The network for 'positive regulation of signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

NameDescriptionProbabilityFunc Analog Organism
SSK2Ssk2p0.903
ERP4Erp4p0.653
PBS2Pbs2p0.504
NBP2Nbp2p0.486
PTC1Ptc1p0.455
ENA5Ena5p0.393
BMH1Bmh1p0.351
ROM2Rom2p0.332
PRK1Prk1p0.244
RHO1Rho1p0.216
PKC1Pkc1p0.187
PAN1Pan1p0.156
FAR11Far11p0.154
IRA1Ira1p0.144
SLA2Sla2p0.135
SSK22Ssk22p0.132
CKA2Cka2p0.128
VPS27Vps27p0.107
STE7Ste7p0.104
AKL1Akl1p0.087
RIO2Rio2p0.085
TOR1Tor1p0.081
SIF2Sif2p0.080
MEH1Meh1p0.079
HHT1Hht1p0.075
RFA1Rfa1p0.073
FUS3Fus3p0.072
TCO89Tco89p0.066
IZH4Izh4p0.065
RTG3Rtg3p0.064
GAL7Gal7p0.059
RGD1Rgd1p0.059
CDC25Cdc25p0.057
OLE1Ole1p0.056
OSH7Osh7p0.053
OSH6Osh6p0.053
ERP3Erp3p0.052
HOS2Hos2p0.049
RAS1Ras1p0.048
ARP2Arp2p0.047
AQR1Aqr1p0.047
VPS64Vps64p0.045
CLA4Cla4p0.044
SLT2Slt2p0.044
HOS4Hos4p0.043
AHP1Ahp1p0.042
YOR1Yor1p0.038
GPR1Gpr1p0.038
ENA2Ena2p0.038
TEL1Tel1p0.037
KOG1Kog1p0.037
BCK1Bck1p0.036
STE5Ste5p0.036
UGP1Ugp1p0.035
KAR5Kar5p0.035
ARC35Arc35p0.034
SPA2Spa2p0.032
BEM2Bem2p0.032
KSS1Kss1p0.032
RDI1Rdi1p0.032
RSC8Rsc8p0.031
SYP1Syp1p0.029
IME2Ime2p0.029
KIN3Kin3p0.028
TOR2Tor2p0.028
PIB2Pib2p0.027
MKK1Mkk1p0.027
BRO1Bro1p0.025
KDX1Kdx1p0.025
SRP54Srp54p0.025
FMP27Fmp27p0.025
FAR1Far1p0.024
ERP2Erp2p0.024
ETR1Etr1p0.024
BEM3Bem3p0.024
STE50Ste50p0.023
MSG5Msg5p0.022
BNI1Bni1p0.022
ARK1Ark1p0.022
RBD2Rbd2p0.022
GPB2Gpb2p0.022
SLG1Slg1p0.022
BEM4Bem4p0.022
BMH2Bmh2p0.022
BCY1Bcy1p0.021
RPS0ARps0ap0.021
COT1Cot1p0.021
CNS1Cns1p0.021
SSK1Ssk1p0.021
PCL9Pcl9p0.021
CPR1Cpr1p0.020
MSI1Msi1p0.020
ROD1Rod1p0.020
SOK1Sok1p0.020
GLO3Glo3p0.019
ELP4Elp4p0.019
HST1Hst1p0.019
KEL3Kel3p0.019
ARF2Arf2p0.019
MTC5Mtc5p0.018
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.976
let-60Protein LET-600.670
pha-4Protein PHA-40.616
ten-1Protein TEN-10.612
daf-11Protein DAF-110.562
pal-1Protein PAL-10.536
mpk-1Protein MPK-10.518
mat-3Protein MAT-30.480
che-13Protein CHE-130.422
pry-1Protein PRY-10.358
bar-1Protein BAR-10.342
hmg-1.2Protein HMG-1.20.341
vab-3Protein VAB-30.296
hlh-2Protein HLH-20.286
msp-36Protein MSP-360.267
lin-45Protein LIN-450.262
sur-2Protein SUR-20.258
sma-6Protein SMA-60.242
eor-1Protein EOR-10.240
unc-40Protein UNC-400.236
osm-6Protein OSM-60.214
H06I04.1Protein H06I04.10.207
inx-3Protein INX-30.202
sel-8Protein SEL-80.195
sek-1Protein SEK-10.187
par-5Protein PAR-50.181
elt-6Protein ELT-60.180
cnd-1Protein CND-10.179
ZK1248.17Protein ZK1248.170.178
msp-38Protein MSP-380.171
nhr-6Protein NHR-60.167
lag-1Protein LAG-10.164
lin-12Protein LIN-120.162
lin-25Protein LIN-250.158
msp-55Protein MSP-550.158
eor-2Protein EOR-20.151
hgrs-1Protein HGRS-10.146
flt-1Protein FLT-10.139
unc-60Protein UNC-600.139
swan-2Protein SWAN-20.138
pkc-3Protein PKC-30.134
msp-78Protein MSP-780.131
msp-77Protein MSP-770.130
unc-32Protein UNC-320.127
sam-10Protein SAM-100.123
hlh-1Protein HLH-10.121
nhr-67Protein NHR-670.118
let-756Protein LET-7560.117
che-11Protein CHE-110.108
lmn-1Protein LMN-10.106
hnd-1Protein HND-10.105
sel-12Protein SEL-120.103
msp-45Protein MSP-450.102
msp-33Protein MSP-330.099
C11E4.6Protein C11E4.60.098
afd-1Protein AFD-10.098
pmk-1Protein PMK-10.094
atg-18Protein ATG-180.094
scd-1Protein SCD-10.093
wsp-1Protein WSP-10.092
let-526Protein LET-5260.091
csn-1Protein CSN-10.089
C31E10.5Protein C31E10.50.089
npp-7Protein NPP-70.089
msp-76Protein MSP-760.089
msp-49Protein MSP-490.087
him-17Protein HIM-170.086
daf-19Protein DAF-190.084
che-1Protein CHE-10.083
gcy-22Protein GCY-220.082
msp-152Protein MSP-1520.080
daf-12Protein DAF-120.079
gei-18Protein GEI-180.077
lin-11Protein LIN-110.076
sax-3Protein SAX-30.076
htz-1Protein HTZ-10.076
unc-94Protein UNC-940.074
F08B4.7Protein F08B4.70.074
unc-130Protein UNC-1300.073
hcf-1Protein HCF-10.072
zyg-9Protein ZYG-90.071
swsn-3Protein SWSN-30.070
ceh-20Protein CEH-200.069
syd-2Protein SYD-20.069
sem-5Protein SEM-50.069
elt-3Protein ELT-30.068
T09A5.9Protein T09A5.90.068
msp-64Protein MSP-640.067
aha-1Protein AHA-10.066
unc-62Protein UNC-620.065
fkh-2Protein FKH-20.064
tag-343Protein TAG-3430.064
clh-5Protein CLH-50.064
let-23Protein LET-230.063
irx-1Protein IRX-10.063
msp-79Protein MSP-790.062
vps-11Protein VPS-110.062
msp-40Protein MSP-400.061
nhr-34Protein NHR-340.061
tps-1Protein TPS-10.061
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
shhasonic hedgehog a0.980
robo3roundabout homolog 30.914
fgf3fibroblast growth factor 30.802
sulf1sulfatase 10.707
otpaorthopedia homolog a0.617
chdchordin0.586
gli1GLI-Kruppel family member 10.556
bmp2bbone morphogenetic protein 2b0.541
furinafurin (paired basic amino acid cleaving enzyme) a0.532
dladeltaA0.526
plcg1phospholipase C, gamma 10.503
bmp2abone morphogenetic protein 2a0.497
cxcr4bchemokine (C-X-C motif), receptor 4b0.481
pax2apaired box gene 2a0.461
csnk1dacasein kinase 1, delta a0.448
tbx1T-box 10.436
gli2aGLI-Kruppel family member GLI2a0.425
appaamyloid beta (A4) precursor protein a0.397
sox9aSRY-box containing gene 9a0.386
wnt2bbwingless-type MMTV integration site family, member 2Bb0.355
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.344
fn1fibronectin 10.338
notch2notch homolog 20.319
hey1hairy/enhancer-of-split related with YRPW motif 10.310
rag1recombination activating gene 10.308
jag2jagged 20.297
lhx2bLIM homeobox 2b0.295
wnt4awingless-type MMTV integration site family, member 4a0.293
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.291
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.289
foxi1forkhead box I10.288
snai1bsnail homolog 1b (Drosophila)0.280
dusp6dual specificity phosphatase 60.267
dharmadharma0.260
ip6k2inositol hexaphosphate kinase 20.260
foxa2forkhead box A20.259
nadl1.1neural adhesion molecule L1.10.256
appbamyloid beta (A4) precursor protein b0.255
jag1bjagged 1b0.254
sparcsecreted acidic cysteine rich glycoprotein0.250
si:ch211-212m21.5si:ch211-212m21.50.248
disp1dispatched homolog 1 (Drosophila)0.244
flt4fms-related tyrosine kinase 40.242
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.237
ihhaIndian hedgehog homolog a0.233
brpf1bromodomain and PHD finger containing, 10.227
pax6apaired box gene 6a0.227
spry4sprouty (Drosophila) homolog 40.225
acvr1lactivin A receptor, type I like0.221
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.221
esr2aestrogen receptor 2a0.216
runx3runt-related transcription factor 30.215
ventventral expressed homeobox0.214
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.208
sox32SRY-box containing gene 320.208
six4.3sine oculis homeobox homolog 4.30.207
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.204
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.203
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.199
pkd2polycystic kidney disease 20.196
tcf7transcription factor 7 (T-cell specific, HMG-box)0.195
atp2b1aATPase, Ca++ transporting, plasma membrane 1a0.195
podxlpodocalyxin-like0.195
lef1lymphocyte enhancer binding factor 10.193
nrp2aneuropilin 2a0.190
ptk2.1protein tyrosine kinase 2a0.190
wnt10awingless-type MMTV integration site family, member 10a0.189
sulf2sulfatase 20.188
robo1roundabout homolog 10.186
brd4bromodomain containing 40.185
tp53bp2tumor protein p53 binding protein, 20.185
spon1bspondin 1b0.184
zfyve26zinc finger, FYVE domain containing 260.184
epha4aeph receptor A4a0.183
wnt5bwingless-type MMTV integration site family, member 5b0.182
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.181
leprleptin receptor0.180
acvr2aactivin receptor IIa0.179
ripk2receptor-interacting serine-threonine kinase 20.179
mmp2matrix metalloproteinase 20.177
efnb2aephrin B2a0.177
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.175
wnt8bwingless-type MMTV integration site family, member 8b0.172
gbx2gastrulation brain homeo box 20.167
phox2bpaired-like homeobox 2b0.165
fzd7afrizzled homolog 7a0.164
twist3twist30.163
dkk1bdickkopf 1b0.160
pdgfaaplatelet-derived growth factor alpha a0.160
mtpmicrosomal triglyceride transfer protein0.160
vegfaavascular endothelial growth factor Aa0.156
sulf2lsulfatase 2, like0.152
kif17kinesin family member 170.146
gro2groucho 20.146
klf4Kruppel-like factor 40.145
irx3airoquois homeobox protein 3a0.145
cd63Cd63 antigen0.143
pcdh18bprotocadherin 18b0.143
runx2brunt-related transcription factor 2b0.142
inhbaainhibin, beta Aa0.139
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
TlToll0.918
Gp150CG5820 gene product from transcript CG5820-RA0.906
Ras85DRas oncogene at 85D0.900
DadDaughters against dpp0.898
Atg1Autophagy-specific gene 10.873
p38bCG7393 gene product from transcript CG7393-RA0.868
p53CG33336 gene product from transcript CG33336-RB0.841
Akt1CG4006 gene product from transcript CG4006-RA0.829
MadMothers against dpp0.809
fzfrizzled0.801
Stat92ESignal-transducer and activator of transcription protein at 92E0.775
babobaboon0.749
WnkCG7177 gene product from transcript CG7177-RA0.739
GugGrunge0.730
dallydivision abnormally delayed0.728
stcksteamer duck0.724
AxnAxin0.713
RhebCG1081 gene product from transcript CG1081-RA0.670
Nrx-IVNeurexin IV0.599
shishibire0.594
Pi3K92ECG4141 gene product from transcript CG4141-RB0.593
SmoxSmad on X0.583
agoarchipelago0.573
HLHm7E(spl) region transcript m70.562
gbbglass bottom boat0.561
dmdiminutive0.556
armarmadillo0.545
HLHmbetaE(spl) region transcript mbeta0.538
sdscalloped0.531
Sin3ACG8815 gene product from transcript CG8815-RC0.529
DabDisabled0.527
InRInsulin-like receptor0.508
panpangolin0.496
HsfHeat shock factor0.487
SosSon of sevenless0.477
kuzkuzbanian0.476
rhorhomboid0.473
spispitz0.472
Tak1TGF-beta activated kinase 10.463
kaykayak0.451
ttvtout-velu0.442
Ced-12CG5336 gene product from transcript CG5336-RA0.442
dcodiscs overgrown0.428
Bx42CG8264 gene product from transcript CG8264-RA0.424
Arp66BActin-related protein 66B0.402
Sulf1Sulfated0.402
MybMyb oncogene-like0.389
mnbminibrain0.386
shnschnurri0.378
Vps35Vacuolar protein sorting 350.373
putpunt0.371
O-fut1O-fucosyltransferase 10.368
Ptp69DProtein tyrosine phosphatase 69D0.363
ykiyorkie0.362
PcafCG4107 gene product from transcript CG4107-RA0.359
frafrazzled0.356
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.356
sbbscribbler0.352
cicubitus interruptus0.352
drkdownstream of receptor kinase0.350
bratbrain tumor0.346
Nf1Neurofibromin 10.346
mewmultiple edematous wings0.345
PtpmegCG1228 gene product from transcript CG1228-RD0.345
robo3CG5423 gene product from transcript CG5423-RA0.343
CaMKIICalcium/calmodulin-dependent protein kinase II0.342
krzkurtz0.337
Src64BSrc oncogene at 64B0.337
phlpole hole0.334
E(spl)Enhancer of split0.332
Lis-1Lissencephaly-10.328
fyfuzzy0.326
slislit0.325
Pp2B-14DProtein phosphatase 2B at 14D0.316
UbxUltrabithorax0.315
tkvthickveins0.314
ushu-shaped0.313
Sema-1bCG6446 gene product from transcript CG6446-RA0.311
domedomeless0.309
nocno ocelli0.308
acachaete0.308
emcextra macrochaetae0.304
HLHmgammaE(spl) region transcript mgamma0.302
Pp1alpha-96AProtein phosphatase 1alpha at 96A0.300
nkdnaked cuticle0.297
bnlbranchless0.296
Jon99CiiiJonah 99Ciii0.296
Aos1CG12276 gene product from transcript CG12276-RA0.296
egreiger0.295
Rm62CG10279 gene product from transcript CG10279-RD0.294
Jon25BiiJonah 25Bii0.292
TrhTryptophan hydroxylase0.288
pntpointed0.287
dosdaughter of sevenless0.285
FsFollistatin0.285
aseasense0.282
sggshaggy0.278
Caf1Chromatin assembly factor 1 subunit0.276
CG11347CG11347 gene product from transcript CG11347-RE0.268
sflsulfateless0.268
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.832
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.745
Lamc1laminin, gamma 10.712
Itgamintegrin, alpha M0.690
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.680
Bcl2B-cell CLL/lymphoma 20.576
Grm7glutamate receptor, metabotropic 70.574
Gng7guanine nucleotide binding protein (G protein), gamma 70.566
Ncr1natural cytotoxicity triggering receptor 10.566
Itpr2inositol 1,4,5-triphosphate receptor, type 20.546
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.543
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.541
Slco2b1solute carrier organic anion transporter family, member 2b10.539
Prrx1paired related homeobox 10.526
Metmet proto-oncogene0.514
Ncanneurocan0.485
Irs1insulin receptor substrate 10.474
Ccl2chemokine (C-C motif) ligand 20.473
Ptafrplatelet-activating factor receptor0.465
Nek9NIMA (never in mitosis gene a)- related kinase 90.433
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.431
Adarb2adenosine deaminase, RNA-specific, B20.409
Cd44Cd44 molecule0.398
