The network for 'regulation of protein metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

NameDescriptionProbabilityFunc Analog Organism
NPL3Npl3p0.874
BCK1Bck1p0.835
SLT2Slt2p0.801
PPH21Pph21p0.775
GLC7Glc7p0.730
SNF4Snf4p0.728
PBS2Pbs2p0.712
SNF1Snf1p0.675
SRO9Sro9p0.639
NBP2Nbp2p0.630
PIL1Pil1p0.610
EFT1Eft1p0.589
CDC28Cdc28p0.583
CLB6Clb6p0.581
CLB3Clb3p0.572
DEF1Def1p0.539
RDH54Rdh54p0.528
SGV1Sgv1p0.518
KSP1Ksp1p0.506
HHO1Hho1p0.502
RSP5Rsp5p0.495
STE7Ste7p0.485
PPH22Pph22p0.473
MOT2Mot2p0.471
CDC55Cdc55p0.459
CTR9Ctr9p0.457
STE20Ste20p0.455
SUI3Sui3p0.437
BMH2Bmh2p0.427
COQ3Coq3p0.402
MAD2Mad2p0.399
FUS3Fus3p0.398
SIC1Sic1p0.393
MYO5Myo5p0.392
PUB1Pub1p0.377
CKA1Cka1p0.377
MPS1Mps1p0.376
SMC3Smc3p0.366
HSL1Hsl1p0.357
STE11Ste11p0.352
BOI1Boi1p0.347
PHO85Pho85p0.346
SUS1Sus1p0.342
SPT6Spt6p0.339
CKS1Cks1p0.334
PHB1Phb1p0.333
NOP1Nop1p0.316
RTF1Rtf1p0.306
CDC20Cdc20p0.305
WWM1Wwm1p0.304
YBP2Ybp2p0.298
ARX1Arx1p0.298
SIT4Sit4p0.283
CDC16Cdc16p0.283
CDC11Cdc11p0.278
SOK1Sok1p0.272
PBP4Pbp4p0.270
AEP1Aep1p0.268
SPT16Spt16p0.266
CRZ1Crz1p0.265
AFT1Aft1p0.265
BMH1Bmh1p0.261
PAF1Paf1p0.255
RPT6Rpt6p0.252
HCR1Hcr1p0.251
CLN2Cln2p0.250
GBP2Gbp2p0.249
TEF2Tef2p0.247
RPS11BRps11bp0.246
YME1Yme1p0.245
DSK2Dsk2p0.243
CKB1Ckb1p0.243
SOD1Sod1p0.243
UBP10Ubp10p0.242
SHO1Sho1p0.241
HRR25Hrr25p0.241
FUN12Fun12p0.239
SSE1Sse1p0.237
BCK2Bck2p0.235
SMT3Smt3p0.235
RTS1Rts1p0.235
SCH9Sch9p0.234
CTF13Ctf13p0.229
TIF4632Tif4632p0.227
HYP2Hyp2p0.223
BRE5Bre5p0.222
IME2Ime2p0.221
DCC1Dcc1p0.219
RPB11Rpb11p0.218
CTK2Ctk2p0.215
SSK1Ssk1p0.213
ATG1Atg1p0.209
SWI5Swi5p0.207
UBP8Ubp8p0.205
NDT80Ndt80p0.202
ATG4Atg4p0.201
STI1Sti1p0.200
GCN5Gcn5p0.199
GSC2Gsc2p0.198
PAT1Pat1p0.198
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
mbk-2Protein MBK-20.549
npp-7Protein NPP-70.447
zyg-8Protein ZYG-80.428
mpk-1Protein MPK-10.422
pry-1Protein PRY-10.363
mex-3Protein MEX-30.339
atn-1Protein ATN-10.337
egl-18Protein EGL-180.296
F26B1.2Protein F26B1.20.276
unc-40Protein UNC-400.272
par-5Protein PAR-50.269
vab-3Protein VAB-30.247
klp-18Protein KLP-180.224
sur-2Protein SUR-20.214
CELE_C17E4.6Protein C17E4.60.209
klp-15Protein KLP-150.202
ntl-4Protein NTL-40.197
vab-1Protein VAB-10.193
mdf-2Protein MDF-20.193
pha-4Protein PHA-40.191
M03C11.6Protein M03C11.60.188
ttx-1Protein TTX-10.186
cam-1Protein CAM-10.186
tam-1Protein TAM-10.179
rps-2Protein RPS-20.178
hpo-32Protein HPO-320.176
T28F4.1Protein T28F4.10.171
asb-1Protein ASB-10.169
sma-6Protein SMA-60.164
mex-5Protein MEX-50.159
CELE_C25A1.4Protein C25A1.40.157
egl-27Protein EGL-270.151
F36D4.5Protein F36D4.50.149
dsh-2Protein DSH-20.149
rla-1Protein RLA-10.148
F21A10.2Protein F21A10.20.143
lmn-1Protein LMN-10.141
pdr-1Protein PDR-10.140
atg-2Protein ATG-20.139
gld-1Protein GLD-10.139
sas-5Protein SAS-50.139
let-502Protein LET-5020.138
ZC506.1Protein ZC506.10.138
smp-1Protein SMP-10.137
daf-1Protein DAF-10.137
ina-1Protein INA-10.136
sel-10Protein SEL-100.134
mut-7Protein MUT-70.134
tct-1Protein TCT-10.133
cdl-1Protein CDL-10.132
pgl-1Protein PGL-10.131
lin-11Protein LIN-110.130
F07A11.2Protein F07A11.20.130
T28D9.4Protein T28D9.40.129
nhr-6Protein NHR-60.125
lntl-1Protein LNTL-10.125
pas-4Protein PAS-40.125
F09G2.8Protein F09G2.80.124
