IMP: Integrative Multi-species Prediction

The network for 'mitotic chromosome condensation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitotic chromosome condensation

The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.

Saccharomyces cerevisiae

Name	Description	Probability
SMC4	Smc4p	0.971
SMC2	Smc2p	0.820
YCS4	Ycs4p	0.809
SMC3	Smc3p	0.735
YCG1	Ycg1p	0.664
BRN1	Brn1p	0.514
SMC1	Smc1p	0.507
PDS5	Pds5p	0.307
IRR1	Irr1p	0.220
SLK19	Slk19p	0.192
SCC2	Scc2p	0.075
POL2	Pol2p	0.044
ESC8	Esc8p	0.029
ALT2	Alt2p	0.028
TOF2	Tof2p	0.028
GEA2	Gea2p	0.026
SCC4	Scc4p	0.024
SRD1	Srd1p	0.024
SPO16	Spo16p	0.023
LEU2	Leu2p	0.022
YLR162W	hypothetical protein	0.022
YLR264C-A	hypothetical protein	0.022
RFC3	Rfc3p	0.020
MER1	Mer1p	0.020
YOL038C-A	hypothetical protein	0.020
STU1	Stu1p	0.018
ARG8	Arg8p	0.018
HO	Hop	0.018
YAR068W	hypothetical protein	0.018
ARP10	Arp10p	0.017
YLR042C	hypothetical protein	0.017
COS12	Cos12p	0.017
SPC97	Spc97p	0.016
POL3	Pol3p	0.016
YPR157W	hypothetical protein	0.016
ORC1	Orc1p	0.016
ATP6	Atp6p	0.016
NUF2	Nuf2p	0.015
USO1	Uso1p	0.015
CUP1-1	Cup1-1p	0.015
SPL2	Spl2p	0.015
CHL1	Chl1p	0.015
RDH54	Rdh54p	0.015
YIR035C	hypothetical protein	0.015
CBF2	Cbf2p	0.015
ESP1	Esp1p	0.015
ORC5	Orc5p	0.014
AUA1	Aua1p	0.014
RFC5	Rfc5p	0.014
SLI15	Sli15p	0.014
SPC42	Spc42p	0.014
URA3	Ura3p	0.014
HPF1	Hpf1p	0.014
FMT1	Fmt1p	0.014
ZPS1	Zps1p	0.014
YBR013C	hypothetical protein	0.014
BSC1	Bsc1p	0.014
YOL013W-A	hypothetical protein	0.013
HXT3	Hxt3p	0.013
KIP1	Kip1p	0.013
IZH4	Izh4p	0.013
RAD53	Rad53p	0.012
MIF2	Mif2p	0.012
SCM4	Scm4p	0.012
YLR040C	hypothetical protein	0.012
GYL1	Gyl1p	0.012
SMC6	Smc6p	0.012
SPS4	Sps4p	0.012
YPR096C	hypothetical protein	0.012
YJL181W	hypothetical protein	0.012
ADH2	Adh2p	0.012
MF(ALPHA)2	Mf(alpha)2p	0.012
CPD1	Cpd1p	0.011
CSM3	Csm3p	0.011
YPL067C	hypothetical protein	0.011
SGO1	Sgo1p	0.011
MF(ALPHA)1	Mf(alpha)1p	0.011
YAR066W	hypothetical protein	0.011
YAL037C-A	hypothetical protein	0.011
RNP1	Rnp1p	0.011
CTF3	Ctf3p	0.011
OPT2	Opt2p	0.011
DIC1	Dic1p	0.011
NRG2	Nrg2p	0.011
UPS3	Ups3p	0.011
PDS1	Pds1p	0.011
SWC7	Swc7p	0.011
YGR035C	hypothetical protein	0.010
NSE4	Nse4p	0.010
YAL064W	hypothetical protein	0.010
YGL006W-A	hypothetical protein	0.010
YIL151C	hypothetical protein	0.010

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Caenorhabditis elegans

Name	Description	Probability
prg-2	Protein PRG-2	0.055
glh-4	Protein GLH-4	0.030
dao-5	Protein DAO-5	0.029
mel-28	Protein MEL-28	0.029
wrm-1	Protein WRM-1	0.029
aspm-1	Protein ASPM-1	0.026
mcm-3	Protein MCM-3	0.022
mcm-7	Protein MCM-7	0.021
mcm-2	Protein MCM-2	0.020
rod-1	Protein ROD-1	0.020
ppw-2	Protein PPW-2	0.019
R05H10.3	Protein R05H10.3	0.019
klp-18	Protein KLP-18	0.018
rad-50	Protein RAD-50	0.018
R11A8.7	Protein R11A8.7	0.017
hsr-9	Protein HSR-9	0.017
zyg-9	Protein ZYG-9	0.017
dsh-2	Protein DSH-2	0.017
F31C3.3	Protein F31C3.3	0.017
CELE_Y48B6A.1	Protein Y48B6A.1	0.016
ttll-5	Protein TTLL-5	0.016
glh-1	Protein GLH-1	0.016
mcm-4	Protein MCM-4	0.016
F33H2.3	Protein F33H2.3	0.016
CELE_T02C12.3	Protein T02C12.3	0.016
mcm-5	Protein MCM-5	0.015
M57.1	Protein M57.1	0.015
K06A5.1	Protein K06A5.1	0.015
C18A3.3	Protein C18A3.3	0.014
csr-1	Protein CSR-1	0.014
hpo-32	Protein HPO-32	0.014
bub-1	Protein BUB-1	0.014
T12F5.2	Protein T12F5.2	0.014
ucr-2.3	Protein UCR-2.3	0.014
knl-1	Protein KNL-1	0.014
got-2.1	Protein GOT-2.1	0.013
acs-4	Protein ACS-4	0.013
F33H2.5	Protein F33H2.5	0.013
pqn-65	Protein PQN-65	0.013
nmy-2	Protein NMY-2	0.013
F32E10.5	Protein F32E10.5	0.013
xpo-2	Protein XPO-2	0.013
swsn-7	Protein SWSN-7	0.013
CELE_Y75B8A.25	Protein Y75B8A.25	0.012
plk-3	Protein PLK-3	0.012
rpl-11.1	Protein RPL-11.1	0.012
air-2	Protein AIR-2	0.012
C30G12.6	Protein C30G12.6	0.012
hpo-40	Protein HPO-40	0.012
set-16	Protein SET-16	0.012
unc-89	Protein UNC-89	0.012
klp-19	Protein KLP-19	0.012
inx-21	Protein INX-21	0.012
cbd-1	Protein CBD-1	0.012
Y47D3A.29	Protein Y47D3A.29	0.012
cin-4	Protein CIN-4	0.011
C53H9.2	Protein C53H9.2	0.011
npp-6	Protein NPP-6	0.011
F10B5.2	Protein F10B5.2	0.011
Y4C6B.1	Protein Y4C6B.1	0.011
C46A5.6	Protein C46A5.6	0.011
pgl-1	Protein PGL-1	0.011
cpb-1	Protein CPB-1	0.011
hcp-1	Protein HCP-1	0.011
rsa-1	Protein RSA-1	0.011
F54E12.2	Protein F54E12.2	0.010
CELE_F23C8.9	Protein F23C8.9	0.010
klp-15	Protein KLP-15	0.010
pdp-1	Protein PDP-1	0.010
cgh-1	Protein CGH-1	0.010
sna-2	Protein SNA-2	0.010
scc-3	Protein SCC-3	0.010
cdc-48.1	Protein CDC-48.1	0.010
rpn-2	Protein RPN-2	0.010
T07A9.14	Protein T07A9.14	0.010
hcp-2	Protein HCP-2	0.010
T08G11.4	Protein T08G11.4	0.010

