The network for 'membrane depolarization during action potential' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

membrane depolarization during action potential

The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide1.000
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide1.000
MPZL2myelin protein zero-like 20.988
MPZL3myelin protein zero-like 30.980
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.976
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.792
SNTG2syntrophin, gamma 20.624
YAP1Yes-associated protein 10.623
SFNstratifin0.258
GHRgrowth hormone receptor0.197
CDC25Bcell division cycle 25 homolog B (S. pombe)0.092
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.035
ATRXalpha thalassemia/mental retardation syndrome X-linked0.033
PTPRBprotein tyrosine phosphatase, receptor type, B0.024
MARK2MAP/microtubule affinity-regulating kinase 20.022
HDAC4histone deacetylase 40.016
SRCIN1SRC kinase signaling inhibitor 10.015
METmet proto-oncogene (hepatocyte growth factor receptor)0.014
IRS1insulin receptor substrate 10.014
JPH2junctophilin 20.013
PTPN2protein tyrosine phosphatase, non-receptor type 20.013
CAMKK1calcium/calmodulin-dependent protein kinase kinase 1, alpha0.012
FRS2fibroblast growth factor receptor substrate 20.012
NEK1NIMA (never in mitosis gene a)-related kinase 10.011
WWC1WW and C2 domain containing 10.011
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ryr2ryanodine receptor 2, cardiac0.946
Scn5asodium channel, voltage-gated, type V, alpha0.688
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.437
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.388
Tbx5T-box 50.321
Tjp1tight junction protein 10.260
Rnf112ring finger protein 1120.096
Gja5gap junction protein, alpha 50.096
Thrbthyroid hormone receptor beta0.059
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.056
Cacnb4calcium channel, voltage-dependent, beta 4 subunit0.046
Scn1asodium channel, voltage-gated, type I, alpha0.044
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.038
Cacna2d2calcium channel, voltage-dependent, alpha 2/delta subunit 20.038
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.037
Nedd4lneural precursor cell expressed, developmentally down-regulated gene 4-like0.033
Sstr3somatostatin receptor 30.027
Tnni2troponin I, skeletal, fast 20.025
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.023
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.023
Tbx3T-box 30.022
Aplnrapelin receptor0.022
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.017
Pcdh12protocadherin 120.017
Kcnk3potassium channel, subfamily K, member 30.016
Krt31keratin 310.015
Oprd1opioid receptor, delta 10.015
Klk6kallikrein related-peptidase 60.015
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.015
Crybb1crystallin, beta B10.014
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.014
KelKell blood group0.013
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.012
Kcnab3potassium voltage-gated channel, shaker-related subfamily, beta member 30.012
Abcc8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.012
Bsnbassoon0.012
Dsc1desmocollin 10.012
Slc17a8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 80.012
Npas1neuronal PAS domain protein 10.012
Ryr1ryanodine receptor 1, skeletal muscle0.011
Kcnj12potassium inwardly-rectifying channel, subfamily J, member 120.011
Kif5akinesin family member 5A0.011
Mpzmyelin protein zero0.010
Itga7integrin alpha 70.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Myoz1myozenin 10.254
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.244
Kykyphoscoliosis peptidase0.176
Inhainhibin alpha0.138
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.129
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.117
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.105
Stmn1stathmin 10.102
Kcnk2potassium channel, subfamily K, member 20.097
Plxna3plexin A30.087
Calm1calmodulin 10.083
Rps6ka2ribosomal protein S6 kinase polypeptide 20.071
Scn4bsodium channel, voltage-gated, type IV, beta0.071
Kcnk3potassium channel, subfamily K, member 30.067
Cplx2complexin 20.066
Myl1myosin, light chain 10.064
Acsl6acyl-CoA synthetase long-chain family member 60.062
Akap6A kinase (PRKA) anchor protein 60.052
Lynx1Ly6/neurotoxin 10.052
Trdntriadin0.046
Cav3caveolin 30.045
Gnao1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.044
Sorbs2sorbin and SH3 domain containing 20.043
Ttntitin0.043
Rimbp2RIMS binding protein 20.041
Ldb3LIM domain binding 30.039
Itpr1inositol 1,4,5-triphosphate receptor, type 10.039
Abcd2ATP-binding cassette, subfamily D (ALD), member 20.038
Scn2bsodium channel, voltage-gated, type II, beta0.037
Fryfurry homolog (Drosophila)0.036
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.036
Cpecarboxypeptidase E0.033
RGD1306750LOC3624510.032
Mcf2lMCF.2 cell line derived transforming sequence-like0.031
Phka1phosphorylase kinase, alpha 10.031
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.031
Unc45bunc-45 homolog B (C. elegans)0.031
Wdr13WD repeat domain 130.030
Obscnobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.030
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.030
Map1amicrotubule-associated protein 1A0.030
Ank2ankyrin 2, neuronal0.029
RGD1310269hypothetical LOC3144720.029
Apobec2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 20.029
Pygmphosphorylase, glycogen, muscle0.028
Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform0.027
TnikTRAF2 and NCK interacting kinase0.027
Dhrs7cdehydrogenase/reductase (SDR family) member 7C0.026
Cacna1ecalcium channel, voltage-dependent, R type, alpha 1E subunit0.026
Lrrc14bleucine rich repeat containing 14B0.026
Ablim2actin binding LIM protein family, member 20.026
Coro6coronin 60.025
Chrndcholinergic receptor, nicotinic, delta0.024
Dpysl2dihydropyrimidinase-like 20.024
Sh3bgrSH3 domain binding glutamic acid-rich protein0.023
Vamp1vesicle-associated membrane protein 10.023
Rnf207ring finger protein 2070.023
Rbm24RNA binding motif protein 240.023
Hhatlhedgehog acyltransferase-like0.023
Nrxn1neurexin 10.022
Nkx2-1NK2 homeobox 10.022
Trim72tripartite motif-containing 720.022
Pgk1phosphoglycerate kinase 10.021
Casq2calsequestrin 2 (cardiac muscle)0.020
Rgs14regulator of G-protein signaling 140.020
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.020
Etl4enhancer trap locus 40.020
Apbb1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.020
Myom2myomesin 20.020
Faim2Fas apoptotic inhibitory molecule 20.019
Asb2ankyrin repeat and SOCS box-containing 20.019
Kif1bkinesin family member 1B0.019
Tubb4tubulin, beta 40.019
Trak1trafficking protein, kinesin binding 10.019
Arhgap21Rho GTPase activating protein 210.019
Rpl3lribosomal protein L3-like0.018
Herc2hect domain and RLD 20.018
Alpk3alpha-kinase 30.018
Kcna5potassium voltage-gated channel, shaker-related subfamily, member 50.018
Yipf7Yip1 domain family, member 70.018
Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.018
Pcyox1prenylcysteine oxidase 10.018
Pde4aphosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)0.018
Tuba1ctubulin, alpha 1C0.017
Rab11fip3RAB11 family interacting protein 3 (class II)0.017
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.017
Epb41l1erythrocyte membrane protein band 4.1-like 10.017
Tmem38atransmembrane protein 38a0.017
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.017
Ank1ankyrin 1, erythrocytic0.017
Dynll1dynein light chain LC8-type 10.016
Slc7a10solute carrier family 7, (neutral amino acid transporter, y+ system) member 100.016
Ninj2ninjurin 20.016
A2bp1ataxin 2 binding protein 10.016
Zfp365zinc finger protein 3650.016
Tnrtenascin R0.016
Phldb1pleckstrin homology-like domain, family B, member 10.016
Neurl2neuralized homolog 2 (Drosophila)0.016
Lrrn2leucine rich repeat neuronal 20.015
Col9a1collagen, type IX, alpha 10.015