bub-1Protein BUB-10.012
cyk-4Protein CYK-40.012
F33H2.3Protein F33H2.30.012
pcn-1Protein PCN-10.012
rpn-6.1Protein RPN-6.10.012
sas-5Protein SAS-50.012
wht-7Protein WHT-70.012
air-2Protein AIR-20.012
T08A11.2Protein T08A11.20.012
mcm-7Protein MCM-70.012
dsh-2Protein DSH-20.012
rod-1Protein ROD-10.011
lin-9Protein LIN-90.011
him-10Protein HIM-100.011
C02B10.5Protein C02B10.50.010
brc-1Protein BRC-10.010
mus-101Protein MUS-1010.010
air-1Protein AIR-10.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
flflfalafel0.426
CycBCyclin B0.203
aslasterless0.184
BubR1Bub1-related kinase0.173
Mcm10Sensitized chromosome inheritance modifier 190.105
aspabnormal spindle0.086
IswiImitation SWI0.059
CycB3Cyclin B30.056
gwlgreatwall0.042
CycACyclin A0.041
ncdnon-claret disjunctional0.041
cnncentrosomin0.040
CycECyclin E0.039
poloCG12306 gene product from transcript CG12306-RA0.037
Pp1-87BProtein phosphatase 1 at 87B0.036
ruxroughex0.035
MybMyb oncogene-like0.030
Cks30ACyclin-dependent kinase subunit 30A0.030
cmetCENP-meta0.029
Klp61FKinesin-like protein at 61F0.026
thrthree rows0.025
nbsCG6754 gene product from transcript CG6754-RC0.023
dupdouble parked0.023
SAKSak kinase0.021
piepineapple eye0.019
NiPp1Nuclear inhibitor of Protein phosphatase 10.019
mus312mutagen-sensitive 3120.019
SMC2CG10212 gene product from transcript CG10212-RA0.018
Cdc37CG12019 gene product from transcript CG12019-RA0.018
mad2CG17498 gene product from transcript CG17498-RA0.018
hayhaywire0.017
nodno distributive disjunction0.016
Nup153Nucleoporin 1530.016
mus301mutagen-sensitive 3010.016
Sep2Septin-20.016
DNApol-alpha60DNA polymerase alpha 60kD0.015
PepProtein on ecdysone puffs0.015
Grip75CG6176 gene product from transcript CG6176-RA0.015
Cap-GCG34438 gene product from transcript CG34438-RF0.015
pimpimples0.015
tefutelomere fusion0.015
enokenoki mushroom0.015
IncenpInner centromere protein0.014
mspsmini spindles0.014
fzyfizzy0.013
pavpavarotti0.013
DetDeterin0.013
SseSeparase0.013
rinrasputin0.012
rad50CG6339 gene product from transcript CG6339-RD0.012
alphaTub67Calpha-Tubulin at 67C0.012
mus209mutagen-sensitive 2090.012
Klp3AKinesin-like protein at 3A0.012
dapdacapo0.011
msb1lCG10364 gene product from transcript CG10364-RA0.011
Axud1CG4272 gene product from transcript CG4272-RA0.011
mus304mutagen-sensitive 3040.010
KP78bCG17216 gene product from transcript CG17216-RB0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CASC5cancer susceptibility candidate 50.674
CCT8chaperonin containing TCP1, subunit 8 (theta)0.543
CDC27cell division cycle 27 homolog (S. cerevisiae)0.505
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.465
CDK2cyclin-dependent kinase 20.332
CBX5chromobox homolog 50.159
CDC20cell division cycle 20 homolog (S. cerevisiae)0.152
SPC24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.137
H2AFXH2A histone family, member X0.089
CCNA2cyclin A20.089
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.071
CCNB1cyclin B10.057
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.050
ANAPC5anaphase promoting complex subunit 50.045
TINF2TERF1 (TRF1)-interacting nuclear factor 20.041
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.039
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.035
ANAPC4anaphase promoting complex subunit 40.034
NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.034
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.033
BRCA2breast cancer 2, early onset0.031
MDC1mediator of DNA-damage checkpoint 10.030
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.028
ANAPC11anaphase promoting complex subunit 110.028
FANCD2Fanconi anemia, complementation group D20.024
FBXO5F-box protein 50.023
SKA1spindle and kinetochore associated complex subunit 10.021
ZWINTZW10 interactor0.021
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.020
SKA3spindle and kinetochore associated complex subunit 30.019
AURKBaurora kinase B0.019