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Danio rerio

Name	Description	Probability	Func Analog Organism

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Drosophila melanogaster

Name	Description	Probability
Orc2	Origin recognition complex subunit 2	0.988
RfC4	Replication factor C subunit 4	0.889
asp	abnormal spindle	0.827
mus209	mutagen-sensitive 209	0.795
Cap-G	CG34438 gene product from transcript CG34438-RF	0.698
ball	ballchen	0.624
barr	barren	0.618
dpa	disc proliferation abnormal	0.598
Klp61F	Kinesin-like protein at 61F	0.589
gwl	greatwall	0.507
BubR1	Bub1-related kinase	0.475
pav	pavarotti	0.416
l(1)dd4	lethal (1) discs degenerate 4	0.412
SMC2	CG10212 gene product from transcript CG10212-RA	0.394
woc	without children	0.367
pita	CG3941 gene product from transcript CG3941-RA	0.338
dup	double parked	0.301
egg	eggless	0.294
Cenp-C	CG31258 gene product from transcript CG31258-RA	0.286
Incenp	Inner centromere protein	0.257
Su(var)205	Suppressor of variegation 205	0.241
vtd	verthandi	0.238
mars	CG17064 gene product from transcript CG17064-RB	0.236
ncd	non-claret disjunctional	0.232
Orc5	Origin recognition complex subunit 5	0.211
CG13350	CG13350 gene product from transcript CG13350-RA	0.210
Ndc80	CG9938 gene product from transcript CG9938-RA	0.207
otu	ovarian tumor	0.194
cmet	CENP-meta	0.175
cav	caravaggio	0.171
polo	CG12306 gene product from transcript CG12306-RA	0.154
Mcm10	Sensitized chromosome inheritance modifier 19	0.151
jumu	jumeau	0.142
Spc25	CG7242 gene product from transcript CG7242-RA	0.140
hd	humpty dumpty	0.137
piwi	CG6122 gene product from transcript CG6122-RA	0.133
Su(var)2-10	Suppressor of variegation 2-10	0.133
CycB	Cyclin B	0.130
ash1	absent, small, or homeotic discs 1	0.130
swa	swallow	0.125
CycB3	Cyclin B3	0.118
Spc105R	Spc105-related	0.116
Klp67A	Kinesin-like protein at 67A	0.111
pzg	putzig	0.107
NiPp1	Nuclear inhibitor of Protein phosphatase 1	0.103
stg	string	0.091
Sse	Separase	0.088
aub	aubergine	0.084
Mcm6	Minichromosome maintenance 6	0.080
Klp3A	Kinesin-like protein at 3A	0.079
mrn	marionette	0.077
mael	maelstrom	0.076
msl-3	male-specific lethal 3	0.074
spn-E	spindle E	0.069
Orc1	Origin recognition complex subunit 1	0.065
Cdc27	CG8610 gene product from transcript CG8610-RA	0.064
vas	vasa	0.064
cid	centromere identifier	0.063
Su(var)3-7	Suppressor of variegation 3-7	0.056
Sas-4	CG10061 gene product from transcript CG10061-RA	0.055
pds5	CG17509 gene product from transcript CG17509-RA	0.055
neb	nebbish	0.053
lat	latheo	0.053
Dhc64C	Dynein heavy chain 64C	0.052
Slbp	Stem-loop binding protein	0.049
Mcm5	Minichromosome maintenance 5	0.049
mus101	mutagen-sensitive 101	0.048
SuUR	Suppressor of Under-Replication	0.046
tum	tumbleweed	0.045
rod	rough deal	0.044
zpg	zero population growth	0.044
kis	kismet	0.043
stwl	stonewall	0.042
Rpd3	CG7471 gene product from transcript CG7471-RA	0.042
Su(z)2	Suppressor of zeste 2	0.041
wisp	wispy	0.040
mus301	mutagen-sensitive 301	0.038
MBD-like	CG8208 gene product from transcript CG8208-RA	0.038
Orc6	Origin recognition complex subunit 6	0.037
RhoGAP54D	CG6477 gene product from transcript CG6477-RA	0.036
Caf1-105	CG12892 gene product from transcript CG12892-RA	0.034
mxc	multi sex combs	0.033
Kmn1	kinetochore Mis12-Ndc80 network component 1	0.032
Hmr	Hybrid male rescue	0.032
Klp10A	CG1453 gene product from transcript CG1453-RA	0.031
pim	pimples	0.031
cnn	centrosomin	0.031
orb	oo18 RNA-binding protein	0.029
His2Av	Histone H2A variant	0.029
png	pan gu	0.028
Suv4-20	CG13363 gene product from transcript CG13363-RA	0.028
SmD3	Small ribonucleoprotein particle protein SmD3	0.027
Nek2	CG17256 gene product from transcript CG17256-RA	0.027
Su(var)3-3	Suppressor of variegation 3-3	0.027
sub	subito	0.026
SelD	Selenide,water dikinase	0.026
Mcm2	Minichromosome maintenance 2	0.026
esc	extra sexcombs	0.026
JIL-1	CG6297 gene product from transcript CG6297-RA	0.025
Cdc37	CG12019 gene product from transcript CG12019-RA	0.025

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Homo sapiens

Name	Description	Probability
SMC4	structural maintenance of chromosomes 4	0.925
NCAPD2	non-SMC condensin I complex, subunit D2	0.889
NCAPH	non-SMC condensin I complex, subunit H	0.786
NCAPG	non-SMC condensin I complex, subunit G	0.705
ORC4	origin recognition complex, subunit 4	0.682
SMC2	structural maintenance of chromosomes 2	0.580
RAD21	RAD21 homolog (S. pombe)	0.225
NCAPH2	non-SMC condensin II complex, subunit H2	0.217
ORC1	origin recognition complex, subunit 1	0.098
TRIP6	thyroid hormone receptor interactor 6	0.091
ORC3	origin recognition complex, subunit 3	0.062
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.037
NCAPG2	non-SMC condensin II complex, subunit G2	0.037
PARP1	poly (ADP-ribose) polymerase 1	0.033
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.029
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.028
CKAP5	cytoskeleton associated protein 5	0.027
BIRC5	baculoviral IAP repeat containing 5	0.021
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.020
KPNA2	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	0.020
RACGAP1	Rac GTPase activating protein 1	0.019
MKI67	antigen identified by monoclonal antibody Ki-67	0.019
KIF20A	kinesin family member 20A	0.018
CDCA8	cell division cycle associated 8	0.016
TACC3	transforming, acidic coiled-coil containing protein 3	0.015
SFPQ	splicing factor proline/glutamine-rich	0.015
KIF11	kinesin family member 11	0.014
GPSM2	G-protein signaling modulator 2	0.013
CDK1	cyclin-dependent kinase 1	0.013
LBR	lamin B receptor	0.012
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.011
AURKA	aurora kinase A	0.011
WHSC1	Wolf-Hirschhorn syndrome candidate 1	0.010
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.010