dep-1Protein DEP-10.124
C56G2.7Protein C56G2.70.119
swsn-6Protein SWSN-60.119
C27H2.2Protein C27H2.20.118
lin-53Protein LIN-530.117
mei-1Protein MEI-10.117
skn-1Protein SKN-10.116
lin-25Protein LIN-250.114
F31D4.2Protein F31D4.20.112
chd-7Protein CHD-70.111
R186.7Protein R186.70.111
R11A8.7Protein R11A8.70.110
plc-1Protein PLC-10.109
eif-3.BProtein EIF-3.B0.109
tiar-1Protein TIAR-10.106
mig-38Protein MIG-380.105
xnp-1Protein XNP-10.105
R90.1Protein R90.10.104
madf-5Protein MADF-50.104
C14C10.5Protein C14C10.50.103
brp-1Protein BRP-10.102
daf-6Protein DAF-60.102
nmy-2Protein NMY-20.101
CELE_Y24F12A.1Protein Y24F12A.10.100
mec-2Protein MEC-20.099
rhgf-2Protein RHGF-20.099
aak-2Protein AAK-20.099
dmd-6Protein DMD-60.099
hda-1Protein HDA-10.098
CELE_F54D5.9Protein F54D5.90.097
Y119C1A.1Protein Y119C1A.10.097
rla-0Protein RLA-00.096
mdt-1.2Protein MDT-1.20.095
imb-2Protein IMB-20.095
cki-2Protein CKI-20.095
xpo-2Protein XPO-20.095
tbb-1Protein TBB-10.094
epn-1Protein EPN-10.094
mel-11Protein MEL-110.093
ceh-20Protein CEH-200.093
his-24Protein HIS-240.092
nhr-34Protein NHR-340.092
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
wnt2bbwingless-type MMTV integration site family, member 2Bb0.711
spry4sprouty (Drosophila) homolog 40.451
rarabretinoic acid receptor, alpha b0.425
baxabcl2-associated X protein, a0.348
dag1dystroglycan 10.329
foxi1forkhead box I10.291
ndr2nodal-related 20.284
dccdeleted in colorectal carcinoma0.277
fgfr1afibroblast growth factor receptor 1a0.269
tardbpTAR DNA binding protein0.260
ef1aelongation factor 1-alpha0.259
nap1l1nucleosome assembly protein 1, like 10.246
bmp4bone morphogenetic protein 40.238
wnt1wingless-type MMTV integration site family, member 10.237
oepone-eyed pinhead0.233
fzd7afrizzled homolog 7a0.228
pou5f1POU domain, class 5, transcription factor 10.225
wnt10awingless-type MMTV integration site family, member 10a0.223
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.223
ctnnb1catenin (cadherin-associated protein), beta 10.222
fgfr3fibroblast growth factor receptor 30.216
aurkbaurora kinase B0.206
wu:fv91b12wu:fv91b120.205
evx1even-skipped homeobox 10.197
fzd5frizzled homolog 50.196
si:ch211-212m21.5si:ch211-212m21.50.193
pax2apaired box gene 2a0.193
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.192
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.187
osr1odd-skipped related 1 (Drosophila)0.186
fgf17fibroblast growth factor 170.182
psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.181
tfectranscription factor EC0.181
bmp2bbone morphogenetic protein 2b0.177
chd7chromodomain helicase DNA binding protein 70.171
ccnb1cyclin B10.168
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.162
tbpl2TATA box binding protein like 20.161
apoebapolipoprotein Eb0.159
plcg1phospholipase C, gamma 10.158
eif4a1aeukaryotic translation initiation factor 4A, isoform 1A0.156
nanos3nanos homolog 30.152
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.151
smc1alstructural maintenance of chromosomes 1A, like0.146
her6hairy-related 60.146
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.142
csnk1dacasein kinase 1, delta a0.139
id1inhibitor of DNA binding 10.138
pcnaproliferating cell nuclear antigen0.136
igf1rbinsulin-like growth factor 1b receptor0.135
lin28alin-28 homolog A (C. elegans)0.135
wnt3awingless-type MMTV integration site family, member 3A0.132
per3period homolog 3 (Drosophila)0.132
tcf12transcription factor 120.130
mgaMAX gene associated0.130
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.128
ube2naubiquitin-conjugating enzyme E2Na0.125
dzip1DAZ interacting protein 10.124
ptenaphosphatase and tensin homolog A0.123
eif3haeukaryotic translation initiation factor 3, subunit H, a0.121
gata5GATA-binding protein 50.120
spns2spinster homolog 2 (Drosophila)0.120
chdchordin0.119
dharmadharma0.119
dedd1death effector domain-containing 10.119
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.117
bactin2bactin20.115
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.114
per2period homolog 2 (Drosophila)0.114
aldocbaldolase C, fructose-bisphosphate, b0.113
ywhaqatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a0.112
eif4e1beukaryotic translation initiation factor 4e 1b0.112
nrp1aneuropilin 1a0.111
bhmtbetaine-homocysteine methyltransferase0.109
cdh1cadherin 1, epithelial0.108
osr2odd-skipped related 2 (Drosophila)0.107
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.107
hhiphedgehog interacting protein0.106
wnt5awingless-type MMTV integration site family, member 5a0.106
mcl1amyeloid cell leukemia sequence 1a0.105
pea3ETS-domain transcription factor pea30.105
tlr3toll-like receptor 30.104
raraaretinoic acid receptor, alpha a0.103
vaspvasodilator-stimulated phosphoprotein0.101
ca15bcarbonic anhydrase XV b0.100
btg2B-cell translocation gene 20.099
xbp1X-box binding protein 10.098
shhasonic hedgehog a0.098
runx2arunt-related transcription factor 2a0.098
runx2brunt-related transcription factor 2b0.095
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.095
pax6apaired box gene 6a0.093
largelike-glycosyltransferase0.093
atp2b4ATPase, Ca++ transporting, plasma membrane 40.093
brd2abromodomain-containing 2a0.091
furinafurin (paired basic amino acid cleaving enzyme) a0.090
gdf6agrowth differentiation factor 6a0.090
zfyve26zinc finger, FYVE domain containing 260.089
coro1acoronin, actin binding protein, 1A0.089
pycardPYD and CARD domain containing0.089
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.998
EgfrEpidermal growth factor receptor0.996
Akt1CG4006 gene product from transcript CG4006-RA0.992
MadMothers against dpp0.992
Fmr1CG6203 gene product from transcript CG6203-RC0.984
drkdownstream of receptor kinase0.978
Rho1CG8416 gene product from transcript CG8416-RB0.974
rlrolled0.965
exexpanded0.955
PtenCG5671 gene product from transcript CG5671-RB0.955
par-1CG8201 gene product from transcript CG8201-RA0.953
nejnejire0.950
EcREcdysone receptor0.931
agoarchipelago0.930
Ras85DRas oncogene at 85D0.928
kaykayak0.927
InRInsulin-like receptor0.924
wtswarts0.918
bratbrain tumor0.910
G-oalpha47AG protein oalpha 47A0.909
msnmisshapen0.909
Su(H)Suppressor of Hairless0.905
pucpuckered0.901
p53CG33336 gene product from transcript CG33336-RB0.899
CycGCyclin G0.895
Rac1CG2248 gene product from transcript CG2248-RA0.894
Atg1Autophagy-specific gene 10.891
rdxroadkill0.873
belbelle0.860
MoeMoesin0.848
nmonemo0.835
S6kRPS6-p70-protein kinase0.834
Socs36ESuppressor of cytokine signaling at 36E0.825
JraJun-related antigen0.823
shotshort stop0.821
cazcabeza0.821
PknProtein kinase related to protein kinase N0.809
ctpcut up0.807
lokloki0.805
dppdecapentaplegic0.795
shnschnurri0.794
spasspastin0.786
dmdiminutive0.785
Galpha49BG protein alpha49B0.779
cactcactus0.777
ThorCG8846 gene product from transcript CG8846-RA0.764
RhebCG1081 gene product from transcript CG1081-RA0.742
notnon-stop0.715
CaMKIICalcium/calmodulin-dependent protein kinase II0.715
Plc21CPhospholipase C at 21C0.712
CG9772CG9772 gene product from transcript CG9772-RB0.708
numbCG3779 gene product from transcript CG3779-RB0.707
rinrasputin0.703
Hsp83Heat shock protein 830.698
Lis-1Lissencephaly-10.698
DadDaughters against dpp0.695
CkIIalphaCasein kinase II alpha subunit0.692
mtsmicrotubule star0.679
twstwins0.667
dncdunce0.664
putpunt0.664
cicubitus interruptus0.658
ththread0.650
Src42ASrc oncogene at 42A0.650
rutrutabaga0.647
Rab5Rab-protein 50.646
hipkhomeodomain interacting protein kinase0.641
flwflapwing0.640
tsrtwinstar0.637
poloCG12306 gene product from transcript CG12306-RA0.636
bchsblue cheese0.631
Klp10ACG1453 gene product from transcript CG1453-RA0.629
AGO1Argonaute-10.626
tkvthickveins0.625
trctricornered0.624
SoxNSoxNeuro0.623
Dap160Dynamin associated protein 1600.620
Sin3ACG8815 gene product from transcript CG8815-RC0.619
AblAbl tyrosine kinase0.618
CycACyclin A0.611
rprreaper0.609
Cdc42CG12530 gene product from transcript CG12530-RA0.600
RanBPMRan-binding protein M0.599
Rab11Rab-protein 110.580
prosprospero0.573
Tab2TAK1-associated binding protein 20.571
Dcr-2Dicer-20.568
MybMyb oncogene-like0.562
fzfrizzled0.562
CakiCalcium/calmodulin-dependent protein kinase0.562
Rac2CG8556 gene product from transcript CG8556-RA0.538
CSN8COP9 complex homolog subunit 80.535
ttktramtrack0.533
HLHm7E(spl) region transcript m70.529
parkparkin0.529
CG9705CG9705 gene product from transcript CG9705-RA0.528
JIL-1CG6297 gene product from transcript CG6297-RA0.524
gishgilgamesh0.522
kluklumpfuss0.520
chicoCG5686 gene product from transcript CG5686-RB0.519
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Egr1early growth response 10.794
Calcrlcalcitonin receptor-like0.784
Junbjun B proto-oncogene0.765
Zfp36zinc finger protein 360.723
Hsp90b1heat shock protein 90, beta, member 10.654
Hsph1heat shock 105/110 protein 10.637
Eef2eukaryotic translation elongation factor 20.584
Stip1stress-induced phosphoprotein 10.584
Dusp1dual specificity phosphatase 10.583
Rap1bRAP1B, member of RAS oncogene family0.580
Dlg1discs, large homolog 1 (Drosophila)0.573
Olr1496olfactory receptor 14960.542
Myo1bmyosin Ib0.540
FosFBJ osteosarcoma oncogene0.539
Akt1v-akt murine thymoma viral oncogene homolog 10.531
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.529
Il1r1interleukin 1 receptor, type I0.529
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.514
Mapk3mitogen activated protein kinase 30.513
Mapk1mitogen activated protein kinase 10.505
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.487
Btg2BTG family, member 20.449
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.441
Ccnd3cyclin D30.437
Homer1homer homolog 1 (Drosophila)0.414
Prss1protease, serine, 1 (trypsin 1)0.397
Rtn4reticulon 40.385
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.385
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.374
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.373
Iappislet amyloid polypeptide0.371
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.367
Errfi1ERBB receptor feedback inhibitor 10.366
Arpc1bactin related protein 2/3 complex, subunit 1B0.366
Metmet proto-oncogene0.365
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.363
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.362
Jak1Janus kinase 10.352
Stat5bsignal transducer and activator of transcription 5B0.351
Casp2caspase 20.348
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.347
Fkbp4FK506 binding protein 40.347
Egr2early growth response 20.341
Gna12guanine nucleotide binding protein (G protein) alpha 120.341
Anxa5annexin A50.340
Casp3caspase 30.337
Mapk9mitogen-activated protein kinase 90.335
Utrnutrophin0.334
Lgals2lectin, galactoside-binding, soluble, 20.330
Fgfr2fibroblast growth factor receptor 20.328
Sod3superoxide dismutase 3, extracellular0.326
Mtpnmyotrophin0.322
Dnm1ldynamin 1-like0.322
Atp6v1fATPase, H transporting, lysosomal V1 subunit F0.322
Apohapolipoprotein H (beta-2-glycoprotein I)0.319
Pdia3protein disulfide isomerase family A, member 30.313
Ptpn1protein tyrosine phosphatase, non-receptor type 10.308
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.304
Nckap1NCK-associated protein 10.303
Anxa4annexin A40.303
Ptprqprotein tyrosine phosphatase, receptor type, Q0.301
Jak2Janus kinase 20.301
Itm2bintegral membrane protein 2B0.298
Pzppregnancy-zone protein0.297
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.295
Nrp1neuropilin 10.294
Prkcdprotein kinase C, delta0.294
JunJun oncogene0.292
Nrp2neuropilin 20.292
Exoc5exocyst complex component 50.287
Ube2d3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.285
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.284
Cxcl2chemokine (C-X-C motif) ligand 20.283
Pthlhparathyroid hormone-like hormone0.282
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.282
Sgk1serum/glucocorticoid regulated kinase 10.282
Ube2hubiquitin-conjugating enzyme E2H0.279
Dnajb1DnaJ (Hsp40) homolog, subfamily B, member 10.279
Usf2upstream transcription factor 2, c-fos interacting0.276
Dynll1dynein light chain LC8-type 10.273
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.263
Homer3homer homolog 3 (Drosophila)0.262
Tp53tumor protein p530.262
S1pr2sphingosine-1-phosphate receptor 20.262
Stat3signal transducer and activator of transcription 30.259
Gzmkgranzyme K0.257
Scarb1scavenger receptor class B, member 10.256
Tlr4toll-like receptor 40.255
Atp12aATPase, H+/K+ transporting, nongastric, alpha polypeptide0.252
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.252
Nek9NIMA (never in mitosis gene a)- related kinase 90.252
Vav1vav 1 guanine nucleotide exchange factor0.251
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.242
Crip2cysteine-rich protein 20.241
Myh9myosin, heavy chain 9, non-muscle0.241
Socs3suppressor of cytokine signaling 30.241
Spink1serine peptidase inhibitor, Kazal type 10.239
Trib1tribbles homolog 1 (Drosophila)0.239
Maoamonoamine oxidase A0.237
Ppp3cbprotein phosphatase 3, catalytic subunit, beta isoform0.237