The network for 'negative regulation of camp mediated signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of camp mediated signaling

Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.978
UBR1ubiquitin protein ligase E3 component n-recognin 10.972
BTRCbeta-transducin repeat containing0.799
RAD18RAD18 homolog (S. cerevisiae)0.717
VPS29vacuolar protein sorting 29 homolog (S. cerevisiae)0.664
FBXW5F-box and WD repeat domain containing 50.612
UBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)0.562
MPDZmultiple PDZ domain protein0.352
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.344
REEP5receptor accessory protein 50.292
INF2inverted formin, FH2 and WH2 domain containing0.246
UBE2Aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.212
LAMTOR3late endosomal/lysosomal adaptor, MAPK and MTOR activator 30.167
BBS10Bardet-Biedl syndrome 100.158
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.125
SSTR2somatostatin receptor 20.115
SKP1S-phase kinase-associated protein 10.107
PNPLA2patatin-like phospholipase domain containing 20.100
RIN3Ras and Rab interactor 30.083
SSTR3somatostatin receptor 30.080
ARL15ADP-ribosylation factor-like 150.077
CORO7coronin 70.071
POLHpolymerase (DNA directed), eta0.067
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.066
NUDT3nudix (nucleoside diphosphate linked moiety X)-type motif 30.065
TUBB2Btubulin, beta 2B0.063
HGShepatocyte growth factor-regulated tyrosine kinase substrate0.058
DNAJB11DnaJ (Hsp40) homolog, subfamily B, member 110.053
PTPRSprotein tyrosine phosphatase, receptor type, S0.047
CHRNA4cholinergic receptor, nicotinic, alpha 40.041
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.040
ZFAND5zinc finger, AN1-type domain 50.040
SPRY2sprouty homolog 2 (Drosophila)0.039
RNF20ring finger protein 200.039
TSG101tumor susceptibility gene 1010.037
RNF126ring finger protein 1260.037
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.036
FBXW11F-box and WD repeat domain containing 110.036
UBA1ubiquitin-like modifier activating enzyme 10.035
ARL4DADP-ribosylation factor-like 4D0.035
CTSBcathepsin B0.034
KCNF1potassium voltage-gated channel, subfamily F, member 10.034
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.030
LRFN1leucine rich repeat and fibronectin type III domain containing 10.030
SERPINB9serpin peptidase inhibitor, clade B (ovalbumin), member 90.030
POMPproteasome maturation protein0.028
ANXA3annexin A30.028
CSTAcystatin A (stefin A)0.026
ARL3ADP-ribosylation factor-like 30.026
MUL1mitochondrial E3 ubiquitin protein ligase 10.026
GSK3Bglycogen synthase kinase 3 beta0.025
TNFSF11tumor necrosis factor (ligand) superfamily, member 110.025
DZIP3DAZ interacting protein 3, zinc finger0.024
RNF11ring finger protein 110.024
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.023
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.022
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.022
OPRD1opioid receptor, delta 10.021
GJD2gap junction protein, delta 2, 36kDa0.021
GPRASP1G protein-coupled receptor associated sorting protein 10.020
POU4F3POU class 4 homeobox 30.020
FEM1Cfem-1 homolog c (C. elegans)0.020
SHANK1SH3 and multiple ankyrin repeat domains 10.019
FSCN2fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)0.019
RHOAras homolog gene family, member A0.018
GPR6G protein-coupled receptor 60.018
MAPK6mitogen-activated protein kinase 60.018
FRZBfrizzled-related protein0.017
FTH1ferritin, heavy polypeptide 10.017
NKX2-8NK2 homeobox 80.017
AVPR1Barginine vasopressin receptor 1B0.017
NAT15N-acetyltransferase 15 (GCN5-related, putative)0.017
AMBPalpha-1-microglobulin/bikunin precursor0.016
NR5A1nuclear receptor subfamily 5, group A, member 10.016
RAB21RAB21, member RAS oncogene family0.016
RHBDL1rhomboid, veinlet-like 1 (Drosophila)0.016
CSNK2A2casein kinase 2, alpha prime polypeptide0.016
HTR2A5-hydroxytryptamine (serotonin) receptor 2A0.016
MED31mediator complex subunit 310.016
CALYcalcyon neuron-specific vesicular protein0.015
CREMcAMP responsive element modulator0.015
PGAM1phosphoglycerate mutase 1 (brain)0.015
RAC3ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)0.015
DRD2dopamine receptor D20.015
ADRA1Dadrenergic, alpha-1D-, receptor0.015
ING2inhibitor of growth family, member 20.014
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.014
KLF5Kruppel-like factor 5 (intestinal)0.014
NEURLneuralized homolog (Drosophila)0.014
DDIT4DNA-damage-inducible transcript 40.014
THtyrosine hydroxylase0.014
NEUROG3neurogenin 30.014
FRA10AC1fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 10.014
KCNK4potassium channel, subfamily K, member 40.014
