The network for 'positive regulation of protein metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

NameDescriptionProbabilityFunc Analog Organism
PBS2Pbs2p0.910
HOG1Hog1p0.605
HSL1Hsl1p0.570
SNF1Snf1p0.427
BMH1Bmh1p0.376
CDC28Cdc28p0.313
BCK1Bck1p0.303
CLA4Cla4p0.301
CLB3Clb3p0.257
SIC1Sic1p0.255
RPP1BRpp1bp0.247
NBP2Nbp2p0.243
LSM1Lsm1p0.234
STE7Ste7p0.226
RSP5Rsp5p0.216
PAF1Paf1p0.208
IMD3Imd3p0.202
CDC12Cdc12p0.202
PPH3Pph3p0.190
PDE2Pde2p0.180
CKS1Cks1p0.177
ECM29Ecm29p0.174
AEP1Aep1p0.173
CTK2Ctk2p0.162
GIC1Gic1p0.158
SLX5Slx5p0.152
SLT2Slt2p0.152
LEO1Leo1p0.145
SIP1Sip1p0.142
MGE1Mge1p0.142
CKA2Cka2p0.141
CDC16Cdc16p0.137
KSS1Kss1p0.137
MSG5Msg5p0.131
PHO85Pho85p0.128
CDC10Cdc10p0.126
UBP6Ubp6p0.123
RIM13Rim13p0.120
CLB1Clb1p0.119
MRM1Mrm1p0.117
RTF1Rtf1p0.116
PAN1Pan1p0.115
MAM3Mam3p0.115
SET2Set2p0.112
CDC55Cdc55p0.110
RHO1Rho1p0.108
RPP2ARpp2ap0.107
STE5Ste5p0.105
RPP1ARpp1ap0.102
HYP2Hyp2p0.102
HIR1Hir1p0.102
DIA2Dia2p0.101
CLB6Clb6p0.100
TIF4632Tif4632p0.100
TPS1Tps1p0.100
PTP2Ptp2p0.099
TEF1Tef1p0.098
ZDS2Zds2p0.098
RPT6Rpt6p0.098
CTR9Ctr9p0.097
KSP1Ksp1p0.097
SDS22Sds22p0.095
YGR126Whypothetical protein0.094
CLB2Clb2p0.093
DAP1Dap1p0.093
HOP1Hop1p0.093
TEC1Tec1p0.091
STE12Ste12p0.090
PSP2Psp2p0.089
LIP2Lip2p0.089
CLB5Clb5p0.088
PTC1Ptc1p0.087
CKA1Cka1p0.087
ATG4Atg4p0.086
SPT16Spt16p0.085
TOR1Tor1p0.085
ERO1Ero1p0.084
SOK1Sok1p0.082
EFT1Eft1p0.082
RPS23ARps23ap0.081
RPB11Rpb11p0.081
MSH4Msh4p0.079
AHP1Ahp1p0.079
KOG1Kog1p0.079
SNF3Snf3p0.079
HSV2Hsv2p0.078
CDC13Cdc13p0.078
CDC23Cdc23p0.077
NSR1Nsr1p0.076
CBK1Cbk1p0.076
RAD53Rad53p0.076
BCK2Bck2p0.076
UBA1Uba1p0.076
LSG1Lsg1p0.076
DOM34Dom34p0.076
TDH2Tdh2p0.075
HFM1Hfm1p0.075
FUS3Fus3p0.075
DED1Ded1p0.075
CRZ1Crz1p0.075
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.381
his-24Protein HIS-240.124
unc-43Protein UNC-430.112
CELE_Y106G6H.6Protein Y106G6H.60.110
T28F4.1Protein T28F4.10.110
cam-1Protein CAM-10.107
par-5Protein PAR-50.102
ntl-4Protein NTL-40.098
sna-1Protein SNA-10.097
K10D6.4Protein K10D6.40.094
nhr-34Protein NHR-340.092
nhr-6Protein NHR-60.084
sur-2Protein SUR-20.084
sma-6Protein SMA-60.077
mel-26Protein MEL-260.074
lin-11Protein LIN-110.073
lin-36Protein LIN-360.068
F21A10.2Protein F21A10.20.067
abl-1Protein ABL-10.066
F07A11.2Protein F07A11.20.063
sel-12Protein SEL-120.062
sel-10Protein SEL-100.062
rps-2Protein RPS-20.061
spk-1Protein SPK-10.061
daf-1Protein DAF-10.060
C48B4.10Protein C48B4.100.060
mcm-7Protein MCM-70.057
T09B4.5Protein T09B4.50.056
ham-1Protein HAM-10.056
R11A8.7Protein R11A8.70.055
ZK507.6Protein ZK507.60.054
mig-38Protein MIG-380.053
mbk-2Protein MBK-20.051
T02G5.12Protein T02G5.120.051
pgl-1Protein PGL-10.051
ced-4Protein CED-40.050
spat-3Protein SPAT-30.050
F22D3.2Protein F22D3.20.049
cdl-1Protein CDL-10.048
pap-1Protein PAP-10.048
cks-1Protein CKS-10.048
ifg-1Protein IFG-10.047
let-60Protein LET-600.046
vab-3Protein VAB-30.046
mel-11Protein MEL-110.046
csn-1Protein CSN-10.046
swan-2Protein SWAN-20.046
mom-2Protein MOM-20.045
R02F2.5Protein R02F2.50.045
uaf-1Protein UAF-10.044
lin-53Protein LIN-530.044
zyg-9Protein ZYG-90.044
C34F6.10Protein C34F6.100.043
sta-1Protein STA-10.043