SKA2spindle and kinetochore associated complex subunit 20.018
ZNF207zinc finger protein 2070.018
CHAF1Achromatin assembly factor 1, subunit A (p150)0.018
HERC2hect domain and RLD 20.016
TP53BP1tumor protein p53 binding protein 10.016
SMC3structural maintenance of chromosomes 30.016
PRC1protein regulator of cytokinesis 10.015
INCENPinner centromere protein antigens 135/155kDa0.014
NBNnibrin0.014
MAD1L1MAD1 mitotic arrest deficient-like 1 (yeast)0.014
UHRF2ubiquitin-like with PHD and ring finger domains 20.013
PPME1protein phosphatase methylesterase 10.013
ANKRD52ankyrin repeat domain 520.012
OTUB1OTU domain, ubiquitin aldehyde binding 10.012
SGOL1shugoshin-like 1 (S. pombe)0.012
CHEK2CHK2 checkpoint homolog (S. pombe)0.011
ANAPC7anaphase promoting complex subunit 70.011
ATAD2ATPase family, AAA domain containing 20.011
CKS1BCDC28 protein kinase regulatory subunit 1B0.011
SKP2S-phase kinase-associated protein 2 (p45)0.011
KAT2BK(lysine) acetyltransferase 2B0.011
ATRXalpha thalassemia/mental retardation syndrome X-linked0.011
CCND1cyclin D10.010
PARP3poly (ADP-ribose) polymerase family, member 30.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.194
Brca1breast cancer 10.155
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.144
Ccnb1cyclin B10.118
C330027C09RikRIKEN cDNA C330027C09 gene0.118
Cdk1cyclin-dependent kinase 10.077
Brca2breast cancer 20.075
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.059
Ezh2enhancer of zeste homolog 2 (Drosophila)0.053
Ccna2cyclin A20.051
Mis18bp1MIS18 binding protein 10.049
Cdk2cyclin-dependent kinase 20.044
Prc1protein regulator of cytokinesis 10.042
Birc5baculoviral IAP repeat-containing 50.040
Ooepoocyte expressed protein homolog (dog)0.039
Dlgap5discs, large (Drosophila) homolog-associated protein 50.036
Aurkaaurora kinase A0.035
Sgol1shugoshin-like 1 (S. pombe)0.033
Kif2ckinesin family member 2C0.030
Dtldenticleless homolog (Drosophila)0.030
Cenpecentromere protein E0.029
Ccnfcyclin F0.029
Chek1checkpoint kinase 1 homolog (S. pombe)0.027
Kif20akinesin family member 20A0.027
Spag5sperm associated antigen 50.026
Cenpkcentromere protein K0.025
Hmmrhyaluronan mediated motility receptor (RHAMM)0.025
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.024
Kif11kinesin family member 110.023
Kif22kinesin family member 220.023
Trim59tripartite motif-containing 590.023
Ect2ect2 oncogene0.023
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.021
Rrm2ribonucleotide reductase M20.021
Kif23kinesin family member 230.021
Kif4kinesin family member 40.020
Ccnb2cyclin B20.019
Wdhd1WD repeat and HMG-box DNA binding protein 10.019
Ccne2cyclin E20.019
BlmBloom syndrome, RecQ helicase-like0.018
Msh2mutS homolog 2 (E. coli)0.018
Lin9lin-9 homolog (C. elegans)0.017
Ccne1cyclin E10.017
Depdc1aDEP domain containing 1a0.016
Ube2cubiquitin-conjugating enzyme E2C0.016
TtkTtk protein kinase0.016
Plk4polo-like kinase 4 (Drosophila)0.015
Cdca8cell division cycle associated 80.015
Smc4structural maintenance of chromosomes 40.014
Ube2tubiquitin-conjugating enzyme E2T (putative)0.013
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.013
Exo1exonuclease 10.013
Cdc25ccell division cycle 25 homolog C (S. pombe)0.013
Trip13thyroid hormone receptor interactor 130.013
Cdkn1bcyclin-dependent kinase inhibitor 1B0.013
Sgol2shugoshin-like 2 (S. pombe)0.013
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.013
E2f8E2F transcription factor 80.013
Gtse1G two S phase expressed protein 10.012
StilScl/Tal1 interrupting locus0.012
Gsg2germ cell-specific gene 20.012
Anlnanillin, actin binding protein0.012
Melkmaternal embryonic leucine zipper kinase0.012
Dna2DNA replication helicase 2 homolog (yeast)0.012
Cdca5cell division cycle associated 50.011
Aurkbaurora kinase B0.010
Mki67antigen identified by monoclonal antibody Ki 670.010
Ckap2cytoskeleton associated protein 20.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism