The network for 'negative regulation of signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.

NameDescriptionProbabilityFunc Analog Organism
KSS1Kss1p0.665
PPH21Pph21p0.640
SSN8Ssn8p0.509
ROM2Rom2p0.507
IRA1Ira1p0.462
SCH9Sch9p0.418
YOL087Chypothetical protein0.388
GSC2Gsc2p0.315
CRZ1Crz1p0.274
REG1Reg1p0.258
MSG5Msg5p0.258
MKK1Mkk1p0.256
PKC1Pkc1p0.254
BOI1Boi1p0.227
KSP1Ksp1p0.225
BCK1Bck1p0.220
TPK1Tpk1p0.216
MSN2Msn2p0.202
PPE1Ppe1p0.202
FAR1Far1p0.189
ICE2Ice2p0.188
VPS36Vps36p0.187
PKH2Pkh2p0.180
CDC25Cdc25p0.162
LHS1Lhs1p0.156
RTS1Rts1p0.142
TIP41Tip41p0.141
BOI2Boi2p0.137
FUS3Fus3p0.136
RHO1Rho1p0.128
TPK3Tpk3p0.121
RTT101Rtt101p0.120
LSB1Lsb1p0.114
HSP60Hsp60p0.112
VPS4Vps4p0.111
ULA1Ula1p0.110
STE7Ste7p0.103
SCP1Scp1p0.103
CDC55Cdc55p0.097
SAC7Sac7p0.096
VPS5Vps5p0.094
CDC34Cdc34p0.094
SIZ1Siz1p0.092
DID4Did4p0.091
TPK2Tpk2p0.089
PBS2Pbs2p0.087
RAS2Ras2p0.086
PEP5Pep5p0.083
GPR1Gpr1p0.083
PSP2Psp2p0.082
YME1Yme1p0.081
VAM3Vam3p0.080
SLG1Slg1p0.078
SLX5Slx5p0.076
KIC1Kic1p0.076
BEM4Bem4p0.076
STE11Ste11p0.075
VPS8Vps8p0.075
FPK1Fpk1p0.074
HOG1Hog1p0.071
SLN1Sln1p0.070
BEM1Bem1p0.069
RUB1Rub1p0.068
TEC1Tec1p0.068
TSC11Tsc11p0.067
CRG1Crg1p0.063
IRA2Ira2p0.063
RPN4Rpn4p0.062
VPS15Vps15p0.061
PSY4Psy4p0.060
BCK2Bck2p0.059
BEM3Bem3p0.059
PTC1Ptc1p0.058
GPB2Gpb2p0.058
WHI2Whi2p0.058
POG1Pog1p0.058
STE5Ste5p0.058
SAP4Sap4p0.057
PRB1Prb1p0.057
EBS1Ebs1p0.054
PMR1Pmr1p0.054
OSH3Osh3p0.054
YIL001Whypothetical protein0.053
RER2Rer2p0.053
SWI1Swi1p0.053
NOG2Nog2p0.052
URN1Urn1p0.052
VAM7Vam7p0.051
MDS3Mds3p0.051
RLM1Rlm1p0.051
MPT5Mpt5p0.051
UBA3Uba3p0.050
NTO1Nto1p0.050
CLA4Cla4p0.049
YCL042Whypothetical protein0.048
GRX5Grx5p0.047
PRR1Prr1p0.046
VAC7Vac7p0.045
RAD23Rad23p0.044
HSV2Hsv2p0.044
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
vab-3Protein VAB-30.745
egl-18Protein EGL-180.527
pry-1Protein PRY-10.288
mec-2Protein MEC-20.219
glp-1Protein GLP-10.207
pha-4Protein PHA-40.155
bar-1Protein BAR-10.149
goa-1Protein GOA-10.143
odr-3Protein ODR-30.141
nhr-67Protein NHR-670.128
K10D6.4Protein K10D6.40.115
che-3Protein CHE-30.108
pkg-1Protein PKG-10.097
egl-8Protein EGL-80.096
lin-25Protein LIN-250.085
unc-7Protein UNC-70.084
lin-66Protein LIN-660.080
sax-7Protein SAX-70.075
daf-10Protein DAF-100.074
itr-1Protein ITR-10.068
pat-12Protein PAT-120.067
mes-3Protein MES-30.066
mpk-1Protein MPK-10.064
abl-1Protein ABL-10.064
daf-12Protein DAF-120.063
kle-2Protein KLE-20.063
R05G6.10Protein R05G6.100.061
eps-8Protein EPS-80.060
akt-1Protein AKT-10.058
inx-13Protein INX-130.057
epg-2Protein EPG-20.056
inx-4Protein INX-40.056
eat-4Protein EAT-40.056
sma-6Protein SMA-60.056
egg-6Protein EGG-60.054
mpz-2Protein MPZ-20.054
peb-1Protein PEB-10.052
zyg-8Protein ZYG-80.052
vang-1Protein VANG-10.048
egl-44Protein EGL-440.048
ifa-1Protein IFA-10.048
unc-42Protein UNC-420.047
ifg-1Protein IFG-10.047
efn-2Protein EFN-20.047
ceh-44Protein CEH-440.046
pad-1Protein PAD-10.046
gpb-1Protein GPB-10.046
gld-1Protein GLD-10.046
ham-1Protein HAM-10.046
soc-2Protein SOC-20.045
skn-1Protein SKN-10.045
exc-5Protein EXC-50.045
C53B4.4Protein C53B4.40.045
egl-27Protein EGL-270.044
daf-6Protein DAF-60.044
T09B4.5Protein T09B4.50.044
sur-2Protein SUR-20.044
pxf-1Protein PXF-10.043
daf-15Protein DAF-150.043
F57B10.4Protein F57B10.40.043
dlk-1Protein DLK-10.042
F31C3.2Protein F31C3.20.042
lin-17Protein LIN-170.042
inx-1Protein INX-10.042
alg-1Protein ALG-10.042
unc-51Protein UNC-510.041
ajm-1Protein AJM-10.041
F13C5.2Protein F13C5.20.041
lag-1Protein LAG-10.040
csnk-1Protein CSNK-10.040
rnp-7Protein RNP-70.039
unc-52Protein UNC-520.039
gsk-3Protein GSK-30.039
his-74Protein HIS-740.039
etr-1Protein ETR-10.039
hlh-2Protein HLH-20.038
npp-7Protein NPP-70.038
ncx-3Protein NCX-30.038
rgs-3Protein RGS-30.038
mig-5Protein MIG-50.038
eor-1Protein EOR-10.038
unc-9Protein UNC-90.037
zen-4Protein ZEN-40.037
nhr-25Protein NHR-250.037
F42H10.3Protein F42H10.30.036
smp-1Protein SMP-10.036
vab-10Protein VAB-100.036
T28F4.1Protein T28F4.10.036
npp-4Protein NPP-40.036
let-756Protein LET-7560.036
lin-49Protein LIN-490.036
cst-1Protein CST-10.035
grk-2Protein GRK-20.035
hlh-1Protein HLH-10.035
ant-1.1Protein ANT-1.10.035
nud-2Protein NUD-20.035
ima-3Protein IMA-30.035
daf-2Protein DAF-20.035
eor-2Protein EOR-20.035
hmg-1.2Protein HMG-1.20.035
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cdh2cadherin 2, neuronal0.933
chdchordin0.925
wnt11rwingless-type MMTV integration site family, member 11, related0.859
tbx1T-box 10.837
sox9bSRY-box containing gene 9b0.786
ndr2nodal-related 20.784
gli1GLI-Kruppel family member 10.752
cdh1cadherin 1, epithelial0.749
egr2bearly growth response 2b0.740
wnt4awingless-type MMTV integration site family, member 4a0.711
pea3ETS-domain transcription factor pea30.707
bmp2bbone morphogenetic protein 2b0.705
fgf8afibroblast growth factor 8 a0.695
per3period homolog 3 (Drosophila)0.630
fgf3fibroblast growth factor 30.625
zbtb4zinc finger and BTB domain containing 40.581
kdrlkinase insert domain receptor like0.577
robo3roundabout homolog 30.557
znf703zinc finger protein 7030.551
lhx2bLIM homeobox 2b0.495
rargaretinoic acid receptor gamma a0.487
spry4sprouty (Drosophila) homolog 40.486
notch1anotch homolog 1a0.449
egr1early growth response 10.441
hmcn1hemicentin 10.427
kif5bbkinesin family member 5B, b0.423
tal1T-cell acute lymphocytic leukemia 10.422
fn1fibronectin 10.419
cxcr4bchemokine (C-X-C motif), receptor 4b0.408
dlx6adistal-less homeobox gene 6a0.404
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.383
mapk3mitogen-activated protein kinase 30.383
wnt2bbwingless-type MMTV integration site family, member 2Bb0.380
ptch2patched 20.377
wnt9bwingless-type MMTV integration site family, member 9B0.370
flhfloating head0.358
rarabretinoic acid receptor, alpha b0.353
tll1tolloid-like 10.348
fzd8afrizzled homolog 8a0.329
igf1rbinsulin-like growth factor 1b receptor0.329
bmp4bone morphogenetic protein 40.321
cx43connexin 430.320
lef1lymphocyte enhancer binding factor 10.320
tbx16T-box gene 160.318
fzd7afrizzled homolog 7a0.315
tp53bp2tumor protein p53 binding protein, 20.302
yap1Yes-associated protein 10.298
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.297
otpaorthopedia homolog a0.290
wnt3wingless-type MMTV integration site family, member 30.290
wnt5bwingless-type MMTV integration site family, member 5b0.282
irx3airoquois homeobox protein 3a0.277
brd4bromodomain containing 40.276
fzd10frizzled homolog 100.273
igf1rainsulin-like growth factor 1a receptor0.270
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.268
acvr1bactivin A receptor, type IB0.265
runx2brunt-related transcription factor 2b0.264
slc30a7solute carrier family 30 (zinc transporter), member 70.257
frem1aFras1 related extracellular matrix 1a0.252
nf1aneurofibromin 1a0.252
efnb2aephrin B2a0.248
csnk1dacasein kinase 1, delta a0.245
mapk1mitogen-activated protein kinase 10.243
si:ch1073-351m12.1si:ch1073-351m12.10.242
zeb2azinc finger E-box binding homeobox 2a0.241
ip6k2inositol hexaphosphate kinase 20.241
itgb1b.2integrin, beta 1b.20.241
twist3twist30.240
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.239
wnt8bwingless-type MMTV integration site family, member 8b0.238
bactin1bactin10.234
nrg1neuregulin 10.233
lama5laminin, alpha 50.232
six4.3sine oculis homeobox homolog 4.30.231
shhbsonic hedgehog b0.230
pax8paired box gene 80.230
fzd5frizzled homolog 50.228
sema3aasemaphorin 3aa0.225
epb4.1l4erythrocyte protein band 4.1-like 40.225
dlbdeltaB0.224
axin1axin 10.216
rbb4retinoblastoma binding protein 40.210
ncf1neutrophil cytosolic factor 10.209
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.208
efna5aephrin A5a0.206
lft1lefty10.206
hdac4histone deacetylase 40.205
alcambactivated leukocyte cell adhesion molecule b0.205
tob1atransducer of ERBB2, 1a0.203
wnt10awingless-type MMTV integration site family, member 10a0.199
pbx4pre-B-cell leukemia transcription factor 40.198
fras1Fraser syndrome 10.196
fibinfin bud initiation factor0.194
cry3cryptochrome 30.194
krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.194
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.194
si:ch211-173b8.2si:ch211-173b8.20.193
gpc4glypican 40.191
baxabcl2-associated X protein, a0.191
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.997
krzkurtz0.972
InRInsulin-like receptor0.969
hephemipterous0.966
wtswarts0.957
rlrolled0.957
MadMothers against dpp0.956
saxsaxophone0.952
dallydivision abnormally delayed0.946
numbCG3779 gene product from transcript CG3779-RB0.940
kaykayak0.939
tkvthickveins0.939
dshdishevelled0.936
Akt1CG4006 gene product from transcript CG4006-RA0.921
hipkhomeodomain interacting protein kinase0.918
cicubitus interruptus0.903
Sulf1Sulfated0.879
rstroughest0.857
dlg1discs large 10.849
CkIIalphaCasein kinase II alpha subunit0.835
smosmoothened0.826
UbxUltrabithorax0.825
shnschnurri0.815
dcodiscs overgrown0.813
Myo31DFMyosin 31DF0.813
EgfrEpidermal growth factor receptor0.813
ph-ppolyhomeotic proximal0.809
giggigas0.808
chicchickadee0.797
mysmyospheroid0.794
wgwingless0.788
S6kRPS6-p70-protein kinase0.784
acachaete0.776
p38bCG7393 gene product from transcript CG7393-RA0.766
EndoGIEndonuclease G inhibitor0.753
fngfringe0.740
flwflapwing0.740
Pk61CProtein kinase 61C0.731
l(2)gllethal (2) giant larvae0.709
sdscalloped0.705
MoeMoesin0.702
ChroChromator0.700
sggshaggy0.696
kiskismet0.666
chercheerio0.662
Tsc1CG6147 gene product from transcript CG6147-RA0.641
toytwin of eyeless0.640
witwishful thinking0.630
SosSon of sevenless0.629
nmonemo0.627
C3GCG42328 gene product from transcript CG42328-RC0.627
Sin3ACG8815 gene product from transcript CG8815-RC0.623
IlkIntegrin linked kinase0.615
drkdownstream of receptor kinase0.613
Rac2CG8556 gene product from transcript CG8556-RA0.613
cindrCIN85 and CD2AP orthologue0.605
Klp64DKinesin-like protein at 64D0.601
sbbscribbler0.601
Su(H)Suppressor of Hairless0.599
babobaboon0.587
shishibire0.583
slmbsupernumerary limbs0.582
Ras85DRas oncogene at 85D0.564
dxdeltex0.563
WnkCG7177 gene product from transcript CG7177-RA0.561
lidlittle imaginal discs0.560
SmoxSmad on X0.550
Sir2CG5216 gene product from transcript CG5216-RA0.547
tantantalus0.535
EcREcdysone receptor0.533
msnmisshapen0.533
inscinscuteable0.530
snssticks and stones0.529
bsblistered0.524
DadDaughters against dpp0.521
hpohippo0.515
S6kIIRPS6-protein kinase-II0.515
agoarchipelago0.506
Chmp1CG4108 gene product from transcript CG4108-RA0.505
NFATNFAT homolog0.503
mspsmini spindles0.500
sogshort gastrulation0.498
CG8155CG8155 gene product from transcript CG8155-RA0.498
Rho1CG8416 gene product from transcript CG8416-RB0.498
Hsp27Heat shock protein 270.493
armarmadillo0.488
CG9772CG9772 gene product from transcript CG9772-RB0.487
eyaeyes absent0.483
Dcr-2Dicer-20.482
Hs6stHeparan sulfate 6-O-sulfotransferase0.478
NetBNetrin-B0.467
tratransformer0.467
notnon-stop0.461
CSN5COP9 complex homolog subunit 50.457
SfmbtScm-related gene containing four mbt domains0.456
sqzsqueeze0.456
panpangolin0.452
mammastermind0.452
Mkp3Mitogen-activated protein kinase phosphatase 30.449
egreiger0.443
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Dusp6dual specificity phosphatase 60.264
Calcrlcalcitonin receptor-like0.260
Cav1caveolin 1, caveolae protein0.258
CnbpCCHC-type zinc finger, nucleic acid binding protein0.246
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.241
DbpD site of albumin promoter (albumin D-box) binding protein0.217
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.215
Ednraendothelin receptor type A0.203
Jak2Janus kinase 20.203
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.195
Bcl2B-cell CLL/lymphoma 20.186
Egr1early growth response 10.182
Cugbp2CUG triplet repeat, RNA binding protein 20.179
Itgamintegrin, alpha M0.174
KitlgKIT ligand0.173
Smad7SMAD family member 70.166
Slit3slit homolog 3 (Drosophila)0.162
Klf2Kruppel-like factor 2 (lung)0.161
Dchs1dachsous 1 (Drosophila)0.149
Zfp36zinc finger protein 360.143
Pctk1PCTAIRE protein kinase 10.135
Csnk1g3casein kinase 1, gamma 30.134
Ptpn6protein tyrosine phosphatase, non-receptor type 60.134
Sirpasignal-regulatory protein alpha0.130
FosFBJ osteosarcoma oncogene0.130
Cishcytokine inducible SH2-containing protein0.129
Usf2upstream transcription factor 2, c-fos interacting0.128
