The network for 'lagging strand elongation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lagging strand elongation

The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork.

NameDescriptionProbabilityFunc Analog Organism
POL12Pol12p0.722
RFA1Rfa1p0.585
POL1Pol1p0.549
POL30Pol30p0.512
RAD5Rad5p0.470
MSH6Msh6p0.424
POL32Pol32p0.388
POL2Pol2p0.380
CDC21Cdc21p0.353
POL3Pol3p0.292
RFA2Rfa2p0.246
MRC1Mrc1p0.184
RFC3Rfc3p0.181
CDC9Cdc9p0.172
SLD5Sld5p0.136
PRI2Pri2p0.135
CDC45Cdc45p0.101
TOF1Tof1p0.093
POL31Pol31p0.091
MSH3Msh3p0.080
RAD53Rad53p0.052
CSM3Csm3p0.042
RNH202Rnh202p0.041
MSH2Msh2p0.034
SRD1Srd1p0.034
MGS1Mgs1p0.033
YLR264C-Ahypothetical protein0.033
TOP3Top3p0.031
RNH203Rnh203p0.030
LEU2Leu2p0.029
YLF2Ylf2p0.028
YLH47Ylh47p0.026
YOL038C-Ahypothetical protein0.025
RFC5Rfc5p0.025
CAC2Cac2p0.025
YLR162Whypothetical protein0.024
ARG8Arg8p0.024
ARP10Arp10p0.023
MER1Mer1p0.023
SCC2Scc2p0.022
PCM1Pcm1p0.022
RAD9Rad9p0.021
MCM4Mcm4p0.021
URA3Ura3p0.021
CUP1-1Cup1-1p0.021
YLR042Chypothetical protein0.021
RFA3Rfa3p0.020
HOHop0.020
YPR157Whypothetical protein0.020
PSF1Psf1p0.019
STB1Stb1p0.019
PRI1Pri1p0.019
SWC7Swc7p0.019
YAR068Whypothetical protein0.018
ATP6Atp6p0.018
EST2Est2p0.018
AUA1Aua1p0.018
REV1Rev1p0.018
ZPS1Zps1p0.018
YIL151Chypothetical protein0.017
YBR013Chypothetical protein0.017
RAD24Rad24p0.017
HXT3Hxt3p0.016
SLD2Sld2p0.016
SRS2Srs2p0.015
PDR16Pdr16p0.015
YOR378Whypothetical protein0.015
MF(ALPHA)2Mf(alpha)2p0.015
HPF1Hpf1p0.015
PTI1Pti1p0.015
YOL013W-Ahypothetical protein0.015
RTT105Rtt105p0.015
SPL2Spl2p0.015
BSC1Bsc1p0.015
FMT1Fmt1p0.014
CPD1Cpd1p0.014
BIO2Bio2p0.014
MET8Met8p0.014
SCM4Scm4p0.014
DIC1Dic1p0.014
DPB2Dpb2p0.014
MFA2Mfa2p0.013
YHR035Whypothetical protein0.013
YAL037C-Ahypothetical protein0.013
MMP1Mmp1p0.013
PDS5Pds5p0.013
CHA1Cha1p0.013
YAL064Whypothetical protein0.013
DUN1Dun1p0.013
TFA1Tfa1p0.013
YPR096Chypothetical protein0.013
UPS3Ups3p0.013
ATO3Ato3p0.013
IZH4Izh4p0.013
TIR3Tir3p0.012
PTR2Ptr2p0.012
YKR075Chypothetical protein0.012
YIR035Chypothetical protein0.012
BNA4Bna4p0.012
OPT2Opt2p0.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.824
CHAF1Achromatin assembly factor 1, subunit A (p150)0.593
MCM5minichromosome maintenance complex component 50.520
RPA1replication protein A1, 70kDa0.233
MCM3minichromosome maintenance complex component 30.222
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.193
MCM7minichromosome maintenance complex component 70.103
FANCGFanconi anemia, complementation group G0.058
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.057
ORC1origin recognition complex, subunit 10.055
POLD2polymerase (DNA directed), delta 2, regulatory subunit 50kDa0.051
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.047
MCM2minichromosome maintenance complex component 20.046
BLMBloom syndrome, RecQ helicase-like0.045
CDK2cyclin-dependent kinase 20.036
POLEpolymerase (DNA directed), epsilon0.032
PRIM1primase, DNA, polypeptide 1 (49kDa)0.028
FOXM1forkhead box M10.026
RPA3replication protein A3, 14kDa0.023
NUDT1nudix (nucleoside diphosphate linked moiety X)-type motif 10.022
DNMT1DNA (cytosine-5-)-methyltransferase 10.021
PRIM2primase, DNA, polypeptide 2 (58kDa)0.020
TIMELESStimeless homolog (Drosophila)0.019
RNASEH2Aribonuclease H2, subunit A0.018
PCNAproliferating cell nuclear antigen0.017
NUP85nucleoporin 85kDa0.016
RPA2replication protein A2, 32kDa0.016
HAUS7HAUS augmin-like complex, subunit 70.016
FEN1flap structure-specific endonuclease 10.015
CDT1chromatin licensing and DNA replication factor 10.013
CCNE1cyclin E10.012
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.011
DTLdenticleless homolog (Drosophila)0.011
LIG1ligase I, DNA, ATP-dependent0.011
CDC6cell division cycle 6 homolog (S. cerevisiae)0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism