The network for 'pentose phosphate shunt' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

pentose phosphate shunt

The process in which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses.

Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
GND1Gnd1p0.793
TAL1Tal1p0.324
TKL2Tkl2p0.143
ERG13Erg13p0.105
ALD6Ald6p0.058
YCL042Whypothetical protein0.056
URA6Ura6p0.053
YNL024Chypothetical protein0.043
GND2Gnd2p0.040
SPE3Spe3p0.035
PFK1Pfk1p0.031
COA3Coa3p0.030
ADH6Adh6p0.029
HXK2Hxk2p0.027
YLR264C-Ahypothetical protein0.027
PDI1Pdi1p0.027
GRE2Gre2p0.025
SRD1Srd1p0.025
URA3Ura3p0.024
LEU2Leu2p0.023
IMD2Imd2p0.023
YDR034W-Bhypothetical protein0.023
ALD4Ald4p0.022
CUP1-1Cup1-1p0.021
YLR162Whypothetical protein0.020
YMR315Whypothetical protein0.020
CAR2Car2p0.020
ARP10Arp10p0.020
TSA2Tsa2p0.019
YOL038C-Ahypothetical protein0.019
LEU4Leu4p0.019
MER1Mer1p0.019
PRO3Pro3p0.019
NCA3Nca3p0.018
YBR016Whypothetical protein0.018
PFK2Pfk2p0.018
CCP1Ccp1p0.018
ARG8Arg8p0.017
ADE17Ade17p0.017
IPP1Ipp1p0.017
YAH1Yah1p0.017
FBA1Fba1p0.016
YLR042Chypothetical protein0.016
MDH2Mdh2p0.016
YIR035Chypothetical protein0.016
ADH1Adh1p0.016
YAR068Whypothetical protein0.016
YPR172Whypothetical protein0.016
HOM6Hom6p0.015
GPD2Gpd2p0.015
GCY1Gcy1p0.015
SUT2Sut2p0.015
HPF1Hpf1p0.015
CIS3Cis3p0.015
YJL118Whypothetical protein0.015
ADK1Adk1p0.015
CWP1Cwp1p0.015
OPT2Opt2p0.015
ATP6Atp6p0.014
MRH1Mrh1p0.014
SPS100Sps100p0.014
YPR157Whypothetical protein0.014
PHO3Pho3p0.014
HBT1Hbt1p0.014
REE1Ree1p0.014
CPD1Cpd1p0.014
PRS2Prs2p0.014
AUA1Aua1p0.014
YOL013W-Ahypothetical protein0.014
SPL2Spl2p0.014
ITR2Itr2p0.014
HXT3Hxt3p0.014
MF(ALPHA)2Mf(alpha)2p0.014
YTP1Ytp1p0.014
FPR1Fpr1p0.014
SCM4Scm4p0.013
YBR013Chypothetical protein0.013
YPR114Whypothetical protein0.013
BSC1Bsc1p0.013
ZPS1Zps1p0.013
RTN2Rtn2p0.013
FMT1Fmt1p0.013
PTR2Ptr2p0.013
ADH2Adh2p0.013
PYK2Pyk2p0.013
PDC5Pdc5p0.013
YNL058Chypothetical protein0.013
SWC7Swc7p0.013
SOL3Sol3p0.013
AQY1Aqy1p0.013
DIC1Dic1p0.012
YPL067Chypothetical protein0.012
YPL247Chypothetical protein0.012
GNP1Gnp1p0.012
ERR3Err3p0.012
IZH4Izh4p0.012
PUT4Put4p0.012
YLR040Chypothetical protein0.012
LRO1Lro1p0.012
OLA1Ola1p0.012
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
GAPDHglyceraldehyde-3-phosphate dehydrogenase0.081
ALDOAaldolase A, fructose-bisphosphate0.033
PGK1phosphoglycerate kinase 10.024
ENO1enolase 1, (alpha)0.014
TPI1triosephosphate isomerase 10.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Aldoaaldolase A, fructose-bisphosphate0.996
Gm5506predicted gene 55060.982
Pgk1phosphoglycerate kinase 10.930
Pkm2pyruvate kinase, muscle0.900
Pgdphosphogluconate dehydrogenase0.844
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.834
Ldhalactate dehydrogenase A0.817
Tpi1triosephosphate isomerase 10.606
Taldo1transaldolase 10.531
Gpi1glucose phosphate isomerase 10.421
Slc25a5solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 50.282
Tkttransketolase0.247
Hsd11b1hydroxysteroid 11-beta dehydrogenase 10.207
Pfklphosphofructokinase, liver, B-type0.125
Prelid1PRELI domain containing 10.085
H6pdhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)0.065
Fasnfatty acid synthase0.053
Sepn1selenoprotein N, 10.049
Garsglycyl-tRNA synthetase0.045
Ak2adenylate kinase 20.045
Hphaptoglobin0.034
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.034
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.033
Fmo5flavin containing monooxygenase 50.030
Hsd3b7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 70.028
Pgam1phosphoglycerate mutase 10.027
G6pdxglucose-6-phosphate dehydrogenase X-linked0.027
AclyATP citrate lyase0.024
Apoeapolipoprotein E0.022
Mpdu1mannose-P-dolichol utilization defect 10.022
Pnppurine-nucleoside phosphorylase0.020
Lrg1leucine-rich alpha-2-glycoprotein 10.020
Tuba1btubulin, alpha 1B0.019
Lrrc59leucine rich repeat containing 590.019
Ldlrlow density lipoprotein receptor0.018
Cscitrate synthase0.018
Scarb1scavenger receptor class B, member 10.018
Slc2a1solute carrier family 2 (facilitated glucose transporter), member 10.017
Acsl5acyl-CoA synthetase long-chain family member 50.016
C3complement component 30.016
Galk1galactokinase 10.016
Mdh2malate dehydrogenase 2, NAD (mitochondrial)0.015
Acsl1acyl-CoA synthetase long-chain family member 10.015
Asnsasparagine synthetase0.015
Plin2perilipin 20.015
Hsd17b12hydroxysteroid (17-beta) dehydrogenase 120.015
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.014
Aarsalanyl-tRNA synthetase0.014
Pdk3pyruvate dehydrogenase kinase, isoenzyme 30.013
Psat1phosphoserine aminotransferase 10.013
Ppa1pyrophosphatase (inorganic) 10.013
Srebf1sterol regulatory element binding transcription factor 10.012
Sfxn1sideroflexin 10.012
Lbplipopolysaccharide binding protein0.012
Ltbrlymphotoxin B receptor0.012
Tspotranslocator protein0.012
Narsasparaginyl-tRNA synthetase0.011
Xdhxanthine dehydrogenase0.011
NadkNAD kinase0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
LOC1003636626-phosphogluconate dehydrogenase, decarboxylating-like0.478
Eno1enolase 1, (alpha)0.103
Cd151CD151 molecule (Raph blood group)0.039
Fabp5fatty acid binding protein 5, epidermal0.035
Tkttransketolase0.034
Ctsbcathepsin B0.025
Syap1synapse associated protein 10.022
Fasnfatty acid synthase0.019
Pgam1phosphoglycerate mutase 1 (brain)0.015