DDR1discoidin domain receptor tyrosine kinase 10.014
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cckbrcholecystokinin B receptor0.303
Cnr1cannabinoid receptor 1 (brain)0.198
Ppp1r9bprotein phosphatase 1, regulatory subunit 9B0.187
Oprk1opioid receptor, kappa 10.145
Prlhrprolactin releasing hormone receptor0.115
Drd3dopamine receptor D30.113
Sertad2SERTA domain containing 20.090
Gad2glutamic acid decarboxylase 20.083
Rgs9regulator of G-protein signaling 90.083
Ikzf4IKAROS family zinc finger 40.081
Ednrbendothelin receptor type B0.081
Gpr27G protein-coupled receptor 270.073
Cd247CD247 antigen0.069
Rhbdf1rhomboid family 1 (Drosophila)0.063
Mybpc3myosin binding protein C, cardiac0.061
Gria1glutamate receptor, ionotropic, AMPA1 (alpha 1)0.061
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.060
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.057
Apc2adenomatosis polyposis coli 20.056
Hras1Harvey rat sarcoma virus oncogene 10.055
Rgs4regulator of G-protein signaling 40.054
Abcc9ATP-binding cassette, sub-family C (CFTR/MRP), member 90.052
TyrobpTYRO protein tyrosine kinase binding protein0.052
Drd2dopamine receptor D20.051
Lrp6low density lipoprotein receptor-related protein 60.049
Syt1synaptotagmin I0.049
Rasa3RAS p21 protein activator 30.047
F7coagulation factor VII0.047
Cul9cullin 90.045
Paip2polyadenylate-binding protein-interacting protein 20.044
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.043
Ifna2interferon alpha 20.043
Ptprbprotein tyrosine phosphatase, receptor type, B0.041
Psmd3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.038
Fam105afamily with sequence similarity 105, member A0.037
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.037
Mchr1melanin-concentrating hormone receptor 10.035
Gabrqgamma-aminobutyric acid (GABA) A receptor, subunit theta0.035
Cacng5calcium channel, voltage-dependent, gamma subunit 50.034
Ptprnprotein tyrosine phosphatase, receptor type, N0.033
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.033
Adcy7adenylate cyclase 70.033
Gpr83G protein-coupled receptor 830.033
Kcnd1potassium voltage-gated channel, Shal-related family, member 10.032
Prl8a9prolactin family8, subfamily a, member 90.032
Sdc3syndecan 30.032
Ly86lymphocyte antigen 860.031
Chrna6cholinergic receptor, nicotinic, alpha polypeptide 60.031
Gucy1b3guanylate cyclase 1, soluble, beta 30.030
Matn1matrilin 1, cartilage matrix protein0.029
Cd8b1CD8 antigen, beta chain 10.029
Oprd1opioid receptor, delta 10.028
Rassf5Ras association (RalGDS/AF-6) domain family member 50.028
Wnt2bwingless related MMTV integration site 2b0.028
Adra2aadrenergic receptor, alpha 2a0.028
Pip4k2aphosphatidylinositol-5-phosphate 4-kinase, type II, alpha0.028
Golt1agolgi transport 1 homolog A (S. cerevisiae)0.028
Ppyr1pancreatic polypeptide receptor 10.028
Mmp24matrix metallopeptidase 240.028
Pthlhparathyroid hormone-like peptide0.028
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.027
Aanatarylalkylamine N-acetyltransferase0.027
Tbrg4transforming growth factor beta regulated gene 40.027
Slc16a8solute carrier family 16 (monocarboxylic acid transporters), member 80.027
Shc3src homology 2 domain-containing transforming protein C30.027
Gpr50G-protein-coupled receptor 500.027
Klk6kallikrein related-peptidase 60.027
Rit2Ras-like without CAAX 20.027
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.027
Ntsr2neurotensin receptor 20.026
Rln1relaxin 10.026
Cd70CD70 antigen0.026
Clec4fC-type lectin domain family 4, member f0.026
Vipr2vasoactive intestinal peptide receptor 20.025
Lhx6LIM homeobox protein 60.025
Ptproprotein tyrosine phosphatase, receptor type, O0.025
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.025
Oprl1opioid receptor-like 10.025
Adam11a disintegrin and metallopeptidase domain 110.025
Grin2cglutamate receptor, ionotropic, NMDA2C (epsilon 3)0.025
Dio2deiodinase, iodothyronine, type II0.025
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.024
Kcna6potassium voltage-gated channel, shaker-related, subfamily, member 60.024
Otporthopedia homolog (Drosophila)0.024
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.024
Angpt1angiopoietin 10.024
Dnajb5DnaJ (Hsp40) homolog, subfamily B, member 50.024
Zfand5zinc finger, AN1-type domain 50.023
EvlEna-vasodilator stimulated phosphoprotein0.023
Mc2rmelanocortin 2 receptor0.023
Kdm5alysine (K)-specific demethylase 5A0.023
Hcn1hyperpolarization-activated, cyclic nucleotide-gated K+ 10.023
DarcDuffy blood group, chemokine receptor0.023
Celcarboxyl ester lipase0.023
Ncs1neuronal calcium sensor 10.023
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism