The network for 'sterol biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

NameDescriptionProbabilityFunc Analog Organism
ERG25Erg25p0.999
ERG28Erg28p0.999
ERG26Erg26p0.998
ERG3Erg3p0.998
ERG27Erg27p0.997
ERG5Erg5p0.991
ERG11Erg11p0.986
ERG6Erg6p0.981
ERG2Erg2p0.944
ERG24Erg24p0.835
MVD1Mvd1p0.812
ERG7Erg7p0.808
HMG1Hmg1p0.804
ERG4Erg4p0.666
ERG1Erg1p0.661
ERG8Erg8p0.659
ERG13Erg13p0.625
ERG9Erg9p0.558
ERG10Erg10p0.469
ERG12Erg12p0.368
BUL2Bul2p0.227
YJU3Yju3p0.174
PHO86Pho86p0.152
SCM4Scm4p0.145
MET4Met4p0.132
ECM22Ecm22p0.103
FRA1Fra1p0.097
ACS2Acs2p0.095
YPL014Whypothetical protein0.094
HMG2Hmg2p0.086
CYB5Cyb5p0.080
HXT3Hxt3p0.079
SAM2Sam2p0.073
HSF1Hsf1p0.073
UPC2Upc2p0.072
ARE2Are2p0.071
HXK2Hxk2p0.068
MOT3Mot3p0.066
CSN9Csn9p0.065
PCD1Pcd1p0.062
ATF2Atf2p0.060
SSK2Ssk2p0.059
RPI1Rpi1p0.058
CYC7Cyc7p0.058
SCS7Scs7p0.057
GIS1Gis1p0.053
ROX1Rox1p0.052
YLR257Whypothetical protein0.051
PHM8Phm8p0.050
PSD2Psd2p0.048
HAP1Hap1p0.048
CSI1Csi1p0.048
ZAP1Zap1p0.045
YJR116Whypothetical protein0.045
YPR157Whypothetical protein0.044
VPS60Vps60p0.043
TRA1Tra1p0.042
NUP157Nup157p0.042
YOR385Whypothetical protein0.041
BSD2Bsd2p0.041
YLR297Whypothetical protein0.041
YEH1Yeh1p0.040
YKL187Chypothetical protein0.039
NRG1Nrg1p0.038
KIC1Kic1p0.037
DIA1Dia1p0.036
OLE1Ole1p0.034
TYE7Tye7p0.034
DAL81Dal81p0.033
AGP1Agp1p0.033
OPY2Opy2p0.033
PDR16Pdr16p0.032
POG1Pog1p0.032
HHO1Hho1p0.032
STF1Stf1p0.032
FAA2Faa2p0.032
PET10Pet10p0.030
WSC4Wsc4p0.029
LCB1Lcb1p0.029
IOC4Ioc4p0.028
EAF3Eaf3p0.028
MSC7Msc7p0.028
PLB2Plb2p0.028
COX13Cox13p0.028
RMA1Rma1p0.027
GLN3Gln3p0.027
MGA2Mga2p0.027
PUT4Put4p0.027
VAC7Vac7p0.026
ODC1Odc1p0.026
GPI11Gpi11p0.026
SMP1Smp1p0.026
NDD1Ndd1p0.026
MNN1Mnn1p0.025
CHA1Cha1p0.025
YIR035Chypothetical protein0.025
GUF1Guf1p0.024
ISC1Isc1p0.024
PIN4Pin4p0.024
SWI1Swi1p0.024
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Cyp12a4CG6042 gene product from transcript CG6042-RA0.577
Ugt35aUDP-glycosyltransferase 35a0.285
Cyp12d1-pCG30489 gene product from transcript CG30489-RA0.200
Cyp4ac1CG14032 gene product from transcript CG14032-RA0.147
sadshadow0.125
Cyp6a21CG10247 gene product from transcript CG10247-RA0.117
Cyp28d1CG10833 gene product from transcript CG10833-RA0.104
Cyp6a23CG10242 gene product from transcript CG10242-RA0.097
dibdisembodied0.095
alpha-Est7alpha-Esterase-70.081
Cyp12d1-dCG33503 gene product from transcript CG33503-RA0.078
CG6834CG6834 gene product from transcript CG6834-RA0.070
Rpb4CG33520 gene product from transcript CG33520-RF0.063
Cyp12a5CG11821 gene product from transcript CG11821-RA0.062
shdshade0.062
JhI-26Juvenile hormone-inducible protein 260.061
Cyp9b2Cytochrome P450-9b20.051
Cyp6d5CG3050 gene product from transcript CG3050-RA0.047
spospook0.038
sroshroud0.035
Npc1bNiemann-Pick type C-1b0.033
Cyp6a13CG2397 gene product from transcript CG2397-RA0.032
Cyp6a2Cytochrome P450-6a20.031
CG12672CG12672 gene product from transcript CG12672-RA0.031
Cyp4p1Cytochrome P450-4p10.030
Cyp4e2Cytochrome P450-4e20.029
Cyp12e1CG14680 gene product from transcript CG14680-RC0.029
Cyp6a9Cytochrome P450-6a90.028
Cyp6g1CG8453 gene product from transcript CG8453-RA0.026
CG6830CG6830 gene product from transcript CG6830-RA0.025
Est-QEsterase Q0.024
CG33120CG33120 gene product from transcript CG33120-RA0.024
Ilp5Insulin-like peptide 50.021
molmoladietz0.019
Osi6Osiris 60.017
CG6908CG6908 gene product from transcript CG6908-RA0.017
CDC45LCG3658 gene product from transcript CG3658-RA0.016
CG10562CG10562 gene product from transcript CG10562-RA0.015
Cyp28a5CG8864 gene product from transcript CG8864-RA0.014
nvdneverland0.014
pex16peroxin 160.013
CG9396CG9396 gene product from transcript CG9396-RA0.013
TotATurandot A0.013
Cyp6w1CG8345 gene product from transcript CG8345-RA0.013
CG10824CG10824 gene product from transcript CG10824-RA0.012
CG33307CG33307 gene product from transcript CG33307-RA0.012
CG10550CG10550 gene product from transcript CG10550-RB0.012
CG8029CG8029 gene product from transcript CG8029-RB0.012
zenzerknullt0.012
CG5819CG5819 gene product from transcript CG5819-RA0.012
CG3759CG3759 gene product from transcript CG3759-RB0.011
CG4630CG4630 gene product from transcript CG4630-RA0.011
CG9360CG9360 gene product from transcript CG9360-RA0.011
CG3091CG3091 gene product from transcript CG3091-RA0.011
Trc8CG2304 gene product from transcript CG2304-RB0.010
CG16799CG16799 gene product from transcript CG16799-RA0.010
lablabial0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)0.919
FGFR2fibroblast growth factor receptor 20.913
SC4MOLsterol-C4-methyl oxidase-like0.903
FDFT1farnesyl-diphosphate farnesyltransferase 10.894
INSIG1insulin induced gene 10.885
DHCR77-dehydrocholesterol reductase0.880
NSDHLNAD(P) dependent steroid dehydrogenase-like0.879
C14orf1chromosome 14 open reading frame 10.863
SQLEsqualene epoxidase0.769
FDPSfarnesyl diphosphate synthase0.753
ACAT2acetyl-CoA acetyltransferase 20.712
SMURF2SMAD specific E3 ubiquitin protein ligase 20.688
SREBF2sterol regulatory element binding transcription factor 20.619
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.584
IDI1isopentenyl-diphosphate delta isomerase 10.559
DHCR2424-dehydrocholesterol reductase0.516
CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 10.403
NEDD4neural precursor cell expressed, developmentally down-regulated 40.232
SCDstearoyl-CoA desaturase (delta-9-desaturase)0.192
FGFR1fibroblast growth factor receptor 10.167
FGF1fibroblast growth factor 1 (acidic)0.150
FGF10fibroblast growth factor 100.125
HPhaptoglobin0.116
LDLRlow density lipoprotein receptor0.113
MVDmevalonate (diphospho) decarboxylase0.085
SLC25A1solute carrier family 25 (mitochondrial carrier; citrate transporter), member 10.076
LSSlanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)0.068
A2Malpha-2-macroglobulin0.047
WWP1WW domain containing E3 ubiquitin protein ligase 10.042
SC5DLsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like0.040
ZFYVE9zinc finger, FYVE domain containing 90.030
FADS1fatty acid desaturase 10.026
SMAD3SMAD family member 30.025
PRDX1peroxiredoxin 10.024
WWP2WW domain containing E3 ubiquitin protein ligase 20.022
MED15mediator complex subunit 150.022
APOC1apolipoprotein C-I0.021
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.019
ANKRD13Aankyrin repeat domain 13A0.016
STARD4StAR-related lipid transfer (START) domain containing 40.015
ACLYATP citrate lyase0.015
MVKmevalonate kinase0.013
FBXL15F-box and leucine-rich repeat protein 150.012
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.012
FGF7fibroblast growth factor 70.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cyp51cytochrome P450, family 511.000
Dhcr77-dehydrocholesterol reductase0.987
Mvdmevalonate (diphospho) decarboxylase0.984
Lsslanosterol synthase0.984
Idi1isopentenyl-diphosphate delta isomerase0.971
Sqlesqualene epoxidase0.971
Ldlrlow density lipoprotein receptor0.968
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 10.945
Apoa1apolipoprotein A-I0.676
Dhcr2424-dehydrocholesterol reductase0.658
Sc4molsterol-C4-methyl oxidase-like0.560
0610007P14RikRIKEN cDNA 0610007P14 gene0.502
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.450
Fdpsfarnesyl diphosphate synthetase0.436
NsdhlNAD(P) dependent steroid dehydrogenase-like0.395
Hsd17b7hydroxysteroid (17-beta) dehydrogenase 70.371
Fasnfatty acid synthase0.369
Acat2acetyl-Coenzyme A acetyltransferase 20.358
Aacsacetoacetyl-CoA synthetase0.255
Tm7sf2transmembrane 7 superfamily member 20.249
Slc25a1solute carrier family 25 (mitochondrial carrier, citrate transporter), member 10.213
Pcyt2phosphate cytidylyltransferase 2, ethanolamine0.179
Stard4StAR-related lipid transfer (START) domain containing 40.165
AclyATP citrate lyase0.164
Sc5dsterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)0.155
Apoeapolipoprotein E0.135
Npc1Niemann Pick type C10.131
Mvkmevalonate kinase0.123
Rdh11retinol dehydrogenase 110.111
Scd2stearoyl-Coenzyme A desaturase 20.111
Scd1stearoyl-Coenzyme A desaturase 10.101
Apobapolipoprotein B0.082
Srebf2sterol regulatory element binding factor 20.081
Cyb5bcytochrome b5 type B0.063
Elovl6ELOVL family member 6, elongation of long chain fatty acids (yeast)0.056
Pmvkphosphomevalonate kinase0.049
Fads2fatty acid desaturase 20.047
Cyldcylindromatosis (turban tumor syndrome)0.044
Slc9a3r1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.043
Tmem97transmembrane protein 970.043
Cyp26c1cytochrome P450, family 26, subfamily c, polypeptide 10.039
Hsd17b12hydroxysteroid (17-beta) dehydrogenase 120.034
Aldobaldolase B, fructose-bisphosphate0.033
Hmgcr3-hydroxy-3-methylglutaryl-Coenzyme A reductase0.033
Insig1insulin induced gene 10.026
Tmem64transmembrane protein 640.024
Fdft1farnesyl diphosphate farnesyl transferase 10.024
Srebf1sterol regulatory element binding transcription factor 10.023
Fads1fatty acid desaturase 10.023
Ebag9estrogen receptor-binding fragment-associated gene 90.023
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.022
Reep6receptor accessory protein 60.021
Rnf11ring finger protein 110.019
Sigmar1sigma non-opioid intracellular receptor 10.018
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.017
Slc4a4solute carrier family 4 (anion exchanger), member 40.017
Lyz2lysozyme 20.016
Srfserum response factor0.016
Apoa2apolipoprotein A-II0.015
Pex3peroxisomal biogenesis factor 30.015
Pgdphosphogluconate dehydrogenase0.014
Apoc3apolipoprotein C-III0.014
Slc31a1solute carrier family 31, member 10.014
F2coagulation factor II0.014
Tmem135transmembrane protein 1350.013
CflarCASP8 and FADD-like apoptosis regulator0.013
Traf6TNF receptor-associated factor 60.012
Grb10growth factor receptor bound protein 100.012
Hnf4ahepatic nuclear factor 4, alpha0.012
Tkttransketolase0.012
Scarb1scavenger receptor class B, member 10.012
Rnf103ring finger protein 1030.011
Lcatlecithin cholesterol acyltransferase0.011
Pparaperoxisome proliferator activated receptor alpha0.011
Eif2ak3eukaryotic translation initiation factor 2 alpha kinase 30.011
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.011
Fgafibrinogen alpha chain0.011
Ambpalpha 1 microglobulin/bikunin0.011
Ndfip1Nedd4 family interacting protein 10.011
Foxa2forkhead box A20.011
Pank3pantothenate kinase 30.010
Tecrtrans-2,3-enoyl-CoA reductase0.010
Apoa4apolipoprotein A-IV0.010
Apomapolipoprotein M0.010
Fggfibrinogen gamma chain0.010
Sec14l2SEC14-like 2 (S. cerevisiae)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)0.779
Fasnfatty acid synthase0.748
Sc4molsterol-C4-methyl oxidase-like0.663
Cyp51cytochrome P450, family 510.656
Sqlesqualene epoxidase0.530
Fdpsfarnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)0.434
Insig1insulin induced gene 10.210
Acat3acetyl-Coenzyme A acetyltransferase 30.167
Idi1isopentenyl-diphosphate delta isomerase 10.113
Fdft1farnesyl diphosphate farnesyl transferase 10.109
Dhcr2424-dehydrocholesterol reductase0.047
Lsslanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)0.036
Tm7sf2transmembrane 7 superfamily member 20.032
Sc5dlsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like0.022
Tmem97transmembrane protein 970.021
NsdhlNAD(P) dependent steroid dehydrogenase-like0.021
Acss2acyl-CoA synthetase short-chain family member 20.011