gsy-1Protein GSY-10.043
gei-8Protein GEI-80.043
thoc-2Protein THOC-20.042
cnt-2Protein CNT-20.042
eea-1Protein EEA-10.041
C11E4.6Protein C11E4.60.041
frm-7Protein FRM-70.041
cul-2Protein CUL-20.041
rgs-7Protein RGS-70.041
dsh-2Protein DSH-20.040
plc-1Protein PLC-10.040
hcf-1Protein HCF-10.040
ten-1Protein TEN-10.040
B0336.3Protein B0336.30.040
rpt-2Protein RPT-20.039
ahcy-1Protein AHCY-10.039
fkh-2Protein FKH-20.039
trr-1Protein TRR-10.039
zyg-1Protein ZYG-10.038
cas-1Protein CAS-10.038
lag-1Protein LAG-10.038
sli-1Protein SLI-10.038
atg-2Protein ATG-20.038
tim-1Protein TIM-10.037
egl-13Protein EGL-130.036
lin-37Protein LIN-370.036
zfp-3Protein ZFP-30.036
eya-1Protein EYA-10.035
zfp-1Protein ZFP-10.035
pry-1Protein PRY-10.035
pup-2Protein PUP-20.035
Y54E5A.7Protein Y54E5A.70.035
akt-2Protein AKT-20.035
mat-3Protein MAT-30.035
daf-2Protein DAF-20.035
C14C10.5Protein C14C10.50.035
rps-9Protein RPS-90.034
iff-1Protein IFF-10.034
epn-1Protein EPN-10.034
zif-1Protein ZIF-10.034
pkc-3Protein PKC-30.034
ceh-27Protein CEH-270.033
rnr-1Protein RNR-10.033
pde-2Protein PDE-20.033
afd-1Protein AFD-10.033
glp-1Protein GLP-10.033
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.475
ccnb1cyclin B10.260
fgfr3fibroblast growth factor receptor 30.247
fzd7afrizzled homolog 7a0.211
bmp2bbone morphogenetic protein 2b0.210
fn1fibronectin 10.209
wu:fv91b12wu:fv91b120.204
smad9MAD homolog 9 (Drosophila)0.203
fzd7bfrizzled homolog 7b0.167
pou5f1POU domain, class 5, transcription factor 10.165
piwil1piwi-like 1 (Drosophila)0.160
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.156
si:ch211-212m21.5si:ch211-212m21.50.146
ihhaIndian hedgehog homolog a0.142
pkd2polycystic kidney disease 20.134
fgfr1afibroblast growth factor receptor 1a0.132
acvr2aactivin receptor IIa0.117
orgoogenesis-related gene0.110
chdchordin0.110
vasavasa homolog0.100
nanos3nanos homolog 30.098
bcl2B-cell leukemia/lymphoma 20.096
wnt2bbwingless-type MMTV integration site family, member 2Bb0.096
otpaorthopedia homolog a0.095
wnt10awingless-type MMTV integration site family, member 10a0.091
kdrlkinase insert domain receptor like0.088
foxi1forkhead box I10.088
epas1bendothelial PAS domain protein 1b0.087
wnt1wingless-type MMTV integration site family, member 10.080
amotl2aangiomotin like 2a0.079
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.078
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.077
baxabcl2-associated X protein, a0.076
mcl1amyeloid cell leukemia sequence 1a0.074
tp53bp2tumor protein p53 binding protein, 20.074
her6hairy-related 60.073
per3period homolog 3 (Drosophila)0.071
wnt11rwingless-type MMTV integration site family, member 11, related0.069
alcamaactivated leukocyte cell adhesion molecule a0.066
pea3ETS-domain transcription factor pea30.065
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.063
leprleptin receptor0.062
pak1p21/Cdc42/Rac1-activated kinase 10.060
rargaretinoic acid receptor gamma a0.060
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.059
dkk1bdickkopf 1b0.056
arf2ADP-ribosylation factor 20.054
mmp2matrix metalloproteinase 20.053
bidaBH3 interacting domain death agonist0.053
rarabretinoic acid receptor, alpha b0.052
