The network for 'dna duplex unwinding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna duplex unwinding

The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.

NameDescriptionProbabilityFunc Analog Organism
MCM4Mcm4p0.924
MCM2Mcm2p0.787
PSF2Psf2p0.730
MCM6Mcm6p0.628
MCM7Mcm7p0.535
MCM10Mcm10p0.454
SLD5Sld5p0.308
MCM3Mcm3p0.292
RAD52Rad52p0.279
SMC2Smc2p0.267
BRN1Brn1p0.254
MEC1Mec1p0.252
SLD2Sld2p0.221
DNA2Dna2p0.203
RFA2Rfa2p0.180
MCM5Mcm5p0.165
RFA1Rfa1p0.164
CTF4Ctf4p0.152
SMC3Smc3p0.151
PSP2Psp2p0.150
RAD53Rad53p0.150
SMC4Smc4p0.115
YOR060Chypothetical protein0.106
CDC45Cdc45p0.092
RAD50Rad50p0.088
UBP1Ubp1p0.076
TOF1Tof1p0.072
MRC1Mrc1p0.066
PSF1Psf1p0.064
IRR1Irr1p0.063
YCG1Ycg1p0.062
SCC2Scc2p0.060
TAH11Tah11p0.059
DBF4Dbf4p0.057
YCS4Ycs4p0.056
CSM3Csm3p0.049
ALG14Alg14p0.049
DPB11Dpb11p0.049
SMC1Smc1p0.039
MPT5Mpt5p0.038
SGS1Sgs1p0.038
PDC2Pdc2p0.036
KEM1Kem1p0.036
INO80Ino80p0.036
MSH3Msh3p0.036
CDC6Cdc6p0.034
ARP4Arp4p0.034
HST3Hst3p0.033
DSS1Dss1p0.032
RTT107Rtt107p0.032
RAD5Rad5p0.030
MSH6Msh6p0.030
SRD1Srd1p0.030
PRS2Prs2p0.029
TOR2Tor2p0.028
RMI1Rmi1p0.028
TOP3Top3p0.027
MOT1Mot1p0.027
YAR068Whypothetical protein0.026
LEU2Leu2p0.025
YLR264C-Ahypothetical protein0.025
YLR162Whypothetical protein0.024
YIR035Chypothetical protein0.024
YOL038C-Ahypothetical protein0.024
RFC4Rfc4p0.023
ACM1Acm1p0.023
MER1Mer1p0.023
SSL1Ssl1p0.023
FAA2Faa2p0.022
HXT3Hxt3p0.022
TEL1Tel1p0.022
YHB1Yhb1p0.022
SMC6Smc6p0.022
POL2Pol2p0.022
URA3Ura3p0.021
PSF3Psf3p0.021
SEN34Sen34p0.021
SEN54Sen54p0.021
HHT2Hht2p0.021
ATP6Atp6p0.021
YBL044Whypothetical protein0.020
ZPS1Zps1p0.020
SPO22Spo22p0.020
MSA2Msa2p0.020
ALT2Alt2p0.020
IES1Ies1p0.020
COS12Cos12p0.020
YAR066Whypothetical protein0.020
NUP157Nup157p0.019
YER039C-Ahypothetical protein0.019
FMP25Fmp25p0.019
TAO3Tao3p0.019
YPR157Whypothetical protein0.019
CUP1-1Cup1-1p0.019
BSC1Bsc1p0.019
YLR042Chypothetical protein0.019
YBR013Chypothetical protein0.019
EST2Est2p0.019
SPL2Spl2p0.019
STU1Stu1p0.019
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
knl-1Protein KNL-10.405
mcm-3Protein MCM-30.363
Y47D3A.29Protein Y47D3A.290.358
isw-1Protein ISW-10.352
rod-1Protein ROD-10.213
mcm-6Protein MCM-60.198
wdr-5.3Protein WDR-5.30.161
npp-15Protein NPP-150.156
smc-4Protein SMC-40.138
CELE_F10C5.2Protein F10C5.20.136
klp-19Protein KLP-190.119
rnr-1Protein RNR-10.111
CELE_C50F4.16Protein C50F4.160.106
pgl-1Protein PGL-10.104
R151.8Protein R151.80.098
pcn-1Protein PCN-10.096
aspm-1Protein ASPM-10.094
mcm-4Protein MCM-40.086
brd-1Protein BRD-10.082
cec-6Protein CEC-60.080
scc-1Protein SCC-10.079
cyk-4Protein CYK-40.078
mog-4Protein MOG-40.075
C05C10.2Protein C05C10.20.072
div-1Protein DIV-10.071
wee-1.3Protein WEE-1.30.068
glp-1Protein GLP-10.065
skp-1Protein SKP-10.064
B0001.2Protein B0001.20.063
mcm-5Protein MCM-50.062
cin-4Protein CIN-40.061
mat-2Protein MAT-20.058
T07C4.10Protein T07C4.100.057
fncm-1Protein FNCM-10.056
D1081.8Protein D1081.80.054
pri-2Protein PRI-20.052
usp-48Protein USP-480.051
lig-1Protein LIG-10.051
cdc-48.1Protein CDC-48.10.048
fcd-2Protein FCD-20.048
pfs-2Protein PFS-20.048
CELE_F17C11.10Protein F17C11.100.047
B0205.1Protein B0205.10.047
B0412.3Protein B0412.30.045
elpc-3Protein ELPC-30.045
ucr-2.3Protein UCR-2.30.045
D2096.11Protein D2096.110.045
CELE_Y105E8A.23Protein Y105E8A.230.043
rpt-3Protein RPT-30.043
acly-2Protein ACLY-20.043
msh-2Protein MSH-20.043
pgl-3Protein PGL-30.042