Junbjun B proto-oncogene0.126
Cd83CD83 molecule0.126
Pacs1phosphofurin acidic cluster sorting protein 10.123
Homer1homer homolog 1 (Drosophila)0.123
Akt1v-akt murine thymoma viral oncogene homolog 10.120
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.117
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.117
Eef2eukaryotic translation elongation factor 20.116
Rgs9regulator of G-protein signaling 90.114
Jak1Janus kinase 10.113
Pim1pim-1 oncogene0.111
Fgfr2fibroblast growth factor receptor 20.109
Atp5bATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.108
Lnpepleucyl/cystinyl aminopeptidase0.107
Errfi1ERBB receptor feedback inhibitor 10.107
Cmklr1chemokine-like receptor 10.106
Slfn2schlafen 20.105
Ptpn7protein tyrosine phosphatase, non-receptor type 70.104
Kcnc3potassium voltage gated channel, Shaw-related subfamily, member 30.100
Tcfe2atranscription factor E2a0.100
Fgd4FYVE, RhoGEF and PH domain containing 40.099
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.095
Dccdeleted in colorectal carcinoma0.094
Sdc3syndecan 30.093
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.093
Nrg1neuregulin 10.093
Inpp5dinositol polyphosphate-5-phosphatase D0.092
Myo9amyosin IXA0.090
Mmp9matrix metallopeptidase 90.089
Creb1cAMP responsive element binding protein 10.089
Dock8dedicator of cytokinesis 80.087
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.086
Gzmbgranzyme B0.086
Egfrepidermal growth factor receptor0.086
Grb2growth factor receptor bound protein 20.086
JunJun oncogene0.085
Prph2peripherin 20.084
Ptger4prostaglandin E receptor 4 (subtype EP4)0.083
Nr3c1nuclear receptor subfamily 3, group C, member 10.083
Rftn2raftlin family member 20.083
Tcf21transcription factor 210.083
Ddr1discoidin domain receptor tyrosine kinase 10.082
Nrd1nardilysin 10.081
Has2hyaluronan synthase 20.081
Nfibnuclear factor I/B0.081
Il1r1interleukin 1 receptor, type I0.080
Tcf4transcription factor 40.080
Klf9Kruppel-like factor 90.079
Tgfbr3transforming growth factor, beta receptor III0.079
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.076
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.075
Bmp7bone morphogenetic protein 70.075
Scarb1scavenger receptor class B, member 10.075
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.075
Gas7growth arrest specific 70.075
Egr2early growth response 20.074
LOC100362824caveolin 2-like0.074
Coro1acoronin, actin binding protein 1A0.074
Slc30a1solute carrier family 30 (zinc transporter), member 10.074
Myo1bmyosin Ib0.073
Jdp2Jun dimerization protein 20.073
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.073
Csnk1g1casein kinase 1, gamma 10.072
Syt8synaptotagmin VIII0.072
Gfi1growth factor independent 1 transcription repressor0.072
Fgbfibrinogen beta chain0.072
Celcarboxyl ester lipase0.071
Akap1A kinase (PRKA) anchor protein 10.071
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.071
Nedd4neural precursor cell expressed, developmentally down-regulated 40.071
Dusp1dual specificity phosphatase 10.070
Lcp1lymphocyte cytosolic protein 10.070
Rhorhodopsin0.070