zfyve26zinc finger, FYVE domain containing 260.051
bmp7bbone morphogenetic protein 7b0.050
gro1groucho 10.050
tagln2transgelin 20.048
sox11bSRY-box containing gene 11b0.048
bcl2l10BCL2-like 10 (apoptosis facilitator)0.048
lmx1b.1LIM homeobox transcription factor 1, beta 10.047
sox32SRY-box containing gene 320.047
oepone-eyed pinhead0.047
e2f5E2F transcription factor 50.047
eporerythropoietin receptor0.046
col8a1acollagen, type VIII, alpha 1a0.046
ptk2.1protein tyrosine kinase 2a0.046
fesfeline sarcoma oncogene0.045
cdh1cadherin 1, epithelial0.045
nrp2bneuropilin 2b0.044
ck2bcasein kinase 2 beta0.043
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.043
wnt9awingless-type MMTV integration site family, member 9A0.043
klf2bKruppel-like factor 2b0.042
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.042
tbpl2TATA box binding protein like 20.041
hgfbhepatocyte growth factor b0.041
dharmadharma0.041
LOC566708FL cytokine receptor-like0.041
mstnbmyostatin b0.041
id1inhibitor of DNA binding 10.041
wnt4awingless-type MMTV integration site family, member 4a0.041
ahcyS-adenosylhomocysteine hydrolase0.040
aurkbaurora kinase B0.040
bbc3BCL2 binding component 30.040
ube2iubiquitin-conjugating enzyme E2I0.040
traf4atnf receptor-associated factor 4a0.040
wnt3awingless-type MMTV integration site family, member 3A0.040
tnfrsfatumor necrosis factor receptor superfamily, member a0.039
sp2sp2 transcription factor0.039
egr2bearly growth response 2b0.038
osr2odd-skipped related 2 (Drosophila)0.038
pknox1.2pbx/knotted 1 homeobox 1.20.038
fbln4fibulin 40.038
rargbretinoic acid receptor, gamma b0.038
ptgs2aprostaglandin-endoperoxide synthase 2a0.037
hoxd4ahomeo box D4a0.037
fzd5frizzled homolog 50.037
ifnphi1interferon phi 10.037
igf1rainsulin-like growth factor 1a receptor0.037
wnt10bwingless-type MMTV integration site family, member 10b0.037
irf6interferon regulatory factor 60.037
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.037
cyt1type I cytokeratin, enveloping layer0.037
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.996
Akt1CG4006 gene product from transcript CG4006-RA0.948
bratbrain tumor0.923
twstwins0.888
sggshaggy0.868
wgwingless0.760
poloCG12306 gene product from transcript CG12306-RA0.759
Sin3ACG8815 gene product from transcript CG8815-RC0.751
rlrolled0.749
rapretina aberrant in pattern0.738
slmbsupernumerary limbs0.729
Su(H)Suppressor of Hairless0.715
spasspastin0.703
stcksteamer duck0.667
kluklumpfuss0.663
Lis-1Lissencephaly-10.629
exdextradenticle0.627
RYBPRing and YY1 Binding Protein0.627
Pi3K92ECG4141 gene product from transcript CG4141-RB0.625
exexpanded0.613
shnschnurri0.612
dapdacapo0.597
drkdownstream of receptor kinase0.568
CycECyclin E0.561
giggigas0.533
Cdc42CG12530 gene product from transcript CG12530-RA0.530
ThorCG8846 gene product from transcript CG8846-RA0.523
bskbasket0.518
Fmr1CG6203 gene product from transcript CG6203-RC0.510
MadMothers against dpp0.508
SaraSmad anchor for receptor activation0.498
belbelle0.488
Fcp1CG12252 gene product from transcript CG12252-RA0.487
Atg1Autophagy-specific gene 10.483
S6kRPS6-p70-protein kinase0.475