plk-1Protein PLK-10.042
hcp-1Protein HCP-10.042
E04D5.1Protein E04D5.10.042
ekl-6Protein EKL-60.041
cdc-6Protein CDC-60.041
ima-2Protein IMA-20.041
npp-6Protein NPP-60.040
T07C4.3Protein T07C4.30.040
D1081.7Protein D1081.70.040
CELE_Y37H2A.1Protein Y37H2A.10.040
scc-3Protein SCC-30.038
F09F7.3Protein F09F7.30.038
ife-3Protein IFE-30.038
emb-27Protein EMB-270.037
hcp-6Protein HCP-60.036
CELE_Y48B6A.1Protein Y48B6A.10.036
mcm-7Protein MCM-70.035
prg-1Protein PRG-10.035
F11E6.7Protein F11E6.70.035
hmg-20Protein HMG-200.033
npp-9Protein NPP-90.032
mel-28Protein MEL-280.032
plk-3Protein PLK-30.032
hpo-40Protein HPO-400.031
CELE_F19F10.11Protein F19F10.110.031
him-10Protein HIM-100.031
unc-59Protein UNC-590.031
rpa-2Protein RPA-20.030
cdl-1Protein CDL-10.030
dna-2Protein DNA-20.030
csr-1Protein CSR-10.030
lin-9Protein LIN-90.029
bub-1Protein BUB-10.029
dcr-1Protein DCR-10.028
F55A3.3Protein F55A3.30.028
gpd-4Protein GPD-40.028
xpo-2Protein XPO-20.028
cec-7Protein CEC-70.028
F33H2.5Protein F33H2.50.028
ddx-19Protein DDX-190.027
smc-3Protein SMC-30.027
ZK370.4Protein ZK370.40.027
T05G5.9Protein T05G5.90.026
cyn-15Protein CYN-150.026
C24F3.2Protein C24F3.20.026
CELE_C25H3.4Protein C25H3.40.026
H14E04.2Protein H14E04.20.025
rme-2Protein RME-20.025
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Mcm2Minichromosome maintenance 20.996
lokloki0.994
mus101mutagen-sensitive 1010.917
RecQ5homolog of RecQ0.689
CG5524CG5524 gene product from transcript CG5524-RA0.576
spn-Bspindle B0.328
CDC45LCG3658 gene product from transcript CG3658-RA0.315
Brca2Breast cancer 2, early onset homolog0.313
rad50CG6339 gene product from transcript CG6339-RD0.299
CG10722CG10722 gene product from transcript CG10722-RA0.219
RfC3Replication factor C subunit 30.191
mre11meiotic recombination 110.182
Rev1CG12189 gene product from transcript CG12189-RA0.172
nbsCG6754 gene product from transcript CG6754-RC0.170
hayhaywire0.147
Psf1CG9187 gene product from transcript CG9187-RA0.145
Smc5CG32438 gene product from transcript CG32438-RE0.142
SlbpStem-loop binding protein0.099
Sld5CG14549 gene product from transcript CG14549-RA0.093
CG3430CG3430 gene product from transcript CG3430-RA0.091
Mcm6Minichromosome maintenance 60.088
okrokra0.084
CG5857CG5857 gene product from transcript CG5857-RA0.078
Mcm7Minichromosome maintenance 70.065
Orc2Origin recognition complex subunit 20.063
hdhumpty dumpty0.058
CG14057CG14057 gene product from transcript CG14057-RA0.055
Ndc80CG9938 gene product from transcript CG9938-RA0.045
Mcm10Sensitized chromosome inheritance modifier 190.043
tefutelomere fusion0.038
WRNexoWRN exonuclease0.038
DNApol-etaCG7143 gene product from transcript CG7143-RA0.037
Mcm5Minichromosome maintenance 50.035
CG13043CG13043 gene product from transcript CG13043-RA0.027
CG5602CG5602 gene product from transcript CG5602-RA0.027
Mcm3Minichromosome maintenance 30.027
asf1anti-silencing factor 10.025
CG5931CG5931 gene product from transcript CG5931-RA0.023
IrbpInverted repeat-binding protein0.023
Cks30ACyclin-dependent kinase subunit 30A0.023
RassfRas association family member0.022
Orc4Origin recognition complex subunit 40.022
orboo18 RNA-binding protein0.021
dltdiscs lost0.021
AtuAnother transcription unit0.020
CG9772CG9772 gene product from transcript CG9772-RB0.020
Gnf1Germ line transcription factor 10.020
mei-9meiotic 90.019
Pabp2CG2163 gene product from transcript CG2163-RA0.018
