The network for 'regulation of molecular function' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of molecular function

Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.

NameDescriptionProbabilityFunc Analog Organism
CKS1Cks1p0.758
SLT2Slt2p0.727
SIC1Sic1p0.708
HSL1Hsl1p0.603
RPT3Rpt3p0.559
CDC28Cdc28p0.459
NAP1Nap1p0.453
PHO85Pho85p0.431
RIM1Rim1p0.427
DBF2Dbf2p0.424
NBP2Nbp2p0.421
SUS1Sus1p0.398
MSN5Msn5p0.395
PKP2Pkp2p0.383
CLB2Clb2p0.381
GCN5Gcn5p0.375
DED1Ded1p0.368
STI1Sti1p0.368
SDS22Sds22p0.367
ASK10Ask10p0.361
MSG5Msg5p0.357
TPK1Tpk1p0.353
STE11Ste11p0.349
PBS2Pbs2p0.336
CDC20Cdc20p0.333
SSK1Ssk1p0.331
HRR25Hrr25p0.331
BCK1Bck1p0.327
YME1Yme1p0.324
SCH9Sch9p0.314
SPA2Spa2p0.314
SPT15Spt15p0.312
ELP4Elp4p0.302
FUS3Fus3p0.297
PPH21Pph21p0.296
CBF2Cbf2p0.276
CDC50Cdc50p0.262
UBR1Ubr1p0.247
TSR1Tsr1p0.245
PIL1Pil1p0.240
CDC24Cdc24p0.239
CDC48Cdc48p0.239
CLB6Clb6p0.236
RHO1Rho1p0.235
SOD1Sod1p0.235
FKH1Fkh1p0.232
PCL8Pcl8p0.231
BEM4Bem4p0.230
BMH1Bmh1p0.223
ADR1Adr1p0.223
GIN4Gin4p0.218
GYL1Gyl1p0.217
CHC1Chc1p0.217
STE4Ste4p0.215
SHS1Shs1p0.213
CDC11Cdc11p0.209
CAK1Cak1p0.208
SWE1Swe1p0.208
MPT5Mpt5p0.208
PKC1Pkc1p0.206
RLM1Rlm1p0.201
FAB1Fab1p0.201
BUD23Bud23p0.201
FAR1Far1p0.201
TPK2Tpk2p0.200
YDJ1Ydj1p0.199
RPT1Rpt1p0.197
PAN1Pan1p0.197
REG1Reg1p0.197
PAM1Pam1p0.193
SHE3She3p0.192
PSK1Psk1p0.191
SAP185Sap185p0.191
STT4Stt4p0.189
AKL1Akl1p0.187
RPM2Rpm2p0.185
GPH1Gph1p0.181
TCO89Tco89p0.181
PCL9Pcl9p0.180
SLM1Slm1p0.180
GLC7Glc7p0.179
STE5Ste5p0.177
ENT1Ent1p0.176
PEX13Pex13p0.173
TOR1Tor1p0.171
LCB4Lcb4p0.171
APC9Apc9p0.170
GCS1Gcs1p0.170
PTP2Ptp2p0.169
YPD1Ypd1p0.169
MYO2Myo2p0.167
CDC6Cdc6p0.167
SSN8Ssn8p0.165
PTK2Ptk2p0.164
CDC23Cdc23p0.163
HOG1Hog1p0.163
BMH2Bmh2p0.162
TFG2Tfg2p0.162
PRK1Prk1p0.162
LHS1Lhs1p0.159
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
vab-3Protein VAB-30.569
egl-18Protein EGL-180.494
itr-1Protein ITR-10.464
sas-4Protein SAS-40.390
sma-6Protein SMA-60.362
mpk-1Protein MPK-10.346
nlg-1Protein NLG-10.335
pkc-3Protein PKC-30.333
spk-1Protein SPK-10.316
bar-1Protein BAR-10.282
let-60Protein LET-600.270
sur-2Protein SUR-20.265
egl-8Protein EGL-80.244
brp-1Protein BRP-10.243
inx-13Protein INX-130.238
mbk-2Protein MBK-20.237
pal-1Protein PAL-10.226
scc-3Protein SCC-30.223
cks-1Protein CKS-10.221
F28B3.1Protein F28B3.10.219
unc-43Protein UNC-430.211
C11E4.6Protein C11E4.60.211
hlh-2Protein HLH-20.209
ZK507.6Protein ZK507.60.205
unc-45Protein UNC-450.202
lag-1Protein LAG-10.199
unc-26Protein UNC-260.199
pat-12Protein PAT-120.198
rab-5Protein RAB-50.197
unc-73Protein UNC-730.193
inx-8Protein INX-80.188
CELE_C01G6.5Protein C01G6.50.186
K10D6.4Protein K10D6.40.180
uig-1Protein UIG-10.179
sli-1Protein SLI-10.175
eef-1A.1Protein EEF-1A.10.174
skn-1Protein SKN-10.173
atp-2Protein ATP-20.171
inx-3Protein INX-30.162
mes-3Protein MES-30.162
T28C6.7Protein T28C6.70.158
unc-6Protein UNC-60.156
gpb-2Protein GPB-20.151
egl-13Protein EGL-130.149
unc-40Protein UNC-400.147
C34F6.10Protein C34F6.100.141
hlh-1Protein HLH-10.141
pkg-1Protein PKG-10.141
tol-1Protein TOL-10.140
eor-1Protein EOR-10.139
F54E4.3Protein F54E4.30.137
tps-1Protein TPS-10.136
vav-1Protein VAV-10.131
let-756Protein LET-7560.130