bowlbrother of odd with entrails limited0.468
cicubitus interruptus0.462
CkIIalphaCasein kinase II alpha subunit0.460
effeffete0.433
piepineapple eye0.433
PknProtein kinase related to protein kinase N0.427
lwrlesswright0.421
eyaeyes absent0.418
bunbunched0.417
rprreaper0.403
Stat92ESignal-transducer and activator of transcription protein at 92E0.394
Dhc64CDynein heavy chain 64C0.393
CycACyclin A0.389
putpunt0.388
Cul-5Cullin-50.386
chicoCG5686 gene product from transcript CG5686-RB0.381
InRInsulin-like receptor0.379
HsfHeat shock factor0.376
Ino80CG31212 gene product from transcript CG31212-RA0.376
wtswarts0.371
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.369
Mekk1CG7717 gene product from transcript CG7717-RB0.362
RelRelish0.356
panpangolin0.351
tkvthickveins0.345
E(spl)Enhancer of split0.341
pydpolychaetoid0.339
grogroucho0.337
agoarchipelago0.330
SerSerrate0.322
aopanterior open0.319
cazcabeza0.318
kiskismet0.314
babobaboon0.313
DabDisabled0.312
TctpTranslationally controlled tumor protein0.310
Pk61CProtein kinase 61C0.308
Dcp-1Death caspase-10.306
Su(var)205Suppressor of variegation 2050.306
LLobe0.303
trctricornered0.296
drprdraper0.293
jarjaguar0.292
Mef2Myocyte enhancer factor 20.291
HLHmgammaE(spl) region transcript mgamma0.286
Vps35Vacuolar protein sorting 350.269
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.262
RagACG11968 gene product from transcript CG11968-RA0.261
JraJun-related antigen0.260
ykiyorkie0.260
par-1CG8201 gene product from transcript CG8201-RA0.259
McrMacroglobulin complement-related0.255
SmoxSmad on X0.255
Mov34CG3416 gene product from transcript CG3416-RA0.246
14-3-3epsilonCG31196 gene product from transcript CG31196-RA0.244
mbcmyoblast city0.239
G-salpha60AG protein salpha 60A0.238
PvrPDGF- and VEGF-receptor related0.238
DadDaughters against dpp0.233
htlheartless0.232
auxauxillin0.231
RhebCG1081 gene product from transcript CG1081-RA0.230
S6kIIRPS6-protein kinase-II0.229
Dsp1Dorsal switch protein 10.226
brmbrahma0.223
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gzmkgranzyme K0.458
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.405
Ccr5chemokine (C-C motif) receptor 50.363
Jak2Janus kinase 20.338
Trim47tripartite motif-containing 470.296
HrasHarvey rat sarcoma virus oncogene0.288
Iappislet amyloid polypeptide0.279
S1pr2sphingosine-1-phosphate receptor 20.272
Ptafrplatelet-activating factor receptor0.270
Tpc1808tropic 18080.268
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.267
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.264
Ednrbendothelin receptor type B0.262
Gja1gap junction protein, alpha 10.257
Mapk1mitogen activated protein kinase 10.256
Ccl3chemokine (C-C motif) ligand 30.253
Jak1Janus kinase 10.242
Il1r1interleukin 1 receptor, type I0.241
Adora2aadenosine A2a receptor0.240
RGD1564664similar to LOC387763 protein0.222
Adam17ADAM metallopeptidase domain 170.222
Ncf4neutrophil cytosolic factor 40.214
Mpeg1macrophage expressed 10.213
Eef2eukaryotic translation elongation factor 20.212
Cdc42cell division cycle 42 (GTP binding protein)0.210
Mapre1microtubule-associated protein, RP/EB family, member 10.204
Arpc1bactin related protein 2/3 complex, subunit 1B0.203