RnrLRibonucleoside diphosphate reductase large subunit0.018
nopono poles0.018
rodrough deal0.017
l(3)S147910lethal (3) S1479100.016
mus209mutagen-sensitive 2090.016
Axud1CG4272 gene product from transcript CG4272-RA0.015
BubR1Bub1-related kinase0.015
CG9752CG9752 gene product from transcript CG9752-RA0.014
RecQ4CG7487 gene product from transcript CG7487-RA0.014
CG9576CG9576 gene product from transcript CG9576-RA0.014
Grip71CG10346 gene product from transcript CG10346-RA0.014
sleslender lobes0.014
mus301mutagen-sensitive 3010.013
Lrr47Leucine-rich repeat 470.013
Grip84gamma-tubulin ring protein 840.012
Ge-1CG6181 gene product from transcript CG6181-RA0.012
CG16908CG16908 gene product from transcript CG16908-RA0.012
Syx13Syntaxin 130.012
mus312mutagen-sensitive 3120.012
Map60Microtubule-associated protein 600.012
Hsc70CbCG6603 gene product from transcript CG6603-RG0.012
spn-Dspindle D0.011
DNApol-deltaDNA-polymerase-delta0.011
CG8885CG8885 gene product from transcript CG8885-RA0.011
Pop2CG5684 gene product from transcript CG5684-RA0.011
CG5789CG5789 gene product from transcript CG5789-RA0.011
mib1mind bomb 10.011
Mes-4CG4976 gene product from transcript CG4976-RA0.011
CG4980CG4980 gene product from transcript CG4980-RA0.010
prdpaired0.010
DNApol-epsilonDNA polymerase epsilon0.010
pngpan gu0.010
dmtdalmatian0.010
CG3420CG3420 gene product from transcript CG3420-RA0.010
CG2118CG2118 gene product from transcript CG2118-RB0.010
CG5366CG5366 gene product from transcript CG5366-RA0.010
Aats-leuLeucyl-tRNA synthetase0.010
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
RPA1replication protein A1, 70kDa0.984
RPA2replication protein A2, 32kDa0.955
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.889
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.888
NBNnibrin0.814
H2AFXH2A histone family, member X0.805
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.796
BRCA1breast cancer 1, early onset0.783
MCM2minichromosome maintenance complex component 20.733
RAD50RAD50 homolog (S. cerevisiae)0.697
NCAPD2non-SMC condensin I complex, subunit D20.681
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.667
MCM6minichromosome maintenance complex component 60.660
PARP1poly (ADP-ribose) polymerase 10.615
MCM5minichromosome maintenance complex component 50.578
MCM7minichromosome maintenance complex component 70.527
TNFSF14tumor necrosis factor (ligand) superfamily, member 140.497
CDC45cell division cycle 45 homolog (S. cerevisiae)0.488
MDC1mediator of DNA-damage checkpoint 10.455
RUVBL1RuvB-like 1 (E. coli)0.442
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.386
GINS2GINS complex subunit 2 (Psf2 homolog)0.342
MCM3minichromosome maintenance complex component 30.339
CHEK2CHK2 checkpoint homolog (S. pombe)0.305
RPA3replication protein A3, 14kDa0.274
CDC7cell division cycle 7 homolog (S. cerevisiae)0.264
ORC1origin recognition complex, subunit 10.263
PPARAperoxisome proliferator-activated receptor alpha0.199
ATRataxia telangiectasia and Rad3 related0.176
FANCD2Fanconi anemia, complementation group D20.172
ATRXalpha thalassemia/mental retardation syndrome X-linked0.158
BRCA2breast cancer 2, early onset0.152
CHD8chromodomain helicase DNA binding protein 80.150
ORC3origin recognition complex, subunit 30.144
BLMBloom syndrome, RecQ helicase-like0.127
MCM10minichromosome maintenance complex component 100.124
E2F1E2F transcription factor 10.116
UNGuracil-DNA glycosylase0.115
CHD7chromodomain helicase DNA binding protein 70.114
GINS4GINS complex subunit 4 (Sld5 homolog)0.105
CUX1cut-like homeobox 10.103
YY1YY1 transcription factor0.102
WRNWerner syndrome, RecQ helicase-like0.095
ACTR5ARP5 actin-related protein 5 homolog (yeast)0.090
RAD52RAD52 homolog (S. cerevisiae)0.089
ATMataxia telangiectasia mutated0.078
MCM4minichromosome maintenance complex component 40.076
TERF2telomeric repeat binding factor 20.076
ACDadrenocortical dysplasia homolog (mouse)0.073
MCM8minichromosome maintenance complex component 80.060
RAD54LRAD54-like (S. cerevisiae)0.058
CHEK1CHK1 checkpoint homolog (S. pombe)0.055
ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.048
EXO1exonuclease 10.047
PALB2partner and localizer of BRCA20.047
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.047
MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 20.043
NCAPD3non-SMC condensin II complex, subunit D30.042
CENPMcentromere protein M0.041
PKMYT1protein kinase, membrane associated tyrosine/threonine 10.039
MNAT1menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)0.038
ORC6origin recognition complex, subunit 60.035
CTCFCCCTC-binding factor (zinc finger protein)0.035
NCAPGnon-SMC condensin I complex, subunit G0.035
CHTF18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.034
RPS4Y1ribosomal protein S4, Y-linked 10.034
SMC1Astructural maintenance of chromosomes 1A0.032
RECQL4RecQ protein-like 40.032
AURKBaurora kinase B0.032
DDX23DEAD (Asp-Glu-Ala-Asp) box polypeptide 230.031
SMC2structural maintenance of chromosomes 20.030
TK1thymidine kinase 1, soluble0.029
SSRP1structure specific recognition protein 10.029
ACTL6Aactin-like 6A0.029
MSH6mutS homolog 6 (E. coli)0.028
MDM2Mdm2 p53 binding protein homolog (mouse)0.027
MATR3matrin 30.027
NCAPH2non-SMC condensin II complex, subunit H20.027
RBBP8retinoblastoma binding protein 80.026
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.025
ESPL1extra spindle pole bodies homolog 1 (S. cerevisiae)0.025
TROAPtrophinin associated protein (tastin)0.024
XRCC3X-ray repair complementing defective repair in Chinese hamster cells 30.024
WDHD1WD repeat and HMG-box DNA binding protein 10.024
UBE2Cubiquitin-conjugating enzyme E2C0.024
MCMBPminichromosome maintenance complex binding protein0.024
RIF1RAP1 interacting factor homolog (yeast)0.024
DTLdenticleless homolog (Drosophila)0.023
EIF1AYeukaryotic translation initiation factor 1A, Y-linked0.023
GTF2H1general transcription factor IIH, polypeptide 1, 62kDa0.023
CENPAcentromere protein A0.023
CCNHcyclin H0.022
E2F3E2F transcription factor 30.022
BNIPLBCL2/adenovirus E1B 19kD interacting protein like0.021
AHRaryl hydrocarbon receptor0.021
GTSE1G-2 and S-phase expressed 10.021
E2F2E2F transcription factor 20.021
ILF2interleukin enhancer binding factor 2, 45kDa0.020
C12orf11chromosome 12 open reading frame 110.020
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.020
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.930
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.860
Cdt1chromatin licensing and DNA replication factor 10.705
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.611
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.507
Brca2breast cancer 20.303
Timelesstimeless homolog (Drosophila)0.276
Brca1breast cancer 10.260
Rrm1ribonucleotide reductase M10.215
Rfc2replication factor C (activator 1) 20.108
Orc1origin recognition complex, subunit 10.096
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.083
Nup93nucleoporin 930.067
Mre11ameiotic recombination 11 homolog A (S. cerevisiae)0.060
Atmataxia telangiectasia mutated homolog (human)0.056
Dnmt1DNA methyltransferase (cytosine-5) 10.045
Ezh2enhancer of zeste homolog 2 (Drosophila)0.042
Ruvbl1RuvB-like protein 10.040
Pold2polymerase (DNA directed), delta 2, regulatory subunit0.037
Nup85nucleoporin 850.036
Rfc1replication factor C (activator 1) 10.034
Hellshelicase, lymphoid specific0.032
Lig1ligase I, DNA, ATP-dependent0.023
Cdca7lcell division cycle associated 7 like0.021
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.021
Rfc3replication factor C (activator 1) 30.020
Fen1flap structure specific endonuclease 10.020
Rad51ap1RAD51 associated protein 10.020
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.020
Wdhd1WD repeat and HMG-box DNA binding protein 10.019
Polepolymerase (DNA directed), epsilon0.018
Pold3polymerase (DNA-directed), delta 3, accessory subunit0.017
Nup107nucleoporin 1070.017
Cdca7cell division cycle associated 70.017
Rfc5replication factor C (activator 1) 50.016
Pola1polymerase (DNA directed), alpha 10.016
Dnajc9DnaJ (Hsp40) homolog, subfamily C, member 90.015
Prim1DNA primase, p49 subunit0.015
Eftud2elongation factor Tu GTP binding domain containing 20.014
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.014
Mdm2transformed mouse 3T3 cell double minute 20.013
Cdc7cell division cycle 7 (S. cerevisiae)0.012
Unguracil DNA glycosylase0.012
Aaasachalasia, adrenocortical insufficiency, alacrimia0.011
Nbnnibrin0.010
Lrwd1leucine-rich repeats and WD repeat domain containing 10.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Anxa2annexin A20.723
Cd151CD151 molecule (Raph blood group)0.383
S100a10S100 calcium binding protein A100.309
Anxa1annexin A10.210
S100a11S100 calcium binding protein A11 (calizzarin)0.202
Vimvimentin0.182
Arpc1bactin related protein 2/3 complex, subunit 1B0.167
Capn2calpain 20.163
Lgals3lectin, galactoside-binding, soluble, 30.158
S100a6S100 calcium binding protein A60.095
Plp2proteolipid protein 2 (colonic epithelium-enriched)0.049
Cpsf3cleavage and polyadenylation specificity factor 30.039
Rfc2replication factor C (activator 1) 20.035
Itgb1integrin, beta 10.033
Ctsbcathepsin B0.031
Anxa5annexin A50.030
Polr2bpolymerase (RNA) II (DNA directed) polypeptide B0.023
Ctnna1catenin (cadherin associated protein), alpha 10.023
Strapserine/threonine kinase receptor associated protein0.020
Lmnalamin A0.018
Clns1achloride channel, nucleotide-sensitive, 1A0.016
Alg8asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)0.016
Cd9CD9 molecule0.016
Zc3h15zinc finger CCCH-type containing 150.013
Chaf1achromatin assembly factor 1, subunit A (p150)0.012
Taglntransgelin0.012
Myadmmyeloid-associated differentiation marker0.012
AhnakAHNAK nucleoprotein0.012
Ctnnbl1catenin, beta like 10.012
S100a4S100 calcium-binding protein A40.011
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.011
Mnat1menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)0.011
Pqlc3PQ loop repeat containing 30.011
Serpinb6aserine (or cysteine) peptidase inhibitor, clade B, member 6a0.011
G6pdglucose-6-phosphate dehydrogenase0.010
Gtf2f1general transcription factor IIF, polypeptide 10.010
LOC684035similar to arginyl aminopeptidase (aminopeptidase B)-like 10.010