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.398
Neurog3neurogenin 30.393
Cd14CD14 molecule0.385
Psen1presenilin 10.382
Timp3TIMP metallopeptidase inhibitor 30.378
Ddr1discoidin domain receptor tyrosine kinase 10.376
Vav1vav 1 guanine nucleotide exchange factor0.375
Smad7SMAD family member 70.368
Shox2short stature homeobox 20.362
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.359
Ghrgrowth hormone receptor0.357
Socs3suppressor of cytokine signaling 30.351
Nrg1neuregulin 10.349
Ifnginterferon gamma0.347
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.335
S1pr2sphingosine-1-phosphate receptor 20.335
Tgfbr2transforming growth factor, beta receptor II0.326
Tcf21transcription factor 210.320
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.314
Jtbjumping translocation breakpoint0.313
Ppyr1pancreatic polypeptide receptor 10.307
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.307
Smad6SMAD family member 60.304
Stat3signal transducer and activator of transcription 30.304
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.300
Acvr1activin A receptor, type I0.298
Atxn1ataxin 10.297
Ednraendothelin receptor type A0.297
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.297
Agtr1aangiotensin II receptor, type 1a0.290
Runx1runt-related transcription factor 10.289
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.283
Il1binterleukin 1 beta0.279
Odf4outer dense fiber of sperm tails 40.278
Map2k2mitogen activated protein kinase kinase 20.277
Leprleptin receptor0.277
Il6interleukin 60.276
Arandrogen receptor0.276
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.275
Bcanbrevican0.274
Pctk2PCTAIRE protein kinase 20.274
Galr3galanin receptor 30.270
Calcrlcalcitonin receptor-like0.270
Hpcal4hippocalcin-like 40.269
Thbdthrombomodulin0.269
Oprm1opioid receptor, mu 10.267
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.264
Map1amicrotubule-associated protein 1A0.264
Jak2Janus kinase 20.263
Tpc1808tropic 18080.263
Sox17SRY (sex determining region Y)-box 170.262
Cd8aCD8a molecule0.261
Atp2b3ATPase, Ca++ transporting, plasma membrane 30.260
Ccdc102acoiled-coil domain containing 102A0.260
Nrxn1neurexin 10.260
Atp12aATPase, H+/K+ transporting, nongastric, alpha polypeptide0.258
Pcdhb12protocadherin beta 120.257
Edn1endothelin 10.255
Nlgn3neuroligin 30.253
Fgfr1Fibroblast growth factor receptor 10.251
Grb2growth factor receptor bound protein 20.249
Flt1FMS-related tyrosine kinase 10.248
Magmyelin-associated glycoprotein0.248
Avparginine vasopressin0.248
Elk3ELK3, ETS-domain protein0.246
Vom2r27vomeronasal 2 receptor, 270.245
Kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.244
Marcksmyristoylated alanine rich protein kinase C substrate0.243
Laptm5lysosomal protein transmembrane 50.242
Anxa5annexin A50.241
Il1ainterleukin 1 alpha0.240
Il10rainterleukin 10 receptor, alpha0.240
Creb1cAMP responsive element binding protein 10.240
Ptk2bPTK2B protein tyrosine kinase 2 beta0.238
Notch1Notch homolog 1, translocation-associated (Drosophila)0.238
Lphn2latrophilin 20.238
FaslgFas ligand (TNF superfamily, member 6)0.235