Prkcdprotein kinase C, delta0.202
Gata4GATA binding protein 40.199
Myo1bmyosin Ib0.198
Ncr1natural cytotoxicity triggering receptor 10.194
Muskmuscle, skeletal, receptor tyrosine kinase0.194
Cd4Cd4 molecule0.190
Slco2a1solute carrier organic anion transporter family, member 2a10.188
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.186
Ghrgrowth hormone receptor0.185
Casp3caspase 30.181
Atxn1ataxin 10.179
S100a8S100 calcium binding protein A80.178
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.173
Cd38CD38 molecule0.172
Ccnd1cyclin D10.171
Vcanversican0.171
Mapk14mitogen activated protein kinase 140.167
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.166
Grm5glutamate receptor, metabotropic 50.165
Rgs12regulator of G-protein signaling 120.164
Adarb2adenosine deaminase, RNA-specific, B20.160
Gipgastric inhibitory polypeptide0.160
Agtr1aangiotensin II receptor, type 1a0.155
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.155
Cdc37cell division cycle 37 homolog (S. cerevisiae)0.153
Olr1496olfactory receptor 14960.153
Ptprqprotein tyrosine phosphatase, receptor type, Q0.151
RorbRAR-related orphan receptor B0.150
Olr416olfactory receptor 4160.149
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.148
Ncanneurocan0.146
Pde3aphosphodiesterase 3A, cGMP inhibited0.146
Egfrepidermal growth factor receptor0.145
Dchs1dachsous 1 (Drosophila)0.145
Has2hyaluronan synthase 20.145
Mr1major histocompatibility complex, class I-related0.145
Cmklr1chemokine-like receptor 10.144
CblCas-Br-M (murine) ecotropic retroviral transforming sequence0.144
Trhrthyrotropin releasing hormone receptor0.143
Ptpn1protein tyrosine phosphatase, non-receptor type 10.143
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.142
Vom2r32vomeronasal 2 receptor, 320.141
Hckhemopoietic cell kinase0.139
Ppp3cbprotein phosphatase 3, catalytic subunit, beta isoform0.139
Cd8aCD8a molecule0.139
Phkg1phosphorylase kinase, gamma 10.138
Anxa2annexin A20.136
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.135
Sox17SRY (sex determining region Y)-box 170.135
Arhgap4Rho GTPase activating protein 40.135
Inpp5dinositol polyphosphate-5-phosphatase D0.135
Creb1cAMP responsive element binding protein 10.135
Gna12guanine nucleotide binding protein (G protein) alpha 120.134
Dsppdentin sialophosphoprotein0.134
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.133
Psen1presenilin 10.133
Wdr26WD repeat domain 260.132
Cabin1calcineurin binding protein 10.132
Nedd4neural precursor cell expressed, developmentally down-regulated 40.130
LOC171573spleen protein 1 precursor0.130
Pftk1PFTAIRE protein kinase 10.129
Irs1insulin receptor substrate 10.128
Sirpasignal-regulatory protein alpha0.128
Smad1SMAD family member 10.127
Usf2upstream transcription factor 2, c-fos interacting0.127
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.127
Gab2GRB2-associated binding protein 20.127
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.126
Castcalpastatin0.126
Vegp2von Ebners gland protein 20.126
Nrp2neuropilin 20.125
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.125
Adaradenosine deaminase, RNA-specific0.123