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Mus musculus

Name	Description	Probability
Hoxa10	homeobox A10	1.000
Hoxa9	homeobox A9	0.998
Hoxd10	homeobox D10	0.994
Hoxc10	homeobox C10	0.976
Prc1	protein regulator of cytokinesis 1	0.955
Ccnb1	cyclin B1	0.890
Ccna2	cyclin A2	0.859
Cdk1	cyclin-dependent kinase 1	0.779
Hoxd9	homeobox D9	0.657
Plk4	polo-like kinase 4 (Drosophila)	0.655
Hoxd8	homeobox D8	0.629
Kif11	kinesin family member 11	0.604
Hoxd3	homeobox D3	0.604
Hoxc8	homeobox C8	0.589
Cdc7	cell division cycle 7 (S. cerevisiae)	0.547
Kif2c	kinesin family member 2C	0.541
2810417H13Rik	RIKEN cDNA 2810417H13 gene	0.540
Hoxb9	homeobox B9	0.538
Anln	anillin, actin binding protein	0.498
Ckap2	cytoskeleton associated protein 2	0.471
Pnn	pinin	0.470
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.462
Plk1	polo-like kinase 1 (Drosophila)	0.424
Ncaph	non-SMC condensin I complex, subunit H	0.405
Kif4	kinesin family member 4	0.388
Tcf12	transcription factor 12	0.383
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.382
Cdca8	cell division cycle associated 8	0.373
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.333
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.329
Haus3	HAUS augmin-like complex, subunit 3	0.329
Chek2	CHK2 checkpoint homolog (S. pombe)	0.319
Iqgap3	IQ motif containing GTPase activating protein 3	0.290
Kif22	kinesin family member 22	0.287
Cenpk	centromere protein K	0.286
Top2a	topoisomerase (DNA) II alpha	0.271
Ttk	Ttk protein kinase	0.261
Kif20a	kinesin family member 20A	0.251
Meis1	Meis homeobox 1	0.247
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.224
Aurkb	aurora kinase B	0.221
Aurka	aurora kinase A	0.206
Dtl	denticleless homolog (Drosophila)	0.203
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.186
Mis18bp1	MIS18 binding protein 1	0.178
Mael	maelstrom homolog (Drosophila)	0.172
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.171
Parp2	poly (ADP-ribose) polymerase family, member 2	0.166
Trim59	tripartite motif-containing 59	0.163
Hoxc4	homeobox C4	0.159
Upf3b	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.158
Mxd3	Max dimerization protein 3	0.153
Hnrnpr	heterogeneous nuclear ribonucleoprotein R	0.152
Hoxa11	homeobox A11	0.151
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.150
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.149
Tcf19	transcription factor 19	0.148
Gtse1	G two S phase expressed protein 1	0.147
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.147
Fam64a	family with sequence similarity 64, member A	0.126
Gmnn	geminin	0.125
Myef2	myelin basic protein expression factor 2, repressor	0.123
Orc4	origin recognition complex, subunit 4	0.121
Kif23	kinesin family member 23	0.119
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.116
Smc2	structural maintenance of chromosomes 2	0.114
Cdkn3	cyclin-dependent kinase inhibitor 3	0.114
Tacc3	transforming, acidic coiled-coil containing protein 3	0.110
E2f1	E2F transcription factor 1	0.109
Rad51ap1	RAD51 associated protein 1	0.107
Cdt1	chromatin licensing and DNA replication factor 1	0.105
Gsg2	germ cell-specific gene 2	0.103
Mybl2	myeloblastosis oncogene-like 2	0.103
Incenp	inner centromere protein	0.102
Hmgb2	high mobility group box 2	0.101
Orc1	origin recognition complex, subunit 1	0.099
Rasa1	RAS p21 protein activator 1	0.098
Ccnb2	cyclin B2	0.098
Dusp9	dual specificity phosphatase 9	0.098
Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	0.098
Cdc45	cell division cycle 45 homolog (S. cerevisiae)	0.097
Ccdc99	coiled-coil domain containing 99	0.093
Racgap1	Rac GTPase-activating protein 1	0.091
Wdhd1	WD repeat and HMG-box DNA binding protein 1	0.089
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.089
Rbbp6	retinoblastoma binding protein 6	0.089
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.088
Cenpa	centromere protein A	0.087
Brca1	breast cancer 1	0.083
Pola1	polymerase (DNA directed), alpha 1	0.082
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.082
Ube2t	ubiquitin-conjugating enzyme E2T (putative)	0.081
Cdca5	cell division cycle associated 5	0.081
Eri2	exoribonuclease 2	0.081
Kif2a	kinesin family member 2A	0.080
Birc5	baculoviral IAP repeat-containing 5	0.079
Blm	Bloom syndrome, RecQ helicase-like	0.078
Xpo1	exportin 1, CRM1 homolog (yeast)	0.078
Topbp1	topoisomerase (DNA) II binding protein 1	0.076
Exo1	exonuclease 1	0.074

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Rattus norvegicus

Name	Description	Probability	Func Analog Organism