rnr-2Protein RNR-20.130
zfp-1Protein ZFP-10.129
kcc-1Protein KCC-10.127
sem-5Protein SEM-50.126
F09A5.4Protein F09A5.40.121
scd-1Protein SCD-10.119
mcm-5Protein MCM-50.118
sto-4Protein STO-40.116
unc-62Protein UNC-620.114
ced-4Protein CED-40.111
CELE_F54D5.5Protein F54D5.50.111
imp-1Protein IMP-10.110
rme-4Protein RME-40.109
kle-2Protein KLE-20.109
nhr-67Protein NHR-670.108
unc-7Protein UNC-70.108
pmk-1Protein PMK-10.107
K08E3.5Protein K08E3.50.104
daf-1Protein DAF-10.102
rhgf-2Protein RHGF-20.102
eat-6Protein EAT-60.102
mes-1Protein MES-10.101
cam-1Protein CAM-10.100
aak-2Protein AAK-20.098
hsr-9Protein HSR-90.097
pqn-44Protein PQN-440.097
T26A5.5Protein T26A5.50.096
ect-2Protein ECT-20.096
T23F11.1Protein T23F11.10.093
unc-9Protein UNC-90.093
eat-18Protein EAT-180.093
mom-2Protein MOM-20.092
nhr-34Protein NHR-340.091
rsa-1Protein RSA-10.091
mat-3Protein MAT-30.091
CELE_R102.2Protein R102.20.091
ten-1Protein TEN-10.090
vps-11Protein VPS-110.090
madf-5Protein MADF-50.090
inx-1Protein INX-10.089
pas-7Protein PAS-70.089
max-2Protein MAX-20.089
syg-1Protein SYG-10.088
wrm-1Protein WRM-10.088
Y54E5A.7Protein Y54E5A.70.088
C46C11.3Protein C46C11.30.088
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
lef1lymphocyte enhancer binding factor 10.724
wnt2bbwingless-type MMTV integration site family, member 2Bb0.688
robo3roundabout homolog 30.526
gata6GATA-binding protein 60.473
cfl2lcofilin 2, like0.409
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.404
gata5GATA-binding protein 50.345
sfrp5secreted frizzled-related protein 50.332
efnb2aephrin B2a0.325
pitx3paired-like homeodomain transcription factor 30.309
dag1dystroglycan 10.303
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.298
cdh1cadherin 1, epithelial0.279
notch3notch homolog 30.277
sox9bSRY-box containing gene 9b0.267
alcambactivated leukocyte cell adhesion molecule b0.264
ascl1aachaete-scute complex-like 1a (Drosophila)0.253
cdh23cadherin-like 230.250
csrp1acysteine and glycine-rich protein 1a0.249
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.240
prkciprotein kinase C, iota0.226
sox7SRY-box containing gene 70.216
park7parkinson disease (autosomal recessive, early onset) 70.213
aldoaaaldolase a, fructose-bisphosphate, a0.211
adra2badrenergic, alpha-2B-, receptor0.210
sox2SRY-box containing gene 20.209
runx2brunt-related transcription factor 2b0.205
egr1early growth response 10.203
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.200
gfra1agdnf family receptor alpha 1a0.200
pdlim1PDZ and LIM domain 1 (elfin)0.187
mef2cbmyocyte enhancer factor 2cb0.187
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.186
yrkYes-related kinase0.186
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.182
fzd5frizzled homolog 50.181
prkczprotein kinase C, zeta0.178
scinlascinderin like a0.176
epas1bendothelial PAS domain protein 1b0.173
wnt10bwingless-type MMTV integration site family, member 10b0.171
thtyrosine hydroxylase0.168
flhfloating head0.166
tnfrsfatumor necrosis factor receptor superfamily, member a0.165
wnt8bwingless-type MMTV integration site family, member 8b0.156
gro2groucho 20.154
cd63Cd63 antigen0.153
fgf3fibroblast growth factor 30.152
anxa1aannexin A1a0.148
fxyd1FXYD domain containing ion transport regulator 1 (phospholemman)0.143
alas2aminolevulinate, delta-, synthetase 20.142
arl4abADP-ribosylation factor-like 4ab0.141
optcopticin0.141
otpaorthopedia homolog a0.137
esr1estrogen receptor 10.137
crhcorticotropin releasing hormone0.136
foxn4forkhead box N40.136
brd4bromodomain containing 40.134
si:dkey-228g21.4si:dkey-228g21.40.133
igf1insulin-like growth factor 10.132
maomonoamine oxidase0.131
pvrl1bpoliovirus receptor-related 1b0.131
ppargperoxisome proliferator activated receptor gamma0.131
lama5laminin, alpha 50.130
hk1hexokinase 10.130
sox11bSRY-box containing gene 11b0.129
cntn1bcontactin 1b0.129
cx43connexin 430.129
socs3asuppressor of cytokine signaling 3a0.128
per2period homolog 2 (Drosophila)0.128
hoxb4ahomeo box B4a0.126
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.126
fbp1bfructose-1,6-bisphosphatase 1b0.125
wnt11rwingless-type MMTV integration site family, member 11, related0.125
ripk2receptor-interacting serine-threonine kinase 20.125
baxabcl2-associated X protein, a0.124
muskmuscle, skeletal, receptor tyrosine kinase0.124
flot2aflotillin 2a0.121
axin2axin 2 (conductin, axil)0.119
mgaMAX gene associated0.119
appbamyloid beta (A4) precursor protein b0.118
mycbp2MYC binding protein 20.117
dkk1bdickkopf 1b0.114
bmp2abone morphogenetic protein 2a0.114
pak2ap21 (CDKN1A)-activated kinase 2a0.112
hmgb1ahigh-mobility group box 1a0.111
dmbx1adiencephalon/mesencephalon homeobox 1a0.111
mef2amyocyte enhancer factor 2a0.111
fgfr1afibroblast growth factor receptor 1a0.110
nrg2aneuregulin 2a0.109
six4.3sine oculis homeobox homolog 4.30.109
msi1musashi homolog 1 (Drosophila)0.109
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.107
pkd2polycystic kidney disease 20.106
per3period homolog 3 (Drosophila)0.106
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.105
cnn2calponin 20.105
ccna2cyclin A20.105
slit3slit (Drosophila) homolog 30.104
ckmacreatine kinase, muscle a0.102
hspa4aheat shock protein 4a0.101
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
NNotch0.930
shnschnurri0.898
Su(H)Suppressor of Hairless0.895
MadMothers against dpp0.840
Pi3K92ECG4141 gene product from transcript CG4141-RB0.822
jebjelly belly0.814
fzfrizzled0.812
Cip4CG15015 gene product from transcript CG15015-RA0.805
PknProtein kinase related to protein kinase N0.776
Rac2CG8556 gene product from transcript CG8556-RA0.761
bsblistered0.741
Stat92ESignal-transducer and activator of transcription protein at 92E0.734
twstwins0.730
Src42ASrc oncogene at 42A0.728
rokRho-kinase0.704
p120ctnAdherens junction protein p1200.663
cactcactus0.655
nejnejire0.626
PakPAK-kinase0.622
Akt1CG4006 gene product from transcript CG4006-RA0.608
LLobe0.594
tshteashirt0.587
CkIIalphaCasein kinase II alpha subunit0.557
rprreaper0.554
bskbasket0.535
eIF-4EEukaryotic initiation factor 4E0.534
fogfolded gastrulation0.526
dcodiscs overgrown0.522
babobaboon0.515
Uba1Ubiquitin activating enzyme 10.513
escextra sexcombs0.512
MtlMig-2-like0.510
Fcp1CG12252 gene product from transcript CG12252-RA0.509
AblAbl tyrosine kinase0.503
Pros54Proteasome 54kD subunit0.496
par-1CG8201 gene product from transcript CG8201-RA0.495
Rho1CG8416 gene product from transcript CG8416-RB0.491
pucpuckered0.474
drkdownstream of receptor kinase0.465
edechinoid0.464
dysdysfusion0.461
rheaCG6831 gene product from transcript CG6831-RA0.461
mbcmyoblast city0.460
kuzkuzbanian0.460
Dsp1Dorsal switch protein 10.459
enaenabled0.458
kaykayak0.457
Aos1CG12276 gene product from transcript CG12276-RA0.449
Pka-C1cAMP-dependent protein kinase 10.448
CycECyclin E0.442
trxtrithorax0.433
kibrakibra ortholog0.432
cicubitus interruptus0.430
mysmyospheroid0.429
CtBPC-terminal Binding Protein0.422
rolsrolling pebbles0.413
Atg1Autophagy-specific gene 10.411
rlrolled0.406
p38bCG7393 gene product from transcript CG7393-RA0.401
mtsmicrotubule star0.401
lgslegless0.400
ShawShaker cognate w0.397
shishibire0.389
CaMKIICalcium/calmodulin-dependent protein kinase II0.387
JraJun-related antigen0.384
sggshaggy0.380
numbCG3779 gene product from transcript CG3779-RB0.379
emcextra macrochaetae0.378
KhcKinesin heavy chain0.378
HLHm7E(spl) region transcript m70.376
ththread0.374
jingCG9397 gene product from transcript CG9397-RI0.371
Sema-2aCG4700 gene product from transcript CG4700-RC0.369
srpserpent0.364
wtswarts0.363
Plc21CPhospholipase C at 21C0.359
mspsmini spindles0.356
Rca1Regulator of cyclin A10.355
CG7158CG7158 gene product from transcript CG7158-RA0.346
zfh2Zn finger homeodomain 20.330
Dcp-1Death caspase-10.329
WnkCG7177 gene product from transcript CG7177-RA0.328
Cul-3Cullin-30.328
CycACyclin A0.328
putpunt0.323
Dcr-2Dicer-20.322
armarmadillo0.321
Socs36ESuppressor of cytokine signaling at 36E0.321
pumpumilio0.320
rapretina aberrant in pattern0.318
EgfrEpidermal growth factor receptor0.317
CadNCadherin-N0.317
nmonemo0.317
ThorCG8846 gene product from transcript CG8846-RA0.316
enengrailed0.315
XNPCG4548 gene product from transcript CG4548-RA0.312
SaraSmad anchor for receptor activation0.311
Galpha49BG protein alpha49B0.305
ik2IkappaB kinase-like 20.302
nebnebbish0.300
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hsph1heat shock 105/110 protein 10.752
Anxa2annexin A20.713
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.694
Cmklr1chemokine-like receptor 10.684
Sox17SRY (sex determining region Y)-box 170.671
Id3inhibitor of DNA binding 30.671
Zfp36zinc finger protein 360.662
Syt8synaptotagmin VIII0.650
Dusp1dual specificity phosphatase 10.649
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.647
Myo1bmyosin Ib0.642
Mapk3mitogen activated protein kinase 30.616
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.615
Cav1caveolin 1, caveolae protein0.613
Vimvimentin0.609
Homer1homer homolog 1 (Drosophila)0.571
Sdc3syndecan 30.566
Pftk1PFTAIRE protein kinase 10.552
Anxa5annexin A50.548
Accn2amiloride-sensitive cation channel 2, neuronal0.531
Slco2b1solute carrier organic anion transporter family, member 2b10.518
Trib1tribbles homolog 1 (Drosophila)0.510
Myl9myosin, light chain 9, regulatory0.508
Il1r1interleukin 1 receptor, type I0.505
Cd4Cd4 molecule0.502
Taok1TAO kinase 10.495
Grm5glutamate receptor, metabotropic 50.493
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.483
Orai1ORAI calcium release-activated calcium modulator 10.479
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.479
Pim1pim-1 oncogene0.475
A3galt2alpha 1,3-galactosyltransferase 20.473
Gria1glutamate receptor, ionotropic, AMPA 10.471
Gja1gap junction protein, alpha 10.463
Arpc1bactin related protein 2/3 complex, subunit 1B0.460
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.460
FosFBJ osteosarcoma oncogene0.456
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.456
Btg2BTG family, member 20.450
S100a10S100 calcium binding protein A100.447
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.447
Pdgfbplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.442
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.438
Homer3homer homolog 3 (Drosophila)0.434
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.432
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.425
Nr4a3nuclear receptor subfamily 4, group A, member 30.423
Jak2Janus kinase 20.421
JunJun oncogene0.420
Stxbp1syntaxin binding protein 10.419
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.415
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.413
Casp3caspase 30.411
Tsc2tuberous sclerosis 20.411
Hsp90b1heat shock protein 90, beta, member 10.404
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.404
S1pr2sphingosine-1-phosphate receptor 20.403
Klf6Kruppel-like factor 60.403
Dlg1discs, large homolog 1 (Drosophila)0.403
Mc4rmelanocortin 4 receptor0.403
Ahsgalpha-2-HS-glycoprotein0.400
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.395
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.391
Bdkrb2bradykinin receptor B20.389
Creb1cAMP responsive element binding protein 10.388
Mgat5mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase0.381
Junbjun B proto-oncogene0.372
Epas1endothelial PAS domain protein 10.372
Adam17ADAM metallopeptidase domain 170.369
Oprm1opioid receptor, mu 10.368
Rhoaras homolog gene family, member A0.367
Flt1FMS-related tyrosine kinase 10.366
Ednrbendothelin receptor type B0.364
Akt1v-akt murine thymoma viral oncogene homolog 10.364
Galnt1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)0.360
Tgfbr1transforming growth factor, beta receptor 10.359
Notch3Notch homolog 3 (Drosophila)0.358
Rims1regulating synaptic membrane exocytosis 10.353
Acrv1acrosomal vesicle protein 10.353
Nos3nitric oxide synthase 3, endothelial cell0.352
Prkcbprotein kinase C, beta0.350
Orm1orosomucoid 10.350
Ahraryl hydrocarbon receptor0.350
Mpeg1macrophage expressed 10.349
Calcrlcalcitonin receptor-like0.349
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.348
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.348
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.347
Pdynprodynorphin0.346
Slc25a5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.343
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.343
Prkcdprotein kinase C, delta0.343
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.342
Inpp5dinositol polyphosphate-5-phosphatase D0.342
Ppiapeptidylprolyl isomerase A (cyclophilin A)0.342
RGD1308350similar to hypothetical protein MGC132510.341
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.341
Nrp2neuropilin 20.338
Atf3activating transcription factor 30.336
Casp2caspase 20.334